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Cited by 15Smoking Behavior and CessationCardiac Health and Mental HealthChronic Obstructive Pulmonary Disease (COPD) Research

Differences in cardiovascular mortality in smokers, past-smokers and non-smokers

Suriñach, J.M., Álvarez, L.R., Coll, R., Carmona, J.A., Sanclemente, C., Aguilar, E., Monreal, M.·2009·European Journal of Internal Medicine
DOI 10.1016/j.ejim.2009.05.007
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Abstract

Background The influence of smoking on outcome in patients with coronary artery disease (CAD) is controversial. Even less is known about its influence in patients with cerebrovascular (CVD), or peripheral artery (PAD) disease.Patients and methods FRENA is an ongoing, observational registry of consecutive outpatients with symptomatic CAD, CVD, or PAD. We reviewed their cardiovascular mortality according to smoking status.Results As of May 2008, 2501 patients had been enrolled in FRENA. Of these, 439 (18%) were current smokers, 1086 (43%) past-smokers, 976 (39%) had never smoked. Current- and past-smokers were 10 years younger, more often males, and more likely to have chronic lung disease, but had diabetes, hypertension, heart failure, or renal insufficiency less often than non-smokers. Over a mean follow-up of 14 months, 123 patients died (cardiovascular death, 68). On univariate analysis, current smokers had a significantly lower rate of cardiovascular death: 1.1 (95% CI: 0.4-2.4) per 100 patient-years in current smokers; 1.9 (95% CI: 1.2-2.8) in past-smokers; 3.5 (95% CI: 2.5-4.7) in non-smokers, with no differences between patients with CAD, CVD or PAD. Mean age at cardiovascular death was 82+/-6.4; 70+/-9.9 and 67+/-15 years, respectively. On multivariate analysis, smoking status was not independently associated with a lower risk for cardiovascular death.Conclusions Current and past-smokers with CAD, CVD or PAD had a less than half cardiovascular mortality than those who never smoked, but this may be explained by the confounding effect of additional variables. They died over 10 years younger than non-smokers.

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Crossref · 10.1016/j.ejim.2009.05.007

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  • Berries were shown to increase plasma antioxidant capacity and to decrease lipid peroxidation in smokers who are at high risk of developing CVD.

    “Berries were also shown to increase plasma antioxidant capacity36 and to decrease lipid peroxidation42 in smokers who are at high risk of developing CVD.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [55]

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Authors
Suriñach, J. M., Álvarez, L. R., Coll, R., Carmona, J. A., Sanclemente, C., Aguilar, E., & Monreal, M.
Affiliations
  • Vall d'Hebron Hospital Universitari (ES)
  • Universitat Autònoma de Barcelona (ES)
  • Hospital Universitari Germans Trias i Pujol (ES)
  • Hospital Alto Guadalquivir (ES)
  • Bellvitge University Hospital (ES)
ORCID
Venue
European Journal of Internal Medicine
Publisher
Elsevier BV
Published
2009-09
Volume
20
Issue
5
Pages
522-526
ISSN
0953-6205 (ISSN-L)
DOI
10.1016/j.ejim.2009.05.007
OpenAlex
W13131959
Cited by
15
References
36
Citations by year
2022: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
1.55
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universidad Autónoma de Madrid
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
smoking, cardiovascular mortality, coronary artery disease, cerebrovascular disease, peripheral arterial disease, current smokers, former smokers, confounding by age, outpatients
MeSH terms
Age Factors, Aged, Aged, 80 and over, Cerebrovascular Disorders, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Registries, Risk Factors, Smoking, Spain, Cohort Studies, Incidence, Case-Control Studies, Peripheral Vascular Diseases, Smoking Cessation

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