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Cited by 27Gastrointestinal motility and disordersNeuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats

Wu, Chiu-Lung, Doong, Ming-Luen, Wang, Paulus S.·2008·European Journal of Pharmacology
DOI 10.1016/j.ejphar.2007.11.024
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Abstract

The effects of oxytocin on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in ovariectomized rats. Gastrointestinal motility was assessed in rats 15 min after intragastric instillation of a test meal containing charcoal and Na2 51CrO4. Gastric emptying was determined by measuring the amount of radiolabeled chromium contained in the small intestine as a percentage of the initial amount received. Gastrointestinal transit was evaluated by calculating the geometric center of distribution of the radiolabeled marker. Blood samples were collected for CCK radioimmunoassay. After administration of oxytocin (0.2-0.8 mg/kg), gastric emptying and gastrointestinal transit were inhibited, whereas plasma concentration of CCK was increased in a dose-dependent manner. Atosiban, an oxytocin receptor antagonist, effectively attenuated the oxytocin-induced inhibition of gastric emptying and gastrointestinal transit. However, administration of atosiban alone had no effect on gastric emptying and gastrointestinal transit. The selective CCK1 receptor antagonists, devazepide and lorglumide, effectively attenuated the oxytocin-induced inhibition of gastric emptying and gastrointestinal transit. L-365, 260, a selective CCK2 receptor antagonist, did not alter the oxytocin-induced inhibition of gastric emptying and gastrointestinal transit. These results suggest that oxytocin inhibits gastric emptying and gastrointestinal transit in ovariectomized rats via a mechanism involving the stimulation of CCK release and CCK1 receptor activation.

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Crossref · 10.1016/j.ejphar.2007.11.024

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  • Studies in rats demonstrate that intraperitoneal oxytocin increases levels of the peripheral satiety hormone CCK and inhibits gastric emptying; these effects are blocked by administration of a CCK-1 receptor antagonist.

    “Studies in rats demonstrate that intraperitoneal oxytocin increases levels of the peripheral satiety hormone CCK and inhibits gastric emptying; these effects are blocked by administration of a CCK-1 receptor antagonist(29, 30).”

    From Oxytocin reduces caloric intake in men (2015) · cites this paper as [30]

  • Oxytocin may reduce food intake by inhibiting gastric emptying.

    “Oxytocin may also reduce food intake by inhibiting gastric emptying.”

    From Oxytocin reduces caloric intake in men (2015) · cites this paper as [30]

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Authors
Wu, C.-L., Doong, M.-L., & Wang, P. S.
Affiliations
  • Hungkuang University (TW)
  • National Yang Ming University (TW)
Corresponding author
Wu, Chiu-Lung
ORCID
Wang, Paulus S.
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2008-02
Volume
580
Issue
3
Pages
407-415
ISSN
0014-2999 (ISSN-L)
DOI
10.1016/j.ejphar.2007.11.024
OpenAlex
W2045003744
Cited by
27
References
78
Citations by year
2023: 2 · 2022: 2 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
oxytocin, cholecystokinin, CCK-A receptor, gastrointestinal motility, gastric emptying, gastrointestinal transit, ovariectomy, atosiban, devazepide, lorglumide, CCK2 receptor, plasma CCK levels, postprandial motility
MeSH terms
Animals, Benzodiazepinones, Cholecystokinin, Dose-Response Relationship, Drug, Eating, Female, Gastric Emptying, Gastrointestinal Motility, Gastrointestinal Transit, Ovariectomy, Oxytocin, Phenylurea Compounds, Proglumide, Radioimmunoassay, Receptors, Cholecystokinin, Sincalide, Vasotocin, Rats, Sprague-Dawley, Receptors, Oxytocin, Devazepide, Receptor, Cholecystokinin A, Rats

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