Pituitary Diseases and Bone
Abstract
Pituitary hormones have direct and indirect effects on bone remodeling, and skeletal fragility is a frequent complication of pituitary diseases. Fragility fractures may occur in many patients with prolactinomas, acromegaly, Cushing disease, and hypopituitarism. As in other forms of secondary osteoporosis, pituitary diseases generally affect bone quality more than bone quantity, and fractures may occur even in the presence of normal or low-normal bone mineral density, making difficult the prediction of fractures in these settings. Treatment of excess and defective pituitary hormone generally improves skeletal health, although some patients remain at high risk for fractures, necessitating treatment with bone-active drugs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pituitary diseases generally affect bone quality more than bone quantity.
“pituitary diseases generally affect bone quality more than bone quantity”
From Pituitary Diseases and Bone (2018) · cites this paper as [1]
Fractures may occur even in the presence of normal or low-normal bone mineral density as measured by dual-energy X-ray absorptiometry, making prediction of fractures difficult.
“fractures may occur even in the presence of normal or lownormal bone mineral density as measured by dual-energy X-ray absorptiometry, making difficult the prediction of fractures in these clinical settings.”
From Pituitary Diseases and Bone (2018) · cites this paper as [1]
Cites
Vertebral Fractures in Patients With Acromegaly: A 3-Year Prospective Study
Mazziotti, G., Bianchi, A., Porcelli, T., Mormando, M., Maffezzoni, F., Cristiano, A., Giampietro, A., De Marinis, L., & Giustina, A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1460 · Cited by 172 · see citing works
Self-citationPrevalence of Vertebral Fractures in Men with Acromegaly
Mazziotti, G., Bianchi, A., Bonadonna, S., Cimino, V., Patelli, I., Fusco, A., Pontecorvi, A., De Marinis, L., & Giustina, A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0791 · Cited by 169 · see citing works
Self-citationMazziotti, G., Sorvillo, F., Piscopo, M., Cioffi, M., Pilla, P., Biondi, B., Iorio, S., Giustina, A., Amato, G., & Carella, C. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041126 · Cited by 126 · see citing works
Self-citationMazziotti, G., Porcelli, T., Bianchi, A., Cimino, V, Patelli, I., Mejia, C., Fusco, A., Giampietro, A., De Marinis, L., & Giustina, A. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0125 · Cited by 68 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Mazziotti, G., Frara, S., & Giustina, A. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00005 · Cited by 181 · see citing works
Self-citationMazziotti, G., Formenti, A. M., Frara, S., Roca, E., Mortini, P., Berruti, A., & Giustina, A. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0154 · Cited by 96 · see citing works
Self-citationPrevalence and predictors of hyperprolactinemia in subclinical hypothyroidism
Sharma, L. K., Sharma, N., Gadpayle, A. K., & Dutta, D. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.07.012 · Cited by 58 · see citing works
- Authors
- Mazziotti, G., Chiavistelli, S., & Giustina, A.
- Affiliations
- University of Brescia (IT)
- Corresponding author
- Giustina, Andrea
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 44
- Issue
- 1
- Pages
- 171-180
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W2052251143
- Cited by
- 46
- References
- 4
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 10 · 2017: 8 · 2016: 6 · 2015: 3
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- pituitary disorders, bone remodeling, fragility fractures, secondary osteoporosis, prolactinoma, acromegaly, Cushing's disease, hypopituitarism, bone mineral density, bone quality, fracture risk prediction
- MeSH terms
- Bone Diseases, Humans, Pituitary Diseases, Fractures, Bone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
