Prenatal ambient air pollution exposure and SOD2 promoter methylation in maternal and cord blood
Abstract
The evidence is increasing that prenatal air pollutant exposure contributes to elevated oxidative stress in children, but the underlying mechanism is unclear. A pilot study was conducted in China to explore the associations between prenatal ambient air pollution exposure and superoxide dismutase 2 (SOD2) promoter methylation in maternal and cord blood. After detection and analyses, SOD2 promoter methylation levels in umbilical cord blood were elevated as maternal SOD2 promoter methylation levels increased. In addition, the SOD2 promoter methylation levels in umbilical cord blood were positively associated with the particulate matter 10 (PM 10 ) exposure concentrations during the entire pregnancy and the second trimester. In maternal peripheral blood, the SOD2 promoter methylation levels were positively associated with the exposure concentrations of PM 10 (during the entire pregnancy and the second trimester) and nitrogen dioxide (NO 2 ) (during the first trimester of pregnancy), whereas the levels were negatively associated with the exposure concentrations of NO 2 during the third trimester of pregnancy. Additionally, interaction analyses revealed that the maternal SOD2 promoter methylation level and sulfur dioxide (SO 2 ) exposure (during the entire pregnancy and the third trimester), as well as NO 2 exposure (during the third trimester of pregnancy), had an interaction effect on the SOD2 promoter methylation level in umbilical cord blood. Furthermore, mediation analysis rev…
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Air pollutant DNA methylation changes are directly linked with oxidative stress, evidenced by significant associations with SOD2 promoter methylation levels in umbilical cord blood.
“Zhou et al. [186] linked air pollutant DNA methylation changes directly with oxidative stress, evidenced by significant associations with SOD2 promoter methylation levels in umbilical cord blood.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [186]
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Self-citation
- Authors
- Zhou, G., He, T., Huang, H., Feng, F., Liu, X., Li, Z., Zhang, Y., & Ba, Y.
- Affiliations
- Zhengzhou University (CN)
- Yale University (US)
- Corresponding author
- Ba, Yue
- Venue
- Ecotoxicology and Environmental Safety
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 181
- Pages
- 428-434
- ISSN
- 0147-6513 (ISSN-L)
- OpenAlex
- W2949435010
- Cited by
- 35
- References
- 36
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 6 · 2019: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ecotoxicology and Environmental Safety (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81673116)
- Henan Department of Science and Technology, China (162300410272)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- prenatal air pollution exposure, ambient air pollution, manganese superoxide dismutase, DNA methylation, umbilical cord blood, maternal blood, PM10, nitrogen dioxide, sulfur dioxide, oxidative stress, epigenetic mediation, pregnancy trimesters
- MeSH terms
- Superoxide Dismutase 2, Air Pollutants, Air Pollution, China, Female, Fetal Blood, Humans, Infant, Newborn, Male, Pilot Projects, Pregnancy, Promoter Regions, Genetic, Risk Factors, Superoxide Dismutase, Maternal Exposure, DNA Methylation
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