Trehalose Against UVB-Induced Skin Photoaging by Suppressing MMP Expression and Enhancing Procollagen I Synthesis in HaCaT cells
Open accessAbstract
Ultraviolet radiation B cause photoaging of the skin by enhancing the high expression of matrix metalloproteinases (MMPs) to degrade collagen and inhibit the synthesis of procollagen. Trehalose (TRE), a widely occurring natural disaccharide, has been shown to play a cytoprotective role in many pathological processes. However, few studies have evaluated whether it has anti-photoaging potential. In this study, we investigated the anti-photoaging and mechanism of action of TRE using Human immortalized keratinocytes (HaCaT) cells. The results indicated that TRE pretreatment effectively scavenges reactive oxygen species (ROS) accumulation induced by UVB and increases the content of certain endogenous antioxidant factors in HaCaT cells. TRE suppressed UVB-induced MMP expression by blocking mitogen-activated protein kinases (MAPKs), activator protein 1 (AP-1) and NF-κB signaling. TRE treatment increased procollagen I synthesis via activating transforming growth factor-β (TGF-β)/Smad pathway and demonstrated that TRE may be a potential natural disaccharide for photoaging therapy in the future.
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Hydroxylated fullerene and trehalose sugar are free radical scavenging antioxidants with protective effects against UV-induced cellular damage.
“The synthetic carbon nanoparticle hydroxylated fullerene and trehalose sugar are both free radical scavenging antioxidants with protective effects against UV-induced cellular damage [34,35].”
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Marine Bioactive Peptides: Anti-Photoaging Mechanisms and Potential Skin Protective Effects
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- Authors
- Xiao, Z., Yang, S., Chen, J., Li, C., Zhou, C., Hong, P., Sun, S., & Qian, Z.-J.
- Affiliations
- Guangdong Ocean University (CN)
- Corresponding author
- Qian, Zhong-Ji
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 74
- Pages
- 104198
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W3087617646
- Cited by
- 54
- References
- 68
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 13 · 2023: 11 · 2022: 8 · 2021: 10
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Science Foundation of Guangdong Province (2020A1515011075)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- trehalose, photoaging, UV-B radiation, matrix metalloproteinases, keratinocytes, reactive oxygen species, antioxidant defense, MAPK signaling, AP-1, NF-κB, TGF-β/Smad signaling, collagen degradation
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