The emerging role of ferroptosis in inflammation

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713 · see citing works

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695 · see citing works

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293 · see citing works

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732 · see citing works

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703 · see citing works

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686 · see citing works

FSP1 is a glutathione-independent ferroptosis suppressor

Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., et al. (2019) · Nature · doi:10.1038/s41586-019-1707-0 · Cited by 3,341 · see citing works

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., & Shao, F. (2017) · Nature · doi:10.1038/nature22393 · Cited by 3,199 · see citing works

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029 · see citing works

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Wang, W., Green, M., Choi, J. E., Gijón, M., Kennedy, P. D., Johnson, J. K., Liao, P., Lang, X., Kryczek, I., Sell, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1170-y · Cited by 2,880 · see citing works

The molecular machinery of regulated cell death

Tang, D., Kang, R., Berghe, T. V., Vandenabeele, P., & Kroemer, G. (2019) · Cell Research · doi:10.1038/s41422-019-0164-5 · Cited by 2,595 · see citing works

Targeting Ferroptosis to Iron Out Cancer

Hassannia, B., Vandenabeele, P., & Berghe, T. V. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.04.002 · Cited by 2,483 · see citing works

Activation of the p62–Keap1–NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Sun, X., Ou, Z., Chen, R., Niu, X., Chen, D., Kang, R., & Tang, D. (2016) · Hepatology · doi:10.1002/hep.28251 · Cited by 2,012 · see citing works

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Viswanathan, V. S., Ryan, M. J., Dhruv, H. D., Gill, S., Eichhoff, O. M., Seashore-Ludlow, B., Kaffenberger, S. D., Eaton, J. K., Shimada, K., Aguirre, A. J., et al. (2017) · Nature · doi:10.1038/nature23007 · Cited by 2,011 · see citing works

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

Smith, W. L., Garavito, R. M., & DeWitt, D. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33157 · Cited by 1,973 · see citing works

Ferroptosis is an autophagic cell death process

Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899 · see citing works

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

Böttcher, J. P., Bonavita, E., Chakravarty, P., Blees, H., Cabeza-Cabrerizo, M., Sammicheli, S., Rogers, N. C., Sahai, E., Zelenay, S., & Reis e Sousa, C. (2018) · Cell · doi:10.1016/j.cell.2018.01.004 · Cited by 1,857 · see citing works

RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631 · see citing works

Regulation of Immune Responses by Prostaglandin E2

Kaliński, P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101029 · Cited by 1,477 · see citing works

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.005 · Cited by 1,470 · see citing works

Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine

Rosa, M. D., Giroud, J. P., & Willoughby, D. A. (1971) · The Journal of Pathology · doi:10.1002/path.1711040103 · Cited by 1,409 · see citing works

Unravelling mechanisms of p53-mediated tumour suppression

Bieging-Rolett, K. T., Mello, S. S., & Attardi, L. D. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3711 · Cited by 1,389 · see citing works

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

Wu, M., Yiang, G.-T., Liao, W.-T., Tsai, A. P., Cheng, Y., Cheng, P., Li, C.-Y., & Li, C. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000489241 · Cited by 1,360 · see citing works

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

Keep, R. F., Hua, Y., & Xi, G. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70104-7 · Cited by 1,308 · see citing works

Hepcidin and iron homeostasis

Ganz, T., & Nemeth, E. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.01.014 · Cited by 1,282 · see citing works

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Angeli, J. P. F., Krysko, D. V., & Conrad, M. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0149-1 · Cited by 1,262 · see citing works

Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy

O’Connor, A. E., Gallagher, W. M., & Byrne, A. T. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00585.x · Cited by 1,191 · see citing works

Synchronized renal tubular cell death involves ferroptosis

Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126 · see citing works

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

Zelenay, S., van der Veen, A. G., Böttcher, J. P., Snelgrove, K. J., Rogers, N. C., Acton, S. E., Chakravarty, P., Girotti, M. R., Marais, R., Quezada, S. A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.015 · Cited by 1,123 · see citing works

Cell Death SignalingPreprint

Green, D. R., & Llambi, F. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006080 · Cited by 1,117 · see citing works

Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes

Deponte, M. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.018 · Cited by 1,104 · see citing works

The chemical basis of ferroptosis

Conrad, M., & Pratt, D. A. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0408-1 · Cited by 1,029 · see citing works

BAP1 links metabolic regulation of ferroptosis to tumour suppression

Zhang, Y., Shi, J., Liu, X., Li, F., Gong, Z., Koppula, P., Sirohi, K., Li, X., Wei, Y., Lee, H., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0178-0 · Cited by 1,024 · see citing works

Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

Ursini, F., Maiorino, M., Valente, M., Ferri, L., & Gregolin, C. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90150-3 · Cited by 884 · see citing works

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Yang, L., Feng, D., Wang, Z., Zhao, Y., Sun, R., Tian, D., Liu, D., Zhang, F., Ning, S., Yao, J., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0299-4 · Cited by 873 · see citing works

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Shah, R., Shchepinov, M. S., & Pratt, D. A. (2018) · ACS Central Science · doi:10.1021/acscentsci.7b00589 · Cited by 782 · see citing works

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Gaschler, M. M., Andia, A. A., Liu, H., Csuka, J. M., Hurlocker, B., Vaiana, C. A., Heindel, D. W., Zuckerman, D. S., Bos, P. H., Reznik, E., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0031-6 · Cited by 750 · see citing works

The tumor suppressor protein p53 and the ferroptosis network

Kang, R., Kroemer, G., & Tang, D. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.074 · Cited by 701 · see citing works

Inhibition of neuronal ferroptosis protects hemorrhagic brain

Li, Q., Han, X., Lan, X., Gao, Y., Wan, J., Durham, F., Cheng, T., Yang, J., Wang, Z., Jiang, C. Q., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.90777 · Cited by 687 · see citing works

The release and activity of HMGB1 in ferroptosis

Wen, Q., Liu, J., Kang, R., Zhou, B., & Tang, D. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.090 · Cited by 683 · see citing works

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

Kajarabille, N., & Latunde-Dada, G. O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194968 · Cited by 680 · see citing works

Mitochondria regulation in ferroptosis

Wang, H., Liu, C., Zhao, Y., & Gao, G. (2019) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2019.151058 · Cited by 655 · see citing works

Regulated necrosis: disease relevance and therapeutic opportunities

Conrad, M., Angeli, J. P. F., Vandenabeele, P., & Stockwell, B. R. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.6 · Cited by 630 · see citing works

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

Ma, S., Henson, E. S., Chen, Y., & Gibson, S. B. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.208 · Cited by 627 · see citing works

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Hassannia, B., Wiernicki, B., Ingold, I., Qu, F., Herck, S. V., Tyurina, Y. Y., Bayır, H., Abhari, B. A., Angeli, J. P. F., Choi, S. M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99032 · Cited by 626 · see citing works

Iron‐dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

Louandre, C., Ezzoukhry, Z., Godin, C., Barbare, J., Mazière, J., Chauffert, B., & Galmiche, A. (2013) · International Journal of Cancer · doi:10.1002/ijc.28159 · Cited by 602 · see citing works

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

Martin-Sanchez, D., Ruiz-Andres, O., Poveda, J., Carrasco, S., Cannata-Ortiz, P., Sanchez-Niño, M. D., Ruiz Ortega, M., Egido, J., Linkermann, A., Ortiz, A., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015121376 · Cited by 564 · see citing works

Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis

Chang, L., Chiang, S.-K., Chen, S., Yu, Y., Chou, R., & Chang, W. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.12.025 · Cited by 561 · see citing works

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

Cramer, S. L., Saha, A., Liu, J., Tadi, S., Tiziani, S., Yan, W., Triplett, K., Lamb, C., Alters, S. E., Rowlinson, S. W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4232 · Cited by 541 · see citing works

Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria

Zhong, H., & Yin, H. (2014) · Redox Biology · doi:10.1016/j.redox.2014.12.011 · Cited by 540 · see citing works

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

Zille, M., Karuppagounder, S. S., Chen, Y., Gough, P. J., Bertin, J., Finger, J. N., Milner, T. A., Jonas, E. A., & Ratan, R. R. (2017) · Stroke · doi:10.1161/strokeaha.116.015609 · Cited by 531 · see citing works

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

Tsurusaki, S., Tsuchiya, Y., Koumura, T., Nakasone, M., Sakamoto, T., Matsuoka, M., Imai, H., Yuet-Yin Kok, C., Okochi, H., Nakano, H., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1678-y · Cited by 529 · see citing works

Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells

Eling, N., Reuter, L., Hazin, J., Hamacher-Brady, A., & Brady, N. R. (2015) · Oncoscience · doi:10.18632/oncoscience.160 · Cited by 524 · see citing works

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

Li, W., Feng, G., Gauthier, J. M., Lokshina, I., Higashikubo, R., Evans, S., Liu, X., Hassan, A., Tanaka, S., Cicka, M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126428 · Cited by 492 · see citing works

The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents

Yan, Y., Xie, Y., Cao, L., Yang, L., Yang, M., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1054549 · Cited by 467 · see citing works

A major role for ferroptosis in <i>Mycobacterium tuberculosis</i> –induced cell death and tissue necrosis

Amaral, E. P., Costa, D. L., Namasivayam, S., Riteau, N., Kamenyeva, O., Mittereder, L., Mayer-Barber, K. D., Andrade, B. B., & Sher, A. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20181776 · Cited by 464 · see citing works

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

Hayano, M., Yang, W., Corn, C. K., Pagano, N. C., & Stockwell, B. R. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.93 · Cited by 462 · see citing works

Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

Shintoku, R., Takigawa, Y., Yamada, K., Kubota, C., Yoshimoto, Y., Takeuchi, T., Koshiishi, I., & Torii, S. (2017) · Cancer Science · doi:10.1111/cas.13380 · Cited by 453 · see citing works

Arachidonic Acid Metabolism and Kidney Inflammation

Wang, T., Fu, X., Chen, Q., Patra, J. K., Wang, D., Wang, Z., & Gai, Z. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153683 · Cited by 435 · see citing works

Reversal of HO‐1 related cytoprotection with increased expression is due to reactive iron

Suttner, D. M., & Dennery, P. A. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.13.1800 · Cited by 426 · see citing works

Personalized genomic analyses for cancer mutation discovery and interpretation

Jones, S., Anagnostou, V., Lytle, K., Parpart-Li, S. T., Nesselbush, M. C., Riley, D. R. J., Shukla, M., Chesnick, B., Kadan, M., Papp, E., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa7161 · Cited by 413 · see citing works

Inflammatory pathways in alcoholic steatohepatitis

Gao, B., Ahmad, M. F., Nagy, L. E., & Tsukamoto, H. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.023 · Cited by 392 · see citing works

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

Biemond, P., van Eijk, H. G., Swaak, A. J., & Koster, J. F. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111364 · Cited by 380 · see citing works

Ferroptosis and necroinflammation, a yet poorly explored link

Proneth, B., & Conrad, M. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0173-9 · Cited by 378 · see citing works

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

Stoyanovsky, D. A., Tyurina, Y. Y., Shrivastava, I. H., Bahar, İ., Tyurin, V. A., Protchenko, O. V., Jadhav, S., Bolevich, S., Kozlov, A. V., Vladimirov, Y. A., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.008 · Cited by 375 · see citing works

Immunosuppression associated with chronic inflammation in the tumor microenvironment

Wang, D., & DuBois, R. N. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv123 · Cited by 358 · see citing works

Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils.

Sperling, R. I., Benincaso, A. I., Knoell, C., Larkin, J. K., Austen, K. F., & Robinson, D. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116245 · Cited by 349 · see citing works

The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression

Wu, Y., Zhang, S.-W., Gong, X., Tam, S., Xiao, D., Liu, S., & Tao, Y. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01157-x · Cited by 341 · see citing works

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

Qi, J., Kim, J.-W., Zhou, Z., Lim, C.-W., & Kim, B. (2020) · The American Journal of Pathology · doi:10.1016/j.ajpath.2019.09.011 · Cited by 338 · see citing works

The isoprostanes—25 years later

Milne, G. L., Dai, Q., & Roberts, L. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.007 · Cited by 335 · see citing works

Formation of 20-Hydroxyeicosatetraenoic Acid, a Vasoactive and Natriuretic Eicosanoid, in Human Kidney

Lasker, J. M., Chen, W. B., Wolf, I., Bloswick, B. P., Wilson, P. D., & Powell, P. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4118 · Cited by 305 · see citing works

Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity

Shimada, K., Hayano, M., Pagano, N. C., & Stockwell, B. R. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2015.11.016 · Cited by 300 · see citing works

Circulating Levels of Inflammatory Cytokines and Risk of Colorectal Adenomas

Kim, S., Keku, T. O., Martin, C., Galanko, J., Woosley, J. T., Schroeder, J. C., Satia, J. A., Halabi, S., & Sandler, R. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2924 · Cited by 298 · see citing works

Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis

Feng, S.-Q., Yao, X., Zhang, Y., Hao, J., Duan, H.-Q., Zhao, C.-X., Sun, C., Li, B., Fan, B.-Y., Wang, X., et al. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.245480 · Cited by 298 · see citing works

Loss of ceramide synthase 3 causes lethal skin barrier disruption

Jennemann, R., Rabionet, M., Gorgas, K., Epstein, S., Dalpke, A. H., Rothermel, U., Bayerle, A., van der Hoeven, F., Imgrund, S., Kirsch, J., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr494 · Cited by 283 · see citing works

Cyclooxygenase 2 is a key enzyme for inflammatory cytokine‐induced angiogenesis

Kuwano, T., Nakao, S., Yamamoto, H., Tsuneyoshi, M., Yamamoto, T., Kuwano, M., & Ono, M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0473com · Cited by 279 · see citing works

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

Duan, X., Wen, Z., Shen, H., Shen, M., & Chen, G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1203285 · Cited by 270 · see citing works

Ferroptosis Promotes Photodynamic Therapy: Supramolecular Photosensitizer-Inducer Nanodrug for Enhanced Cancer Treatment

Zhu, T., Shi, L., Yu, C., Dong, Y., Qiu, F., Shen, L., Qian, Q., Zhou, G., & Zhu, X. (2019) · Theranostics · doi:10.7150/thno.32867 · Cited by 266 · see citing works

Cell death mechanisms in eukaryotes

Nirmala, J. G., & Lopus, M. (2019) · Cell Biology and Toxicology · doi:10.1007/s10565-019-09496-2 · Cited by 266 · see citing works

Concepts of tissue injury and cell death in inflammation: a historical perspective

Wallach, D., Kang, T., & Kovalenko, A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3561 · Cited by 264 · see citing works

Voltage-dependent Anion Channels Modulate Mitochondrial Metabolism in Cancer Cells

Maldonado, E. N., Sheldon, K. L., DeHart, D. N., Patnaik, J. R., Manevich, Y., Townsend, D. M., Bezrukov, S. M., Rostovtseva, T. K., & Lemasters, J. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.433847 · Cited by 262 · see citing works

NEOPLASIA AND NEOPLASMS

(1985) · The Lancet · doi:10.1016/s0140-6736(85)90708-1 · Cited by 260 · see citing works

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

Chen, X., Xu, S., Zhao, C., & Liu, B. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.06.015 · Cited by 259 · see citing works

COX-2-derived endocannabinoid metabolites as novel inflammatory mediators

Alhouayek, M., & Muccioli, G. G. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.03.001 · Cited by 253 · see citing works

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

Dar, H. H., Tyurina, Y. Y., Mikulska-Ruminska, K., Shrivastava, I., Ting, H.-C., Tyurin, V. A., Krieger, J., St. Croix, C. M., Watkins, S., Bayir, E., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99490 · Cited by 251 · see citing works

Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage

Zhang, Z., Wu, Y. H., Yuan, S., Zhang, P., Zhang, J., Li, H., Li, X., Shen, H., Wang, Z., & Chen, G. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.012 · Cited by 240 · see citing works

Eicosanoid Transcellular Biosynthesis: From Cell-Cell Interactions to in Vivo Tissue Responses

Folco, G., & Murphy, R. C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.8 · Cited by 228 · see citing works

An Inflammatory Perspective on Necroptosis

Kearney, C. J., & Martin, S. J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.024 · Cited by 227 · see citing works

Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1

Li, X., Duan, L., Yuan, S., Zhuang, X., Qiao, T., & He, J. (2019) · Journal of Inflammation · doi:10.1186/s12950-019-0216-0 · Cited by 214 · see citing works

Origin and Consequences of Necroinflammation

Sarhan, M., Land, W. G., Tonnus, W., Hugo, C., & Linkermann, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00041.2016 · Cited by 210 · see citing works

Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma.

Marrogi, A. J., Travis, W. D., Welsh, J. A., Ma, K., Rahim, H., Tazelaar, H. D., Pairolero, P. C., Trastek, V. F., Jett, J. R., Caporaso, N., et al. (2000) · PubMed · Cited by 205 · see citing works

Role of the Lipoperoxidation Product 4-Hydroxynonenal in the Pathogenesis of Severe Malaria Anemia and Malaria Immunodepression

Schwarzer, E., Arese, P., & Skorokhod, O. A. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/638416 · Cited by 202 · see citing works

A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System

Stockwell, B. R., & Jiang, X. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.012 · Cited by 201 · see citing works

LEUKOTRIENE B4, AN INFLAMMATORY MEDIATOR IN GOUT

Rae, S., Davidson, E. M., & Smith, M. J. H. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92785-4 · Cited by 195 · see citing works

Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone.

Weitzel, F., & Wendel, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53251-8 · Cited by 194 · see citing works

Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer

Zheng, Z., & Li, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041456 · Cited by 191 · see citing works

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

Hinman, A., Holst, C. R., Latham, J. C., Bruegger, J. J., Ulas, G., McCusker, K. P., Amagata, A., Davis, D., Hoff, K. G., Kahn-Kirby, A. H., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201369 · Cited by 190 · see citing works

Cell Death in the Kidney

Priante, G., Gianesello, L., Ceol, M., Prete, D. D., & Anglani, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143598 · Cited by 184 · see citing works

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

Li, C., Deng, X., Xie, X., Liu, Y., Friedmann Angeli, J. P., & Lai, L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01120 · Cited by 183 · see citing works

Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death

Probst, L., Dächert, J., Schenk, B., & Fulda, S. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.06.112 · Cited by 176 · see citing works

Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation

Kim, E. H., Wong, S., & Martinez, J. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0179-3 · Cited by 176 · see citing works

The enzymology of prostaglandin endoperoxide H synthases-1 and -2

Smith, W. L., & Song, I. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00025-4 · Cited by 173 · see citing works

Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress

Terasaki, Y., Ohsawa, I., Terasaki, M., Takahashi, M., Kunugi, S., Kang, D., Urushiyama, H., Amenomori, S., Kaneko-Togashi, M., Kuwahara, N., et al. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00008.2011 · Cited by 162 · see citing works

Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury

Zhang, Y., Sun, C., Zhao, C., Hao, J., Zhang, Y., Fan, B., Li, B., Duan, H., Liu, C., Kong, X., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2018.10.023 · Cited by 153 · see citing works

A ferroptosis–based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis

Devos, D., Moreau, C., Kyheng, M., Garçon, G., Rolland, A., Blasco, H., Gelé, P., Lenglet, T., Veyrat‐Durebex, C., Corcia, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39739-5 · Cited by 138 · see citing works

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

Zhou, Z., Ye, T. J., DeCaro, E., Buehler, B., Stahl, Z., Bonavita, G. J., Daniels, M. J., & You, M. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.09.012 · Cited by 131 · see citing works

Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: Protection by Melatonin

NaveenKumar, S. K., Hemshekhar, M., Kemparaju, K., & Girish, K. S. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.05.009 · Cited by 127 · see citing works

The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria

Qu, J., Chen, W., Hu, R., & Feng, H. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2592935 · Cited by 122 · see citing works

Immunogenic Cell Death: Can It Be Exploited in PhotoDynamic Therapy for Cancer?

Panzarini, E., Inguscio, V., & Dini, L. (2012) · BioMed Research International · doi:10.1155/2013/482160 · Cited by 117 · see citing works

The Role of Prostaglandin E 2 in Tumor-Associated Immunosuppression

Wang, D., & DuBois, R. N. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.11.003 · Cited by 114 · see citing works

The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy

Toyokuni, S. (2016) · Pathology International · doi:10.1111/pin.12396 · Cited by 111 · see citing works

Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury

Lee, J. C., Krochak, R., Blouin, A., Kanterakis, S., Chatterjee, S., Arguiri, E., Vachani, A., Solomides, C., Cengel, K. A., & Christofidou‐Solomidou, M. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.1.7092 · Cited by 106 · see citing works

5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach

Sinha, S., Doble, M., & Manju, S. L. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.06.040 · Cited by 105 · see citing works

Cellular Senescence and Iron Dyshomeostasis in Alzheimer’s Disease

Masaldan, S., Belaidi, A. A., Ayton, S., & Bush, A. I. (2019) · Pharmaceuticals · doi:10.3390/ph12020093 · Cited by 103 · see citing works

ATP induces caspase-3/gasdermin E-mediated pyroptosis in NLRP3 pathway-blocked murine macrophages

Zeng, C., Li, C., Shu, J., Xu, L., Ouyang, D., Mai, F., Zeng, Q., Zhang, C., Li, R.-M., & He, X. (2019) · APOPTOSIS · doi:10.1007/s10495-019-01551-x · Cited by 96 · see citing works

Regulated Necrosis in Pulmonary Disease. A Focus on Necroptosis and Ferroptosis

Minagawa, S., Yoshida, M., Araya, J., Hara, H., Imai, H., & Kuwano, K. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0337tr · Cited by 86 · see citing works

A powerful cell-protection system prevents cell death by ferroptosis

Stockwell, B. R. (2019) · Nature · doi:10.1038/d41586-019-03145-8 · Cited by 85 · see citing works

Iron Exposure and the Cellular Mechanisms Linked to Neuron Degeneration in Adult Mice

Li, L.-B., Chai, R., Zhang, S., Xu, S., Zhang, Y., Li, H., Fan, Y., & Guo, C. (2019) · Cells · doi:10.3390/cells8020198 · Cited by 83 · see citing works

New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases

Zhang, X., Ding, M., Zhu, P., Huang, H., Zhuang, Q., Shen, J., Cai, Y., Zhao, M., & He, Q. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3214196 · Cited by 81 · see citing works

Involvement of regulated necrosis in blinding diseases: Focus on necroptosis and ferroptosis

Peng, J.-J., Song, W., Yao, F., Zhang, X., Peng, J., Luo, X., & Xia, X. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.107922 · Cited by 80 · see citing works

Population Dynamics in Cell Death: Mechanisms of Propagation

Riegman, M., Bradbury, M. S., & Overholtzer, M. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.07.008 · Cited by 77 · see citing works

Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia

Ebel, P., Imgrund, S., Dorp, K. V., Hofmann, K., Maier, H., Drake, H., Degen, J., Dörmann, P., Eckhardt, M., Franz, T., et al. (2014) · Biochemical Journal · doi:10.1042/bj20131242 · Cited by 74 · see citing works

Folic acid improves abnormal behavior via mitigation of oxidative stress, inflammation, and ferroptosis in the BTBR T+ tf/J mouse model of autism

Zhang, Q., Wu, H., Zou, M., Li, L., Li, Q., Sun, C., Xia, W. T., Cao, Y., & Wu, L. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.05.002 · Cited by 74 · see citing works

Emerging cellular functions of the lipid metabolizing enzyme 15‐Lipoxygenase‐1

Çolakoğlu, M., Tunçer, S., & Banerjee, S. (2018) · Cell Proliferation · doi:10.1111/cpr.12472 · Cited by 72 · see citing works

Cysteinyl‐leukotriene receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl leukotrienes

Gennaro, A. D., Carnini, C., Buccellati, C., Ballerio, R., Zarini, S., Fumagalli, F., Viappiani, S., Librizzi, L., Hernández, A., Murphy, R. C., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0599fje · Cited by 71 · see citing works

Membrane Redox State and Apoptosis: Death by Peroxide

Loscalzo, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.004 · Cited by 68 · see citing works

Oxidative stress as an iceberg in carcinogenesis and cancer biology

Toyokuni, S. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.025 · Cited by 66 · see citing works

The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity

Umemura, M., Kim, J., Aoyama, H., Hoshino, Y., Fukumura, H., Nakakaji, R., Sato, I., Ohtake, M., Akimoto, T., Narikawa, M., et al. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.07.002 · Cited by 62 · see citing works

ELZA KRIUGER

KOVALENKO, G. (1996) · Experiment · doi:10.1163/2211730x96x00180 · Cited by 57 · see citing works

The Eicosanoids, Redox-Regulated Lipid Mediators in Immunometabolic Disorders

de Araújo, A. C. J., Wheelock, C. E., & Haeggström, J. Z. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7332 · Cited by 57 · see citing works

12/15 lipoxygenase: A crucial enzyme in diverse types of cell death

Li, Q.-Q., Li, Q., Jia, J.-N., Liu, Z., Zhou, H., & Mao, X. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.04.002 · Cited by 55 · see citing works

COX-2, the dominant source of prostacyclin

Ricciotti, E., Yu, Y., Großer, T., & FitzGerald, G. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219073110 · Cited by 53 · see citing works

COX-2 inhibitors and the heart: are all coxibs the same?

Sooriakumaran, P. (2006) · Postgraduate Medical Journal · doi:10.1136/pgmj.2005.042234 · Cited by 52 · see citing works

Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancer

Arbiser, J. L., Bonner, M. Y., Ward, N. L., Elsey, J., & Rao, S. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.05.018 · Cited by 52 · see citing works

The Evolutionary Origins of Programmed Cell Death SignalingPreprint

Hofmann, K. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036442 · Cited by 51 · see citing works

MicroRNA-548 regulates high mobility group box 1 expression in patients with preterm birth and chorioamnionitis

Son, G., Kim, Y., Lee, J. J., Lee, K.-Y., Ham, H., Song, J., Park, S. T., & Kim, Y. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-56327-9 · Cited by 46 · see citing works

The universe of arachidonic acid metabolites in inflammatory bowel disease

Stenson, W. F. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000075 · Cited by 43 · see citing works

Mitigating the Cardiovascular and Renal Effects of NSAIDs: Table 1

Curiel, R., & Katz, J. D. (2013) · Pain Medicine · doi:10.1111/pme.12275 · Cited by 42 · see citing works

Polyunsaturated fatty acids and signalling via phospholipase C-β and A2 in myocardium

de Jonge, H. W., Dekkers, D. H. W., & Lamers, J. M. J. (1996) · Molecular and Cellular Biochemistry · doi:10.1007/bf00227899 · Cited by 39 · see citing works

COX-2 Blockade in Cancer Prevention and Therapy

Harris, B. D. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-302-6 · Cited by 35 · see citing works

Myocardial protection by the leukotriene synthesis inhibitor BAY X1005: importance of transcellular biosynthesis of cysteinyl-leukotrienes.

Rossoni, G., Sala, A., Berti, F., Testa, T., Buccellati, C., Molta, C., Müller-Peddinghaus, R., Maclouf, J., & Folco, G. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12270-2 · Cited by 35 · see citing works

FMLP Causes Eicosanoid-dependent Vasoconstriction and Edema in Lungs from Endotoxin-primed Rats

Voelkel, N. F., Czartolomna, J., Simpson, J., & Murphy, R. C. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.3.701 · Cited by 32 · see citing works

Cancer cells uptake porphyrinsviaheme carrier protein 1

Hiyama, K., Matsui, H., Tamura, M., Shimokawa, O., Hiyama, M., Kaneko, T., Nagano, Y. N., Hyodo, I., Tanaka, J., Miwa, Y., et al. (2012) · Journal of Porphyrins and Phthalocyanines · doi:10.1142/s1088424612501192 · Cited by 32 · see citing works

Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A 2 Proves Renal Origins of Urinary PGI-M and TX-M

Mitchell, J. A., Knowles, R., Kirkby, N. S., Reed, D. M., Edin, M. L., White, W. E., Chan, M. V., Longhurst, H. J., Yaqoob, M. M., Milne, G. L., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312144 · Cited by 30 · see citing works

ESSENTIAL FATTY ACID METABOLISM IN THE MICROPREMIE

Uauy, R. D., Mena, P., & Rojas, C. (2000) · Clinics in Perinatology · doi:10.1016/s0095-5108(05)70007-5 · Cited by 25 · see citing works

Induction of ferroptosis by singlet oxygen generated from naphthalene endoperoxide

Homma, T., Kobayashi, S., & Fujii, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.073 · Cited by 25 · see citing works

Cyclooxygenase-2 and Cancer

Koki, A. T., Leahy, K. M., Harmon, J. M., & Masferrer, J. L. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-302-6_12 · Cited by 21 · see citing works

High Mobility Group Box 1 and TLR4 Signaling Pathway in Gnotobiotic Piglets Colonized/Infected with L. amylovorus, L. mucosae, E. coli Nissle 1917 and S. Typhimurium

Šplı́chal, I., Donovan, S. M., Jenistova, V., Šplíchalová, I., Salmonová, H. Š., Vlková, E., Bunešová, V., Šinkora, M., Killer, J., Skřivanová, E., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246294 · Cited by 21 · see citing works

Binding of arachidonic acid and two flavonoid inhibitors to human 12- and 15-lipoxygenases: a steered molecular dynamics study

Mascayano, C., Núñez, G., Acevedo, W., & Rezende, M. C. (2009) · Journal of Molecular Modeling · doi:10.1007/s00894-009-0616-9 · Cited by 20 · see citing works

Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition

Brito, H., Marques, V., Afonso, M. B., Brown, D. G., Börjesson, U., Selmi, N., Smith, D. M., Roberts, I. O., Fitzek, M., Aniceto, N., et al. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-0240-0 · Cited by 19 · see citing works

Inflammation and aging: signaling pathways and intervention therapies

Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works

Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis

Rochette, L., Dogon, G., Rigal, E., Zeller, M., Cottin, Y., & Vergely, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010449 · Cited by 945 · see citing works

Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy

Liu, J., Han, X., Zhang, T., Tian, K., Li, Z., & Luo, F. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01512-7 · Cited by 718 · see citing works

The interaction between ferroptosis and inflammatory signaling pathways

Chen, Y., Fang, Z., Yi, X., Wei, X., & Jiang, D. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05716-0 · Cited by 589 · see citing works

GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

Liu, Y., Wan, Y., Jiang, Y., Zhang, L., & Cheng, W. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188890 · Cited by 536 · see citing works

Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment

Hsu, S., Li, C., Lin, I., Syue, W.-J., Chen, Y., Cheng, K., Teng, Y., Lin, Y., Yen, C., & Chiu, C. (2021) · Theranostics · doi:10.7150/thno.62521 · Cited by 487 · see citing works

GPX4, ferroptosis, and diseases

Zhang, W., Liu, Y., Yan, L., Zhu, C., & Zou, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116512 · Cited by 450 · see citing works

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

Reichert, C. O., de Freitas, F. A., Sampaio‐Silva, J., Rokita-Rosa, L., Barros, P. D. L., Levy, D., & Bydlowski, S. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228765 · Cited by 426 · see citing works

Pyroptosis in health and disease: mechanisms, regulation and clinical perspective

Liu, Y., Pan, R., Ouyang, Y., Gu, W., Xiao, T., Yang, H., Tang, L. Y., Wang, H., Xiang, B., & Chen, P. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01958-2 · Cited by 364 · see citing works

Carbon Quantum Dots-Based Nanozyme from Coffee Induces Cancer Cell Ferroptosis to Activate Antitumor Immunity

Lu, Y., Zhao, M., Luo, Q.-W., Zhang, Y., Liu, T.-T., Yang, Z., Liao, M., Tu, P., & Zeng, K. (2022) · ACS Nano · doi:10.1021/acsnano.2c01619 · Cited by 293 · see citing works

Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury

Zhang, Q., Jia, M., Wang, Y., Wang, Q., & Wu, J. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03697-8 · Cited by 295 · see citing works

Molecular mechanisms of ferroptosis and relevance to inflammation

Deng, L., He, S., Guo, N., Tian, W., Zhang, W., & Luo, L. (2022) · Inflammation Research · doi:10.1007/s00011-022-01672-1 · Cited by 269 · see citing works

Ferroptosis and its emerging roles in cardiovascular diseases

Li, N., Jiang, W., Wang, W., Xiong, R., Wu, X., & Geng, Q. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105466 · Cited by 254 · see citing works

The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators

Habib, H. M., Ibrahim, S., Zaim, A., & Ibrahim, W. H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111228 · Cited by 253 · see citing works

Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment

Wang, Y., Cheng, H., Wang, T., Zhang, K., Zhang, Y., & Kang, X. (2023) · Cell Proliferation · doi:10.1111/cpr.13448 · Cited by 239 · see citing works

Programmed cell death in atherosclerosis and vascular calcification

Li, M., Wang, Z., Fang, L., Cheng, S.-Q., Wang, X., & Liu, N. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04923-5 · Cited by 229 · see citing works

Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation

Shou, Y., Yang, L., Yang, Y., & Xu, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04284-5 · Cited by 222 · see citing works

Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation

Ryter, S. W. (2021) · Cells · doi:10.3390/cells10030515 · Cited by 221 · see citing works

Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis

Zhang, B., Chen, X., Ru, F., Gan, Y., Li, B., Xia, W., Dai, G., He, Y., & Chen, Z. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04137-1 · Cited by 218 · see citing works

Targeting ferroptosis in acute kidney injury

Ni, L., Cheng, Y., & Wu, X. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04628-9 · Cited by 225 · see citing works

Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression

Cui, Y., Zhang, Z., Zhou, X., Zhao, Z., Zhao, R., Xu, X., Kong, X., Ren, J., Yao, X., Wen, Q., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02231-x · Cited by 206 · see citing works

Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction

Xiao, Z., Kong, B., Fang, J., Qin, T., Dai, C., Shuai, W., & Huang, H. (2021) · Bioengineered · doi:10.1080/21655979.2021.2001913 · Cited by 199 · see citing works

Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?

Edeas, M., Saleh, J., & Peyssonnaux, C. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.05.110 · Cited by 194 · see citing works

Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study

Sonnweber, T., Boehm, A., Sahanic, S., Pizzini, A., Aichner, M., Sonnweber, B., Kurz, K., Koppelstätter, S., Haschka, D., Petzer, V., et al. (2020) · Respiratory Research · doi:10.1186/s12931-020-01546-2 · Cited by 177 · see citing works

Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery

Ge, J., Liu, Z., Zhong, Z., Wang, L., Zhuo, X., Li, J., Jiang, X., Ye, X., Xie, T., & Bai, R. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105817 · Cited by 183 · see citing works

Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation

Jin, X., Tang, J., Qiu, X., Nie, X., Ou, S., Wu, G., Zhang, R., & Zhu, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01825-7 · Cited by 182 · see citing works

Plasmalogens and Chronic Inflammatory Diseases

Bozelli, J. C., Azher, S., & Epand, R. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.730829 · Cited by 180 · see citing works

Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis

Wang, Y., Niu, H., Li, L., Han, J., Liu, Z., Chu, M., Sha, X., & Zhao, J. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01862-x · Cited by 175 · see citing works

Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure

Vats, K., Kruglov, O., Mizes, A., Самович, С. Н., Amoscato, A. A., Tyurin, V. A., Tyurina, Y. Y., Kagan, V. E., & Bunimovich, Y. L. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102143 · Cited by 157 · see citing works

Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation

Xie, S., Deng, Y., Guo, S., Li, J., Zhou, Y.-C., Liao, J., Wu, D., & Lan, W. (2022) · Scientific Reports · doi:10.1038/s41598-022-06848-7 · Cited by 150 · see citing works

NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis

Ramos, S., Hartenian, E., Santos, J. C., Walch, P., & Brož, P. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00055-y · Cited by 156 · see citing works

Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications

Qin, Y., Qiao, Y., Wang, D., Tang, C., & Yan, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111872 · Cited by 146 · see citing works

Role of Ferroptosis in Stroke

Xu, Y., Li, K., Zhao, Y., Zhou, L., Liu, Y., & Zhao, J. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01196-6 · Cited by 149 · see citing works

Connecting the “Dots”: From Free Radical Lipid Autoxidation to Cell Pathology and Disease

Foret, M. K., Lincoln, R., Carmo, S. D., Cuello, A. C., & Cosa, G. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00761 · Cited by 144 · see citing works

Recent advances in small-molecule fluorescent probes for studying ferroptosis

Qi, Y., Wang, H., Chen, L., Duan, Y., Yang, S., & Zhu, H. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01167g · Cited by 138 · see citing works

Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis

Wang, B., Yang, L., Yang, L., Liang, Y., Guo, F., Fu, P., & Ma, L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01156-w · Cited by 135 · see citing works

Implication of ferroptosis in aging

Mazhar, M., Din, A. U., Ali, H., Yang, G., Ren, W., Wang, L., Fan, X., & Yang, S. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00553-6 · Cited by 133 · see citing works

Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies

Guo, M., Zhu, Y., Shi, Y., Meng, X., Dong, X., Zhang, H., Wang, X., Du, M., & Yan, H. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102541 · Cited by 135 · see citing works

Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective

Hu, X., Li, Z., Lin, R., Shan, J.-Q., Yu, Q., Wang, R., Liao, L., Yan, W., Zhen, W., Shang, L., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.634690 · Cited by 127 · see citing works

Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review

Ohnishi, T., Iwasaki, N., & Sudo, H. (2022) · Cells · doi:10.3390/cells11030394 · Cited by 128 · see citing works

Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes

Wang, X., Li, H., Peng, P., Gong, Z., Huang, J. X., & Peng, H. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110148 · Cited by 125 · see citing works

Astaxanthin attenuates ferroptosis via Keap1-Nrf2/HO-1 signaling pathways in LPS-induced acute lung injury

Luo, L., Huang, F., Zhong, S., Ding, R., Su, J., & Li, X. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121091 · Cited by 124 · see citing works

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis

Wei, X.-B., Jiang, W.-Q., Zeng, J.-H., Huang, L.-Q., Ding, H.-G., Jing, Y.-W., Han, Y.-L., Li, Y.-C., & Chen, S.-L. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02738-1 · Cited by 123 · see citing works

STAT3-mediated ferroptosis is involved in ulcerative colitis

Huang, F., Zhang, S., Li, X., Huang, Y., He, S., & Luo, L. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.06.242 · Cited by 118 · see citing works

Paraptosis: a unique cell death mode for targeting cancer

Hanson, S., Dharan, A., Jinsha, P. V., Pal, S., Nair, B. G., Kar, R., & Mishra, N. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1159409 · Cited by 117 · see citing works

Unleashing the power of porphyrin photosensitizers: Illuminating breakthroughs in photodynamic therapy

Akbar, A., Khan, S., Chatterjee, T., & Ghosh, M. (2023) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2023.112796 · Cited by 115 · see citing works

Glycyrrhizin Attenuates Hypoxic‐Ischemic Brain Damage by Inhibiting Ferroptosis and Neuroinflammation in Neonatal Rats via the HMGB1/GPX4 Pathway

Zhu, K., Zhu, X. Q., Liu, S., Yu, J., Wu, S., & Hei, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8438528 · Cited by 114 · see citing works

Curcumin Attenuates Ferroptosis-Induced Myocardial Injury in Diabetic Cardiomyopathy through the Nrf2 Pathway

Zhang, W., Shaohuan, Q., Pinfang, K., & Chao, S. (2022) · Cardiovascular Therapeutics · doi:10.1155/2022/3159717 · Cited by 113 · see citing works

Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy

Lin, H., Xiong, W. G., Fu, L., Yi, J., & Yang, J. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00305-3 · Cited by 118 · see citing works

The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases

Xu, B., Chen, L., Zhan, Y., Marquez, K. N. S., Zhuo, L., Qi, S., Zhu, J., He, Y., Chen, X., Zhang, H., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.857919 · Cited by 104 · see citing works

AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye

Zuo, X., Zeng, H., Wang, B., Yang, X., He, D., Wang, L., Ouyang, H., & Yuan, J. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.10.3 · Cited by 110 · see citing works

Ferroptosis and EMT: key targets for combating cancer progression and therapy resistance

Ren, Y., Mao, X., Xu, H. J., Dang, Q., Weng, S., Zhang, Y., Chen, S., Liu, S., Ba, Y., Zhou, Z., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04907-4 · Cited by 113 · see citing works

The role of ferroptosis mediated by NRF2/ERK-regulated ferritinophagy in CdTe QDs-induced inflammation in macrophage

Liu, N., Liang, Y., Wei, T., Zou, L., Huang, X., Kong, L., Tang, M., & Zhang, T. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129043 · Cited by 106 · see citing works

Ferroptosis and Autophagy-Related Genes in the Pathogenesis of Ischemic Cardiomyopathy

Zheng, Y., Gao, W., Zhang, Q., Cheng, X., Liu, Y., Qi, Z., & Li, T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.906753 · Cited by 106 · see citing works

Microplastics induced inflammation and apoptosis via ferroptosis and the NF-κB pathway in carp

Xu, T., Cui, J., Xu, R., Cao, J., & Guo, M. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106659 · Cited by 104 · see citing works

Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling

Xiao, J., Luo, C., Li, A., Cai, F.-L., Wang, Y., Pan, X., Liu, X., Wang, Z., Xing, Z., Yu, L., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112010 · Cited by 108 · see citing works

Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis

Xu, X.-Q., Xu, T., Ji, W., Wang, C., Ren, Y., Xiong, X., Zhou, X., Lin, S., Xu, Y., & Qiu, Y. (2022) · mBio · doi:10.1128/mbio.02370-22 · Cited by 102 · see citing works

SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18

Su, G., Yang, W. P., Wang, S., Geng, C., & Guan, X. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.05.011 · Cited by 99 · see citing works

The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism

Long, H.-Z., Zhou, Z.-W., Cheng, Y., Luo, H.-Y., Li, F.-J., Xu, S., & Gao, L.-C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.888989 · Cited by 94 · see citing works

Role of Histone Post-Translational Modifications in Inflammatory Diseases

Lin, Y., Qiu, T., Wei, G., Que, Y., Wang, W., Kong, Y., Xie, T., & Chen, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.852272 · Cited by 95 · see citing works

The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis

Nguyen, K. T., Mun, S.-H., Yang, J., Lee, J., Seok, O.-H., Kim, E., Kim, D., An, S. Y., Seo, D.-Y., Suh, J., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00973-1 · Cited by 95 · see citing works

Neutral polysaccharide from Gastrodia elata alleviates cerebral ischemia–reperfusion injury by inhibiting ferroptosis‐mediated neuroinflammation via the NRF2 / HO ‐1 signaling pathway

Zhang, Y., Ye, P., Zhu, H., Gu, L., Li, Y., Feng, S., Zeng, Z., Chen, Q., Zhou, B., & Xiong, X. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14456 · Cited by 94 · see citing works

Inflammation Triggers Chondrocyte Ferroptosis in TMJOA via HIF-1α/TFRC

Chen, B., Pathak, J. L., Lin, H., Guo, W. Q., Chen, W. J., Luo, G., Wang, L. J., Sun, X., Ding, Y., Li, J., et al. (2024) · Journal of Dental Research · doi:10.1177/00220345241242389 · Cited by 93 · see citing works

Immunogenic Cell Death, DAMPs and Prothymosin α as a Putative Anticancer Immune Response Biomarker

Birmpilis, A. I., Paschalis, A., Mourkakis, A., Christodoulou, P., Kostopoulos, I. V., Antimissari, E., Terzoudi, G. I., Georgakilas, A. G., Armpilia, C., Papageorgis, P., et al. (2022) · Cells · doi:10.3390/cells11091415 · Cited by 91 · see citing works

HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma

Zeng, Z., Huang, H., Zhang, J., Liu, Y., Zhong, W., Chen, W., Lu, Y., Qiao, Y., Zhao, H., Meng, X., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101977rr · Cited by 93 · see citing works

Resveratrol attenuates rotenone-induced inflammation and oxidative stress via STAT1 and Nrf2/Keap1/SLC7A11 pathway in a microglia cell line

Sun, W., Li, H., Shen, Y., & Xiao, H. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153576 · Cited by 90 · see citing works

Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy

Ebrahimi, N., Adelian, S., Shakerian, S., Afshinpour, M., Chaleshtori, S. R., Ravari, N. R., Rezaei‐Tazangi, F., Beiranvand, S., Hamblin, M. R., & Aref, A. R. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.01.006 · Cited by 90 · see citing works

Ferroptosis-Mediated Inflammation Promotes Pulmonary Hypertension

Kazmirczak, F., Vogel, N. T., Prisco, S. Z., Patterson, M. T., Annis, J. S., Moon, R. T., Hartweck, L. M., Mendelson, J. B., Kim, M., Mancipe, N. C., et al. (2024) · Circulation Research · doi:10.1161/circresaha.123.324138 · Cited by 102 · see citing works

Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis

Wang, Y., Wang, S., Yu, X., Zhang, J., Wang, S., Yang, Z. R., & Liu, C. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119551 · Cited by 89 · see citing works

The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders

Xu, Y., Jia, B., Li, J., Li, Q., & Luo, C. (2024) · Antioxidants · doi:10.3390/antiox13040395 · Cited by 92 · see citing works

Resveratrol Alleviates Diabetic Periodontitis-Induced Alveolar Osteocyte Ferroptosis Possibly via Regulation of SLC7A11/GPX4

Li, Y., Huang, Z., Pan, S.-S., Feng, Y., He, H., Cheng, S.-G., Wang, L., Wang, L., & Pathak, J. (2023) · Nutrients · doi:10.3390/nu15092115 · Cited by 87 · see citing works

Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis‑induced cardiomyopathy

Lin, X., Xiaoxia, Z., Chen, Q., Wang, X., Wu, Y., & Zhao, H. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5319 · Cited by 82 · see citing works

Swine influenza virus triggers ferroptosis in A549 cells to enhance virus replication

Cheng, J., Tao, J., Li, B., Shi, Y., & Liu, H. (2022) · Virology Journal · doi:10.1186/s12985-022-01825-y · Cited by 81 · see citing works

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis

Zheng, X., Chen, W., Yi, J., Wan, L., Liu, J.-Y., Fu, W.-Q., Ren, L., Li, S., Ge, B.-B., Yang, Y., et al. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00917-3 · Cited by 80 · see citing works

A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis

Ying, Y., Huang, Z., Tu, Y., Wu, Q., Li, Z., Zhang, Y., Yu, H., Zeng, A., Huang, H., Ye, J., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.09.019 · Cited by 79 · see citing works

Cross Talk Between Ferroptosis and Cerebral Ischemia

She, X., Lan, B., Tian, H.-M., & Tang, B. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00776 · Cited by 79 · see citing works

Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis

Liu, Y., Cui, H., Mei, C., Cui, M., He, Q., Wang, Q., Li, D., Song, Y., Li, J., Chen, S., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06216-x · Cited by 77 · see citing works

Ferroptosis: an important player in the inflammatory response in diabetic nephropathy

Li, J., Li, L., Zhang, Z., Chen, P., Shu, H., Yang, C., Chu, Y., & Liu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1294317 · Cited by 81 · see citing works

Ferroptosis, pyroptosis and necroptosis in acute respiratory distress syndrome

Zheng, Y., Huang, Y., Xu, Y., Sang, L., Liu, X., & Li, Y. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01369-2 · Cited by 76 · see citing works

Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway

Yang, M., Shen, Z., Zhang, X., Song, Z., Zhang, Y., Lin, Z., & Chen, L. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.08.020 · Cited by 77 · see citing works

Photodynamic therapy, priming and optical imaging: Potential co-conspirators in treatment design and optimization — a Thomas Dougherty Award for Excellence in PDT paper

Silva, P. D., Saad, M. A., Thomsen, H., Bano, S., Ashraf, S., & Hasan, T. G. (2020) · Journal of Porphyrins and Phthalocyanines · doi:10.1142/s1088424620300098 · Cited by 74 · see citing works

Restoring neuronal iron homeostasis revitalizes neurogenesis after spinal cord injury

Geng, H., Li, Z., Li, Z., Zhang, Y., Gao, Z., Sun, L., Li, X., Cui, J., Ni, S., & Hao, J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2220300120 · Cited by 76 · see citing works

Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death

Hwang, J., Park, J.-H., Park, B., Kim, H., Kim, J.-J., Sim, W., Mishchenko, N. P., Fedoreyev, S. A., Васильева, Е. А., Ban, K., et al. (2021) · Antioxidants · doi:10.3390/antiox10101624 · Cited by 74 · see citing works

Emerging Roles of the Iron Chelators in Inflammation

Paola, A. D., Tortora, C., Argenziano, M., Marrapodi, M. M., & Rossi, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147977 · Cited by 78 · see citing works

Modes of Brain Cell Death Following Intracerebral Hemorrhage

Zhang, Y., Khan, S., Liu, Y., Zhang, R., Li, H., Wu, G., Tang, Z., Xue, M., & Yong, V. W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.799753 · Cited by 71 · see citing works

Postconditioning with Irisin Attenuates Lung Ischemia/Reperfusion Injury by Suppressing Ferroptosis via Induction of the Nrf2/HO‐1 Signal Axis

Wang, Y., Dong, Z., Zhang, Z., Wang, Y., Yang, K., & Li, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9911167 · Cited by 74 · see citing works

The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation

Huo, C., Li, G., Hu, Y., & Sun, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214195 · Cited by 75 · see citing works

Hypermethylation of the Nrf2 Promoter Induces Ferroptosis by Inhibiting the Nrf2-GPX4 Axis in COPD

Zhang, Z., Fu, C., Liu, J., Sai, X., Qin, C., Di, T., Yang, Y., Wu, Y., & Bian, T. (2021) · International Journal of COPD · doi:10.2147/copd.s340113 · Cited by 69 · see citing works

Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms

Cai, C., Hu, W., & Chu, T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.817104 · Cited by 69 · see citing works

Extracellular CIRP Promotes GPX4-Mediated Ferroptosis in Sepsis

Shimizu, J., Murao, A., Nofi, C. P., Wang, P., & Aziz, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.903859 · Cited by 70 · see citing works

The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion

He, Y., Wang, J., Ying, C., Xu, K. L., Luo, J., Wang, B., Gao, J., Yin, Z., & Zhang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1482386 · Cited by 72 · see citing works

Types of necroinflammation, the effect of cell death modalities on sterile inflammation

Mázló, A., Jenei, V., Sára, B., Molnár, T., Bácsi, A., & Koncz, G. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04883-w · Cited by 65 · see citing works

From immune dysregulation to organ dysfunction: understanding the enigma of Sepsis

Liu, Z., Ting, Y., Li, M., Li, Y., Tan, Y., & Long, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1415274 · Cited by 74 · see citing works

Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective

Logie, E., & Berghe, W. V. (2020) · Antioxidants · doi:10.3390/antiox9111107 · Cited by 67 · see citing works

SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?

Yang, M., & Lai, C. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00369-w · Cited by 66 · see citing works

Mechanisms of sepsis-induced acute liver injury: a comprehensive review

Guo, Y., Guo, W., Chen, H., Sun, J., & Yin, Y. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1504223 · Cited by 73 · see citing works

Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota

Huang, W., Chen, H., He, Q. Z., Xie, W., peng, Z., Ma, Q., Huang, Q., Chen, Z., & Liu, Y. (2023) · Food & Function · doi:10.1039/d3fo01684f · Cited by 66 · see citing works

Extracellular Matrix and Oxidative Stress Following Traumatic Spinal Cord Injury: Physiological and Pathophysiological Roles and Opportunities for Therapeutic Intervention

Chio, J. C. T., Punjani, N., Hejrati, N., Zavvarian, M.-M., Hong, J., & Fehlings, M. G. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0120 · Cited by 67 · see citing works

Ferroptosis as a therapeutic target for inflammation-related intestinal diseases

Zhang, X., Ma, Y., Lv, G., & Wang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1095366 · Cited by 65 · see citing works

Molecular mechanisms of ferroptosis and their role in inflammation

Wang, F., He, J., Xing, R., Sha, T., & Sun, B. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.2016739 · Cited by 49 · see citing works

Editorial: Ferroptosis as a novel therapeutic target for inflammation-related diseases

Liang, Y., Su, Z., Mao, X., Wan, S., & Luo, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1152326 · Cited by 2 · see citing works

Molecular mechanisms of ferroptosis and relevance to inflammation

Deng, L., He, S., Guo, N., Tian, W., Zhang, W., & Luo, L. (2022) · Inflammation Research · doi:10.1007/s00011-022-01672-1 · Cited by 269 · see citing works

Inflammation in a ferroptotic environment

Wickert, A., Schwantes, A., Fuhrmann, D. C., & Brüne, B. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1474285 · Cited by 27 · see citing works

Ferroptosis in infection, inflammation, and immunity

Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210518 · Cited by 829 · see citing works