Cited by 598Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesOral microbiology and periodontitis research

Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes

Musso, Giovanni, Gambino, Roberto, Cassader, Maurizio·2011·Annual Review of Medicine

Abstract

Novel, culture-independent, molecular and metagenomic techniques have provided new insight into the complex interactions between the mammalian host and gut microbial species. It is increasingly evident that gut microbes may shape the host metabolic and immune network activity and ultimately influence the development of obesity and diabetes. We discuss the evidence connecting gut microflora to obesity and to type 1 and type 2 diabetes, and we present recent insights into potential mechanisms underlying this relationship: increased nutrient absorption from the diet, prolonged intestinal transit time, altered bile acid entero-hepatic cycle, increased cellular uptake of circulating triglycerides, enhanced de novo lipogenesis, reduced free fatty acid oxidation, altered tissue composition of biologically active polyunsaturated fatty acid, chronic low-grade inflammation triggered by the endotoxin toll-like receptor 4 axis, and altered intestinal barrier function.

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Crossref · 10.1146/annurev-med-012510-175505

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99 of 99 references verified0 citation errors · 0 not checkable

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  • Microbiota-produced SCFAs affect a range of host processes including control of colonic pH, with consequent effects on microbiota composition, intestinal motility, gut permeability and epithelial cell proliferation.

    “The microbiota-produced SCFAs affect a range of host processes including control of colonic pH, with consequent effects on microbiota composition, intestinal motility, gut permeability and epithelial cell proliferation [77].”

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Authors
Musso, G., Gambino, R., & Cassader, M.
Affiliations
  • Ospedale Humanitas Gradenigo (IT)
  • University of Turin (IT)
Venue
Annual Review of Medicine
Published
2011-02-18
Volume
62
Issue
1
Pages
361-380
ISSN
  • 0066-4219 (ISSN-L)
  • 1545-326X
OpenAlex
W2153670376
Cited by
598
References
99
Citations by year
2026: 8 · 2025: 13 · 2024: 31 · 2023: 30 · 2022: 35 · 2021: 55 · 2020: 45 · 2019: 39 · 2018: 66 · 2017: 36 · 2016: 37 · 2015: 53 · 2014: 49 · 2013: 49 · 2012: 40
FWCI
2.84
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
gut microbiota, host-microbe interactions, obesity, type 2 diabetes, type 1 diabetes, nutrient absorption, intestinal transit time, triglyceride uptake, de novo lipogenesis, fatty acid oxidation, polyunsaturated fatty acids, low-grade inflammation, TLR4, endotoxin, intestinal barrier function
MeSH terms
Angiopoietin-Like Protein 4, Animals, Bile Acids and Salts, Choline, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Energy Metabolism, Humans, Inflammation, Obesity, Cyclic AMP-Dependent Protein Kinases, Endotoxemia, Gastrointestinal Tract, Angiopoietins, Linoleic Acids, Conjugated, Carbohydrate Metabolism, Toll-Like Receptor 4, Mice, Rats, Metagenome

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