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Cited by 287

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Enhanced Immunosuppressive Properties of Human Mesenchymal Stem Cells Primed by Interferon-γ

Open access
Kim, Dae Seong, Jang, In Keun, Lee, Myoung Woo, Ko, Young Jong, Lee, Doo-Hoon, Lee, Ji Won, Sung, Ki Woong, Koo, Hong Hoe, Yoo, Keon Hee·2018·EBioMedicine
DOI 10.1016/j.ebiom.2018.01.002
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Abstract

Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-related diseases owing to their immunosuppressive properties. In this study, we aimed to identify the effect of interferon (IFN)-γ priming on immunomodulation by MSCs and elucidate the possible mechanism underlying their properties for the clinical treatment of allogeneic conflicts. Infusion of MSCs primed with IFN-γ significantly reduced the symptoms of graft-versus-host disease (GVHD) in NOD-SCID mice, thereby increasing survival rate when compared with naïve MSC-infused mice. However, infusion of IFN-γ-primed MSCs in which indoleamine 2,3-dioxygenase (IDO) was downregulated did not elicit this effect. The IDO gene was expressed in MSCs via the IFN-γ-Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) pathway, and the infusion of IDO-over-expressing MSCs increased survival rate in an in vivo GVHD model, similar to infusion of IFN-γ-primed MSCs. These data indicate that IFN-γ production by activated T-cells is correlated with the induction of IDO expression in MSCs via the IFN-γ-JAK-STAT1 pathway, which in turn results in the suppression of T-cell proliferation. Our findings also suggest that cell therapy based on MSCs primed with IFN-γ can be used for the clinical treatment of allogeneic conflicts, including GVHD.

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Metadata

Authors
Kim, D. S., Jang, I. K., Lee, M. W., Ko, Y. J., Lee, D.-H., Lee, J. W., Sung, K. W., Koo, H. H., & Yoo, K. H.
Venue
EBioMedicine
Publisher
Elsevier BV
Published
2018-02
Volume
28
Pages
261-273
ISSN
2352-3964 (ISSN-L)
DOI
10.1016/j.ebiom.2018.01.002
OpenAlex
W2783211174
Cited by
287
References
45
FWCI
13.13
Type
journal article
Language
en
Open access
gold

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The paper
Kim, D. S., Jang, I. K., Lee, M. W., Ko, Y. J., Lee, D.-H., Lee, J. W., Sung, K. W., Koo, H. H., & Yoo, K. H. (2018). Enhanced Immunosuppressive Properties of Human Mesenchymal Stem Cells Primed by Interferon-γ. EBioMedicine. https://doi.org/10.1016/j.ebiom.2018.01.002

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.