Cited by 54Skin Protection and Agingmelanin and skin pigmentationProtease and Inhibitor Mechanisms

Trehalose Against UVB-Induced Skin Photoaging by Suppressing MMP Expression and Enhancing Procollagen I Synthesis in HaCaT cells

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Xiao, Zhenbang, Yang, Shengtao, Chen, Jiali, Li, Chengyong, Zhou, Chunxia, Hong, Pengzhi, Sun, Shengli, Qian, Zhong-Ji·2020·Journal of Functional Foods

Abstract

Ultraviolet radiation B cause photoaging of the skin by enhancing the high expression of matrix metalloproteinases (MMPs) to degrade collagen and inhibit the synthesis of procollagen. Trehalose (TRE), a widely occurring natural disaccharide, has been shown to play a cytoprotective role in many pathological processes. However, few studies have evaluated whether it has anti-photoaging potential. In this study, we investigated the anti-photoaging and mechanism of action of TRE using Human immortalized keratinocytes (HaCaT) cells. The results indicated that TRE pretreatment effectively scavenges reactive oxygen species (ROS) accumulation induced by UVB and increases the content of certain endogenous antioxidant factors in HaCaT cells. TRE suppressed UVB-induced MMP expression by blocking mitogen-activated protein kinases (MAPKs), activator protein 1 (AP-1) and NF-κB signaling. TRE treatment increased procollagen I synthesis via activating transforming growth factor-β (TGF-β)/Smad pathway and demonstrated that TRE may be a potential natural disaccharide for photoaging therapy in the future.

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Authors
Xiao, Z., Yang, S., Chen, J., Li, C., Zhou, C., Hong, P., Sun, S., & Qian, Z.-J.
Affiliations
Guangdong Ocean University (CN)
Corresponding author
Qian, Zhong-Ji
Venue
Journal of Functional Foods
Publisher
Elsevier BV
Published
2020-11
Volume
74
Pages
104198
ISSN
1756-4646 (ISSN-L)
OpenAlex
W3087617646
Cited by
54
References
68
Citations by year
2026: 4 · 2025: 8 · 2024: 13 · 2023: 11 · 2022: 8 · 2021: 10
FWCI
5.22
Type
journal article
Language
en
Open access
Locations
  • Journal of Functional Foods (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Natural Science Foundation of Guangdong Province (2020A1515011075)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords
trehalose, photoaging, UV-B radiation, matrix metalloproteinases, keratinocytes, reactive oxygen species, antioxidant defense, MAPK signaling, AP-1, NF-κB, TGF-β/Smad signaling, collagen degradation

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