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Cited by 468Heart Rate Variability and Autonomic ControlSleep and Work-Related FatigueCircadian rhythm and melatonin

Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation

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Zhong, Xu, Hilton, H. John, Gates, Gregory J., Jelic, Sanja, Stern, Yaakov, Bartels, Matthew N., DeMeersman, Ronald E., Basner, Robert C.·2005·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00620.2004
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Abstract

Cardiovascular autonomic modulation during 36 h of total sleep deprivation (SD) was assessed in 18 normal subjects (16 men, 2 women, 26.0 +/- 4.6 yr old). ECG and continuous blood pressure (BP) from radial artery tonometry were obtained at 2100 on the first study night (baseline) and every subsequent 12 h of SD. Each measurement period included resting supine, seated, and seated performing computerized tasks and measured vigilance and executive function. Subjects were not supine in the periods between measurements. Spectral analysis of heart rate variability (HRV) and BP variability (BPV) was computed for cardiac parasympathetic modulation [high-frequency power (HF)], sympathetic modulation [low-frequency power (LF)], sympathovagal balance (LF/HF power of R-R variability), and BPV sympathetic modulation (at LF). All spectral data were expressed in normalized units [(total power of the components/total power-very LF) x 100]. Spontaneous baroreflex sensitivity (BRS), based on systolic BP and pulse interval powers, was also measured. Supine and sitting, BPV LF was significantly increased from baseline at 12, 24, and 36 h of SD. Sitting, HRV LF was increased at 12 and 24 h of SD, HRV HF was decreased at 12 h SD, and HRV LF/HF power of R-R variability was increased at 12 h of SD. BRS was decreased at 24 h of SD supine and seated. During the simple reaction time task (vigilance testing), the significantly increased sympathetic and decreased parasympathetic cardiac modulation and BRS extended through 36 h of SD. In summary, acute SD was associated with increased sympathetic and decreased parasympathetic cardiovascular modulation and decreased BRS, most consistently in the seated position and during simple reaction-time testing.

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Crossref · 10.1152/japplphysiol.00620.2004

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  • After 36 hours of continuous sleep deprivation, sympathetic modulation of BP variability significantly increased and parasympathetic modulation of heart rate variability significantly decreased.

    “This study also observed a significant increase in sympathetic modulation of BP variability and reduction in parasympathetic modulation of heart rate variability, which suggests increased sympathetic nervous activity.”

    From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]

  • The increase in sympathetic modulation of BP variability and reduction in parasympathetic modulation of HRV after 36 hours of continuous sleep deprivation suggests increased sympathetic nervous activity.

    “This study also observed a significant increase in sympathetic modulation of BP variability and reduction in parasympathetic modulation of heart rate variability, which suggests increased sympathetic nervous activity.”

    From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]

  • After 36 hours of continuous sleep deprivation in 18 subjects seated upright, there were no significant differences in SBP, DBP, or mean arterial pressure.

    “Another study found no significant differences in SBP, DBP, or mean arterial pressure (MAP) after 36 hours of continuous sleep deprivation in 18 subjects seated in an upright position while the measurements were taken, but arterial baroreflex sensitivity significantly decreased [69].”

    From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]

  • After 36 hours of continuous sleep deprivation in 18 subjects seated upright, arterial baroreflex sensitivity significantly decreased.

    “Another study found no significant differences in SBP, DBP, or mean arterial pressure (MAP) after 36 hours of continuous sleep deprivation in 18 subjects seated in an upright position while the measurements were taken, but arterial baroreflex sensitivity significantly decreased [69].”

    From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]

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Authors
Zhong, X., Hilton, H. J., Gates, G. J., Jelic, S., Stern, Y., Bartels, M. N., DeMeersman, R. E., & Basner, R. C.
Affiliations
Columbia University (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2005-06
Volume
98
Issue
6
Pages
2024-2032
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00620.2004
OpenAlex
W2112789469
Cited by
468
References
59
Citations by year
2026: 10 · 2025: 27 · 2024: 18 · 2023: 30 · 2022: 32 · 2021: 27 · 2020: 22 · 2019: 27 · 2018: 26 · 2017: 27 · 2016: 24 · 2015: 26 · 2014: 21 · 2013: 26 · 2012: 29
FWCI
6.61
Type
journal article
Language
en
Open access
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Columbia Academic Commons (Columbia University)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
sleep deprivation, cardiovascular autonomic modulation, sympathetic nervous system, parasympathetic nervous system, heart rate variability, blood pressure variability, baroreflex sensitivity, sympathovagal balance, sustained attention, reaction time, posture
MeSH terms
Adolescent, Adult, Blood Pressure, Female, Heart, Heart Rate, Hemostasis, Humans, Male, Parasympathetic Nervous System, Reference Values, Sleep Deprivation, Sympathetic Nervous System, Baroreflex

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