Curcumin loaded solid lipid nanoparticles: an efficient formulation approach for cerebral ischemic reperfusion injury in rats.
Abstract
Scope To evaluate curcumin loaded solid lipid nanoparticles (C-SLNs) in the experimental paradigm of cerebral ischemia (BCCAO model) in rats.Methods and results Oral administration of free curcumin and C-SLNs (25 and 50 mg/kg) was started 5 days prior and continued for 3 days after BCCAO. Alleviation in behavioral, oxidative and nitrosative stress, acetylcholinesterase, mitochondrial enzyme complexes, and physiological parameters were assessed. Confirmation of effective brain delivery of C-SLNs (p.o) was done using biodistribution studies in mice and confocal microscopy of rat brain section. There was an improvement of 90% in cognition and 52% inhibition of acetylcholinesterase versus cerebral ischemic group (I/R). Neurological scoring improved by 79%. Levels of superoxide dismutase, catalase, glutathione, and mitochondrial complex enzyme activities were significantly increased, while lipid peroxidation, nitrite, and acetylcholinesterase levels decreased (p<0.05) after C-SLNs administration. It is noteworthy to report the restoration of SOD, GSH, catalase, and mitochondrial complex enzyme levels equivalent to sham control values. Gamma-scintigraphic studies show 16.4 and 30 times improvement in brain bioavailability (AUC) upon oral and i.v administration of C-SLNs versus solubilized curcumin (C-S).Conclusions Study indicates protective role of curcumin against cerebral ischemic insult; provided it is packaged suitably for improved brain delivery.
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Solid lipid nanoparticles of curcumin alleviate behavioral, oxidative, and nitrosative stress; acetylcholinesterase; mitochondrial enzyme complex; and physiological parameters in cerebral ischemic reperfusion injury in rats.
“Alleviated behavioral, oxidative, and nitrosative stress; acetylcholinesterase; and mitochondrial enzyme complex, and physiological parameters in cerebral ischemic reperfusion injury in rats”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Kakkar et al., 2013
Cites
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221 · see citing works
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061 · see citing works
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works
Jollow, D. J., Mitchell, J. R., ZAMPAGLIONE, N. G., & Gillette, J. R. (2008) · Pharmacology · doi:10.1159/000136485 · Cited by 3,291 · see citing works
AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA
Sottocasa, G. L., Kuylenstierna, B., Ernster, L., & Bergstrand, A. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.32.2.415 · Cited by 2,316 · see citing works
Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
Guido, S., Joy, D. C., Joseph, T., Majeed, M. A., Rajendran, R., & Srinivas, P. (1998) · Planta Medica · doi:10.1055/s-2006-957450 · Cited by 1,976 · see citing works
Kono, Y. (1978) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(78)90479-4 · Cited by 1,787 · see citing works
Mechanisms of lipid peroxide formation in animal tissues
Wills, E. D. (1966) · Biochemical Journal · doi:10.1042/bj0990667 · Cited by 1,348 · see citing works
Shaikh, J., Ankola, D. D., Beniwal, V., Singh, D., & Kumar, M. N. V. R. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.02.019 · Cited by 970 · see citing works
Berman, S. B., & Hastings, T. G. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731127.x · Cited by 664 · see citing works
Potential of solid lipid nanoparticles in brain targeting.
Kaur, I. P., Bhandari, R., Bhandari, S., & Kakkar, V. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.018 · Cited by 615 · see citing works
Self-citationHuang, M., Lysz, T. W., Ferraro, T., Abidi, T. F., Laskin, D. L., & Conney, A. H. (1991) · PubMed · Cited by 571 · see citing works
[58] Preparation of succinate dehydrogenase and reconstitution of succinate oxidase
King, T. E. (1967) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(67)10061-x · Cited by 533 · see citing works
Handbook of Methods for Oxygen Radical Research
Thomas, D. W. (1988) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.1988.tb09539.x · Cited by 444 · see citing works
Potential markers of oxidative stress in stroke
Cherubini, A., Ruggiero, C., Polidori, M. C., & Mecocci, P. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.025 · Cited by 427 · see citing works
Rogers, D. C., Campbell, C. A., Stretton, J. L., & Mackay, K. B. (1997) · Stroke · doi:10.1161/01.str.28.10.2060 · Cited by 413 · see citing works
Involvement of the β-diketone moiety in the antioxidative Mechanism of Tetrahydrocurcumin
Sugiyama, Y., Kawakishi, S., & Osawa, T. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00302-4 · Cited by 387 · see citing works
Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin
Kakkar, V., Singh, S., Singla, D., & Kaur, I. P. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000310 · Cited by 352 · see citing works
Self-citationBarry, J., Fritz, M., Brender, J., Smith, P. E. S., Lee, D.-K., & Ramamoorthy, A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809217u · Cited by 315 · see citing works
[52] Preparations and properties of soluble NADH dehydrogenases from cardiac muscle
King, T. E., & Howard, R. L. (1967) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(67)10055-4 · Cited by 292 · see citing works
Lipid Peroxidation In Vivo Induced by Reversible Global Ischemia in Rat Brain
Watson, B. D., Busto, R., Goldberg, W. J., Santiso, M., Yoshida, S., & Ginsberg, M. D. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb09728.x · Cited by 283 · see citing works
Babu, P. S., & Srinivasan, K. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006819605211 · Cited by 282 · see citing works
Curcumin and Especially Tetrahydrocurcumin Ameliorate Oxidative Stress-Induced Renal Injury in Mice
Okada, K., Wangpoengtrakul, C., Tanaka, T. U., Toyokuni, S., Uchida, K., & Osawa, T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.8.2090 · Cited by 274 · see citing works
Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats
Tuzcu, M., & Baydaş, G. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.024 · Cited by 272 · see citing works
Piper, J. (1998) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(98)00015-6 · Cited by 252 · see citing works
Reddy, D. S., & Kulkarni, S. K. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00419-3 · Cited by 225 · see citing works
Novel Antioxidative Metabolites in Rat Liver with Ingested Sesamin
Nakai, M., Harada, M., Nakahara, K., Akimoto, K., Shibata, H., Miki, W., & Kiso, Y. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0258961 · Cited by 218 · see citing works
Kakkar, V., & Kaur, I. P. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.08.006 · Cited by 212 · see citing works
Self-citationBehavioral performance of rats following transient forebrain ischemia.
Volpe, B. T., Pulsinelli, W. A., Tribuna, J., & Davis, H. P. (1984) · Stroke · doi:10.1161/01.str.15.3.558 · Cited by 193 · see citing works
Nitric oxide and neurological disorders
Duncan, A., & Heales, S. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.09.004 · Cited by 189 · see citing works
Ray, B., Bisht, S., Maitra, A., Maitra, A., & Lahiri, D. K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101374 · Cited by 177 · see citing works
Volpe, B. T., Davis, H. P., Towle, A. C., & Dunlap, W. P. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.3.457 · Cited by 175 · see citing works
Pharmacology of cerebral ischemia
Polinsky, R. J. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)90034-9 · Cited by 164 · see citing works
Oxidative stress in acute ischemic stroke
Özkul, A., Akyol, A., Yenisey, Ç., Arpaci, E., Kıylıoğlu, N., & Tataroğlu, C. (2007) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2006.11.008 · Cited by 151 · see citing works
Curcumin modulates free radical quenching in myocardial ischaemia in rats
Panchatcharam, M., Miriyala, S., Srinivasan, A., Manohar, B. M., Lokanadam, B., & Puvanakrishnan, R. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.01.030 · Cited by 150 · see citing works
Volpe, B. T., Davis, H. P., Towle, A. C., et al. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.3.457 · Cited by 143 · see citing works
Jaspers, R. M. A., Block, F., Heim, C. C., & Sontag, K. ‐. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90135-v · Cited by 131 · see citing works
Luo, Y., Hattori, A., Munoz, J. R., Qin, Z.-H., & Roth, G. S. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.2.254 · Cited by 120 · see citing works
Sharma, M., & Gupta, Y. K. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00611-6 · Cited by 107 · see citing works
Nirmala, C., & Puvanakrishnan, R. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)02118-3 · Cited by 93 · see citing works
Jones, E. A., & Shoskes, D. A. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67871-8 · Cited by 87 · see citing works
Lin, J., & Shih, C.-A. (1994) · Carcinogenesis · doi:10.1093/carcin/15.8.1717 · Cited by 83 · see citing works
Zhang, L., Fu, F.-H., Zhang, X., Zhu, M. J., Wang, T., & Fan, H. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.05.001 · Cited by 65 · see citing works
Enhanced Apoptotic Effect of Curcumin Loaded Solid Lipid Nanoparticles
Kakkar, V., Bhushan, S., Santosh, K. G., & Pal, K. I. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300209k · Cited by 65 · see citing works
Self-citationNMDA/NR2B Selective Antagonists in the Treatment of Ischemic Brain Injury
Wang, C., & Shuaib, A. M. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007053544183 · Cited by 62 · see citing works
Babbar, A. K., Singh, A. K., Goel, H. C., Chauhan, U. P. S., & Sharma, R. K. (2000) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(00)00092-5 · Cited by 59 · see citing works
Mitochondrial electron transport chain complexes in aging rat brain and lymphocytes
Sandhu, S. K., & Kaur, G. (2003) · Biogerontology · doi:10.1023/a:1022473219044 · Cited by 57 · see citing works
Kakkar, V., Singh, S., Singla, D., Sahwney, S., Chauhan, A. S., Singh, G., & Kaur, I. P. (2010) · Journal of Chromatography B · doi:10.1016/j.jchromb.2010.10.017 · Cited by 56 · see citing works
Self-citationKakkar, V., Mishra, A. K., Chuttani, K., Chopra, K., & Kaur, I. P. (2011) · Rejuvenation Research · doi:10.1089/rej.2011.1193 · Cited by 54 · see citing works
Self-citationImpairment of brain mitochondrial function by hydrogen peroxide
Sims, N. R., Anderson, M. F., Hobbs, L. M., Kong, J. Y., Phillips, S., Powell, J. A., & Zaidan, E. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00049-8 · Cited by 48 · see citing works
Cano, C., Bermúdez, V., Atencio, H., Medina, M., Anilsa, A., Souki, A., Molina, O. M., Restrepo, H. F., Vargas, M., N????ez, M., et al. (2003) · American Journal of Therapeutics · doi:10.1097/00045391-200311000-00018 · Cited by 39 · see citing works
Time dependent changes of striatal interneurons after focal cerebral ischemia in rats
Sakuma, M., Hyakawa, N., Kato, H., & Araki, T. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-007-0860-z · Cited by 35 · see citing works
Jingtao, J., Sato, S., & Yamanaka, N. (1999) · Medical Molecular Morphology · doi:10.1007/s007950050025 · Cited by 28 · see citing works
Initiation and propagation of lipid peroxidation in cerebral infarction models: Experimental studies
Imaizumi, S., Tominaga, T., Uenohara, H., Yoshimoto, T., Suzuki, J., & Fujita, Y. (1986) · Neurological Research · doi:10.1080/01616412.1986.11739757 · Cited by 24 · see citing works
Characterization of LY231617 Protection Against Hydrogen Peroxide Toxicity
Fuson, K. S., Mark, R. J., Panetta, J. A., & May, P. C. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721154.x · Cited by 18 · see citing works
Yu, G., Liu, L., Zhang, P., & Li, Y. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-s1-s33 · Cited by 8 · see citing works
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Amalraj, A., Pius, A., Gopi, S., & Gopi, S. (2016) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2016.05.005 · Cited by 976 · see citing works
Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects
Kotha, R. R., & Luthria, D. L. (2019) · Molecules · doi:10.3390/molecules24162930 · Cited by 919 · see citing works
Naksuriya, O., Okonogi, S., Schiffelers, R. M., & Hennink, W. E. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.090 · Cited by 844 · see citing works
Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects
Montoto, S. S., Muraca, G., & Ruiz, M. E. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.587997 · Cited by 672 · see citing works
Tapeinos, C., Battaglini, M., & Ciofani, G. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.08.033 · Cited by 541 · see citing works
Nanocurcumin: A Promising Candidate for Therapeutic Applications
Karthikeyan, A., Senthil, N., & Min, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00487 · Cited by 417 · see citing works
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Yallapu, M. M., Nagesh, P. K. B., Jaggi, M., & Chauhan, S. C. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9811-z · Cited by 397 · see citing works
Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB
Satapathy, M. K., Yen, T.-L., Jan, J.-S., Tang, R.-D., Wang, J.-Y., Taliyan, R., & Yang, C.-H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081183 · Cited by 318 · see citing works
Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease
Fonseca‐Santos, B., Chorilli, M., & Gremião, M. P. D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s87148 · Cited by 313 · see citing works
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Naqvi, S., Panghal, A., & Flora, S. J. S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00494 · Cited by 305 · see citing works
Lin, C.-H., Chen, C., Lin, Z., & Fang, J. (2017) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2017.02.001 · Cited by 299 · see citing works
Sood, S., Jain, K., & Gowthamarajan, K. (2014) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2013.09.030 · Cited by 289 · see citing works
Nanotechnology-Applied Curcumin for Different Diseases Therapy
Ghalandarlaki, N., Alizadeh, A. M., & Ashkani‐Esfahani, S. (2014) · BioMed Research International · doi:10.1155/2014/394264 · Cited by 289 · see citing works
Ashabi, G., Khalaj, L., Khodagholi, F., Goudarzvand, M., & Sarkaki, A. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9632-2 · Cited by 256 · see citing works
Maiti, P., & Dunbar, G. L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061637 · Cited by 236 · see citing works
Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers
Kabir, M. T., Rahman, M. H., Akter, R., Behl, T., Kaushik, D. K., Mittal, V., Pandey, P., Akhtar, M. F., Saleem, A., Albadrani, G. M., et al. (2021) · Biomolecules · doi:10.3390/biom11030392 · Cited by 217 · see citing works
Sandhir, R., Yadav, A., Mehrotra, A., Sunkaria, A., Singh, A., & Sharma, S. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8261-y · Cited by 204 · see citing works
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Ashfaq, R., Rasul, A., Asghar, S., Kovács, A., Berkó, S., & Budai-Szűcs, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115764 · Cited by 193 · see citing works
Formulations of Curcumin Nanoparticles for Brain Diseases
Del Prado-Audelo, M. L., Caballero-Florán, I. H., Meza-Toledo, J. A., Mendoza-Muñoz, N., González-Torres, M., Florán, B., Cortés, H., & Leyva-Gómez, G. (2019) · Biomolecules · doi:10.3390/biom9020056 · Cited by 191 · see citing works
“3 Cerebral ischemic injury (in vivo model) [86]”
BackgroundGanesan, P., Ramalingam, P., Karthivashan, G., Ko, Y. T., & Choi, D. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s155593 · Cited by 184 · see citing works
Tagde, P., Tagde, P., Islam, F., Tagde, S., Shah, M., Hussain, Z., Rahman, M., Najda, A., Alanazi, I. S., Germoush, M., et al. (2021) · Molecules · doi:10.3390/molecules26237109 · Cited by 160 · see citing works
Curcumin loaded solid lipid nanoparticles ameliorate adjuvant‐induced arthritis in rats
Arora, R., Kuhad, A., Kaur, I. P., & Chopra, K. (2014) · European Journal of Pain · doi:10.1002/ejp.620 · Cited by 162 · see citing works
Self-citationTang, C., Chen, H.-L., & Dong, J.-R. (2023) · Applied Sciences · doi:10.3390/app13031726 · Cited by 145 · see citing works
Abbaszadeh, F., Fakhri, S., & Khan, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105069 · Cited by 121 · see citing works
Nanoparticle‐Based Therapeutics for Brain Injury
Bharadwaj, V. N., Nguyen, D. T., Kodibagkar, V. D., & Stabenfeldt, S. E. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700668 · Cited by 125 · see citing works
Wang, P., Zhang, L., Peng, H., Li, Y., Xiong, J. P., & Xu, Z. (2013) · Materials Science and Engineering C · doi:10.1016/j.msec.2013.07.047 · Cited by 122 · see citing works
Neuroprotection by curcumin: A review on brain delivery strategies
Askarizadeh, A., Barreto, G. E., Henney, N. C., Majeed, M. A., & Sahebkar, A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119476 · Cited by 120 · see citing works
Nano-antioxidants: An emerging strategy for intervention against neurodegenerative conditions
Sandhir, R., Yadav, A., Sunkaria, A., & Singhal, N. K. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.011 · Cited by 119 · see citing works
Mohammed, H. A., Khan, R. A., Singh, V., Yusuf, M., Akhtar, N., Sulaiman, G. M., Albukhaty, S., Abdellatif, A. A. H., Khan, M., Mohammed, S. A. A., et al. (2023) · Nanotechnology Reviews · doi:10.1515/ntrev-2022-0517 · Cited by 124 · see citing works
Ganesan, P., Ko, H.-M., Kim, I., & Choi, D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s93918 · Cited by 119 · see citing works
Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art
Pagliaro, B., Santolamazza, C., Simonelli, F., & Rubattu, S. D. (2015) · BioMed Research International · doi:10.1155/2015/918069 · Cited by 115 · see citing works
Protective Effects of Curcumin Against Ischemia-Reperfusion Injury in the Nervous System
Bavarsad, K., Barreto, G. E., Hadjzadeh, M., & Sahebkar, A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1169-7 · Cited by 115 · see citing works
Kakkar, V., Mishra, A. K., Chuttani, K., & Kaur, I. P. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.03.046 · Cited by 114 · see citing works
Self-citationAhangarpour, A., Oroojan, A. A., Khorsandi, L., Kouchak, M., & Badavi, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7496936 · Cited by 113 · see citing works
Martinelli, C., Pucci, C., Battaglini, M., Marino, A., & Ciofani, G. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201901589 · Cited by 111 · see citing works
Sarısözen, C., Dhokai, S., Tsikudo, E. G., Luther, E., Rachman, I. M., & Torchilin, V. P. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.08.013 · Cited by 108 · see citing works
Dodging blood brain barrier with “nano” warriors: Novel strategy against ischemic stroke
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Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery
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Sesamol-loaded solid lipid nanoparticles for treatment of skin cancer
Geetha, T., Kapila, M., Prakash, O., Deol, P. K., Kakkar, V., & Kaur, I. P. (2014) · Journal of drug targeting · doi:10.3109/1061186x.2014.965717 · Cited by 96 · see citing works
Self-citationLipid-based nanoformulations in the treatment of neurological disorders
Pottoo, F. H., Sharma, S., Javed, M. N., Barkat, M. A., Harshita, Alam, M. S., Naim, M. J., Alam, O., Ansari, M. A., Barreto, G. E., et al. (2020) · Drug Metabolism Reviews · doi:10.1080/03602532.2020.1726942 · Cited by 96 · see citing works
Dual responsive PNIPAM–chitosan targeted magnetic nanopolymers for targeted drug delivery
Yadavalli, T., Ramasamy, S., Chandrasekaran, G., Michael, I., Therese, H. A., & Chennakesavulu, R. (2014) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2014.09.035 · Cited by 92 · see citing works
In vivo fate of lipid-based nanoparticles
Qi, J., Zhuang, J., Lü, Y., Dong, X., Zhao, W., & Wu, W. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.09.024 · Cited by 89 · see citing works
Nanostructured drug delivery for better management of tuberculosis
Kaur, I. P., & Singh, H. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.04.009 · Cited by 89 · see citing works
Self-citationTransferrin-functionalized lipid nanoparticles for curcumin brain delivery
Neves, A. R., van der Putten, L., Queiroz, J. F., Pinheiro, M., & Reis, S. (2021) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2021.03.010 · Cited by 87 · see citing works
Amphiphilic Nanocarrier Systems for Curcumin Delivery in Neurodegenerative Disorders
Rakotoarisoa, M., & Angelova, A. (2018) · Medicines · doi:10.3390/medicines5040126 · Cited by 84 · see citing works
Role of curcumin and its nanoformulations in neurotherapeutics: A comprehensive review
Mandal, M., Jaiswal, P., & Mishra, A. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22478 · Cited by 86 · see citing works
Kumar, M., Kakkar, V., Mishra, A. K., Chuttani, K., & Kaur, I. P. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.11.038 · Cited by 82 · see citing works
Self-citationHazzah, H. A., Farid, R. M., Nasra, M. M. A., Hazzah, W., EL-Massik, M. A. E., & Abdallah, O. Y. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24590 · Cited by 81 · see citing works
Wang, T., Xue, J., Hu, Q., Zhou, M., & Luo, Y. (2017) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2017.07.090 · Cited by 81 · see citing works
Recent advances in nanocarriers for nutrient delivery
Gorantla, S., Wadhwa, G., Jain, S., Sankar, S., Nuwal, K., Mahmood, A., Dubey, S. K., Taliyan, R., Kesharwani, P., & Singhvi, G. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01097-z · Cited by 84 · see citing works
Toden, S., & Goel, A. (2017) · Journal of Restorative Medicine · doi:10.14200/jrm.2017.6.0101 · Cited by 78 · see citing works
Kakkar, V., Kaur, I. P., Kaur, A. P., Saini, K., & Singh, K. K. (2018) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2018.1492607 · Cited by 78 · see citing works
Self-citationFakhri, S., Abdian, S., Zarneshan, S. N., Moradi, S. Z., Farzaei, M. H., & Abdollahi, M. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s347187 · Cited by 80 · see citing works
Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery
Mendoza‐Muñoz, N., Urbán‐Morlán, Z., Leyva‐Gómez, G., Zambrano‐Zaragoza, M. L., Piñón‐Segundo, E., & Quintanar‐Guerrero, D. (2021) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/jpps31788 · Cited by 77 · see citing works
Solubility Enhancement and Delivery Systems of Curcumin a Herbal Medicine: A Review
Hani, U., & Shivakumar, H. G. (2014) · Current Drug Delivery · doi:10.2174/1567201811666140825130003 · Cited by 76 · see citing works
Protective effects of curcumin against ischemia-reperfusion injury in the liver
Bavarsad, K., Riahi, M. M., Saadat, S., Barreto, G. E., Atkin, S. L., & Sahebkar, A. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.014 · Cited by 74 · see citing works
Kim, S., Diab, R., Joubert, O., Canilho, N., & Pasc, A. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.12.040 · Cited by 71 · see citing works
Advances of nano drug delivery system for the theranostics of ischemic stroke
Lv, W., Liu, Y., Li, S., Lv, L., Lu, H., & Xin, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01450-5 · Cited by 69 · see citing works
Abouzeid, A. H., Patel, N. R., Rachman, I. M., Senn, S., & Torchilin, V. P. (2013) · Journal of drug targeting · doi:10.3109/1061186x.2013.840639 · Cited by 61 · see citing works
Abouzeid, A. H., Patel, N. R., Sarısözen, C., & Torchilin, V. P. (2014) · Pharmaceutical Research · doi:10.1007/s11095-013-1295-x · Cited by 59 · see citing works
Ramires, O., Alves, B. M. D. S., Barros, P., Rodrigues, J. L., Ferreira, S. P., Monteiro, L. K. S., Araújo, G. D. M. S., Fernandes, S. S., Vaz, G., Dora, C. L., et al. (2021) · Neurotoxicity research · doi:10.1007/s12640-021-00362-w · Cited by 44 · see citing works
Islam, F., Islam, M. R., Meem, A. F. K., Nafady, M. H., Islam, M. R., Akter, A., Mitra, S., Alhumaydhi, F. A., Emran, T. B., Khusro, A., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.136020 · Cited by 54 · see citing works
RetractedNovel approaches for the delivery of therapeutics in ischemic stroke
Nozohouri, S., Sifat, A. E., Vaidya, B., & Abbruscato, T. J. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.01.007 · Cited by 54 · see citing works
Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
González‐Nieto, D., Fernández-Serra, R., Pérez‐Rigueiro, J., Panetsos, F., Martínez‐Murillo, R., & Guinea, G. V. (2020) · Cells · doi:10.3390/cells9051074 · Cited by 53 · see citing works
Chen, Y., Jia, D., Wang, Q., Sun, Y., Rao, Z., Lei, X., Zhao, J., Zeng, K., Xu, Z., & Ming, J. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120650 · Cited by 52 · see citing works
Lipid-Based Nanocarriers via Nose-to-Brain Pathway for Central Nervous System Disorders
Nguyen, T. T., Nguyen, T. T. D., An, T. N. M., & Giau, V. V. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03488-7 · Cited by 52 · see citing works
Grilc, N. K., Sova, M., & Kristl, J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122137 · Cited by 51 · see citing works
Application of Nanodiagnostics and Nanotherapy to CNS Diseases
Zhang, W., Wang, W., Yu, D. X., Xiao, Z., & He, Z. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0163 · Cited by 50 · see citing works
Neuroprotective Strategies in Neonatal Brain Injury
Parikh, P., & Juul, S. E. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.08.031 · Cited by 49 · see citing works
Dibaei, M., Rouini, M. R., Sheikholeslami, B., Gholami, M., & Dinarvand, R. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s199624 · Cited by 49 · see citing works
Derakhshankhah, H., Sajadimajd, S., Jafari, S., Izadi, Z., Sarvari, S., Sharifi, M., Falahati, M., Moakedi, F., Muganda, W. C. A., Müller, M., et al. (2020) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2020.102149 · Cited by 48 · see citing works
Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia
Feng, F., & Meng, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.893118 · Cited by 48 · see citing works
Nano Traditional Chinese Medicine: Current Progresses and Future Challenges
Huang, Y., Zhao, Y., Liu, F., & Liu, S. (2015) · Current Drug Targets · doi:10.2174/1389450116666150309122334 · Cited by 47 · see citing works
Free radical biology in neurological manifestations: mechanisms to therapeutics interventions
Tripathi, R. S., Gupta, R. V., Sahu, M., Srivastava, D., Das, A., Ambasta, R. K., & Kumar, P. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16693-2 · Cited by 52 · see citing works
Curcumin: A therapeutic potential in ageing-related disorders
Vaiserman, A. M., Koliada, A. K., Zayachkivska, A., & Lushchak, O. V. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100226 · Cited by 44 · see citing works
A comprehensive review of the therapeutic potential of curcumin nanoformulations
Khezri, K., Saeedi, M., Mohammadamini, H., & Zakaryaei, A. S. (2021) · Phytotherapy Research · doi:10.1002/ptr.7190 · Cited by 46 · see citing works
Ahmad, M. Z., Akhter, S., Mohsin, N., Abdel‐Wahab, B. A., Ahmad, J., Warsi, M. H., Rahman, M., Mallick, N., & Ahmad, F. J. (2014) · Current Drug Discovery Technologies · doi:10.2174/1570163811666140616153436 · Cited by 45 · see citing works
Hassanzadeh, P., Atyabi, F., & Dinarvand, R. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.06.001 · Cited by 46 · see citing works
Fang, C., Xu, H., Yuan, L., Zhu, Z., Wang, X., Liu, Y., Zhang, A., Shao, A., & Lou, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1949718 · Cited by 43 · see citing works
The nanotech potential of turmeric (Curcuma longa L.) in food technology: A review
Serpa, A., Hoyos, C. G., Velásquez-Cock, J. A., Acosta, L. M. V., Gañán, P. F., Giraldo, A. M. V., & Zuluaga, R. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1604490 · Cited by 42 · see citing works
Samal, J., Rebelo, A. L., & Pandit, A. S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.012 · Cited by 40 · see citing works
Nanodelivery of phytobioactive compounds for treating aging-associated disorders
Lushchak, O. V., Strilbytska, O. M., Koliada, A. K., Zayachkivska, A., Burdyliuk, N., Yurkevych, I. S., Storey, K. B., & Vaiserman, A. M. (2020) · GeroScience · doi:10.1007/s11357-019-00116-9 · Cited by 40 · see citing works
Alzheimer’s Disease Targeted Nano-Based Drug Delivery Systems
Altinoglu, G., & Adalı, T. (2019) · Current Drug Targets · doi:10.2174/1389450120666191118123151 · Cited by 42 · see citing works
Curcumin-incorporated albumin nanoparticles and its tumor image
Gong, G., Pan, Q., Wang, K., Wu, R., Sun, Y., & Lu, Y. (2015) · Nanotechnology · doi:10.1088/0957-4484/26/4/045603 · Cited by 40 · see citing works
Luckanagul, J. A., Bhuket, P. R. N., Muangnoi, C., Rojsitthisak, P., Wang, Q., & Rojsitthisak, P. (2021) · Polymers · doi:10.3390/polym13020194 · Cited by 39 · see citing works
Soares, T., Loureiro, L., Carvalho, A. M., Oliveira, M. E. C. D. R., Dias, A. C. P., Sarmento, B. F. C. C., & Lúcio, M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.04.004 · Cited by 37 · see citing works
Dhumal, D. M., Kothari, P. R., Kalhapure, R. S., & Akamanchi, K. G. (2015) · RSC Advances · doi:10.1039/c5ra18112g · Cited by 36 · see citing works
Alavian, F., & Shams, N. (2019) · Current Clinical Pharmacology · doi:10.2174/1574884714666190704115345 · Cited by 36 · see citing works
Etodolac loaded solid lipid nanoparticle based topical gel for enhanced skin delivery
Patel, D. K., Kesharwani, R., & Kumar, V. (2020) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2020.101810 · Cited by 35 · see citing works
Protective effects of curcumin on ischemia/reperfusion injury
Mohamadian, M., Parsamanesh, N., Chiti, H., Sathyapalan, T., & Sahebkar, A. (2022) · Phytotherapy Research · doi:10.1002/ptr.7620 · Cited by 35 · see citing works
Jojo, G. M., & Kuppusamy, G. (2019) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12808 · Cited by 34 · see citing works
Ayan, A. K., Yenilmez, A., & Eroğlu, H. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.02.114 · Cited by 33 · see citing works
Sugasini, D., & Lokesh, B. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1736-1 · Cited by 29 · see citing works
Current opinion in Alzheimer's disease therapy by nanotechnology-based approaches
Ansari, S. A., Satar, R., Perveen, A., & Ashraf, G. M. (2016) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000310 · Cited by 31 · see citing works
Kumar, P. P., Kumar, K. T. S., Nainita, M. K., Tarun, A. S., Ramudu, B. G. R., Deepika, K., Pramoda, A., & Yasmeen, C. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00098-8 · Cited by 29 · see citing works
Bu, Y., Lee, K., Jung, H., & Moon, S. (2013) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-013-1341-2 · Cited by 28 · see citing works
Ashique, S., Afzal, O., Yasmin, S., Hussain, A., Altamimi, M. A., Webster, T. J., & Altamimi, A. S. A. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122614 · Cited by 28 · see citing works
Yang, X., Xu, L., Zhao, H., Xie, T., Wang, J., Wang, L., & Yang, J. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.02.009 · Cited by 27 · see citing works
Han, D., Wang, M., Dong, N., Zhang, J., Li, D., Ma, X., Ma, Y., Wang, S., Zhu, Y., & Wang, C. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.020 · Cited by 27 · see citing works
- Authors
- Kakkar, V., Muppu, S. K., Chopra, K., & Kaur, I. P.
- Affiliations
- Panjab University (IN)
- Corresponding author
- Kaur, Indu Pal
- Venue
- European Journal of Pharmaceutics and Biopharmaceutics
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 85
- Issue
- 3
- Pages
- 339-345
- ISSN
- 0939-6411 (ISSN-L)
- OpenAlex
- W2090136445
- Cited by
- 222
- References
- 56
- Citations by year
- 2026: 3 · 2025: 16 · 2024: 15 · 2023: 24 · 2022: 26 · 2021: 22 · 2020: 26 · 2019: 16 · 2018: 14 · 2017: 12 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 8
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- curcumin, solid lipid nanoparticles, cerebral ischemia-reperfusion injury, brain drug delivery, brain bioavailability, oxidative stress, nitrosative stress, acetylcholinesterase inhibition, mitochondrial enzyme activity, superoxide dismutase, catalase, glutathione, lipid peroxidation, neuroprotection, cognitive impairment, tissue distribution
- MeSH terms
- Administration, Oral, Animals, Antioxidants, Brain, Brain Ischemia, Curcumin, Dose-Response Relationship, Drug, Lipids, Male, Mitochondria, Tissue Distribution, Lipid Peroxidation, Reperfusion Injury, Rats, Wistar, Oxidative Stress, Microscopy, Confocal, Area Under Curve, Mice, Rats, Nanoparticles, Administration, Intravenous
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