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Vitamin D and Diabetes
Open accessAbstract
There has been increasing evidence that vitamin D may have a role in modifying risk of diabetes. Vitamin D has both direct and indirect effects on various mechanisms related to the pathophysiology of type 2 diabetes, including pancreatic beta cell dysfunction, impaired insulin action and systemic inflammation. This article describes the biologic plausibility behind the potential association between vitamin D and type 2 diabetes and summarizes the current evidence from human studies that suggests but does not prove a relation between vitamin D and type 2 diabetes, and briefly reports on the potential association between vitamin D and type 1 diabetes.
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“In addition, there is insufficient evidence to support the routine use of herbal supplements and micronutrients, such as cinnamon (220), curcumin, vitamin D (221), aloe vera, or chromium, to improve glycemia in people with diabetes (70,222).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:Standards of Care in Diabetes—2023 (2023) · cites this paper as [221]
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“Vitamin D reduces inflammation, and its levels exhibit an inverse relationship with T2DM-associated β-cell death and insulin resistance (Kazemi et al. 2022; Mitri and Pittas 2014), prompting its inclusion in the long-term treat-ment algorithm for T2DM.”
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Vitamin D Deficiency Adds an Element of Risk to Insulin Resistance in Colorectal Neoplasms
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Metadata
- Authors
- Mitri, J., & Pittas, A. G.
- Affiliations
- Tufts Medical Center (US)
- Corresponding author
- Mitri, Joanna
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 43
- Issue
- 1
- Pages
- 205-232
- ISSN
- 0889-8529 (ISSN-L)
- PMC
- PMC3942667
- OpenAlex
- W2001344972
- Cited by
- 258
- References
- 116
- Citations by year
- 2026: 15 · 2025: 19 · 2024: 31 · 2023: 22 · 2022: 36 · 2021: 24 · 2020: 17 · 2019: 21 · 2018: 21 · 2017: 17 · 2016: 19 · 2015: 13 · 2014: 3
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076092, U34DK091958, U01DK098245)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- vitamin D, type 2 diabetes, type 1 diabetes, diabetes risk, beta-cell dysfunction, insulin resistance, systemic inflammation, vitamin D supplementation
- MeSH terms
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Vitamin D
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