Cited by 127Sleep and Work-Related FatigueHeart Rate Variability and Autonomic ControlCircadian rhythm and melatonin

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One night on-call: Sleep deprivation affects cardiac autonomic control and inflammation in physicians

Tobaldini, Eleonora, Cogliati, Chiara, Fiorelli, Elisa M., Nunziata, Vanessa, Wu, Maddalena A., Prado, Marta, Bevilacqua, Maurizio, Trabattoni, Daria, Porta, Alberto, Montano, Nicola·2013·European Journal of Internal Medicine

DOI 10.1016/j.ejim.2013.03.011

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Abstract

Background Sleep loss is associated with increased cardiovascular morbidity and mortality. It is known that chronic sleep restriction affects autonomic cardiovascular control and inflammatory response. However, scanty data are available on the effects of acute sleep deprivation (ASD) due to night shifts on the cardiovascular system and its capability to respond to stressor stimuli. The aim of our study was to investigate whether a real life model of ASD, such as "one night on-call", might alter the autonomic dynamic response to orthostatic challenge and modify the immune response in young physicians.Methods Fifteen healthy residents in Internal Medicine were studied before and after one night on-call at Rest and during a gravitational stimulus (head up-tilt test, HUT). Heart rate variability (HRV), blood pressure variability (BPV) and baroreflex sensitivity (BRS) were analyzed during Rest and HUT before and after ASD. Plasmatic hormones (epinephrine, norepinephrine, cortisol, renin, aldosterone, ACTH) and tissue inflammatory cytokines were measured at baseline and after ASD.Result HRV analysis revealed a predominant sympathetic modulation and a parasympathetic withdrawal after ASD. During HUT, the sympathovagal balance shifted towards a sympathetic predominance before and after ASD. However, the magnitude of the autonomic response was lower after ASD. BPV and BRS remained unchanged before and after ASD as the hormone levels, while IFN-γ increased after ASD compared to baseline.Conclusion In summary, one night of sleep deprivation, at least in this real-life model, seems to affect cardiovascular autonomic response and immune modulation, independently by the activation of the hypothalamic-pituitary axis.

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Authors: Tobaldini, E., Cogliati, C., Fiorelli, E. M., Nunziata, V., Wu, M. A., Prado, M., Bevilacqua, M., Trabattoni, D., Porta, A., & Montano, N.
Affiliations: University of Milan (IT)
Luigi Sacco Hospital (IT)
Corresponding author: Montano, Nicola
ORCID: Tobaldini, Eleonora
Cogliati, Chiara
Fiorelli, Elisa M.
Wu, Maddalena A.
Bevilacqua, Maurizio
Trabattoni, Daria
Porta, Alberto
Montano, Nicola
Venue: European Journal of Internal Medicine
Publisher: Elsevier BV
Published: 2013-10
Volume: 24
Issue: 7
Pages: 664-670
ISSN: 0953-6205 (ISSN-L)
DOI: 10.1016/j.ejim.2013.03.011
OpenAlex: W2004911664
Semantic Scholar: 67cb7726663cf6cb3d989d8cb7daaeea1bb9d6c7
Cited by: 127
References: 50
Citations by year: 2026: 2 · 2025: 12 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 9 · 2017: 10 · 2016: 6 · 2015: 14 · 2014: 7 · 2013: 2
FWCI: 13.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: acute sleep deprivation, night shift work, cardiac autonomic control, inflammation, heart rate variability, baroreflex sensitivity, blood pressure variability, sympathovagal balance, hypothalamic-pituitary axis, cytokines, interferon-gamma, physicians, internal medicine residents, orthostatic challenge
MeSH terms: Adult, Autonomic Nervous System, Blood Pressure, Female, Heart Rate, Hormones, Humans, Inflammation, Male, Medical Staff, Hospital, Night Care, Personnel Staffing and Scheduling, Sleep Deprivation, Work Schedule Tolerance, Biomarkers, Baroreflex

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One night on-call: Sleep deprivation affects cardiac autonomic control and inflammation in physicians

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