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Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey

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LENZEN, M·2004·European Heart Journal

Abstract

AIMS: Due to a lack of clinical trials, scientific evidence regarding the management of patients with chronic heart failure and preserved left ventricular function (PLVF) is scarce. The EuroHeart Failure Survey provided information on the characteristics, treatment and outcomes of patients with PLVF as compared to patients with a left ventricular systolic dysfunction (LVSD). METHODS AND RESULTS: We performed a secondary analysis using data from the EuroHeart Failure Survey, only including patients with a measurement of LV function (n = 6806). We selected two groups: patients with LVSD (54%) and patients with a PLVF (46%). Patients with a PLVF were, on average, 4 years older and more often women (55% vs. 29%, respectively, p < 0.001) as compared to LVSD patients, and were more likely to have hypertension (59% vs. 50%, p < 0.001) and atrial fibrillation (25% vs. 23%, p = 0.01). PLVF patients received less cardiovascular medication compared to PLVF patients, with the exception of calcium antagonists. Multivariate analysis revealed that LVSD was an independent predictor for mortality, while no differences in treatment effect on mortality between the two groups was observed. A sensitivity analysis, using different thresholds to separate patients with and without LVSD revealed comparable findings. CONCLUSIONS: In the EuroHeart Failure Survey, a high percentage of heart failure patients had PLVF. Although major clinical differences were seen between the groups, morbidity and mortality was high in both groups.

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Metadata

Authors
LENZEN, M.
Venue
European Heart Journal
Published
2004-07
Volume
25
Issue
14
Pages
1214-1220
ISSN
0195-668X (ISSN-L)
OpenAlex
W2165842183
Cited by
369
References
42
FWCI
14.66
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey. https://app.cochat.ai/papers/10.1016/j.ehj.2004.06.006
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LENZEN, M. (2004). Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey. European Heart Journal. https://doi.org/10.1016/j.ehj.2004.06.006

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