Poly (lactide-co-glycolide) particles of different physicochemical properties and their uptake by peyer's patches in mice
Abstract
Nano-and microparticles of poly(lactide-co-glycolide) (PLGA) were formulated using poly(vinyl alcohol) (PVA) or hydrophobically modified hydroxyethylcellulose (HMHEC) or polyethyleneimine (PEI) as stabilizers. The uptake by murine Peyer's patches (PPs) and the binding to Peyer's patches-free tissue (PPFT) of these particles was investigated using fluorescence microscopy providing qualitative information about the tissue distribution of particles. Observations of intestinal cryo-sections showed significant discrimination in the uptake by PP of nano-and microparticles. The uptake by PPs of PLGA-PVA and PLGA-HMHEC nano-and microparticles, of negative and neutral zeta potential, respectively, was comparable, whereas a smaller number was observed in the case of nano-and microparticles of PLGA-PEI, positively charged. Moreover, particle uptake by PPs appeared to be strongly size-dependent. The number of particles of mean diameter around 0.3 and 1 microm observed in PPs was much greater than that of particles of diameter average close to 3 microm. However, in all cases, particles were found in the PPFT for at least 48 h. In conclusion, regarding the tissue samples we have observed, it appeared that the uptake of particles by PPs and binding to PPFT could be influenced by the physicochemical properties of the particles but this may not have been true at all sites of the intestine and may differ between animals.
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Particle size is pivotal for stability, distribution, release of encapsulated antigens, and induction of immune responses.
“The particles’ size is pivotal for stability, distribution, release of the encapsulated antigens and induction of immune responses [36,37].”
From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [37]
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“he most significant techniques in the formulation of drug-loaded LGA particles are the emulsification-diffusion of solvent method, he double emulsion/solvent evaporation (DE/SEV) method, and he nanoprecipitation method (Dillen et al., 2004; Holgado et al., 008; Shakweh et al., 2005; Vauthier and Bouchemal, 2009).”
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“Another approach involves the blending or adsorption of functional polymers such as PEG, PCL [11,12], copolymers as poly(L-lysine)-gpoly(ethylene glycol) (PLL-g-PEG)[13] or polycationic polymers such as chitosan [14] or PEI [15], onto the preformed PLGA particles.”
BackgroundSelf-citationUse of lectin-functionalized particles for oral immunotherapy
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Spray-dried microparticles: a potential vehicle for oral delivery of vaccines
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“…other hand, it has been found that the strong electrostatic interaction between positive charge (þ30 to þ50 mV) of particle and negative charge of mucus layer can result in lower penetration across follicle associated epithelium and hence lower uptake of particles in M-cells (Shakweh et al., 2005).”
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“…NPs has further provided the confirmation of PODO/ETOPO encapsulation in PLA NPs. Morphological characterisation of podophyllotoxin and etoposide-loaded PLA nanoparticles The size of NPs is crucial for stability, cellular uptake, and release of drugs (Lamprecht et al., 2001; Shakweh et al., 2005).”
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Formulation Design Considerations for Oral Vaccines
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Assessing toxicity of copper nanoparticles across five cladoceran species
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“significantly influence their uptake route [23] and toxicokinetics”
BackgroundEvidence of Oral Translocation of Anionic G6.5 Dendrimers in Mice
Thiagarajan, G., Sadekar, S., Greish, K. F., Ray, A., & Ghandehari, H. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300436c · Cited by 33 · see citing works
Improved delivery of the natural anticancer drug tetrandrine
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“This is an important factor for cellular uptake and anti-cancer efficiency of the nanoparticles but also for drug encapsulation and release behavior (Shakweh et al., 2005).”
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Microencapsulation of Vaccine Antigens and Adjuvants for Mucosal Targeting
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“Shakwei et al. [ 31 ] reported higher Peyer’s patch uptake of PVA stabilized-PLGA nano and microparticles with neutral or negative zeta potential compared to PEI stabilized-PLGA nano and microparticles”
BackgroundMethodInfluentialBioadhesive delivery systems for mucosal vaccine delivery
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“…depending on their size particles could be retained within the lymphoid tissue (>3 μm) (Florence, 2005), or they could be internalized by phagocytic cells and subsequently transported to another lymphoid tissue through the lymphatic vessels that innervate the PP dome area (Shakweh et al., 2005).”
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Advances in Predictive, Preventive and Personalised Medicine
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Nanotechnology and site-targeted drug delivery
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Preparation and passive target of 5-fluorouracil solid lipid nanoparticles
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“In addition, the nanoparticles can naturally be taken up by enterocytes and/or the lymphoid tissues,([27,28]) so the bioavailability of the 5-FU-SLN formulation is obviously increased.”
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Influences of surface coating of PLGA nanoparticles on immune activation of macrophages
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Synthesis, Colloidal Properties and Cytotoxicity of Biopolymer Nanoparticles
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Nanomaterials for Enhanced Immunity as an Innovative Paradigm in Nanomedicine
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Battle of the milky way: Lymphatic targeted drug delivery for pathogen eradication
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Nanometric Biopolymer Devices for Oral Delivery of Macromolecules with Clinical Significance
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An Insight into the Polymeric Nanoparticles Applications in Diabetes Diagnosis and Treatment
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Biocoating—A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles
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Metal Nanoparticle Health Risk Assessment
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Effect of Divalent Cations on Pore Formation and Degradation of Poly(D,L-lactide-co-glycolide)
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- Authors
- Shakweh, M., Besnard, M., Nicolas, V., & Fattal, E.
- Affiliations
- Université Paris-Sud (FR)
- Venue
- European Journal of Pharmaceutics and Biopharmaceutics
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 61
- Issue
- 1-2
- Pages
- 1-13
- ISSN
- 0939-6411 (ISSN-L)
- OpenAlex
- W1984520012
- Cited by
- 161
- References
- 27
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 7 · 2014: 18 · 2013: 8 · 2012: 14
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- poly(lactic-co-glycolic acid), PLGA nanoparticles, PLGA microspheres, Peyer's patches, particle uptake, polyvinyl alcohol, polyethyleneimine, zeta potential, particle size, oral drug delivery, intestinal mucosa
- MeSH terms
- Administration, Oral, Animals, Drug Carriers, Drug Stability, Male, Mice, Inbred Strains, Microscopy, Electron, Scanning, Particle Size, Peyer's Patches, Polyglactin 910, Surface Properties, Nanostructures, Mice
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