The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Mitochondrial Dysfunction in Type 2 Diabetes and Obesity
Abstract
Insulin resistance in skeletal muscle is a major hallmark of type 2 diabetes mellitus (T2D) and obesity that is characterized by impaired insulin-mediated glucose transport and glycogen synthesis and by increased intramyocellular content of lipid metabolites. Several studies have provided evidence for mitochondrial dysfunction in skeletal muscle of type 2 diabetic and prediabetic subjects, primarily due to a lower content of mitochondria (mitochondrial biogenesis) and possibly to a reduced functional capacity per mitochondrion. This article discusses the latest advances in the understanding of the molecular mechanisms underlying insulin resistance in human skeletal muscle in T2D and obesity, with a focus on possible links between insulin resistance and mitochondrial dysfunction.
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In the citing paper
“suggest that this mitochondrial defect contributes to the increased intramyocellar fat content.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [19]
In the citing paper
“Recent studies have reported a mitochondrial defect in oxidative phosphorylation in skeletal muscle in variety of insulin resistant states.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [19]
Citations
Cites
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Adiponectin and Adiponectin Receptors
Kadowaki, T., & Yamauchi, T. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0005 · Cited by 2,634
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
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Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
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Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655
Pathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670
Comprehensive review on lactate metabolism in human health
Adeva‐Andany, M. M., López-Ojén, M., Funcasta-Calderón, R., Ameneiros-Rodríguez, E., Donapetry, C., Vila-Altesor, M., & Rodríguez-Seijas, J. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.05.007 · Cited by 636
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
Kendrick, A. A., Choudhury, M., Rahman, S. M., McCurdy, C. E., Friederich, M., Van Hove, J. L. K., Watson, P. A., Birdsey, N., Bao, J., Gius, D., et al. (2011) · Biochemical Journal · doi:10.1042/bj20100791 · Cited by 382
Bjørndal, B., Burri, L., Staalesen, V., Skorve, J., & Berge, R. K. (2011) · Journal of Obesity · doi:10.1155/2011/490650 · Cited by 395
Metadata
- Authors
- Højlund, K., Mogensen, M., Sahlin, K., & Beck-Nielsen, H.
- Affiliations
- Odense University Hospital (DK)
- University of Southern Denmark (DK)
- Corresponding author
- Højlund, Kurt
- ORCID
- Højlund, Kurt
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 37
- Issue
- 3
- Pages
- 713-731
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W2107088422
- Semantic Scholar
- 31431014b8af686b99bb75eb8c7c784d89c4fca3
- Cited by
- 135
- References
- 102
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 12 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 7
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- Diabetesforeningen
- Sundhed og Sygdom, Det Frie Forskningsråd
- Novo Nordisk UK Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- mitochondrial dysfunction, type 2 diabetes, obesity, insulin resistance, skeletal muscle, mitochondrial biogenesis, glucose transport, glycogen synthesis, intramyocellular lipid, prediabetes
- MeSH terms
- Organelle Biogenesis, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Mitochondria, Obesity, Oxidation-Reduction, Proteomics
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