Toxic Effects of Tetracycline and Its Degradation Products on Freshwater Green Algae
Abstract
Tetracycline antibiotics are the most widely used antibiotics in the world and the most common veterinary drugs and feed additives used in livestock, poultry and aquaculture operations. Because antibiotics cannot be completely removed by currently existing sewage treatment facilities, these materials enter the environment directly via sewage treatment plant discharge, where they degrade. Accordingly, the metabolism and the ecological toxicity of tetracycline degradation products are worthy of attention. Herein, we investigated the effects of tetracycline and its degradation products (anhydrotetracycline and epitetracycline hydrochloride) on the growth, cell structure and algal cell oxidative stress of common Chlorella vulgaris. The results showed that the 96h-EC 50 values of tetracycline (TC), anhydrotetracycline (ATC) and epitetracycline (ETC) on algal cells were 7.73, 5.96 and 8.42 mg/L, respectively. Moreover, the permeability of algal cells exposed to high concentrations of these three drugs was significantly enhanced. In addition, there were structural changes in the cells such as plasmolysis and starch granule deposition appeared, the thylakoid lamellae in the chloroplasts became blurred and deformed, and the vacuoles became larger. Exposure to higher concentrations (>5 mg/L) of TC and its degradation products ATC and ETC significantly upregulated the activity of ROS, as well as the antioxidants SOD and CAT. The levels of the lipid peroxidation product MDA also showed the same trend. Finally, ATC had the strongest toxicity toward algal cells, followed by TC and then ETC.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The drugs used in aquaculture eventually end up in the aquaculture environment, leading to the problem of veterinary drug residues in the produced algae food.
“Both results show that the drugs used in aquaculture eventually end up in the aquaculture environment, leading to the problem of veterinary drug residues in the produced algae food.”
From Current Status and Future Trends in Removal, Control, and Mitigation of Algae Food Safety Risks for Human Consumption (2022) · cites this paper as [114]
Cites
Zhang, Q.-Q., Ying, G., Pan, C., Liu, Y., & Zhao, J. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b00729 · Cited by 3,861 · see citing works
Sarmah, A. K., Meyer, M. T., & Boxall, A. B. A. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.03.026 · Cited by 3,326 · see citing works
Hou, J., Wan, W., Mao, D., Wang, C., Mu, Q., Qin, S., & Luo, Y. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3632-y · Cited by 282 · see citing works
Rapid analytical technique for the assessment of cell metabolic activity in marine microalgae
Dorsey, J. A., Yentsch, C. M., Mayo, S., & McKenna, C. (1989) · Cytometry · doi:10.1002/cyto.990100518 · Cited by 186 · see citing works
THE ROLE OF REACTIVE OXYGEN SPECIES IN COPPER TOXICITY TO TWO FRESHWATER GREEN ALGAE 1
Knauert, S., & Knauer, K. (2008) · Journal of Phycology · doi:10.1111/j.1529-8817.2008.00471.x · Cited by 174 · see citing works
Mackie, R. I., Koike, S., Krapac, I. G., Chee‐Sanford, J. C., Maxwell, S., & Aminov, R. I. (2006) · Animal Biotechnology · doi:10.1080/10495390600956953 · Cited by 170 · see citing works
Comparative toxicity of racemic metolachlor and S-metolachlor to Chlorella pyrenoidosa
Liu, H., & Xiong, M. (2009) · Aquatic Toxicology · doi:10.1016/j.aquatox.2009.04.006 · Cited by 152 · see citing works
Toxicity studies of tetracycline on Microcystis aeruginosa and Selenastrum capricornutum
Yang, W.-W., Tang, Z., Zhou, F., Zhang, W., & Song, L. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.01.006 · Cited by 143 · see citing works
Halling‐Sørensen, B., Lykkeberg, A. K., Ingerslev, F., Blackwell, P. A., & Tjørnelund, J. (2003) · Chemosphere · doi:10.1016/s0045-6535(02)00766-x · Cited by 133 · see citing works
Wen, Y., Chen, H., Shen, C., Zhao, M., & Liu, W. (2011) · Environmental Science & Technology · doi:10.1021/es2003793 · Cited by 118 · see citing works
Tetracycline-induced reproductive toxicity in male rats: Effects of vitamin C and N-acetylcysteine
Farombi, E. O., Ugwuezunmba, M. C., Ezenwadu, T. T., Oyeyemi, M. O., & Ekor, M. (2008) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2008.02.002 · Cited by 109 · see citing works
An, J., Zhou, Q., Sun, Y., & Xu, Z. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2009.06.004 · Cited by 96 · see citing works
Liu, H., Xia, Y., Weidan, C., Yina, Z., Zhang, X., & Du, S. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.01.028 · Cited by 71 · see citing works
Yin, H.-Q., Kim, M., Kim, J.-H., Kong, G., Lee, M., Kang, K., Yoon, B., Kim, H., & Lee, B.-H. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl078 · Cited by 68 · see citing works
Chen, Z., Wang, J., Chen, H., Wen, Y., & Liu, W. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b04252 · Cited by 36 · see citing works
Tetracycline uptake and metabolism by vetiver grass (Chrysopogon zizanioides L. Nash)
Sengupta, A., Sarkar, D., Das, P., Panja, S., Parikh, C., Ramanathan, D., Bagley, S. T., & Datta, R. (2016) · Environmental Science and Pollution Research · doi:10.1007/s11356-016-7688-8 · Cited by 32 · see citing works
Binding of the Highly Toxic Tetracycline Derivative, Anhydrotetracycline, to Bovine Serum Albumin
Burgos, I., Fernández, R. A., Celej, M. S., Rossi, L. I., Fidelio, G. D., & Dassie, S. A. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1301 · Cited by 19 · see citing works
Topal, M., & Topal, E. I. A. (2015) · Aquaculture Research · doi:10.1111/are.12834 · Cited by 17 · see citing works
Li, J. (2009) · Journal of Instrumental Analysis · Cited by 2 · see citing works
The DNA damage and joint effects of two typical veterinary drugs on the earthworm Eisenia foetida
Zhou, Q. (2011) · Acta Scientiae Circumstantiae · Cited by 1 · see citing works
[A study of the toxicity of the epimeric pairs of tetracycline].
Lj, K., & Hl, S. (1966) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 22 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Xu, L., Zhang, H., Xiong, P., Zhu, Q., Liao, C., & Jiang, G. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.141975 · Cited by 1,214 · see citing works
Scaria, J., Anupama, K. V., & Nidheesh, P. V. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145291 · Cited by 597 · see citing works
The Impact of Tetracycline Pollution on the Aquatic Environment and Removal Strategies
Amangelsin, Y., Semenova, Y. M., Dadar, M., Aljofan, M., & Bjørklund, G. (2023) · Antibiotics · doi:10.3390/antibiotics12030440 · Cited by 564 · see citing works
Removal of tetracycline from wastewater using g-C3N4 based photocatalysts: A review
Balakrishnan, A., Chinthala, M., Polagani, R. K., & Vo, D. N. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114660 · Cited by 307 · see citing works
Zhang, T., Liu, Y., Rao, Y., Li, X., Yuan, D., Tang, S., & Zhao, Q. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.123350 · Cited by 248 · see citing works
Treatment of real wastewater by photoelectrochemical methods: An overview
Divyapriya, G., Singh, S., Martínez-Huitle, C. A., Scaria, J., Karim, A. V., & Nidheesh, P. V. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.130188 · Cited by 165 · see citing works
Degradation of tetracycline antibiotics by Arthrobacter nicotianae OTC-16
Shi, Y., Lin, H., Ma, J., Zhu, R., Sun, W., Lin, X., Zhang, J., Zheng, H., & Zhang, X. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.123996 · Cited by 149 · see citing works
Wan, L., Wu, Y., Benhao, Z., Yang, W., Ding, H., & Zhang, W. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124518 · Cited by 148 · see citing works
McCorquodale‐Bauer, K., Grosshans, R., Zvomuya, F., & Cicek, N. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161876 · Cited by 141 · see citing works
Antibiotic removal by microalgae-bacteria consortium: Metabolic pathways and microbial responses
Eheneden, I., Wang, R., & Zhao, J. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164489 · Cited by 129 · see citing works
Zhong, S., Yang, B., Xiong, Q., Cai, W.-W., Lan, Z., & Ying, G. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.113063 · Cited by 126 · see citing works
Degradation of tetracycline antibiotics by Fe2+-catalyzed percarbonate oxidation
Pimentel, J. A. I., Dong, C., Garcia‐Segura, S., Abarca, R. R. M., Chen, C.-W., & de Luna, M. D. G. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146411 · Cited by 101 · see citing works
Remediation of pharmaceuticals from contaminated water by molecularly imprinted polymers: a review
Zare, E. N., Fallah, Z., Le, V. T., Doan, V., Mudhoo, A., Joo, S., Vasseghian, Y., Tajbakhsh, M., Moradi, O., Sillanpää, M. E. T., et al. (2022) · Environmental Chemistry Letters · doi:10.1007/s10311-022-01439-4 · Cited by 103 · see citing works
Long, S., Hamilton, P. B., Wang, C., Li, C., Xue, X., Zhao, Z., Wu, P., Gu, E., Uddin, M. M., Li, B., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133787 · Cited by 96 · see citing works
Impact of Antibiotics as Waste, Physical, Chemical, and Enzymatical Degradation: Use of Laccases
Mora-Gamboa, M. P. C., Rincón-Gamboa, S. M., Ardila-Leal, L. D., Poutou‐Piñales, R. A., Pedroza-Rodríguez, A. M., & Quevedo-Hidalgo, B. E. (2022) · Molecules · doi:10.3390/molecules27144436 · Cited by 90 · see citing works
Fayaz, T., Renuka, N., & Ratha, S. K. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.140822 · Cited by 88 · see citing works
Wang, Z., Li, Y., Wang, J., & Li, S. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.175126 · Cited by 84 · see citing works
How do freshwater microalgae and cyanobacteria respond to antibiotics?
Le, V. V., Tran, Q., Ko, S.-R., Lee, S., Oh, H., Kim, H.-S., & Ahn, C. (2022) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2022.2026870 · Cited by 82 · see citing works
Li, J., Min, Z., Li, W., Xu, L., Han, J., & Li, P. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.110156 · Cited by 79 · see citing works
Zhang, S., & Wang, J. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128941 · Cited by 79 · see citing works
Tan, H., Kong, D., Li, Q., Zhou, Y., Jiang, X., Wang, Z., Parales, R. E., & Ruan, Z. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119299 · Cited by 78 · see citing works
Tan, Z., Chen, J., Liu, Y., Chen, L., Xu, Y., Zou, Y., Li, Y., & Gong, B. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125067 · Cited by 77 · see citing works
Remediation of tetracycline pollution using MXene and nano-zero-valent iron materials: a review
Rameshwar, S. S., Sivaprakash, B., Rajamohan, N., Mohamed, B. A., & Vo, D. N. (2023) · Environmental Chemistry Letters · doi:10.1007/s10311-023-01623-0 · Cited by 75 · see citing works
Zhu, Y., Wei, M., Pan, Z., Li, L., Liang, J., Yu, K., & Zhang, Y. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135960 · Cited by 71 · see citing works
Olusegun, S. J., Larrea, G., Osial, M. E., Jackowska, K., & Krysiński, P. (2021) · Catalysts · doi:10.3390/catal11101243 · Cited by 69 · see citing works
Deka, M. J., Chowdhury, D., & Nath, B. K. (2022) · Carbon letters · doi:10.1007/s42823-022-00347-5 · Cited by 69 · see citing works
Xu, Z., Jia, Y., Zhang, X., Hu, S., Luo, Y., He, H., Chen, B., Huang, B., & Pan, X. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.143724 · Cited by 69 · see citing works
Resistance of cyanobacteria Microcystis aeruginosa to erythromycin with multiple exposure
Wu, Y., Wan, L., Zhang, W., Ding, H., & Yang, W. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126147 · Cited by 68 · see citing works
Siedlewicz, G., Żak, A., Sharma, L., Kosakowska, A., & Pazdro, K. (2020) · Oceanologia · doi:10.1016/j.oceano.2019.12.002 · Cited by 67 · see citing works
Effects of humic acids on biotoxicity of tetracycline to microalgae Coelastrella sp.
Tong, M., Li, X., Luo, Q., Yang, C., Lou, W., Liu, H., Du, C., Nie, L., & Zhong, Y. (2020) · Algal Research · doi:10.1016/j.algal.2020.101962 · Cited by 65 · see citing works
Wu, D., Dai, S., Feng, H., Karunaratne, S. H. P. P., Yang, M., & Zhang, Y. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122904 · Cited by 65 · see citing works
Transformation products of tetracyclines in three typical municipal wastewater treatment plants
Zhong, S., Yang, B., Lei, H., Xiong, Q., Zhang, Q.-Q., Liu, F., & Ying, G. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154647 · Cited by 60 · see citing works
Bhatt, P., Jeon, C.-H., & Kim, W. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134344 · Cited by 59 · see citing works
Fan, Y., Wang, H., Sun, C., Wang, Y., Jin, C., Zhao, Y., Gao, M., & Guo, L. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.145560 · Cited by 57 · see citing works
Li, Y., Ma, Y., Yang, L., Duan, S., Zhou, F., Chen, J., Liu, Y., & Zhang, B. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110573 · Cited by 54 · see citing works
Toxicity effects of microplastics and nanoplastics with cadmium on the alga Microcystis aeruginosa
Wang, Q., Wang, J., Chen, H., & Zhang, Y. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-23278-0 · Cited by 52 · see citing works
Semenova, Y. M., Makalkina, L., Glushkova, N., & Gaipov, A. (2025) · Antibiotics · doi:10.3390/antibiotics14121183 · Cited by 51 · see citing works
Wu, G., Zhuang, D., Chew, K. W., Ling, T. C., Khoo, K. S., Van Quyen, D., Feng, S., & Show, P. L. (2022) · Molecules · doi:10.3390/molecules27196633 · Cited by 51 · see citing works
Wang, Y., Gong, X., Huang, D., & Zhang, J. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.131917 · Cited by 50 · see citing works
Zhang, Y., Li, M., Chang, F., Yi, M., Ge, H., Fu, J., & Dang, C. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158723 · Cited by 48 · see citing works
Sheng, S., Zhang, Z., Wang, M., He, X., Jiang, C., & Wang, Y. (2022) · Electrochimica Acta · doi:10.1016/j.electacta.2022.140441 · Cited by 47 · see citing works
Lan, J., Zhang, Q., Yang, G., Liu, Z., & Peng, F. (2023) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2023.110481 · Cited by 47 · see citing works
Xia, M., Niu, Q., Qu, X., Zhang, C., Qu, X., Li, H., & Yang, C. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122728 · Cited by 45 · see citing works
Zhang, Y., Zhang, X., Guo, R., Zhang, Q., Cao, X., Suranjana, M., & Liu, Y. (2020) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2020.108764 · Cited by 45 · see citing works
Dairy, Plant, and Novel Proteins: Scientific and Technological Aspects
Liu, Y., Aimutis, W. R., & Drake, M. A. (2024) · Foods · doi:10.3390/foods13071010 · Cited by 47 · see citing works
Sivanesan, J., Sivaprakash, B., Rajamohan, N., Phanindra, V. S. S., Sonne, C., Liew, R. K., & Lam, S. S. (2024) · Environmental Chemistry Letters · doi:10.1007/s10311-024-01777-5 · Cited by 43 · see citing works
Zhang, S., Liu, Y., Mohisn, A., Zhang, G., Wang, Z., & Wu, S. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133485 · Cited by 39 · see citing works
Toxicity of tetracycline and its transformation products to a phosphorus removing Shewanella strain
Long, S., Yang, Y., Pavlostathis, S. G., Xiang, F., Sun, P., Li, N., & Zhao, L. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125681 · Cited by 39 · see citing works
Tetracycline affects the toxicity of P25 n-TiO2 towards marine microalgae Chlorella sp.
Thiagarajan, V., Natarajan, L., Seenivasan, R., Chandrasekaran, N., & Mukherjee, A. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108808 · Cited by 36 · see citing works
Khatiwada, J. R., Madsen, C., Warwick, C., Shrestha, S., Chio, C., & Qin, W. (2023) · Environmental Advances · doi:10.1016/j.envadv.2023.100399 · Cited by 35 · see citing works
Effects of 4-epianhydrotetracycline on oxidative stress in zebrafish (Danio rerio) embryos
Wang, M., Zhao, J., Wu, L., & Ma, T. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.149047 · Cited by 32 · see citing works
Removal of Tetracycline Oxidation Products in the Nanofiltration Process
Żyłła, R., Ledakowicz, S., Boruta, T., Olak-Kucharczyk, M., Foszpańczyk, M., Mrozińska, Z., & Balcerzak, J. (2021) · Water · doi:10.3390/w13040555 · Cited by 33 · see citing works
Yang, J., Zhao, Z.-Q., Wang, M., Yu, K.-F., Zhang, T., Lin, H., & Zheng, H. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129716 · Cited by 32 · see citing works
Mao, H., Yang, H., Xu, Z., Peng, Q., Yang, S., Zhu, L., Yang, Y., & Li, Z. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132994 · Cited by 32 · see citing works
Pharmaceutical Wastewater Remediation: A Review of Treatment Techniques
Date, M., & Jaspal, D. K. (2023) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.3c02451 · Cited by 31 · see citing works
Wang, Y., Fan, H., Wong, P. K., Wu, Y., & Rittmann, B. E. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.124638 · Cited by 31 · see citing works
Zhang, S., Rong, F., Huang, S., Zhao, S., Wang, M., He, L., Zhang, Z., & Du, M. (2022) · Separation and Purification Technology · doi:10.1016/j.seppur.2022.120530 · Cited by 31 · see citing works
The enhanced degradation and detoxification of chlortetracycline by Chlamydomonas reinhardtii
Zhao, F., Zhang, D., Xu, C., Liu, J., & Shen, C. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110552 · Cited by 30 · see citing works
Wang, W., Wan, Q., Li, Y., Ge, J., Feng, F., & Yu, X. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c03523 · Cited by 30 · see citing works
Chen, Y., Zuo, W., Sun, H., Liu, Y., Hou, J., Xie, H., & Wang, L. (2024) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2024.112604 · Cited by 29 · see citing works
Lin, Y., Yu, J., Wang, M., & Wu, L. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120543 · Cited by 29 · see citing works
Chen, Z., Ou, D., Gu, G., Gao, S., Li, X., Hu, C., Liang, X., & Zhang, Y. (2022) · Journal of Environmental Management · doi:10.1016/j.jenvman.2022.116693 · Cited by 28 · see citing works
Involvement of oxidative stress in the sensitivity of two algal species exposed to roxithromycin
Han, Q., Zheng, Y., Qi, Q., Peng, J., Song, J., Guo, J., & Guo, J. (2020) · Ecotoxicology · doi:10.1007/s10646-020-02192-6 · Cited by 28 · see citing works
Yin, B., Zhang, M., Zeng, Y., Chen, H., Fan, T., Wu, Z., Cao, L., & Zhao, Q. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.129097 · Cited by 27 · see citing works
Li, J., Li, W., Min, Z., Zheng, Q., Han, J., & Li, P. (2021) · Aquatic Toxicology · doi:10.1016/j.aquatox.2021.105911 · Cited by 27 · see citing works
Combined toxicity of erythromycin and roxithromycin and their removal by Chlorella pyrenoidosa
Liu, K., Li, J., Zhou, Y., Li, W., Cheng, H., & Han, J. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114929 · Cited by 26 · see citing works
Toxic Effects of Tetracycline and Its Removal by the Freshwater Microalga Chlorella pyrenoidosa
Tang, J., Yang, J., Zhao, S., Wang, X., & Xie, Z. (2022) · Agronomy · doi:10.3390/agronomy12102497 · Cited by 27 · see citing works
Li, Y.-X., Duan, W.-L., Ren, B., Luan, J., & Guo, F. M. (2023) · Separation and Purification Technology · doi:10.1016/j.seppur.2023.123337 · Cited by 26 · see citing works
Responses of Hydrocharis dubia (Bl.) Backer and Trapa bispinosa roxb. to tetracycline exposure
Liu, Y., Pang, Y., Yang, L., Ning, S., Wang, D., & Wu, Z. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110890 · Cited by 25 · see citing works
Gou, W., Alshehri, S., Pirestani, N., Soltani, S., Roghanizad, A., Shirazian, S., & Soltani, R. (2025) · Applied Water Science · doi:10.1007/s13201-025-02560-9 · Cited by 25 · see citing works
Zeng, Z.-Y., Zhou, D., Yang, S.-T., Su, M.-M., & Yang, Z. (2023) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2023.111336 · Cited by 25 · see citing works
A Mild Method for Preparation of Highly Selective Magnetic Biochar Microspheres
Zhao, T., Chen, R., & Wang, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113752 · Cited by 24 · see citing works
Thiagarajan, V., Seenivasan, R., Jenkins, D., Chandrasekaran, N., & Mukherjee, A. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.152241 · Cited by 24 · see citing works
Zhang, X., Hou, X., Jiang, X., Chen, D., Ge, S., Wang, L., & Shen, J. (2020) · ACS ES&T Water · doi:10.1021/acsestwater.0c00112 · Cited by 23 · see citing works
Effects of Tetracycline on Scenedesmus obliquus Microalgae Photosynthetic Processes
Chen, Z., Gu, G., Wang, Z., Ou, D., Liang, X., Hu, C., & Li, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810544 · Cited by 23 · see citing works
Feng, P., Wu, J., Cui, H., Huang, X. F., Wang, C., Wang, C., Li, X., & Duan, W. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116851 · Cited by 22 · see citing works
2D Graphene-TiO2 Composite and Its Photocatalytic Application in Water Pollutants
Zhou, X., Zhang, X., Wang, Y., & Wu, Z. (2021) · Frontiers in Energy Research · doi:10.3389/fenrg.2020.612512 · Cited by 22 · see citing works
Zhang, X., Jiang, N., Hou, X., Li, Y., Ge, S., Mu, Y., & Shen, J. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129981 · Cited by 22 · see citing works
Sulaimana, A. S., Chang, C., Hou, C., Yudhistira, B., Punthi, F., Lung, C.-T., Cheng, K., Santoso, S. P., & Hsieh, C. (2021) · Processes · doi:10.3390/pr9061011 · Cited by 21 · see citing works
Yang, J., Ahmed, W., Mehmood, S., Ou, W., Li, J., Xu, W., Wang, L., Mahmood, M., & Li, W. (2023) · Plants · doi:10.3390/plants12132547 · Cited by 19 · see citing works
Growth Inhibition and Oxidative Stress in Two Green Algal Species Exposed to Erythromycin
Ma, Z., Yang, F., Ren, J., Fan, R. G., Duan, Q., Guo, J., & Guo, J. (2021) · JAWRA Journal of the American Water Resources Association · doi:10.1111/1752-1688.12915 · Cited by 19 · see citing works
Nanocellulose enhances the dispersion and toxicity of ZnO NPs to green algae Eremosphaera viridis
Yin, J., Huang, G., An, C., & Feng, R. (2021) · Environmental Science Nano · doi:10.1039/d1en00881a · Cited by 19 · see citing works
Guo, Z., Zhang, T., Yang, H., Zhu, X., Lu, S., Chen, A., Fan, M., & Qu, J. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.178959 · Cited by 19 · see citing works
Kottarathil, S., Abhinand, O. V., & Sridharan, K. (2025) · Applied Surface Science · doi:10.1016/j.apsusc.2025.164869 · Cited by 18 · see citing works
Wang, J., Chen, X., Sun, H., Li, X., Lü, Q., Qin, P., Yang, Y., Lai, D., Luo, L., Peng, X. X., et al. (2025) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2025.115424 · Cited by 17 · see citing works
Li, Y., Sun, Z., Wang, S., Duan, R., Wang, S., Li, S., Lan, B., & Gao, L. (2023) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2023.111315 · Cited by 17 · see citing works
Zhou, Y., Yue, Y., Chen, X., Wu, F., Li, W., Li, P., & Han, J. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.170460 · Cited by 17 · see citing works
Mravcová, L., Amrichová, A., Navrkalová, J., Hamplová, M., Sedlář, M., Gargošová, H. Z., & Fučík, J. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-33492-7 · Cited by 17 · see citing works
Wang, Y., Lv, M., Dong, H., Hassan, M., Wang, D., & Gong, Z. (2024) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2024.105656 · Cited by 17 · see citing works
Zhang, Y., Zhang, J., Hao, J., Ma, Q., Meng, Y., Zhai, R., Qi, K., Wang, D., & Li, Z. (2024) · Nano Research · doi:10.26599/nr.2025.94907495 · Cited by 17 · see citing works
Wang, Y., Gao, C., Qu, Z., & Li, M. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16594-4 · Cited by 16 · see citing works
Ng'andu, C., & Nsibande, S. A. (2025) · Talanta · doi:10.1016/j.talanta.2025.128706 · Cited by 15 · see citing works
Periyasamy, S., Hou, J., Li, Y., Viswanathan, N., Yang, Z., You, G., Wu, J., & Huang, Z. (2025) · Journal of Environmental Management · doi:10.1016/j.jenvman.2025.127596 · Cited by 15 · see citing works
Emerging antibiotic pollution and its remedy by waste based biochar adsorbents: a review
Hamid, I., Ahmadipour, M., Ahmed, M. J., Rizvi, M. A., Shalla, A. H., & Khanday, W. A. (2025) · Environmental Science and Pollution Research · doi:10.1007/s11356-025-36253-2 · Cited by 15 · see citing works
Zhou, X., Jiang, X., Gao, S., Wan, Z., & Gao, P. (2020) · Journal of Oceanology and Limnology · doi:10.1007/s00343-020-9214-6 · Cited by 15 · see citing works
Yu, C. W., Liu, Y., Zhang, Y., Shen, M.-Z., Wang, J., & Chi, Z. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173643 · Cited by 14 · see citing works
Zhong, Z., Zhang, X., Dai, R., Wang, C., Zhao, F., & Zeng, B. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.136815 · Cited by 14 · see citing works
Huang, X., Zhang, X., Huang, Y., & Xu, X. (2020) · Environmental Technology · doi:10.1080/09593330.2020.1754472 · Cited by 14 · see citing works
Qi, X., Chen, Z., He, X., & Xiong, J.-Q. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.165234 · Cited by 13 · see citing works
Sun, L., Zhao, C., Sun, S., Hu, C., Zhao, Y., & Liu, J. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16341-9 · Cited by 13 · see citing works
- Authors
- Xu, D., Xiao, Y., Pan, H., & Mei, Y.
- Affiliations
- ZheJiang Academy of Agricultural Sciences (CN)
- Corresponding author
- Xu, Dongmei
- Venue
- Ecotoxicology and Environmental Safety
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 174
- Pages
- 43-47
- ISSN
- 0147-6513 (ISSN-L)
- OpenAlex
- W2917006278
- Cited by
- 212
- References
- 22
- Citations by year
- 2026: 26 · 2025: 50 · 2024: 41 · 2023: 27 · 2022: 26 · 2021: 19 · 2020: 19 · 2019: 4
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ecotoxicology and Environmental Safety (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Zhejiang Province (LY18B070005)
- Zhejiang Shuren University
- Topics
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Pollution › Pesticide and Herbicide Environmental Studies
- Keywords
- tetracycline, anhydrotetracycline, antibiotic degradation products, Chlorella vulgaris, freshwater green algae, algal growth inhibition, oxidative stress, reactive oxygen species, antioxidant enzymes, lipid peroxidation, membrane permeability, plasmolysis, chloroplast ultrastructure
- MeSH terms
- Anti-Bacterial Agents, Antioxidants, Fresh Water, Tetracycline, Tetracyclines, Lipid Peroxidation, Oxidative Stress, Chlorella vulgaris
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
