Cited by 258Vitamin D Research StudiesNutritional Studies and DietDiabetes Treatment and Management

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Vitamin D and Diabetes

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Mitri, Joanna, Pittas, Anastassios G.·2014·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2013.09.010PMC PMC3942667

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Abstract

There has been increasing evidence that vitamin D may have a role in modifying risk of diabetes. Vitamin D has both direct and indirect effects on various mechanisms related to the pathophysiology of type 2 diabetes, including pancreatic beta cell dysfunction, impaired insulin action and systemic inflammation. This article describes the biologic plausibility behind the potential association between vitamin D and type 2 diabetes and summarizes the current evidence from human studies that suggests but does not prove a relation between vitamin D and type 2 diabetes, and briefly reports on the potential association between vitamin D and type 1 diabetes.

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Background
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Background
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“Pre-clinical studies have shown that vitamin D plays a role in regulating insulin secretion and therefore could affect insulin sensitivity [35].”

Authors: Mitri, J., & Pittas, A. G.
Affiliations: Tufts Medical Center (US)
Corresponding author: Mitri, Joanna
ORCID: Mitri, Joanna
Pittas, Anastassios G.
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2014-03
Volume: 43
Issue: 1
Pages: 205-232
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2013.09.010
PMC: PMC3942667
OpenAlex: W2001344972
Cited by: 258
References: 116
Citations by year: 2026: 15 · 2025: 19 · 2024: 31 · 2023: 22 · 2022: 36 · 2021: 24 · 2020: 17 · 2019: 21 · 2018: 21 · 2017: 17 · 2016: 19 · 2015: 13 · 2014: 3
FWCI: 1.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076092, U34DK091958, U01DK098245)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: vitamin D, type 2 diabetes, type 1 diabetes, diabetes risk, beta-cell dysfunction, insulin resistance, systemic inflammation, vitamin D supplementation
MeSH terms: Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Vitamin D

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