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Cited by 35

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1)

Yuan, Hu, Lu, Weiqiang, Wang, Liyan, Shan, Lei, Li, Honglin, Huang, Jin, Sun, Qingyan, Zhang, Weidong·2013·European Journal of Medicinal Chemistry
DOI 10.1016/j.ejmech.2012.09.047
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Abstract

A series of MMP-1 inhibitors have been identified based upon a methyl rosmarinate scaffold using structure-based drug design methods. The best compound in the series showed an IC50 value of 0.4 μM. A docking study was conducted for compound (S)-10n in order to investigate its binding interactions with MMP-1. The structure-activity relationships (SAR) were also briefly discussed. Useful SAR was established which provides important guidelines for the design of future generations of potent inhibitors against MMP-1.

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Cited by

Metadata

Authors
Yuan, H., Lu, W., Wang, L., Shan, L., Li, H., Huang, J., Sun, Q., & Zhang, W.
Venue
European Journal of Medicinal Chemistry
Publisher
Elsevier BV
Published
2013-04
Volume
62
Pages
148-157
ISSN
0223-5234
DOI
10.1016/j.ejmech.2012.09.047
Cited by
35
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • NCET Foundation
  • NSFC (30725045)

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