The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview
Open accessAbstract
Matrix metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to degrade the extracellular matrix (ECM) components and has important role in the pathophysiological functions. Overexpression and dysregulation of MMP-9 is associated with various diseases. Thus, regulation and inhibition of MMP-9 is an important therapeutic approach for combating various diseases including cancer. Inhibitors of MMP-9 can be used as anticancer agents. Till date no selective MMP-9 inhibitors passed the clinical trials. In this review the structure, activation, function and inhibitors of MMP-9 are mainly focused. Some highly active and/or selective MMP-9 inhibitors have been discussed which may be helpful to explore the structural significance of MMP-9 inhibitors. This study may be useful to design new potent and selective MMP-9 inhibitors against cancer in future.
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Cites
Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Van Wart, H. E., & Birkedal-Hansen, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5578 · Cited by 1,475
Strategies for MMP inhibition in cancer: innovations for the post-trial era
Overall, C. M., & López-Otín, C. (2002) · Nature Reviews Cancer · doi:10.1038/nrc884 · Cited by 1,349
Cited by
Multifunctional intracellular matrix metalloproteinases: implications in disease
Bassiouni, W., Ali, M. A. M., & Schulz, R. (2021) · The FEBS Journal · doi:10.1111/febs.15701 · Cited by 377
Targeting the tumor stroma for cancer therapy
Xu, M., Zhang, T., Xia, R., Wei, Y., & Wei, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01670-1 · Cited by 319
Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis
Li, S., Pritchard, D. M., & Yu, L.-G. (2022) · Cancers · doi:10.3390/cancers14133263 · Cited by 82
Pizani, R. S., Viganó, J., de Souza Mesquita, L. M., Contieri, L. S., Sanches, V. L., Chaves, J. O., Souza, M. C., da Silva, L. C., & Rostagno, M. A. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.07.001 · Cited by 57
The role of matrix metalloproteinases in liver function and disease
Mitropoulou, G., Kompoura, V., Saffioti, F., & Mavroeidis, V. K. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl27127 · Cited by 14
Metadata
- Authors
- Mondal, S., Adhikari, N., Banerjee, S., Amin, S. A., & Jha, T.
- Venue
- European Journal of Medicinal Chemistry
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 194
- Pages
- 112260
- ISSN
- 0223-5234 (ISSN-L)
- OpenAlex
- W3011825303
- Cited by
- 556
- References
- 4
- FWCI
- 20.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Mondal, S., Adhikari, N., Banerjee, S., Amin, S. A., & Jha, T. (2020). Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview. European Journal of Medicinal Chemistry. https://doi.org/10.1016/j.ejmech.2020.112260
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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