Cited by 135Metabolism, Diabetes, and CancerMitochondrial Function and PathologyAdipose Tissue and Metabolism

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Mitochondrial Dysfunction in Type 2 Diabetes and Obesity

Højlund, Kurt, Mogensen, Martin, Sahlin, Kent, Beck-Nielsen, Henning·2008·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2008.06.006

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Abstract

Insulin resistance in skeletal muscle is a major hallmark of type 2 diabetes mellitus (T2D) and obesity that is characterized by impaired insulin-mediated glucose transport and glycogen synthesis and by increased intramyocellular content of lipid metabolites. Several studies have provided evidence for mitochondrial dysfunction in skeletal muscle of type 2 diabetic and prediabetic subjects, primarily due to a lower content of mitochondria (mitochondrial biogenesis) and possibly to a reduced functional capacity per mitochondrion. This article discusses the latest advances in the understanding of the molecular mechanisms underlying insulin resistance in human skeletal muscle in T2D and obesity, with a focus on possible links between insulin resistance and mitochondrial dysfunction.

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Authors: Højlund, K., Mogensen, M., Sahlin, K., & Beck-Nielsen, H.
Affiliations: Odense University Hospital (DK)
University of Southern Denmark (DK)
Corresponding author: Højlund, Kurt
ORCID: Højlund, Kurt
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2008-09
Volume: 37
Issue: 3
Pages: 713-731
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2008.06.006
OpenAlex: W2107088422
Semantic Scholar: 31431014b8af686b99bb75eb8c7c784d89c4fca3
Cited by: 135
References: 102
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 12 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 7
FWCI: 0.95
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: Diabetesforeningen
Sundhed og Sygdom, Det Frie Forskningsråd
Novo Nordisk UK Research Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: mitochondrial dysfunction, type 2 diabetes, obesity, insulin resistance, skeletal muscle, mitochondrial biogenesis, glucose transport, glycogen synthesis, intramyocellular lipid, prediabetes
MeSH terms: Organelle Biogenesis, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Mitochondria, Obesity, Oxidation-Reduction, Proteomics

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Mitochondrial Dysfunction in Type 2 Diabetes and Obesity

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