The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Impaired spermatogenesis in COVID-19 patients
Open accessAbstract
Background The current study aimed to determine the impact of SARS-CoV-2 infection on male fertility. Methods This is a single-center, hospital-based observational study that included autopsied testicular and epididymal specimens of deceased COVID-19 male patients ( n =6) and recruited recovering COVID-19 inpatients ( n =23) with an equal number of age-matched controls, respectively. We performed histopathological examinations on testicular and epididymal specimens, and also performed TUNEL assay and immunohistochemistry. Whereas, we investigated the semen specimen for sperm parameters and immune factors. Findings Autopsied testicular and epididymal specimens of COVID-19 showed the presence of interstitial edema, congestion, red blood cell exudation in testes, and epididymides. Thinning of seminiferous tubules was observed. The number of apoptotic cells within seminiferous tubules was significantly higher in COVID-19 compared to control cases. It also showed an increased concentration of CD3+ and CD68+ in the interstitial cells of testicular tissue and the presence of IgG within seminiferous tubules. Semen from COVID-19 inpatients showed that 39.1% ( n =9) of them have oligozoospermia, and 60.9% ( n =14) showed a significant increase in leucocytes in semen. Decreased sperm concentration, and increased seminal levels of IL-6, TNF-α, and MCP-1 compared to control males were observed. Interpretation Impairment of spermatogenesis was observed in COVID-19 patients, which could be partially explained as a result of an elevated immune response in testis. Additionally, autoimmune orchitis occurred in some COVID-19 patients. Further research on the reversibility of impairment and developing treatment are warranted. Funding This study was supported by Ministry of Science and Technology of China Plan, Hubei Science and Technology Plan, National Key Research and Development Program of China, HUST COVID-19 Rapid Response Call, China and National Natural Science Foundation of China; these funding bodies are public institutions, and they had no role in study conception, design, interpretation of results, and manuscript preparation.
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Self-citationProjecting the transmission dynamics of SARS-CoV-2 through the postpandemic period
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Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019
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Covid‐19 and the digestive system
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Metadata
- Authors
- Li, H., Xiao, X., Zhang, J., Zafar, M. I., Wu, C., Long, Y., Lu, W., Pan, F., Meng, T., Zhao, K., Zhou, L., Shen, S., Liu, L., Liu, Q., & Xiong, C.
- Venue
- EClinicalMedicine
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 28
- Pages
- 100604
- ISSN
- 2589-5370 (ISSN-L)
- OpenAlex
- W3093916012
- Cited by
- 282
- References
- 26
- FWCI
- 38.52
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, H., Xiao, X., Zhang, J., Zafar, M. I., Wu, C., Long, Y., Lu, W., Pan, F., Meng, T., Zhao, K., Zhou, L., Shen, S., Liu, L., Liu, Q., & Xiong, C. (2020). Impaired spermatogenesis in COVID-19 patients. EClinicalMedicine. https://doi.org/10.1016/j.eclinm.2020.100604
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