Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress
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The molecular constituents of endocannabinoid (eCB) signaling are abundantly expressed within the mammalian amygdaloid complex, consistent with the robust role of eCB signaling in the modulation of emotional behavior, learning, and stress-response physiology. Here, we detail the anatomical distribution of eCB signaling machinery in the amygdala and the role of this system in the modulation of excitatory and inhibitory neuroplasticity in this region. We also summarize recent findings demonstrating dynamic alternations in eCB signaling that occur in response to stress exposure, as well as known behavioral consequences of eCB-mediated modulation of amygdala function. Finally, we discuss how integrating anatomical and physiological data regarding eCB signaling in the amygdala could help elucidate common functional motifs of this system in relation to broader forebrain function.
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Stimulation of CB1R recruits various signaling pathways, including Gi/o coupling that reduces adenylyl cyclase and downregulates cAMP/PKA signaling, Gβγ-induced PLC-β-mediated calcium influx, and activation of MAP kinases.
“Stimulation of CB1R recruits various signaling pathways [22]. These pathways include CB1R coupling to Gi/o proteins that reduces adenylyl cyclase activity and downregulates cyclic AMP/protein kinase A signaling [23], by Gβγ-induced phospholipase C-β-mediated increases in intracellular calcium influx, and by activation of mitogen-activated protein kinases [24,25].”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [22]
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- Authors
- Ramikie, T. S., & Patel, S.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Patel, S.
- ORCID
- Patel, S.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 204
- Pages
- 38-52
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3236282
- OpenAlex
- W1965729696
- Cited by
- 62
- References
- 93
- Citations by year
- 2026: 4 · 2025: 2 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K08MH090412)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- endocannabinoid signaling, amygdala, synaptic signaling, neuroplasticity, stress response, emotional behavior, stress adaptation, excitatory and inhibitory neurons, cannabinoid receptors
- MeSH terms
- Adaptation, Physiological, Adaptation, Psychological, Amygdala, Animals, Behavior, Animal, Stress, Psychological, Synapses, Signal Transduction, Cannabinoid Receptor Modulators, Endocannabinoids
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