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Cited by 712Mesenchymal stem cell researchPeriodontal Regeneration and TreatmentsHematopoietic Stem Cell Transplantation

Challenges and advances in clinical applications of mesenchymal stromal cells

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Zhou, Tian, Yuan, Zenan, Weng, Jianyu, Pei, Duanqing, Du, Xin, He, Chang, Lai, Peilong·2021·Journal of Hematology & Oncology
DOI 10.1186/s13045-021-01037-xPMC PMC7880217
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Abstract

Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been intensely investigated for clinical applications within the last decades. However, the majority of registered clinical trials applying MSC therapy for diverse human diseases have fallen short of expectations, despite the encouraging pre-clinical outcomes in varied animal disease models. This can be attributable to inconsistent criteria for MSCs identity across studies and their inherited heterogeneity. Nowadays, with the emergence of advanced biological techniques and substantial improvements in bio-engineered materials, strategies have been developed to overcome clinical challenges in MSC application. Here in this review, we will discuss the major challenges of MSC therapies in clinical application, the factors impacting the diversity of MSCs, the potential approaches that modify MSC products with the highest therapeutic potential, and finally the usage of MSCs for COVID-19 pandemic disease.

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  • High costs, regulatory concerns, and MSC sourcing variability limit widespread clinical adoption of MSC therapies.

    “However, logistical, and ethical challenges, including high costs, regulatory concerns, and MSC sourcing variability such as bone marrow-derived vs. adipose-derived MSCs, limit widespread clinical adoption [99].”

    From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [99]

    The Heterogeneity of MSCs section (page unavailable) describes differences between bone marrow- and adipose-derived MSCs, and the bench-to-bedside section links inconsistent MSC characteristics to clinical-development failures and FDA disapprovals. The paper mentions high costs specifically as a limitation of MSC priming approaches, not as a general barrier to adopting MSC therapies; it also does not identify the cited sourcing differences as an ethical challenge. (LLM, conf=0.84)

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Authors
Zhou, T., Yuan, Z., Weng, J., Pei, D., Du, X., He, C., & Lai, P.
Affiliations
  • Sun Yat-sen University (CN)
  • Third Affiliated Hospital of Sun Yat-sen University (CN)
  • Guangdong Academy of Medical Sciences (CN)
  • Guangzhou Institutes of Biomedicine and Health (CN)
Corresponding author
  • Du, Xin
  • He, Chang
  • Lai, Peilong
ORCID
Venue
Journal of Hematology & Oncology
Publisher
Springer Science and Business Media LLC
Published
2021-02-12
Volume
14
Issue
1
Pages
24-24
ISSN
1756-8722 (ISSN-L)
DOI
10.1186/s13045-021-01037-x
PMC
PMC7880217
OpenAlex
W3127853020
Cited by
712
References
8
Citations by year
2026: 101 · 2025: 196 · 2024: 180 · 2023: 131 · 2022: 80 · 2021: 24
FWCI
15.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Hematology & Oncology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Key Research and Development Project of China (2017YFE0131600)
  • National Natural Science Foundation of China (81870121, 81671585, 82070176, 81700825)
  • Natural Science Foundation of Guangdong Province (2019B151502006, 2019B020236004)
  • Science and Technology Program of Guangzhou (201906010076, 201803040005)
  • Science and Technology Planning Project of Guangdong Province (2017B020230004)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
mesenchymal stem cells, clinical translation, MSC heterogeneity, cell therapy, COVID-19 treatment
MeSH terms
Extracellular Vesicles, COVID-19, Animals, Artificial Intelligence, Cell Differentiation, Cell Movement, Clinical Trials as Topic, Genetic Engineering, Humans, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, CRISPR-Cas Systems

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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