The DOI matches its Crossref record; 355 of the 355 references it cites were found in a registry or an index.
Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro
Abstract
Advances in cell culture methods, multidisciplinary research, clinical need to replace lost skin tissues and regulatory need to replace animal models with alternative test methods has led to development of three dimensional models of human skin. In general, these in vitro models of skin consist of keratinocytes cultured over fibroblast-populated dermal matrices. Accumulating evidences indicate that mesenchyme-derived signals are essential for epidermal morphogenesis, homeostasis and differentiation. Various studies show that fibroblasts isolated from different tissues in the body are dynamic in nature and are morphologically and functionally heterogeneous subpopulations. Further, these differences seem to be dictated by the local biological and physical microenvironment the fibroblasts reside resulting in "positional identity or memory". Furthermore, the heterogeneity among the fibroblasts play a critical role in scarless wound healing and complete restoration of native tissue architecture in fetus and oral mucosa; and excessive scar formation in diseased states like keloids and hypertrophic scars. In this review, we summarize current concepts about the heterogeneity among fibroblasts and their role in various wound healing environments. Further, we contemplate how the insights on fibroblast heterogeneity could be applied for the development of next generation organotypic skin models.
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Cites
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Cited by
The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
Solé-Boldo, L., Raddatz, G., Schütz, S., Mallm, J.-P., Rippe, K., Lonsdorf, A. S., Rodríguez-Paredes, M., & Lyko, F. (2020) · Communications Biology · doi:10.1038/s42003-020-0922-4 · Cited by 559
Direct 3D cell-printing of human skin with functional transwell system
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Modelling the Complexity of Human Skin In Vitro
Hofmann, E., Schwarz, A., Fink, J., Kamolz, L.-P., & Kotzbeck, P. (2023) · Biomedicines · doi:10.3390/biomedicines11030794 · Cited by 129
Metadata
- Authors
- Sriram, G., Bigliardi, P. L., & Bigliardi-Qi, M.
- Venue
- European Journal of Cell Biology
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 94
- Issue
- 11
- Pages
- 483-512
- ISSN
- 0171-9335 (ISSN-L)
- OpenAlex
- W1449541226
- Cited by
- 269
- References
- 355
- FWCI
- 22.29
- Type
- journal article
- Language
- en
- Open access
- closed
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