RETRACTED: The anti-inflammatory activity of 1,25-dihydroxyvitamin D3 in macrophages
Abstract
In a previous study we demonstrated a down-regulatory effect of vitamin D active metabolite (1,25(OH)(2)D(3)) and its vitamin D(2) analog (1,24(OH)(2)D(2)) on TNFalpha expression in macrophages. We also found an inhibitory effect in the physiological concentration (10(-10)M) of 1,25(OH)(2)D(3) which was dose-dependent. This down-regulation, caused by the decrease in NFkappaB activity by 1,25(OH)(2)D(3) and 1,24(OH)(2)D(2), was demonstrated in P388D1 cells transfected with NFkappaB reporter gene (p NFkappaB-Luc) and by EMSA. In our present study we investigated the processes leading to reduced NFkappaB activity on P388D1 cells. A decrease in nuclei NFkappaB-p65 and an increase in cytosolic NFkappaB-p65, were measured, while no changes in total NFkappaB-p65 mRNA and protein levels were observed. Simultaneously, a significant increase in both mRNA and protein levels of the NFkappaB-cytosolic inhibitor, IkappaBalpha, were determined. The half-life of IkappaBalpha-mRNA increased, with a parallel decrease in the phosphorylation of its protein, as the first step of ubiquitinization and degradation. The present results demonstrate that 1,25(OH)(2)D(3) and 1,24(OH)(2)D(2) inhibit TNFalpha expression in macrophages, by increasing IkappaBalpha and decreasing NFkappaB activity. Since NFkappaB is a major transcription factor for TNFalpha and other inflammatory mediators, these findings suggest that 1,25(OH)(2)D(3) and 1,24(OH)(2)D(2) may be used therapeutically as anti-inflammatory agents.
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Reduced energy intake is paramount compared with the nature of low-energy food; decreased inflammatory markers occur with low-energy fat-rich and low-energy carbohydrate-rich diets.
“Early studies have shown that reduced energy intake is paramount compared with the nature of low-energy food, i.e. decreased concentrations of inflammatory markers are observed with a low-energy, fat-rich as well as with a low-energy, carbohydrate-rich diet (279) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [279]
Cites
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842 · see citing works
Signal transduction through NF-κB
May, M. J., & Ghosh, S. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01197-3 · Cited by 1,098 · see citing works
A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.Preprint
Baeuerle, P. A., & Baltimore, D. (1989) · Genes & Development · doi:10.1101/gad.3.11.1689 · Cited by 478 · see citing works
Vitamin D decreases NFκB activity by increasing IκBα levels
Cohen, M., Shany, S., Tobvin, D., Chaimovitz, C., & Douvdevani, A. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfi254 · Cited by 290 · see citing works
1,25-Dihydroxyvitamin D 3 Attenuates of Expression of Experimental Murine Lupus of MRL/1 Mice
Lemire, J. M., Ince, A., & Takashima, M. (1992) · Autoimmunity · doi:10.3109/08916939209150321 · Cited by 240 · see citing works
TNF-α Gene Expression in Macrophages: Regulation by NF-κB Is Independent of c-Jun or C/EBPβ
Liu, H., Sidiropoulos, P. I., Song, G., Pagliari, L. J., Birrer, M. J., Stein, B., Anrather, J., & Pope, R. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4277 · Cited by 209 · see citing works
Biology of tumor necrosis factor‐α– implications for psoriasis
Schottelius, A. J. G., Moldawer, L. L., Dinarello, C. A., Asadullah, K., Sterry, W., & Edwards, C. K. (2004) · Experimental Dermatology · doi:10.1111/j.0906-6705.2004.00205.x · Cited by 194 · see citing works
Complex NF-κB Interactions at the Distal Tumor Necrosis Factor Promoter Region in Human Monocytes
Udalova, I. A., Knight, J. C., Vidal, V., Nedospasov, S. A., & Kwiatkowski, D. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21178 · Cited by 118 · see citing works
Immunoregulation Through 1,25-Dihydroxyvitamin D 3 and its Analogs
May, E., Asadullah, K., & Zügel, U. (2004) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010042634596 · Cited by 85 · see citing works
Partial prevention of active Heymann nephritis by 1α, 25 dihydroxyvitamin D3
Branisteanu, D., Leenaerts, P. L., Damme, B. V., & Bouillon, R. (1993) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1993.tb08210.x · Cited by 75 · see citing works
Regulation of TNF-α by 1α,25-dihydroxyvitamin D3 in human macrophages from CAPD patients
Cohen, M., Douvdevani, A., Chaimovitz, C., & Shany, S. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00467.x · Cited by 63 · see citing works
Shany, S., Levy, Y., & Cohen, M. (2001) · Steroids · doi:10.1016/s0039-128x(00)00154-9 · Cited by 30 · see citing works
Metabolism of 25-OH-vitamin D3 by peritoneal macrophages from CAPD patients
Shany, S., Rapoport, J., Zuili, I., Gavriel, A., Lavi, N., & Chaimovitz, C. (1991) · Kidney International · doi:10.1038/ki.1991.127 · Cited by 18 · see citing works
DQ 65–79, a Peptide Derived from HLA Class II, Induces IκB Expression
Jiang, Y., Chen, D. S., Lyu, S., Ling, X. B., Krensky, A. M., & Clayberger, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3323 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Liu, E., Meigs, J. B., Pittas, A. G., McKeown, N. M., Economos, C. D., Booth, S. L., & Jacques, P. F. (2008) · Journal of Nutrition · doi:10.3945/jn.108.093831 · Cited by 310 · see citing works
Berry, D. J., Hesketh, K. R., Power, C., & Hyppönen, E. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001991 · Cited by 271 · see citing works
The effect of vitamin D on insulin resistance in patients with type 2 diabetes
Talaei, A., Mohamadi, M., & Adgi, Z. (2013) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-5-8 · Cited by 267 · see citing works
Vitamin D: emerging new roles in insulin sensitivity
Teegarden, D., & Donkin, S. S. (2009) · Nutrition Research Reviews · doi:10.1017/s0954422409389301 · Cited by 260 · see citing works
Serum 25‐hydroxyvitamin D and IgE – a significant but nonlinear relationship
Hyppönen, E., Berry, D. J., Wjst, M., & Power, C. (2009) · Allergy · doi:10.1111/j.1398-9995.2008.01865.x · Cited by 241 · see citing works
Mitri, J., & Pittas, A. G. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.010 · Cited by 258 · see citing works
Focus on Vitamin D, Inflammation and Type 2 Diabetes
Chagas, C. E. A., Borges, M. C., Martini, L. A., & Rogero, M. M. (2012) · Nutrients · doi:10.3390/nu4010052 · Cited by 217 · see citing works
Gröber, U., Spitz, J., Reichrath, J., Kisters, K., & Holick, M. F. (2013) · Dermato-Endocrinology · doi:10.4161/derm.26738 · Cited by 198 · see citing works
Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes
Marcotorchino, J., Gouranton, E., Romier, B., Tourniaire, F., Astier, J., Malezet‐Desmoulins, C., Amiot, M. J., & Landrier, J. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200383 · Cited by 155 · see citing works
Current perspectives on vitamin D, immune system, and chronic diseases
Borges, M. C., Martini, L. A., & Rogero, M. M. (2010) · Nutrition · doi:10.1016/j.nut.2010.07.022 · Cited by 139 · see citing works
Krishnan, A. V., & Feldman, D. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0139 · Cited by 136 · see citing works
Robien, K., Oppeneer, S. J., Kelly, J. A., & Hamilton‐Reeves, J. M. (2013) · Nutrition in Clinical Practice · doi:10.1177/0884533612467824 · Cited by 135 · see citing works
The impact of vitamin D deficiency on diabetes and cardiovascular risk
Baz-Hecht, M., & Goldfine, A. B. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283372859 · Cited by 135 · see citing works
Kim, M.-J., Frankel, A., Donaldson, M., Darch, S. J., Pusey, C. D., Hill, P. D., Mayr, M., & Tam, F. W. K. (2011) · Kidney International · doi:10.1038/ki.2011.224 · Cited by 133 · see citing works
Janjetovic, Z., Zmijewski, M. A., Tuckey, R. C., DeLeon, D. A., Nguyen, M. N., Pfeffer, L. M., & Slominski, A. T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005988 · Cited by 130 · see citing works
Ding, C., Wilding, J. P. H., & Chen, B. Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061707 · Cited by 117 · see citing works
Novel roles of vitamin D in disease: What is new in 2011?
Makariou, S. E., Liberopoulos, E. N., Elisaf, M., & Challa, A. S. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.04.012 · Cited by 116 · see citing works
Vitamin D Promotes Vascular Regeneration
Wong, M. S. K., Leisegang, M. S., Kruse, C., Vogel, J., Schürmann, C., Dehne, N., Weigert, A., Herrmann, E. M., Brüne, B., Shah, A. M., et al. (2014) · Circulation · doi:10.1161/circulationaha.114.010650 · Cited by 116 · see citing works
Possible renoprotection by vitamin D in chronic renal disease: beyond mineral metabolism
Doorenbos, C. R. C., van den Born, J., Navis, G. J., & de Borst, M. H. (2009) · Nature Reviews Nephrology · doi:10.1038/nrneph.2009.185 · Cited by 113 · see citing works
Cekic, M. M., Sayeed, I., & Stein, D. G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.002 · Cited by 109 · see citing works
Janjetovic, Z., Tuckey, R. C., Nguyen, M. N., Thorpe, E. M., & Slominski, A. T. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.21992 · Cited by 103 · see citing works
Vitamin D status is associated with sociodemographic factors, lifestyle and metabolic health
Jääskeläinen, T., Knekt, P., Marniemi, J., Sares‐Jäske, L., Männistö, S., Heliövaara, M., & Järvinen, R. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0354-0 · Cited by 103 · see citing works
Mackawy, A. M. H., & Badawy, M. E.-S. (2014) · Meta Gene · doi:10.1016/j.mgene.2014.07.002 · Cited by 93 · see citing works
Sacco, R. E., Nonnecke, B. J., Palmer, M. V., Waters, W. R., Lippolis, J. D., & Reinhardt, T. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033074 · Cited by 89 · see citing works
Inhibition of cytokine secretion from adipocytes by 1,25‐dihydroxyvitamin D 3 via the NF‐κB pathway
Mutt, S. J., Karhu, T., Lehtonen, S. T., Lehenkari, P. P., Carlberg, C., Saarnio, J., Sebert, S. P., Hyppönen, E., Järvelin, M., & Herzig, K. (2012) · The FASEB Journal · doi:10.1096/fj.12-210880 · Cited by 85 · see citing works
Bucharles, S. G. E., Barberato, S. H., Stinghen, A. E. M., Gruber, B., Piekala, L., Dambiski, A. C., Custódio, M. R., & Pecoits‐Filho, R. (2011) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2011.07.001 · Cited by 82 · see citing works
Robien, K., Butler, L. M., Wang, R., Beckman, K. B., Walek, D., Koh, W., & Yuan, J. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001675 · Cited by 81 · see citing works
Vitamin D and Type 2 Diabetes Mellitus
Issa, C. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-56017-5_16 · Cited by 79 · see citing works
Assessment of evidence for a protective role of vitamin D in multiple sclerosis
Hanwell, H., & Banwell, B. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.07.017 · Cited by 79 · see citing works
Nikbakht, H., Aminmansour, B., Ghorbani, A., Rezvani, M., Rahmani, P., Torkashvand, M., Nourian, M., & Moradi, M. (2012) · Advanced Biomedical Research · doi:10.4103/2277-9175.100176 · Cited by 77 · see citing works
Increased telomerase activity and vitamin D supplementation in overweight African Americans
Zhu, H., Guo, D. S., Li, K., Pedersen-White, J., Stallmann-Jorgensen, I. S., Huang, Y., Parikh, S. J., Liu, K., & Dong, Y. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.197 · Cited by 75 · see citing works
Suzuki, Y., Ichiyama, T., Ohsaki, A., Hasegawa, S., Shiraishi, M., & Furukawa, S. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.12.004 · Cited by 75 · see citing works
Serum Vitamin D Concentrations and Unexplained Elevation in ALT Among US Adults
Liangpunsakul, S., & Chalasani, N. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1707-x · Cited by 73 · see citing works
Classical and Emerging Roles of Vitamin D in Hepatitis C Virus Infection
Gutierrez, J. A., Parikh, N. D., & Branch, A. D. (2011) · Seminars in Liver Disease · doi:10.1055/s-0031-1297927 · Cited by 68 · see citing works
Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV
Coussens, A. K., Martineau, A. R., & Wilkinson, R. J. (2014) · Scientifica · doi:10.1155/2014/903680 · Cited by 66 · see citing works
Rostkowska-Nadolska, B., Sliupkas-Dyrda, E., Potyka, J., Kuśmierz, D., Frączek, M., Kr̨ecicki, T., Kubik, P., Zatoński, M., & Latocha, M. T. (2010) · Advances in Medical Sciences · doi:10.2478/v10039-010-0012-9 · Cited by 65 · see citing works
CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds
Tongkao-on, W., Carter, S., Reeve, V. E., Dixon, K. M., Gordon-Thomson, C., Halliday, G. M., Tuckey, R. C., & Mason, R. S. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.015 · Cited by 63 · see citing works
McNally, P., Coughlan, C. A., Bergsson, G., Doyle, M., Taggart, C. C., Adorini, L., Uskoković, M. R., Elnazir, B., Murphy, P. G., Greally, P., et al. (2011) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2011.06.013 · Cited by 62 · see citing works
Wu, S., Xia, Y., Liu, X., & Sun, J. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.012 · Cited by 56 · see citing works
Yuan, Y., Das, S. K., & Li, M. (2018) · Bioscience Reports · doi:10.1042/bsr20171294 · Cited by 55 · see citing works
RetractedKudo, K., Hasegawa, S., Suzuki, Y., Hirano, R., Wakiguchi, H., Kittaka, S., & Ichiyama, T. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.07.003 · Cited by 54 · see citing works
Aly, Y. E., Abdou, A. S., Rashad, M. M., & Nassef, M. M. (2016) · Journal of Advanced Research · doi:10.1016/j.jare.2016.07.001 · Cited by 53 · see citing works
Rachamallu, A., Jagu, S., Roy, K. R., Reddy, G. S., Robinson, M., Uskoković, M. R., Reddy, G. V., & Reddanna, P. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21749 · Cited by 52 · see citing works
Vitamin D protects against diabetic nephropathy: Evidence-based effectiveness and mechanism
Hu, X., Liu, W., Yan, Y., Liu, H., Huang, Q., Xiao, Y., Gong, Z., & Du, J. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.09.037 · Cited by 52 · see citing works
Is there any correlation between vitamin D insufficiency and diabetic retinopathy?
Bonakdaran, S., & Shoeibi, N. (2015) · Europe PMC (PubMed Central) · doi:10.3980/j.issn.2222-3959.2015.02.20 · Cited by 51 · see citing works
Mehta, S., Mugusi, F. M., Spiegelman, D. L., Villamor, E., Finkelstein, J. L., Hertzmark, E., Giovannucci, E. L., Msamanga, G., & Fawzi, W. W. (2011) · AIDS Patient Care and STDs · doi:10.1089/apc.2011.0182 · Cited by 50 · see citing works
Heulens, N., Korf, H., Cielen, N., Smidt, E. D., Maes, K., Gysemans, C. A., Verbeken, E. K., Gayan‐Ramirez, G., Mathieu, C., & Janssens, W. (2015) · Respiratory Research · doi:10.1186/s12931-015-0271-x · Cited by 49 · see citing works
Vitamin D and chronic obstructive pulmonary disease: hype or reality?
Janssens, W., Decramer, M., Mathieu, C., & Korf, H. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70102-4 · Cited by 49 · see citing works
de Carvalho, J. T. G., Schneider, M., Cuppari, L., Grabulosa, C. C., Aoike, D. T., Quinto, B. M. R., Batista, M. C., Cendoroglo, M. N., Moysés, R. M. A., & Dalboni, M. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179540 · Cited by 49 · see citing works
Effect of vitamin D and β-sitosterol on immune function of macrophages
Alappat, L., Valerio, M. S., & Awad, A. B. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.08.003 · Cited by 47 · see citing works
Tan, Z.-X., Chen, Y., Xu, S., Qin, H.-Y., Zhang, C., Zhao, H., & Xu, D. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.10.022 · Cited by 45 · see citing works
Nimitphong, H., Guo, W., Holick, M. F., Fried, S. K., & Lee, M. (2021) · Obesity · doi:10.1002/oby.23109 · Cited by 44 · see citing works
Vitamin D status among long-term survivors of hematopoietic cell transplantation
Robien, K., Strayer, L., Majhail, N. S., Lazovich, D., Baker, K. S., Smith, A. R., Mulrooney, D. A., & Burns, L. J. (2011) · Bone Marrow Transplantation · doi:10.1038/bmt.2010.326 · Cited by 44 · see citing works
Vitamin D modulates airway smooth muscle function in COPD
Banerjee, A., & Panettieri, R. A. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.01.014 · Cited by 44 · see citing works
Yuan, Y. F., Das, S. K., & Li, M. Q. (2018) · Journal of Diabetes Research · doi:10.1155/2018/1757925 · Cited by 41 · see citing works
Vitamin D and its emerging role in immunopathology
Haroon, M., & FitzGerald, O. (2011) · Clinical Rheumatology · doi:10.1007/s10067-011-1880-5 · Cited by 40 · see citing works
Askari, G., Foroughi, M., & Maghsoudi, Z. (2016) · Iranian Journal of Nursing and Midwifery Research · doi:10.4103/1735-9066.174759 · Cited by 38 · see citing works
Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects
Bachali, S., Dasu, K., Ramalingam, K., & Naidu, J. N. (2012) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-012-0239-2 · Cited by 39 · see citing works
Regulatory Effect of 25-hydroxyvitamin D3on Nitric Oxide Production in Activated Microglia
Hur, J., Lee, P., Kim, M. J., & Cho, Y. (2014) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2014.18.5.397 · Cited by 39 · see citing works
EFSA Panel on Dietetic Products, N. A. A. (. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1468 · Cited by 38 · see citing works
Mohamad, M. I., Elsherbeny, E. E., & Bekhet, M. M. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1026427 · Cited by 37 · see citing works
Vitamin D and the Immune System from the Nephrologist's Viewpoint
Lang, C.-L., Wang, M., Chiang, C., & Lu, K. (2014) · ISRN Endocrinology · doi:10.1155/2014/105456 · Cited by 37 · see citing works
Pathogenesis of Pediatric Multiple Sclerosis
Vargas-Lowy, D., & Chitnis, T. (2012) · Journal of Child Neurology · doi:10.1177/0883073812456084 · Cited by 37 · see citing works
Plasma Vitamin D Level and Change in Albuminuria and eGFR According to Sodium Intake
Velde‐Keyzer, C. A. T., Lambers-Heerspink, H. J., Joosten, M. M., Deetman, P. E., Gansevoort, R. T., Navis, G. J., Kema, I. P., de Zeeuw, D., Bakker, S. J. L., & de Borst, M. H. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03830415 · Cited by 33 · see citing works
Bucharles, S. G. E., Barberato, S. H., Stinghen, A. E. M., Gruber, B., Meister, H., Mehl, A., Piekala, L., Dambiski, A. C., de Souza, A. M., Olandoski, M., et al. (2011) · Nephron Clinical Practice · doi:10.1159/000323664 · Cited by 34 · see citing works
Vitamin D and risk of CVD: a review of the evidence
Fry, C. M., & Sanders, T. A. B. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115000014 · Cited by 31 · see citing works
Vitamin‐regulated cytokines and growth factors in the CNS and elsewhere
Scalabrino, G. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06417.x · Cited by 29 · see citing works
Wang, Q., Zhou, X., Zhang, P., Zhao, P., Nie, L., Ji, N., Ding, Y., & Wang, Q. (2020) · Steroids · doi:10.1016/j.steroids.2019.108570 · Cited by 29 · see citing works
Trayhurn, P., O'Hara, A., & Chen, B. (2011) · Adipobiology · doi:10.14748/adipo.v3.269 · Cited by 28 · see citing works
Al‐Rawaf, H. A., Gabr, S. A., & Alghadir, A. H. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/4352470 · Cited by 25 · see citing works
RetractedUlutaş, Ö., Taşkapan, H., Taşkapan, M. Ç., & Temel, İ. (2012) · International Urology and Nephrology · doi:10.1007/s11255-012-0308-8 · Cited by 23 · see citing works
Agbalalah, T., Hughes, S. F., Freeborn, E. J., & Mushtaq, S. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.01.015 · Cited by 23 · see citing works
Mehta, A. A., Agrawal, A. D., Appanna, V. D., & Chaudagar, K. K. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0323 · Cited by 22 · see citing works
Vitamin D receptor agonists as anti-inflammatory agents
Adorini, L., Amuchastegui, S., Corsiero, E., LAVERNY, G., Meur, T. L., & Penna, G. (2007) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.3.4.477 · Cited by 20 · see citing works
The nondietary determinants of vitamin D status in pediatric inflammatory bowel disease
Collen, L. V., Maranda, L., & Nwosu, B. U. (2015) · Nutrition · doi:10.1016/j.nut.2015.03.010 · Cited by 20 · see citing works
Nada, A. M., & Shaheen, D. (2017) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s132344 · Cited by 15 · see citing works
Pathogenese der Parodontitis bei rheumatischen Erkrankungen
Detert, J., Pischon, N., Burmester, G. R., & Buttgereit, F. (2010) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-009-0560-1 · Cited by 15 · see citing works
Impact of Vitamin D Status and Obesity on C-Reactive Protein in Kidney-Transplant Patients
Ewers, B., Gasbjerg, A., Zerahn, B., & Marckmann, P. (2008) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2007.11.004 · Cited by 14 · see citing works
Strisciuglio, C., Cenni, S., Giugliano, F. P., Miele, E., Cirillo, G., Martinelli, M., Vitale, A., Tolone, C., Staiano, A., del Giudice, E. M., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002049 · Cited by 13 · see citing works
Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions
Mizwicki, M. T., & Norman, A. W. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10015-0 · Cited by 12 · see citing works
Influencing factors on serum 25-hydroxyvitamin D3 levels in Japanese chronic hepatitis C patients
Atsukawa, M., Tsubota, A., Shimada, N., Yoshizawa, K., Abe, H., Asano, T., Ohkubo, Y., Araki, M., Ikegami, T., Kondo, C., et al. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-015-1020-y · Cited by 11 · see citing works
Low-Dose Calcitriol Decreases Aortic Renin, Blood Pressure, and Atherosclerosis in Apoe-Null Mice
Ish‐Shalom, M., Sack, J., Vechoropoulos, M., Shaish, A., Entin‐Meer, M., Kamari, Y., Maysel-Auslender, S., Keren, G., Harats, D., Stern, N., et al. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.9621 · Cited by 11 · see citing works
Tian, L., Yu, Y., Jin, M., Duan, H., Huang, G., & Zhang, M. (2021) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.67.84 · Cited by 9 · see citing works
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Hermann, M., & Ruschitzka, F. T. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0010-5 · Cited by 7 · see citing works
Do, M. H., Kim, M. K., Choi, S. Y., Lee, P., Kim, Y., & Hur, J. (2021) · Applied Biological Chemistry · doi:10.1186/s13765-021-00604-7 · Cited by 7 · see citing works
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Branch, A. D., Kang, M., Hollabaugh, K. M., Wyatt, C. M., Chung, R. T., & Glesby, M. J. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.048785 · Cited by 6 · see citing works
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Krishnan, A. V., & Feldman, D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7188-3_3 · Cited by 5 · see citing works
Pérez, A., Centeno, V. A., & de Talamoni, N. G. T. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.10.011 · Cited by 4 · see citing works
Al-Shami, A. S., Alzumor, M., Al-Adhal, A., & Al-Saban, A. M. (2025) · BMC Endocrine Disorders · doi:10.1186/s12902-025-01972-7 · Cited by 3 · see citing works
Ibrahim, M. A., Sany, D., Shahawy, Y. E., & Awdallah, A. (2012) · Renal Failure · doi:10.3109/0886022x.2012.706877 · Cited by 3 · see citing works
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Mabley, J. G., & Szabó, C. (2008) · Future Rheumatology · doi:10.2217/17460816.3.2.169 · Cited by 3 · see citing works
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Pittas, A. G., & Dawson‐Hughes, B. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10098-8 · Cited by 3 · see citing works
Amer, O. E., Khattak, M. N. K., Alnaami, A. M., Aljohani, N., & Al‐Daghri, N. M. (2020) · Nutrients · doi:10.3390/nu12092880 · Cited by 3 · see citing works
- Authors
- Cohen-Lahav, M., Douvdevani, A., Chaimovitz, C., & Shany, S.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Shany, Shraga
- ORCID
- Douvdevani, Amos
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 103
- Issue
- 3-5
- Pages
- 558-562
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W382757940
- Cited by
- 118
- References
- 14
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 16
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- 1,25-dihydroxyvitamin D3, vitamin D analogs, macrophages, anti-inflammatory activity, TNF-α expression, NF-κB, IκBα, ubiquitination, P388D1 cells, retraction
- MeSH terms
- NF-KappaB Inhibitor alpha, Calcitriol, Cell Line, Cell Nucleus, Ergocalciferols, Gene Expression Regulation, Macrophages, Phosphorylation, RNA, Messenger, NF-kappa B, Inflammation Mediators, I-kappa B Proteins, Protein Transport
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