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Alterations in cecal microbiota and intestinal barrier function of laying hens fed on fluoride supplemented diets

Miao, Liping, Gong, Yujie, Li, Huaiyu, Xie, Chao, Xu, Qianqian, Dong, Xinyang, Elwan, Hamada A.M., Zou, Xiaoting·2020·Ecotoxicology and Environmental Safety
DOI 10.1016/j.ecoenv.2020.110372
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Abstract

The objective of this study was to investigate the effects of fluorine at levels of 31, 431, 1237 mg/kg feed on cecum microbe, short-chain fatty acids (SCFAs) and intestinal barrier function of laying hens. The results showed that the intestinal morphology and ultrastructure were damaged by dietary high F intake. The mRNA expression levels of zonula occludens-1, zonula occludens-2, claudin-1, and claudin-4 were decreased in jejunum and ileum. However, the concentrations of serum diamine oxidase, and D-lactic acid and intestinal contents of interleukin 1 beta, interleukin 6, and Tumor necrosis factor-alpha were increased. Consistent with this, dietary high F intake altered the cecum microbiota, with increasing the concentration of pathogens, such as Proteobacteria and Escherichia-Shigella, as well as, decreasing the contents of beneficial bacteria, such as Lactobacillus, and expectedly, reduced the SCFAs concentrations. In conclusion, the actual results confirmed that (1) high dietary F intake could damage the intestinal structure and function, with impaired intestinal barrier and intestinal inflammation, and (2) destroy the cecum microbial homeostasis, and decrease the concentrations of SCFAs, which aggravate the incidence of intestinal inflammation in laying hens.

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Metadata

Authors
Miao, L., Gong, Y., Li, H., Xie, C., Xu, Q., Dong, X., Elwan, H. A. M., & Zou, X.
Venue
Ecotoxicology and Environmental Safety
Publisher
Elsevier BV
Published
2020-04
Volume
193
Pages
110372
ISSN
0147-6513
DOI
10.1016/j.ecoenv.2020.110372
Cited by
45
References
0
Language
en
Licence
Funders
  • Modern Argo-Industry Technology Research System of China (CARS-40-K10)
  • Leading Innovation Team Project of South Taihu Elite Program

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