Cited by 258Vitamin D Research StudiesNutritional Studies and DietDiabetes Treatment and Management

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Vitamin D and Diabetes

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Mitri, Joanna, Pittas, Anastassios G.·2014·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2013.09.010PMC PMC3942667

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Abstract

There has been increasing evidence that vitamin D may have a role in modifying risk of diabetes. Vitamin D has both direct and indirect effects on various mechanisms related to the pathophysiology of type 2 diabetes, including pancreatic beta cell dysfunction, impaired insulin action and systemic inflammation. This article describes the biologic plausibility behind the potential association between vitamin D and type 2 diabetes and summarizes the current evidence from human studies that suggests but does not prove a relation between vitamin D and type 2 diabetes, and briefly reports on the potential association between vitamin D and type 1 diabetes.

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1 retracted

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Vitamin D supplementation and diabetes-related autoimmunity in the ABIS study
Brekke, H. K., & Ludvigsson, J. (2007) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2006.00223.x · Cited by 109 · cited 1×
“Other studies have found that increased vitamin D intake during pregnancy [13] or during infancy [14] is associated with reduced diabetes-related autoimmunity, providing indirect evidence for a beneficial role of vitamin D on the pathophysiology of type 1 diabetes.”
Background
Effect of vitamin D3 on the pancreatic secretion of insulin and somatostatin
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Lack of Association Between 25(OH)D Levels and Incident Type 2 Diabetes in Older Women
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Cytosolic Calcium and Insulin Resistance in Elderly Patients With Essential Hypertension
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Effect of Serum 25-Hydroxyvitamin D on Risk for Type 2 Diabetes May Be Partially Mediated by Subclinical Inflammation
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Vitamin D and Diabetes
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Seasonality of birth in children and young adults (0–29 years) with type 1 diabetes in Ukraine
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The de novo synthesis of numerous proteins is decreased during vitamin D3 deficiency and is gradually restored by 1, 25-dihydroxyvitamin D3 repletion in the islets of langerhans of rats
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Postprandial Changes in Cytosolic Free Calcium and Glucose Uptake in Adipocytes in Obesity and Non-Insulin-Dependent Diabetes Mellitus
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“These studies have reported an inverse association between intake of vitamin D supplements during lactation [10] or infancy [11], or intake of cod liver oil (a major source of vitamin D in certain countries) during pregnancy or infancy [12] and incident type 1 diabetes.”
Background
Effects of Hypocalcemia and Theophylline on Glucose Tolerance and Insulin Release in Human Beings
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Authors: Mitri, J., & Pittas, A. G.
Affiliations: Tufts Medical Center (US)
Corresponding author: Mitri, Joanna
ORCID: Mitri, Joanna
Pittas, Anastassios G.
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2014-03
Volume: 43
Issue: 1
Pages: 205-232
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2013.09.010
PMC: PMC3942667
OpenAlex: W2001344972
Cited by: 258
References: 116
Citations by year: 2026: 15 · 2025: 19 · 2024: 31 · 2023: 22 · 2022: 36 · 2021: 24 · 2020: 17 · 2019: 21 · 2018: 21 · 2017: 17 · 2016: 19 · 2015: 13 · 2014: 3
FWCI: 1.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076092, U34DK091958, U01DK098245)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: vitamin D, type 2 diabetes, type 1 diabetes, diabetes risk, beta-cell dysfunction, insulin resistance, systemic inflammation, vitamin D supplementation
MeSH terms: Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Vitamin D

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