Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of huntington’s disease.
Abstract
Till date, an exact causative pathway responsible for neurodegeneration in Huntington's disease (HD) remains elusive; however, mitochondrial dysfunction appears to play an important role in HD pathogenesis. Therefore, strategies to attenuate mitochondrial impairments could provide a potential therapeutic intervention. In the present study, we used curcumin encapsulated solid lipid nanoparticles (C-SLNs) to ameliorate 3-nitropropionic acid (3-NP)-induced HD in rats. Results of MTT (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) assay and succinate dehydrogenase (SDH) staining of striatum revealed a marked decrease in Complex II activity. However, C-SLN-treated animals showed significant increase in the activity of mitochondrial complexes and cytochrome levels. C-SLNs also restored the glutathione levels and superoxide dismutase activity. Moreover, significant reduction in mitochondrial swelling, lipid peroxidation, protein carbonyls and reactive oxygen species was observed in rats treated with C-SLNs. Quantitative PCR and Western blot results revealed the activation of nuclear factor-erythroid 2 antioxidant pathway after C-SLNs administration in 3-NP-treated animals. In addition, C-SLN-treated rats showed significant improvement in neuromotor coordination when compared with 3-NP-treated rats. Thus, the results of this study suggest that C-SLNs administration might be a promising therapeutic intervention to ameliorate mitochondrial dysfunctions in HD.
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Solid-lipid-based curcumin nanoformulation attenuates 3-nitropropionic-acid-induced Huntington's disease in rats by increasing complex II activity and restoring glutathione and superoxide dismutase.
“Attenuated 3-nitropropionic-acid- induced Huntington’s disease in rats by increasing complex II activity, restoring the glutathione and superoxide dismutase”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Sandhir et al., 2014
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- Authors
- Sandhir, R., Yadav, A., Mehrotra, A., Sunkaria, A., Singh, A., & Sharma, S.
- Affiliations
- Panjab University (IN)
- Post Graduate Institute of Medical Education and Research (IN)
- Corresponding author
- Sandhir, Rajat
- Venue
- NeuroMolecular Medicine
- Published
- 2013-09-06
- Volume
- 16
- Issue
- 1
- Pages
- 106-118
- ISSN
- 1535-1084 (ISSN-L)
- 1559-1174
- OpenAlex
- W1992478997
- Cited by
- 204
- References
- 72
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 23 · 2023: 28 · 2022: 29 · 2021: 14 · 2020: 19 · 2019: 20 · 2018: 9 · 2017: 9 · 2016: 2 · 2015: 12 · 2014: 8
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- NeuroMolecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- University Grants Commission
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- curcumin, solid lipid nanoparticles, Huntington's disease, 3-nitropropionic acid, mitochondrial dysfunction, neuroprotection, oxidative stress, glutathione, superoxide dismutase, lipid peroxidation, protein carbonylation, succinate dehydrogenase, striatum, neurobehavioral deficits
- MeSH terms
- Animals, Ataxia, Corpus Striatum, Curcumin, Disease Models, Animal, Drug Evaluation, Preclinical, Female, Glutathione, Humans, Huntington Disease, Lameness, Animal, Phytotherapy, Mitochondria, Motor Activity, Nitro Compounds, Propionates, Random Allocation, Superoxide Dismutase, Lipid Peroxidation, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, NF-E2-Related Factor 2, Rats, Nanoparticles
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