Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma
Abstract
Unlabelled In women monitored for thyroid carcinoma, short-term stimulation with rhTSH induced an acute decrease in serum C-telopeptides of type-1 collagen and an increase in serum BALP levels without any effect on OPG production. The inhibitory effect of TSH on bone resorption occurred only in postmenopausal women who showed low BMD and a high bone turnover rate as an effect of L-thyroxine suppressive therapy. Introduction It has been recently shown that thyrotropin (TSH) has an inhibitory activity on skeletal remodeling in in vitro conditions. Here, we have aimed at evaluating whether TSH has similar effects in vivo. For this purpose, we have evaluated the sequential profile of serum bone metabolism markers during acute stimulation with recombinant human TSH (rhTSH) in thyroidectomized women monitored for thyroid carcinoma. Materials and methods The study group included 66 thyroidectomized patients, of whom 38 were premenopausal and 28 postmenopausal, who underwent routine rhTSH-assisted whole body radioactive iodine scanning for differentiated thyroid carcinoma. The patients were sequentially evaluated for TSH, free triiodothyronine (FT3), free thyroxine (FT4), bone alkaline phosphatase (BALP), C-telopeptides of type-1 collagen (CrossLaps), and osteoprotegerin (OPG) levels during rhTSH stimulation. The samples were drawn just before and 2 and 7 days after the first administration of rhTSH. BMD was evaluated by ultrasonography at baseline. Seventy-one healthy women (41 prem…
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These effects were independent of thyroid hormones because the women did not have a thyroid gland, and replacement therapy with L-thyroxine was stable during the study period.
“Of note, these effects were independent of thyroid hormones because the women did not have a thyroid gland, and replacement therapy with L-thy- roxine was stable during the study period.”
From Pituitary Diseases and Bone (2018) · cites this paper as [257]
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- Authors
- Mazziotti, G., Sorvillo, F., Piscopo, M., Cioffi, M., Pilla, P., Biondi, B., Iorio, S., Giustina, A., Amato, G., & Carella, C.
- Affiliations
- University of Campania "Luigi Vanvitelli" (IT)
- Department of General Pathology, Second University of Naples, Naples, Italy
- University of Naples Federico II (IT)
- University of Brescia (IT)
- Corresponding author
- Carella, Carlo
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-03-01
- Volume
- 20
- Issue
- 3
- Pages
- 480-486
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W1991154677
- Cited by
- 126
- References
- 36
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 10 · 2017: 10 · 2016: 7 · 2015: 2 · 2014: 4 · 2013: 8 · 2012: 10
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Funders
- Seconda Università degli Studi di Napoli
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- recombinant human TSH, bone resorption, bone turnover markers, bone-specific alkaline phosphatase, osteoprotegerin, postmenopausal women, differentiated thyroid cancer, bone mineral density, subclinical thyrotoxicosis
- MeSH terms
- Adult, Aged, Animals, Bone Resorption, Carcinoma, Female, Glycoproteins, Humans, Middle Aged, Recombinant Proteins, Thyroid Neoplasms, Thyrotropin, Biomarkers, Premenopause, Postmenopause, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Osteoprotegerin
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