Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala
Abstract
This research was designed to examine the effect of three weeks of administration of corticosterone (20 mg/kg) on endocannabinoid content and cannabinoid CB1 receptor binding in the amygdala. It was found that the endocannabinoid 2-arachidonylglycerol was significantly increased in the amygdala following chronic corticosterone treatment. However, there was no change in either the maximal binding (Bmax) or binding affinity (KD) of [3H]-CP 55,940 to the CB1 receptor in the amygdala. Given the role of amygdalar endocannabinoids in the regulation of emotionality, this suggests that the ability of glucocorticoids to influence affective behavior may involve interactions with regulation of endocannabinoid content.
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Exposure to stress causes significant reductions in amygdalar and hippocampal AEA content.
“On the other hand, exposure to stress causes significant reductions in amygdalar and hippocampal AEA content (Patel et al, 2005a;Hill et al, 2005;Rademacher et al, 2008;Gorzalka et al, 2008).”
From Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress (2012) · cites this paper as Hill et al, 2005
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- Authors
- Hill, M. N., Ho, W.-S. V., Meier, S. E., Gorzalka, B. B., & Hillard, C. J.
- Affiliations
- University of British Columbia (CA)
- Medical College of Wisconsin (US)
- Corresponding author
- Hillard, Cecilia J.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 528
- Issue
- 1-3
- Pages
- 99-102
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2149468746
- Cited by
- 40
- References
- 20
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Michael Smith Health Research BC
- National Institutes of Health
- Natural Sciences and Engineering Research Council of Canada
- National Institute on Drug Abuse (DA 16967, R01DA016967)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- corticosterone, endocannabinoids, 2-arachidonoylglycerol, amygdala, CB1 receptor, emotional behavior, emotionality
- MeSH terms
- Amygdala, Animals, Arachidonic Acids, Cannabinoids, Corticosterone, Cyclohexanols, Glycerides, Male, Signal Transduction, Rats, Long-Evans, Receptor, Cannabinoid, CB1, Rats, Cannabinoid Receptor Modulators, Endocannabinoids
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