Cited by 222Curcumin's Biomedical ApplicationsAdvanced Drug Delivery SystemsNeurological Disorders and Treatments

Curcumin loaded solid lipid nanoparticles: an efficient formulation approach for cerebral ischemic reperfusion injury in rats.

Kakkar, Vandita, Muppu, Sravan Kumar, Chopra, Kanwaljit, Kaur, Indu Pal·2013·European Journal of Pharmaceutics and Biopharmaceutics

Abstract

Scope To evaluate curcumin loaded solid lipid nanoparticles (C-SLNs) in the experimental paradigm of cerebral ischemia (BCCAO model) in rats.Methods and results Oral administration of free curcumin and C-SLNs (25 and 50 mg/kg) was started 5 days prior and continued for 3 days after BCCAO. Alleviation in behavioral, oxidative and nitrosative stress, acetylcholinesterase, mitochondrial enzyme complexes, and physiological parameters were assessed. Confirmation of effective brain delivery of C-SLNs (p.o) was done using biodistribution studies in mice and confocal microscopy of rat brain section. There was an improvement of 90% in cognition and 52% inhibition of acetylcholinesterase versus cerebral ischemic group (I/R). Neurological scoring improved by 79%. Levels of superoxide dismutase, catalase, glutathione, and mitochondrial complex enzyme activities were significantly increased, while lipid peroxidation, nitrite, and acetylcholinesterase levels decreased (p<0.05) after C-SLNs administration. It is noteworthy to report the restoration of SOD, GSH, catalase, and mitochondrial complex enzyme levels equivalent to sham control values. Gamma-scintigraphic studies show 16.4 and 30 times improvement in brain bioavailability (AUC) upon oral and i.v administration of C-SLNs versus solubilized curcumin (C-S).Conclusions Study indicates protective role of curcumin against cerebral ischemic insult; provided it is packaged suitably for improved brain delivery.

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Crossref · 10.1016/j.ejpb.2013.02.005

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  • Solid lipid nanoparticles of curcumin alleviate behavioral, oxidative, and nitrosative stress; acetylcholinesterase; mitochondrial enzyme complex; and physiological parameters in cerebral ischemic reperfusion injury in rats.

    “Alleviated behavioral, oxidative, and nitrosative stress; acetylcholinesterase; and mitochondrial enzyme complex, and physiological parameters in cerebral ischemic reperfusion injury in rats”

    From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Kakkar et al., 2013

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Authors
Kakkar, V., Muppu, S. K., Chopra, K., & Kaur, I. P.
Affiliations
Panjab University (IN)
Corresponding author
Kaur, Indu Pal
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2013-11
Volume
85
Issue
3
Pages
339-345
ISSN
0939-6411 (ISSN-L)
OpenAlex
W2090136445
Cited by
222
References
56
Citations by year
2026: 3 · 2025: 16 · 2024: 15 · 2023: 24 · 2022: 26 · 2021: 22 · 2020: 26 · 2019: 16 · 2018: 14 · 2017: 12 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 8
FWCI
7.37
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
Keywords
curcumin, solid lipid nanoparticles, cerebral ischemia-reperfusion injury, brain drug delivery, brain bioavailability, oxidative stress, nitrosative stress, acetylcholinesterase inhibition, mitochondrial enzyme activity, superoxide dismutase, catalase, glutathione, lipid peroxidation, neuroprotection, cognitive impairment, tissue distribution
MeSH terms
Administration, Oral, Animals, Antioxidants, Brain, Brain Ischemia, Curcumin, Dose-Response Relationship, Drug, Lipids, Male, Mitochondria, Tissue Distribution, Lipid Peroxidation, Reperfusion Injury, Rats, Wistar, Oxidative Stress, Microscopy, Confocal, Area Under Curve, Mice, Rats, Nanoparticles, Administration, Intravenous

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