Mitochondrial Dysfunction in Type 2 Diabetes and Obesity

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197

Global and societal implications of the diabetes epidemic

Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139

Adiponectin and Adiponectin Receptors

Kadowaki, T., & Yamauchi, T. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0005 · Cited by 2,634

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes

Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166

Metabolic control through the PGC-1 family of transcription coactivators

Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130

Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging

Zhang, H., Muhetarijiang, M., Chen, R. J., Hu, X., Han, J., Zheng, L., & Chen, T. (2024) · Aging and Disease · doi:10.14336/ad.2024.0058 · Cited by 12

Roux-en-Y gastric bypass improves glucose homeostasis, reduces oxidative stress and inflammation in livers of obese rats and in Kupffer cells via an AMPK-dependent pathway

Peng, Y., Li, J. Z., You, M., & Murr, M. M. (2017) · Surgery · doi:10.1016/j.surg.2017.01.012 · Cited by 10

Different Expression of Mitochondrial and Endoplasmic Reticulum Stress Genes in Epicardial Adipose Tissue Depends on Coronary Atherosclerosis

Kratochvílová, H., Mráz, M., Kasperová, B. J., Hlaváček, D., Mahrík, J., Laňková, I., Cinkajzlová, A., Matloch, Z., Lacinová, Z., Trnovská, J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094538 · Cited by 9

Influence of Nutritional Intake of Carbohydrates on Mitochondrial Structure, Dynamics, and Functions during Adipogenesis

Delcourt, M., Tagliatti, V., Delsinne, V., Colet, J., & Declèves, A. (2020) · Nutrients · doi:10.3390/nu12102984 · Cited by 8

Genetic Determinants of the Effects of Training on Muscle and Adipose Tissue Homeostasis in Obesity Associated with Lymphedema

Vettori, A., Paolacci, S., Maltese, P. E., Herbst, K. L., Cestari, M., Michelini, S., Michelini, S., Samaja, M., & Bertelli, M. (2020) · Lymphatic Research and Biology · doi:10.1089/lrb.2020.0057 · Cited by 8

mtDNA Single-Nucleotide Variants Associated with Type 2 Diabetes

Gaona, E. G., García-Gregorio, A., Jiménez, C. G., López-Olaiz, M. A., Mendoza-Ramírez, P., Fernandez‐Guzman, D., Sánchez, R. A. P., Pacheco, A. D. S., Zúñiga, L. Y., Parada, M. G. S., et al. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45110548 · Cited by 8

Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

Snogdal, L. S., Wod, M., Grarup, N., Vestmar, M. A., Sparsø, T., Jørgensen, T., Lauritzen, T., Beck‐Nielsen, H., Henriksen, J. E., Pedersen, O. B., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2377-0 · Cited by 7

Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants

Santos, A. L., & Sinha, S. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_15 · Cited by 8

Does diabetes affect the intensity of staining of interstitial cells and neuronal tissue in the bladder, prostate and urethra of rabbits?

Canda, A. E., Aktaş, S., Turna, B., & Çınar, M. (2009) · Open Medicine · doi:10.2478/s11536-009-0064-z · Cited by 7

The cross-talk between neurodegeneration and metabolic disorders

Emanuele, E., Minoretti, P., Yilmaz, Y. N., Khoramipour, K., Crespo‐Escobar, P., País, M. M., López‐Ortiz, S., Santos‐Lozano, A., & Lista, S. (2025) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2025.86 · Cited by 6

Chapter 5 Selective Enrichment in Phosphopeptides for the Identification of Phosphorylated Mitochondrial Proteins

Pòcsfalvi, G. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(09)05005-8 · Cited by 6

Allogenic Mitochondria and Associated Organelle Complex Treatment Attenuates High-Fat Diet-Induced Adipose Tissue Remodeling

Liu, T., Shimizu, Y., Ota, H., Hayashi, T., Luo, H., Che, Y., Matsuoka, Y., Tsai, R. C., Suganuma, M., & Murohara, T. (2025) · Circulation Reports · doi:10.1253/circrep.cr-25-0045 · Cited by 5

Linking Mitochondrial Function to Insulin Resistance: Focusing on Comparing the Old and the Young

Wang, J., Wu, J., Li, W., Wang, X., Liu, R., Liu, T., & Xiao, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.892719 · Cited by 5

Comparative effects of high-intensity interval training versus moderate-intensity continuous training on body composition and blood pressure in overweight adolescents: a systematic review and meta-analysis of randomized controlled trials

Li, X., Cui, Z., Tan, Z., Li, J., & Yang, C. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1636792 · Cited by 5

Whole body lipid oxidation during exercise is impaired with poor insulin sensitivity but not with obesity per se

Arad, A. D., DiMenna, F. J., Kittrell, H. D., Kissileff, H. R., & Albu, J. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00042.2022 · Cited by 4

Enhanced glucose utilization of skeletal muscle after 4 weeks of intermittent hypoxia in a mouse model of type 2 diabetes

Zhao, Y., Li, C., Zhou, S., He, Y., Wang, Y., Zhang, Y., & Wen, L. (2024) · PLoS ONE · doi:10.1371/journal.pone.0296815 · Cited by 4

Systemic modelling of human bioenergetics and blood circulation

Lim, K. M., Yang, S.-H., & Shim, E. B. (2012) · IET Systems Biology · doi:10.1049/iet-syb.2011.0035 · Cited by 2

Cell non-autonomous effect of hepatic growth differentiation factor 15 on the thyroid gland

Jeong, S., Lee, S. G., Kim, K. H., Zhu, X., Lee, W. K., Lee, H. Y., Park, S., Lee, M., Cheng, S.-Y., Lee, J., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.966644 · Cited by 2

Metabolism

Saghiv, M. S., & Sagiv, M. S. (2020) · Springer eBooks · doi:10.1007/978-3-030-48806-2_2 · Cited by 2

Modification of Cysteine Residues in Protein by Endogenous Oxidants and Electrophiles

Frizzell, N., & Baynes, J. (2009) · Wiley eBooks · doi:10.1002/9783527628100.ch2 · Cited by 2

Preventing Adipogenesis and Preserving Mitochondria and GLUT-4 Functions by Extracts and Isolated Compounds of Australian Acacia saligna

Asmara, A. P., Chen, H., & Ung, A. T. (2023) · Molecules · doi:10.3390/molecules28186677 · Cited by 1

Genomic Medicine and Obesity

Martínez, J. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374934-5.00051-9 · Cited by 1

mtDNA Single Nucleotide Variants Associated with Type 2 DiabetesPreprint

Gaona, E. G., García-Gregorio, A., Jiménez, C. G., López-Olaiz, M. A., Mendoza-Ramírez, P., Fernandez‐Guzman, D., Sánchez, R. A. P., Pacheco, A. D. S., Zúñiga, L. Y., Parada, M. G. S., et al. (2023) · Preprints.org · doi:10.20944/preprints202309.0086.v1

Subcellular proteomic profiling of human skeletal muscle reveals exercise-induced coordinated and compartment-specific protein remodelingPreprint

Reisman, E. G., Taylor, D. F., Yu, D., Huang, C., Bishop, D. J., Caruana, N. J., Hawley, J. A., & Hoffman, N. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.08.703653 · Cited by 1

Mitochondria‐Specific Mouse Gene Array and its Application in Toxicogenomics

Desai, V. G. (2009) · Wiley eBooks · doi:10.1002/9780470744307.gat209

Cellular functional roles of celastrol on mitochondrial dysfunction-induced insulin resistance

Bakar, A., & Bakar, M. H. A. (2015)

Utilising the therapeutic potential of xenin and related molecules for diabetes and obesity

Craig, S. L. (2020) · Ulster University Research Portal (Ulster University)

Efeitos da suplementação de coenzima q10 em mulheres com síndrome metabólica e esteatose hepática: ensaio clínico randomizado controlado duplo-cego

Casagrande, D. S. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2021.tde-11062021-075151

Diabetes, Obesity, and Oxidative Stress

Apostolova, N., Rafailovska, E., Dinevska-Ќovkarovska, S., & Miova, B. (2023) · Contemporary Endocrinology · doi:10.1007/978-3-031-39721-9_4

Association between Metabolic flexibility and Hepatic fat content in individuals with Non- alcoholic fatty liver diseasePreprint

Huang, W., He, Y., Ruan, W., Zhai, H., Lin, Y., Dai, X., Wang, T., Huo, C., Zhuang, J., & Jin, L. (2024) · Research Square · doi:10.21203/rs.3.rs-4336762/v1

Associations of dietary factors with amyotrophic lateral sclerosis: A Mendelian randomization study

Xu, F., Liu, H., Yin, Z., Xing, X., & Chen, X. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.01.042

Mitochondrial-derived peptides (Humanin, MOTS-c, and SHLP2) protect pancreatic islet cells and delay the onset and progression of type 2 diabetes mellitus in mice

Paul, T., Banerjee, O., Das, S., Maji, B. K., Goswami, S., & Mukherjee, S. (2026) · PharmaNutrition · doi:10.1016/j.phanu.2026.100480 · Cited by 1

Modulation of mitochondrial quality control in sepsis by traditional Chinese medicine: mechanistic insights and translational perspectives

Chang, M., Hu, D., Zhang, K., Liu, S., Xue, H., Zhu, Y., Chen, S., Liu, L., Wu, C., Fu, H., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1865750

The influence of body composition and physical activity on inflamm-aging, fatigue and function in older adults

Valentine, R. J., McAuley, E., Evans, E. M., Woods, J. A., & Dantzer, R. (2011) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Physiopathologie de l’insulinorésistance dans le muscle squelettique et implication des fonctions mitochondriales

Barquissau, V., & Morio, B. (2011) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2011.07.003 · Cited by 5

The role of mitochondrial function in skeletal muscle insulin resistance

Zhang, K., & Du, J. (2011) · Intern J Endocrinol Metab · doi:10.3760/cma.j.issn.1673-4157.2011.05.010

KS: Skeletal muscle mitochondrial dysfunction & diabetes

Sreekumar, R., & Nair, K. S. (2015)

Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus

Abdul-Ghani, M. A., & DeFronzo, R. A. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0030-1 · Cited by 146

Skeletal muscle mitochondrial dysfunction & diabetes.

Raghavakaimal, S., & Nair, K. S. (2007) · PubMed · Cited by 31