Role of oxytocin signaling in the regulation of body weight
Open accessAbstract
Obesity and its associated metabolic disorders are growing health concerns in the US and worldwide. In the US alone, more than two-thirds of the adult population is classified as either overweight or obese [1], highlighting the need to develop new, effective treatments for these conditions. Whereas the hormone oxytocin is well known for its peripheral effects on uterine contraction during parturition and milk ejection during lactation, release of oxytocin from somatodendrites and axonal terminals within the central nervous system (CNS) is implicated in both the formation of prosocial behaviors and in the control of energy balance. Recent findings demonstrate that chronic administration of oxytocin reduces food intake and body weight in diet-induced obese (DIO) and genetically obese rodents with impaired or defective leptin signaling. Importantly, chronic systemic administration of oxytocin out to 6 weeks recapitulates the effects of central administration on body weight loss in DIO rodents at doses that do not result in the development of tolerance. Furthermore, these effects are coupled with induction of Fos (a marker of neuronal activation) in hindbrain areas (e.g. dorsal vagal complex (DVC)) linked to the control of meal size and forebrain areas (e.g. hypothalamus, amygdala) linked to the regulation of food intake and body weight. This review assesses the potential central and peripheral targets by which oxytocin may inhibit body weight gain, its regulation by anorexigenic and orexigenic signals, and its potential use as a therapy that can circumvent leptin resistance and reverse the behavioral and metabolic abnormalities associated with DIO and genetically obese models.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The reliability of peripheral vasopressin and oxytocin levels as biomarkers of anorexia nervosa is weakened by global hypothalamic-pituitary dysfunction, the impact of fluid and sodium restriction and purging behaviours in anorexia nervosa, and the putative role of the two hormones in the regulation of the gut-brain axis and energy homeostasis.
“The reliability of peripheral ADH and OT levels as biomarkers of AN is weakened by the global hypothalamic-pituitary dysfunction, the impact of fluid and sodium restriction and purging behaviours observed in AN and the putative role of the two hormones in the regulation of the gut brain axis and energy homeostasis (Blevins and Ho, 2013).”
From Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis (2016) · cites this paper as Blevins and Ho, 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works
Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.
Flegal, K., Carroll, M., Kit, B., & Ogden, C. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.39 · Cited by 5,523 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
Prevalence of obesity in the United States, 2009-2010.
Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2012) · PubMed · Cited by 2,070 · see citing works
Prevalence of obesity in the United States.
Ogden, C., Carroll, M., & Flegal, K. (2014) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2014.6228 · Cited by 1,588 · see citing works
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · see citing works
Hypothalamic CART is a new anorectic peptide regulated by leptin
Kristensen, P. L., Judge, M. E., Thim, L., Ribel, U., Christjansen, K. N., Wulff, B. S., Clausen, J. T., Jensen, P. B., Madsen, O. D., Vrang, N., et al. (1998) · Nature · doi:10.1038/29993 · Cited by 1,282 · see citing works
De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2005) · Endocrinology · doi:10.1210/en.2004-1520 · Cited by 1,171 · see citing works
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150 · see citing works
Sawchenko, P. E., & Swanson, L. W. (1982) · Brain Research Reviews · doi:10.1016/0165-0173(82)90010-8 · Cited by 1,141 · see citing works
Deconstruction of a neural circuit for hunger
Atasoy, D., Betley, J. N., Su, H. H., & Sternson, S. M. (2012) · Nature · doi:10.1038/nature11270 · Cited by 969 · see citing works
Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951 · see citing works
Inactivation of the Fto gene protects from obesity
Fischer, J., Koch, L., Emmerling, C., Vierkotten, J., Peters, T., Brüning, J. C., & Rüther, U. (2009) · Nature · doi:10.1038/nature07848 · Cited by 943 · see citing works
Obesity and leptin resistance: distinguishing cause from effect
Myers, M. G., Leibel, R. L., Seeley, R. J., & Schwartz, M. W. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.002 · Cited by 906 · see citing works
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887 · see citing works
Fitzgerald, K. R. (2013) · Journal of Vascular Nursing · doi:10.1016/j.jvn.2013.06.004 · Cited by 875 · see citing works
Diet-induced obese mice develop peripheral, but not central, resistance to leptin.
van Heek, M., Compton, D. S., France, C. F., Tedesco, R. P., Fawzi, A. B., Graziano, M. P., Sybertz, E. J., Strader, C. D., & Davis, H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119171 · Cited by 752 · see citing works
Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737 · see citing works
Overexpression of Fto leads to increased food intake and results in obesity
Church, C., Moir, L., McMurray, F., Girard, C. A. J., Banks, G. T., Teboul, L., Wells, S. E., Brüning, J. C., Nolan, P. M., Ashcroft, F. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.713 · Cited by 725 · see citing works
Larsen, P. J., Tang-Christensen, M., Holst, J. J., & Ørskov, C. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00434-4 · Cited by 663 · see citing works
Neuronal PTP1B regulates body weight, adiposity and leptin action
Bence, K. K., Delibegovic, M., Xue, B., Gorgun, C. Z., Hotamisligil, G. S., Neel, B. G., & Kahn, B. B. (2006) · Nature Medicine · doi:10.1038/nm1435 · Cited by 633 · see citing works
Yoshida, M., Takayanagi, Y., Inoue, K., Kimura, T., Young, L. J., Onaka, T., & Nishimori, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5593-08.2009 · Cited by 608 · see citing works
Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice
Lin, S., Thomas, T. C., Storlien, L., & Huang, X. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801209 · Cited by 570 · see citing works
Melanocortin receptors in leptin effects
Seeley, R. J., Yagaloff, K. A., Fisher, S. L., Burn, P., Thiele, T. E., van Dijk, G., Baskin, D. G., & Schwartz, M. W. (1997) · Nature · doi:10.1038/37016 · Cited by 522 · see citing works
Alhadeff, A. L., Rupprecht, L. E., & Hayes, M. R. (2012) · Endocrinology · doi:10.1210/en.2011-1443 · Cited by 515 · see citing works
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511 · see citing works
The central organization of the vagus nerve innervating the stomach of the rat
Shapiro, R. E., & Miselis, R. R. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902380411 · Cited by 496 · see citing works
Swaab, D. F., Purba, J. S., & Hofman, M. A. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.2.7852523 · Cited by 421 · see citing works
Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
L., J., Jr. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.1.101 · Cited by 400 · see citing works
Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat
LEIBOWITZ, S. F., Hammer, N. J., & Chang, K. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90366-8 · Cited by 384 · see citing works
Common cellular and molecular mechanisms in obesity and drug addiction
Kenny, P. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3105 · Cited by 382 · see citing works
Oxytocin, motherhood and bonding
Kendrick, K. M. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00014.x · Cited by 378 · see citing works
Liu, H., Kishi, T., Roseberry, A. G., Cai, X., Lee, C. E., Montez, J. M., Friedman, J. M., & Elmquist, J. K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07143.2003 · Cited by 375 · see citing works
Oxytocin–dopamine interactions mediate variations in maternal behavior in the rat
Shahrokh, D. K., Zhang, T.-Y., Diorio, J., Gratton, A., & Meaney, M. J. (2010) · Endocrinology · doi:10.1210/en.2009-1271 · Cited by 366 · see citing works
Mens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90478-x · Cited by 360 · see citing works
A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research
MacDonald, E., Dadds, M. R., Brennan, J. L., Williams, K., Levy, F., & Cauchi, A. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.015 · Cited by 352 · see citing works
Impaired transport of leptin across the blood-brain barrier in obesity☆
Banks, W. A., DiPalma, C., & Farrell, C. L. (1999) · Peptides · doi:10.1016/s0196-9781(99)00139-4 · Cited by 334 · see citing works
Blevins, J. E., Schwartz, M. W., & Baskin, D. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2003 · Cited by 332 · see citing works
Self-citationFood Intake and the Regulation of Body Weight
Woods, S. C., Schwartz, M. W., Baskin, D. G., & Seeley, R. J. (2000) · Annual Review of Psychology · doi:10.1146/annurev.psych.51.1.255 · Cited by 332 · see citing works
Influence of oxytocin on feeding behavior in the rat
Arletti, R., Benelli, A., & Bertolini, A. (1989) · Peptides · doi:10.1016/0196-9781(89)90082-x · Cited by 328 · see citing works
A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
Church, C., Lee, S., Bagg, E. A. L., McTaggart, J. S., Deacon, R. M. J., Gerken, T., Lee, A., Moir, L., Mecinović, J., Quwailid, M. M., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000599 · Cited by 325 · see citing works
Wheeler, E., Huang, N., Bochukova, E. G., Keogh, J. M., Lindsay, S., Garg, S., Henning, E., Blackburn, H., Loos, R. J. F., Wareham, N. J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2607 · Cited by 323 · see citing works
Ring, R. H., Malberg, J. E., Potestio, L., Ping, J., Boikess, S., Luo, B., Schechter, L. E., Rizzo, S., Rahman, Z., & Rosenzweig-Lipson, S. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0293-z · Cited by 319 · see citing works
Maejima, Y., Sedbazar, U., Suyama, S., Kohno, D., Onaka, T., Takano, E., Yoshida, N., Koike, M., Uchiyama, Y., Fujiwara, K., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.002 · Cited by 317 · see citing works
Oldfield, B. J., Giles, M., Watson, A. M. D., Anderson, C. R., Colvill, L. M., & McKinley, M. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00555-3 · Cited by 317 · see citing works
Larsen, P. J., Tang‐Christensen, M., & Jessop, D. S. (1997) · Endocrinology · doi:10.1210/endo.138.10.5270 · Cited by 316 · see citing works
Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake
Sandoval, D. A., Bagnol, D., Woods, S. C., D’Alessio, D. A., & Seeley, R. J. (2008) · Diabetes · doi:10.2337/db07-1824 · Cited by 316 · see citing works
Hyperleptinemia Is Required for the Development of Leptin Resistance
Knight, Z. A., Hannan, K. S., Greenberg, M. L., & Friedman, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011376 · Cited by 311 · see citing works
Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
Fan, W., Ellacott, K. L. J., Halatchev, I. G., Takahashi, K. A., Yu, P., & Cone, R. D. (2004) · Nature Neuroscience · doi:10.1038/nn1214 · Cited by 306 · see citing works
Oxytocin receptor-deficient mice developed late-onset obesity
Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3283021ca9 · Cited by 294 · see citing works
Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats
Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90176-p · Cited by 283 · see citing works
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.001 · Cited by 283 · see citing works
VanItallie, T. B. (1996) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70360-1 · Cited by 273 · see citing works
Moos, F., Freund‐Mercier, M. J., Guerné, Y., Jm, G., Stoeckel, M. E., & Richard, P. (1984) · Journal of Endocrinology · doi:10.1677/joe.0.1020063 · Cited by 269 · see citing works
A conditional knockout mouse line of the oxytocin receptor
Lee, H.-J., Caldwell, H. K., Macbeth, A. H., Tolu, S. G., & Young, W. S. (2008) · Endocrinology · doi:10.1210/en.2007-1710 · Cited by 269 · see citing works
Delfs, J. M., Zhu, Y., Druhan, J. P., & Aston‐Jones, G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00672-6 · Cited by 267 · see citing works
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265 · see citing works
Glucagon-Like Peptide 1 Receptors in Nucleus Accumbens Affect Food Intake
Dossat, A. M., Lilly, N., Kay, K. E., & Williams, D. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3262-11.2011 · Cited by 254 · see citing works
Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats
Deblon, N., Veyrat-Durebex, C., Bourgoin, L., Caillon, A., Bussier, A.-L., Petrosino, S., Piscitelli, F., Legros, J.-J., Geenen, V., Foti, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025565 · Cited by 254 · see citing works
Chang, S. W. C., Barter, J. W., Ebitz, R. B., Watson, K. K., & Platt, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114621109 · Cited by 252 · see citing works
REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
Viéro, C., Shibuya, I., Kitamura, N., Verkhratsky, A., Fujihara, H., Katoh, A., Ueta, Y., Zingg, H. H., Chvátal, A., Syková, E., et al. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00185.x · Cited by 250 · see citing works
Oxytocin inhibits food and fluid intake in rats
Arletti, R., Benelli, A., & Bertolini, A. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90234-u · Cited by 246 · see citing works
Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus
Rinaman, L. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.2.r582 · Cited by 243 · see citing works
Blouet, C., Jo, Y., Li, X., & Schwartz, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1668-09.2009 · Cited by 240 · see citing works
Oxytocin Deficiency Mediates Hyperphagic Obesity of Sim1 Haploinsufficient Mice
Kublaoui, B. M., Gemelli, T., Tolson, K. P., Wang, Y., & Zinn, A. R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0067 · Cited by 239 · see citing works
Lockie, S. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat‐Durebex, C., Ananthakrishnan, G., Rohner‐Jeanrenaud, F., Drucker, D. J., DiMarchi, R. D., et al. (2012) · Diabetes · doi:10.2337/db11-1556 · Cited by 238 · see citing works
Low sympathetic tone and obese phenotype in oxytocin-deficient mice
Camerino, C. (2009) · Obesity · doi:10.1038/oby.2009.12 · Cited by 235 · see citing works
Jansen, A. S. P., Wessendorf, M. W., & Loewy, A. D. (1995) · Brain Research · doi:10.1016/0006-8993(95)00276-v · Cited by 229 · see citing works
Hayes, M. R., Bradley, L. E., & Grill, H. J. (2009) · Endocrinology · doi:10.1210/en.2008-1479 · Cited by 228 · see citing works
Peripheral oxytocin is associated with reduced symptom severity in schizophrenia
Rubin, L. H., Carter, C. S., Drogos, L. L., Pournajafi‐Nazarloo, H., Sweeney, J. A., & Maki, P. M. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.09.014 · Cited by 228 · see citing works
Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass
Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., & Yada, T. (2011) · Aging · doi:10.18632/aging.100408 · Cited by 220 · see citing works
Alternative role for prolactin-releasing peptide in the regulation of food intake
Lawrence, C. B., Celsi, F., Brennand, J. C., & Luckman, S. M. (2000) · Nature Neuroscience · doi:10.1038/76597 · Cited by 217 · see citing works
High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats
Milagro, F. I., Campión, J., García‐Díaz, D. F., Goyenechea, E., Paternain, L., & Martínez, J. A. (2009) · Journal of Physiology and Biochemistry · doi:10.1007/bf03165964 · Cited by 214 · see citing works
Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats
Morton, G. J., Thatcher, B. S., Reidelberger, R. D., Ogimoto, K., Wolden-Hanson, T., Baskin, D. G., Schwartz, M. W., & Blevins, J. E. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2011 · Cited by 213 · see citing works
Self-citationRat heart: A site of oxytocin production and action
Jankowski, M., Hajjar, F., Kawas, S. A., Mukaddam‐Daher, S., Hoffman, G. E., McCann, S. M., & Gutkowska, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14558 · Cited by 212 · see citing works
Zhang, G., Bai, H., Zhang, H., Dean, C., Wu, Q., Li, J., Guariglia, S., Meng, Q., & Cai, D. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.036 · Cited by 208 · see citing works
Emergent Synchronous Bursting of Oxytocin Neuronal Network
Rossoni, E., Feng, J., Tirozzi, B., Brown, D., Leng, G., & Moos, F. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000123 · Cited by 207 · see citing works
Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons
Vrang, N., Phifer, C. B., Corkern, M. M., & Berthoud, H. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00732.2002 · Cited by 204 · see citing works
Stanley, S. A., Pinto, S., Segal, J., Pérez, C. A., Viale, A. J., DeFalco, J., Cai, X., Heisler, L. K., & Friedman, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002790107 · Cited by 203 · see citing works
Baskin, D. G., Schwartz, M. W., Seeley, R. J., Woods, S. C., Porte, D., Breininger, J. F., Jonak, Z., Schaefer, J., Krouse, M., Burghardt, C., et al. (1999) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549904700309 · Cited by 200 · see citing works
McMahon, L. R., & Wellman, P. J. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.1.r23 · Cited by 198 · see citing works
Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats
Slattery, D. A., & Neumann, I. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.038 · Cited by 195 · see citing works
Appleyard, S. M., Bailey, T. W., Doyle, M. W., Jin, Y., Smart, J. L., Low, M. J., & Andresen, M. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4177-04.2005 · Cited by 195 · see citing works
Preproglucagon neurons project widely to autonomic control areas in the mouse brain
Llewellyn-Smith, I. J., Reimann, F., Gribble, F. M., & Trapp, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.023 · Cited by 194 · see citing works
Scott, M. M., Williams, K. W., Rossi, J., Lee, C. E., & Elmquist, J. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43703 · Cited by 191 · see citing works
Cholecystokinin and gastric distension activate oxytocinergic cells in rat hypothalamus
Renaud, L. P., Tang, M., McCann, M. J., Stricker, E. M., & Verbalis, J. G. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.253.4.r661 · Cited by 190 · see citing works
Gossen, A., Hahn, A., Westphal, L., Prinz, S., Schultz, R. T., Gründer, G., & Spreckelmeyer, K. N. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.07.001 · Cited by 189 · see citing works
Kendrick, K. M., Keverne, E. B., Baldwin, B. A., & Sharman, D. F. (2008) · Neuroendocrinology · doi:10.1159/000124638 · Cited by 187 · see citing works
Lukas, M., Bredewold, R., Neumann, I. D., & Veenema, A. H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.020 · Cited by 183 · see citing works
An obligate role of oxytocin neurons in diet induced energy expenditure
Wu, Z., Xu, Y., Zhu, Y., Sutton, A. K., Zhao, R., Lowell, B. B., Olson, D. P., & Tong, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045167 · Cited by 181 · see citing works
OLSON, B. R., DRUTAROSKY, M. D., STRICKER, E. M., & VERBALIS, J. G. (1991) · Endocrinology · doi:10.1210/endo-129-2-785 · Cited by 180 · see citing works
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance
Loh, K., Fukushima, A., Zhang, X., Galić, S., Briggs, D. I., Enriori, P. J., Simonds, S. E., Wiede, F., Reichenbach, A., Hauser, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.011 · Cited by 180 · see citing works
Yosten, G. L. C., & Samson, W. K. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00804.2009 · Cited by 177 · see citing works
Norepinephrine and the control of food intake
Wellman, P. J. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00415-9 · Cited by 174 · see citing works
Oxytocin and vasopressin secretion in response to stimuli producing learned taste aversions in rats.
Verbalis, J. G., McHale, C. M., Gardiner, T. W., & Stricker, E. M. (1986) · Behavioral Neuroscience · doi:10.1037//0735-7044.100.4.466 · Cited by 171 · see citing works
Zhang, G., & Cai, D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2011 · Cited by 171 · see citing works
Rogers, R. C., & Hermann, G. E. (1987) · Peptides · doi:10.1016/0196-9781(87)90017-9 · Cited by 168 · see citing works
Rinaman, L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-31-10084.2003 · Cited by 166 · see citing works
Rinaman, L., Verbalis, J. G., Stricker, E. M., & Hoffman, G. E. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903380402 · Cited by 165 · see citing works
Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin
Blevins, J. E., Eakin, T. J., Murphy, J. A., Schwartz, M. W., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.036 · Cited by 164 · see citing works
Self-citationRats maintained on high-fat diets exhibit reduced satiety in response to CCK and bombesin
Covașă, M., & Ritter, R. C. (1998) · Peptides · doi:10.1016/s0196-9781(98)00096-5 · Cited by 164 · see citing works
Microarray profiling of gene expression in human adipocytes in response to anthocyanins
Tsuda, T., Ueno, Y., Yoshikawa, T., Kojo, H., & Osawa, T. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.042 · Cited by 163 · see citing works
Vrang, N., Larsen, P. J., Kristensen, P., & Tang‐Christensen, M. (2000) · Endocrinology · doi:10.1210/endo.141.2.7295 · Cited by 160 · see citing works
Baroreflex control of heart rate by oxytocin in the solitary-vagal complex
Higa, K. T., Mori, E., Viana, F. F., Morris, M., & Michelini, L. C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00806.2000 · Cited by 157 · see citing works
Moos, F., & Richard, P. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017442 · Cited by 156 · see citing works
Olson, B. R., Freilino, M. L., Hoffman, G. E., Stricker, E. M., Sved, A. F., & Verbalis, J. G. (1993) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1993.1011 · Cited by 155 · see citing works
Barrera, J. G., Jones, K. R., Herman, J. P., D’Alessio, D. A., Woods, S. C., & Seeley, R. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2212-10.2011 · Cited by 154 · see citing works
Schick, R., Zimmermann, J., Walde, T. V., & SCHUSDZIARRA, V. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00479.2002 · Cited by 152 · see citing works
Neuronal activation in the hypothalamus and brainstem during feeding in rats
Johnstone, L. E., Fong, T. M., & Leng, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.08.003 · Cited by 152 · see citing works
Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius
Hisadome, K., Reimann, F. M., Gribble, F. M., & Trapp, S. (2010) · Diabetes · doi:10.2337/db10-0128 · Cited by 150 · see citing works
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149 · see citing works
Carson, D. S., Cornish, J. L., Guastella, A. J., Hunt, G. E., & McGregor, I. S. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.018 · Cited by 146 · see citing works
Oxytocin and vasopressin secretion in response to stimuli producing learned taste aversions in rats.
Verbalis, J. G., McHale, C. M., Gardiner, T. W., et al. (1986) · Behavioral Neuroscience · doi:10.1037/0735-7044.100.4.466 · Cited by 146 · see citing works
Brainstem Nutrient Sensing in the Nucleus of the Solitary Tract Inhibits Feeding
Blouet, C., & Schwartz, G. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.003 · Cited by 145 · see citing works
Olson, B. R., Hoffman, G. E., Sved, A. F., Stricker, E. M., & Verbalis, J. G. (1992) · Brain Research · doi:10.1016/0006-8993(92)90635-m · Cited by 141 · see citing works
Sutton, G. M., Duos, B., Patterson, L. M., & Berthoud, H. (2005) · Endocrinology · doi:10.1210/en.2005-0562 · Cited by 140 · see citing works
Visceral Afferents Directly Activate Catecholamine Neurons in the Solitary Tract Nucleus
Appleyard, S. M., Marks, D. L., Kobayashi, K., Okano, H., Low, M. J., & Andresen, M. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3502-07.2007 · Cited by 140 · see citing works
Gould, B. R., & Zingg, H. H. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00283-5 · Cited by 138 · see citing works
Mejias-Aponte, C., Drouin, C., & Aston-Jones, G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4632-08.2009 · Cited by 137 · see citing works
Boccia, M. L., Goursaud, A.-P. S., Bachevalier, J., Anderson, K. D., & Pedersen, C. A. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.009 · Cited by 136 · see citing works
Rubinow, D. R., Crowder, V. L., Schmidt, P. J., & Rubinow, K. B. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10036-8 · Cited by 136 · see citing works
Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus
Peters, J. H., McDougall, S. J., Kellett, D. O., Jordan, D., Llewellyn-Smith, I. J., & Andresen, M. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3419-08.2008 · Cited by 135 · see citing works
Welch, M. G., Tamir, H., Gross, K. J., Chen, J. C., Anwar, M., & Gershon, M. D. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21872 · Cited by 132 · see citing works
Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions
Sclafani, A. J., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00826.2006 · Cited by 131 · see citing works
Qi, J., Yang, J.-Y., Song, M., Li, Y., Wang, F., & Wu, C.-F. (2008) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0245-8 · Cited by 129 · see citing works
Sawchenko, P. E., Arias, C. M., & Bittencourt, J. C. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902910209 · Cited by 128 · see citing works
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward
Olszewski, P. K., Fredriksson, R., Olszewska, A. M., Stephansson, O., Alsiö, J., Radomska, K. J., Levine, A. S., & Schiöth, H. B. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-129 · Cited by 127 · see citing works
Carson, D. S., Hunt, G. E., Guastella, A. J., Barber, L., Cornish, J. L., Arnold, J. C., Boucher, A. A., & McGregor, I. S. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00247.x · Cited by 126 · see citing works
Role of Noradrenergic Signaling by the Nucleus Tractus Solitarius in Mediating Opiate Reward
Olson, V. G., Heusner, C. L., Bland, R. J., During, M. J., Weinshenker, D., & Palmiter, R. D. (2006) · Science · doi:10.1126/science.1119311 · Cited by 126 · see citing works
Gaetani, S., Fu, J., Cassano, T., Dipasquale, P., Romano, A., Righetti, L., Cianci, S., Laconca, L., Giannini, E., Scaccianoce, S., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0036-10.2010 · Cited by 124 · see citing works
Prolactin-Releasing Peptide as a Novel Stress Mediator in the Central Nervous System
Maruyama, M., Matsumoto, H., Fujiwara, K., Noguchi, J., Kitada, C., Fujino, M., & Inoue, K. (2001) · Endocrinology · doi:10.1210/endo.142.5.8118 · Cited by 124 · see citing works
Gastric distension-induced c-fos expression in catecholaminergic neurons of rat dorsal vagal complex
Willing, A. E., & Berthoud, H. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.1.r59 · Cited by 124 · see citing works
Oxytocin action in the ventral tegmental area affects sucrose intake
Mullis, K., Kay, K., & Williams, D. L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.026 · Cited by 122 · see citing works
Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion
Amico, J. A., Vollmer, R. R., Cai, H.-M., Miedlar, J. A., & Rinaman, L. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00558.2005 · Cited by 120 · see citing works
Central endogenous opioid inhibition of supraoptic oxytocin neurons in pregnant rats
Douglas, A., Neumann, I. D., van der Meeren, H. L. M., Leng, G., Johnstone, L. E., Munro, G., & Russell, J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05049.1995 · Cited by 119 · see citing works
Oxytocin excites gastric-related neurones in rat dorsal vagal complex
McCann, M. J., & Rogers, R. C. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018202 · Cited by 118 · see citing works
Nesfatin-1: An Overview and Future Clinical Application
Shimizu, H., Oh-I, S., Okada, S., & Mori, M. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-117 · Cited by 115 · see citing works
Goldman, M. B., Gomes, A. M., Carter, C. S., & Lee, R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2193-8 · Cited by 112 · see citing works
Tung, Y. L., Ma, M. K. L., Piper, S., Coll, A. P., O’Rahilly, S., & Yeo, G. S. H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3412-08.2008 · Cited by 111 · see citing works
LiCl and CCK inhibit gastric emptying and feeding and stimulate OT secretion in rats
McCann, M. J., Verbalis, J. G., & Stricker, E. M. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.256.2.r463 · Cited by 110 · see citing works
Central opioids and consumption of sweet tastants: When reward outweighs homeostasis
Olszewski, P. K., & Levine, A. S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.01.011 · Cited by 109 · see citing works
Douglas, A. J., Johnstone, L. E., & Leng, G. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.012 · Cited by 108 · see citing works
Oxytocin predominantly excites putative oxytocin neurons in the rat supraoptic nucleus in vitro
Yamashita, H., Okuya, S., Inenaga, K., Kasai, M., Uesugi, S., Kannan, H., & Kaneko, T. (1987) · Brain Research · doi:10.1016/0006-8993(87)90920-6 · Cited by 107 · see citing works
Olszewski, P. K., Klockars, A., Olszewska, A. M., Fredriksson, R., Schiöth, H. B., & Levine, A. S. (2010) · Endocrinology · doi:10.1210/en.2010-0151 · Cited by 104 · see citing works
Crawley, J. N., & Kiss, J. Z. (1985) · Peptides · doi:10.1016/0196-9781(85)90324-9 · Cited by 104 · see citing works
Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case–control study
Montag, C., Brockmann, E.-M., Bayerl, M., Rujescu, D., Müller, D. J., & Gallinat, J. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.677547 · Cited by 104 · see citing works
Distribution of oxytocin in the brain of a eusocial rodent
Rosen, G. J., de Vries, G. J., Goldman, S. L., Goldman, B. D., & Forger, N. G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.039 · Cited by 102 · see citing works
Dhuria, S. V., Hanson, L. R., & Frey, W. H. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.145565 · Cited by 102 · see citing works
Dorsomedial hindbrain participation in cholecystokinin-induced satiety
Edwards, G. L., Ladenheim, E. E., & Ritter, R. C. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.251.5.r971 · Cited by 102 · see citing works
Ablation of Sim1 Neurons Causes Obesity through Hyperphagia and Reduced Energy Expenditure
Xi, D., Gandhi, N. M., Lai, M., & Kublaoui, B. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036453 · Cited by 100 · see citing works
Oxytocin is expressed throughout the human gastrointestinal tract
Ohlsson, B., Truedsson, M., Djerf, P., & Sundler, F. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.03.008 · Cited by 99 · see citing works
High fat maintenance diet attenuates hindbrain neuronal response to CCK
Covașă, M., Grahn, J. C., & Ritter, R. C. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(99)00084-1 · Cited by 97 · see citing works
Hisadome, K., Reimann, F. M., Gribble, F. M., & Trapp, S. (2011) · Diabetes · doi:10.2337/db11-0489 · Cited by 97 · see citing works
The Prolactin-Releasing Peptide Receptor (GPR10) Regulates Body Weight Homeostasis in Mice
Gu, W., Geddes, B. J., Zhang, C., Foley, K. P., & Stricker‐Krongrad, A. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:22:1-2:93 · Cited by 96 · see citing works
Rinaman, L., & Rothe, E. E. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00008.2002 · Cited by 95 · see citing works
Maolood, N., & Meister, B. (2008) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2008.12.007 · Cited by 94 · see citing works
Gravati, M., Busnelli, M., Bulgheroni, E., Reversi, A., Spaiardi, P., Parenti, M. D., Toselli, M., & Chini, B. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06861.x · Cited by 92 · see citing works
Acute effects of intranasal oxytocin on subjective and behavioral responses to social rejection.
Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2010) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0019719 · Cited by 92 · cited 1× · see citing works
“Regardless, this route of administration has yielded positive prosocial effects in nonhuman primates [223], male and female schizophrenics [228, 229], and in men and women who experience social rejection [230].”
Garfield, A. S., Patterson, C. M., Skora, S., Gribble, F. M., Reimann, F. M., Evans, M. L., Myers, M. G., & Heisler, L. K. (2012) · Endocrinology · doi:10.1210/en.2012-1282 · Cited by 92 · see citing works
Sutton, G. M., Patterson, L. M., & Berthoud, H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2764-04.2004 · Cited by 91 · see citing works
Endogenous prolactin-releasing peptide regulates food intake in rodents
Takayanagi, Y., Matsumoto, H., Nakata, M., Mera, T., Fukusumi, S., Hinuma, S., Ueta, Y., Yada, T., Leng, G., & Onaka, T. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34682 · Cited by 88 · see citing works
Qin, J., Feng, M., Wang, C., Ye, Y., Wang, P. S., & Liu, C. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01282.x · Cited by 86 · see citing works
Verbalis, J. G., Blackburn, R. E., Hoffman, G. E., & Stricker, E. M. (1995) · PubMed · Cited by 85 · see citing works
Perelló, M., & Raingo, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059625 · Cited by 84 · see citing works
The blood–brain barrier as a regulatory interface in the gut–brain axes
Banks, W. A. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.07.004 · Cited by 84 · see citing works
Neurochemical phenotype of sympathetic nervous system outflow from brain to white fat
Shi, H., & Bartness, T. J. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00455-x · Cited by 83 · see citing works
Prolactin-Releasing Peptide Mediates Cholecystokinin-Induced Satiety in Mice
Bechtold, D. A., & Luckman, S. M. (2006) · Endocrinology · doi:10.1210/en.2006-0753 · Cited by 81 · see citing works
The Promise and Perils of Oxytocin
Miller, G. (2013) · Science · doi:10.1126/science.339.6117.267 · Cited by 76 · cited 1× · see citing works
“Additional studies should continue to address the long-term neuroendocrine and behavioral effects following multiple doses in developing animals [233, 234].”
Hypothesis paper brain talks with fat-evidence for a hypothalamic-pituitary-adipose axis?
Schäffler, A., Binart, N., Schölmerich, J., & Büchler, C. (2005) · Neuropeptides · doi:10.1016/j.npep.2005.06.003 · Cited by 76 · see citing works
Flak, J. N., Jankord, R., Solomon, M. B., Krause, E. G., & Herman, J. P. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.002 · Cited by 76 · see citing works
Oral-pharyngeal-esophageal and gastric cues contribute to meal-induced c-fos expression
Fraser, K. A., Raizada, E., & Davison, J. S. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.268.1.r223 · Cited by 76 · see citing works
PVN-hindbrain pathway involved in the hypothalamic hyperphagia-obesity syndrome
Kirchgessner, A. L., & Sclafani, A. J. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90153-9 · Cited by 74 · see citing works
Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C. W., Kassiou, M., Hunt, G. E., & McGregor, I. S. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02311.x · Cited by 73 · see citing works
Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
Blevins, J. E., Morton, G. J., Williams, D. L., Caldwell, D. W., Bastian, L. S., Wisse, B. E., Schwartz, M. W., & Baskin, D. G. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90544.2008 · Cited by 73 · see citing works
Self-citationReduced sensitivity to the satiation effect of intestinal oleate in rats adapted to high-fat diet
Covașă, M., & Ritter, R. C. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.1.r279 · Cited by 73 · see citing works
A New Oxytocin-Saporin Cytotoxin for Lesioning Oxytocin-Receptive Neurons in the Rat Hindbrain
Baskin, D. G., Kim, F., Gelling, R. W., Russell, B. J., Schwartz, M. W., Morton, G. J., Simhan, H. N., Moralejo, D. H., & Blevins, J. E. (2010) · Endocrinology · doi:10.1210/en.2010-0295 · Cited by 72 · see citing works
Self-citationProteins Activate Satiety-Related Neuronal Pathways in the Brainstem and Hypothalamus of Rats3
Faipoux, R., Tomé, D., Gougis, S., Darcel, N., & Fromentin, G. (2008) · Journal of Nutrition · doi:10.1093/jn/138.6.1172 · Cited by 72 · see citing works
Blevins, J. E., Chelikani, P. K., Haver, A. C., & Reidelberger, R. D. (2007) · Peptides · doi:10.1016/j.peptides.2007.11.003 · Cited by 71 · see citing works
Self-citationDombret, C., Nguyen, T., Schakman, O., Michaud, J. L., Hardin‐Pouzet, H., Bertrand, M. J. M., & Backer, O. D. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds310 · Cited by 70 · see citing works
Coming Full Circle: Contributions of Central and Peripheral Oxytocin Actions to Energy Balance
Ho, J. M., & Blevins, J. E. (2012) · Endocrinology · doi:10.1210/en.2012-1751 · Cited by 67 · see citing works
Self-citationManiscalco, J. W., Kreisler, A. D., & Rinaman, L. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00199 · Cited by 66 · see citing works
Blood–Brain Barrier and Energy Balance
Banks, W. A. (2006) · Obesity · doi:10.1038/oby.2006.315 · Cited by 65 · see citing works
Wang, Z.-J., Rao, Z., & Shi, J.-W. (1992) · Brain Research · doi:10.1016/0006-8993(92)90269-f · Cited by 64 · see citing works
den Hertog, C. E. C., de Groot, A. N. J. A., & van Dongen, P. W. J. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00311-0 · Cited by 64 · see citing works
Wu, Q., Howell, M. P., & Palmiter, R. D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2449-08.2008 · Cited by 63 · see citing works
Effects of oxytocin and vasopressin on thoracic sympathetic preganglionic neurones in the cat
Backman, S. B., & Henry, J. L. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90201-6 · Cited by 61 · see citing works
Mitra, A., Gosnell, B. A., Schiöth, H. B., Grace, M. K., Klockars, A., Olszewski, P. K., & Levine, A. S. (2010) · Peptides · doi:10.1016/j.peptides.2010.04.005 · Cited by 61 · see citing works
Olszewski, P. K., Shi, Q., Billington, C. J., & Levine, A. S. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1504 · Cited by 57 · see citing works
Lokrantz, C.-M., Uvnäs‐Moberg, K., & Kaplan, J. M. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00021-8 · Cited by 57 · see citing works
Valentine, J. D., Matta, S. G., & Sharp, B. M. (1996) · Endocrinology · doi:10.1210/endo.137.2.8593811 · Cited by 57 · see citing works
GPR10 deficiency in mice results in altered energy expenditure and obesity
Bjursell, M., Lennerås, M., Göransson, M., Elmgren, A., & Bohlooly‐Y, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.09.016 · Cited by 55 · see citing works
Role of α-MSH in the regulation of consummatory behavior: immunohistochemical evidence
Olszewski, P. K., Wirth, M. M., Shaw, T. J., Grace, M. K., Billington, C. J., Giraudo, S. Q., & Levine, A. S. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.2.r673 · Cited by 55 · see citing works
A study of the role of neuro-glial remodeling in the oxytocin system at lactation
Catheline, G., Touquet, B., Lombard, M. C., Poulain, D. A., & Theodosis, D. T. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.042 · Cited by 54 · see citing works
Yamashita, M., Takayanagi, Y., Yoshida, M., Nishimori, K., Kusama, M., & Onaka, T. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12019 · Cited by 52 · see citing works
Histochemical identification of a PVN-hindbrain feeding pathway
Kirchgessner, A. L., Sclafani, A. J., & Nilaver, G. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90154-0 · Cited by 51 · see citing works
Wu, C.-L., Hung, C.-R., Chang, F.-Y., Francis Pau, K.-Y., & Wang, P. S. (2003) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-003-0690-y · Cited by 51 · see citing works
Brunton, P. J., Sabatier, N., Leng, G., & Russell, J. A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04614.x · Cited by 50 · see citing works
Li, G., Zhang, Y., Rodrigues, E., Zheng, D., Matheny, M. E., Cheng, K., & Scarpace, P. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00451.2006 · Cited by 50 · see citing works
Oxytocin‐immunoreactive innervation of identified neurons in the rat dorsal vagal complex
Llewellyn‐Smith, I. J., Kellett, D. O., Jordan, D., Browning, K. N., & Travagli, R. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01851.x · Cited by 49 · see citing works
Daily caloric intake in intact and chronic decerebrate rats.
Kaplan, J. M., Seeley, R. J., & Grill, H. J. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.5.876 · Cited by 46 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748 · see citing works
The determinants of food choice
Leng, G., Adan, R. A. H., Belot, M., Brunstrom, J. M., de Graaf, K., Dickson, S. L., Hare, T. A., Maier, S. U., Menzies, J., Preissl, H., et al. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s002966511600286x · Cited by 435 · see citing works
The determinants of food choice
Leng, G., Adan, R. A. H., Belot, M. V. K., Brunstrom, J. M., de Graaf, K. C., Dickson, S. L., Hare, T. A., Maier, S. U., Menzies, J. R. W., Preissl, H. T., et al. (2017) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-146390 · Cited by 255 · see citing works
Serotonin, food intake, and obesity
van Galen, K. A., ter Horst, K. W., & Serlie, M. J. M. (2021) · Obesity Reviews · doi:10.1111/obr.13210 · Cited by 206 · see citing works
Peters, S., Slattery, D. A., Uschold‐Schmidt, N., Reber, S. O., & Neumann, I. D. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.021 · Cited by 180 · see citing works
Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome
Burnett, L. C., LeDuc, C. A., Sulsona, C. R., Paull, D. J., Rausch, R. N., Eddiry, S., Carli, J. F. M., Morabito, M. V., Skowronski, A. A., Hubner, G., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88648 · Cited by 174 · see citing works
Vercruysse, P., Vieau, D., Blum, D., Petersén, Å., & Dupuis, L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00002 · Cited by 172 · see citing works
The physiological control of eating: signals, neurons, and networks
Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168 · see citing works
The role of oxytocin in male and female reproductive behavior
Veening, J. G., A, T. R. D. J., Waldinger, M. D., Korte, S. M., & Olivier, B. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.045 · Cited by 156 · see citing works
Rutigliano, G., Rocchetti, M., Paloyelis, Y., Gilleen, J., Sardella, A., Cappucciati, M., Palombini, E., Dell’Osso, L., Caverzasi, E., Politi, P., et al. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.04.117 · Cited by 149 · see citing works
“…levels as biomarkers of AN is weakened by the global hypothalamic-pituitary dysfunction, the impact of fluid and sodium restriction and purging behaviours observed in AN and the putative role of the two hormones in the regulation of the gut brain axis and energy homeostasis (Blevins and Ho, 2013).”
Decreased Circulating Levels of Oxytocin in Obesity and Newly Diagnosed Type 2 Diabetic Patients
Qian, W., Zhu, T., Tang, B., Yu, S., Hu, H., Sun, W., Pan, R., Wang, J., Wang, D., Yang, L., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2206 · Cited by 149 · see citing works
Appetite Regulation: Hormones, Peptides, and Neurotransmitters and Their Role in Obesity
Miller, G. D. (2017) · American Journal of Lifestyle Medicine · doi:10.1177/1559827617716376 · Cited by 126 · see citing works
Oxytocin in metabolic homeostasis: implications for obesity and diabetes management
Ding, C., Leow, M., & Magkos, F. (2018) · Obesity Reviews · doi:10.1111/obr.12757 · Cited by 101 · see citing works
Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00118.2014 · Cited by 102 · see citing works
From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders
Romano, A., Tempesta, B., Bonaventura, M. V. M. D., & Gaetani, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00497 · Cited by 102 · see citing works
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Kerem, L., & Lawson, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147737 · Cited by 94 · see citing works
Kim, Y., Eom, J.-S., Yang, J., Kang, J., & Treasure, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137514 · Cited by 85 · see citing works
Oxytocin during Development: Possible Organizational Effects on Behavior
Miller, T. V., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00076 · Cited by 79 · see citing works
Role of Body Mass Index and gestational weight gain on preterm birth and adverse perinatal outcomes
Silva, F. P., Souza, R. T., Cecatti, J. G., Passini, R., Tedesco, R. P., Lajos, G. J., Nomura, M. L., Rehder, P. M., Dias, T. Z., Oliveira, P. F., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49704-x · Cited by 73 · see citing works
Johnson, L., Manzardo, A. M., Miller, J. L., Driscoll, D. J., & Butler, M. G. (2015) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37488 · Cited by 73 · see citing works
Oxytocin in survivors of childhood-onset craniopharyngioma
Daubenbüchel, A. M. M., Hoffmann, A., Eveslage, M., Özyurt, J., Lohle, K., Reichel, J. F., Thiel, C. M., Martens, H., Geenen, V. G., & Muller, H. L. (2016) · Endocrine · doi:10.1007/s12020-016-1084-5 · Cited by 69 · see citing works
Erdman, S. E., & Poutahidis, T. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.07.004 · Cited by 68 · see citing works
Starch digestion in the upper gastrointestinal tract of humans
Brownlee, I. A., Gill, S., Wilcox, M. D., Pearson, J. P., & Chater, P. I. (2017) · Starch - Stärke · doi:10.1002/star.201700111 · Cited by 65 · see citing works
Altirriba, J., Poher, A.-L., & Rohner‐Jeanrenaud, F. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00119 · Cited by 63 · see citing works
Hoffmann, A., Özyurt, J., Lohle, K., Reichel, J. F., Thiel, C. M., & Muller, H. L. (2017) · Endocrine · doi:10.1007/s12020-017-1257-x · Cited by 60 · see citing works
Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors
Song, Z., Levin, B. E., Stevens, W., & Sladek, C. D. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00520.2013 · Cited by 58 · see citing works
Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children
Binay, Ç., Paketçi, C., Güzel, S., & Samancı, N. (2017) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.3963 · Cited by 55 · see citing works
A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling
Wallace Fitzsimons, S. E., Chruścicka, B., Druelle, C., Stamou, P., Nally, K., Dinan, T. G., Cryan, J. F., & Schellekens, H. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.022 · Cited by 49 · see citing works
Obesity-Linked Homologues TfAP-2 and Twz Establish Meal Frequency in Drosophila melanogaster
Williams, M. J., Goergen, P., Rajendran, J., Zheleznyakova, G. Y., Hägglund, M. G., Perland, E., Bagchi, S., Kalogeropoulou, A., Khan, Z., Fredriksson, R., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004499 · Cited by 45 · see citing works
Espinoza, S. E., Lee, J. L., Wang, C.-P., Ganapathy, V., MacCarthy, D., Pascucci, C., Musi, N., & Volpi, E. (2021) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2021.04.015 · Cited by 44 · see citing works
Peptides in the regulation of glucagon secretion
Andersen, D. B., & Holst, J. J. (2021) · Peptides · doi:10.1016/j.peptides.2021.170683 · Cited by 46 · see citing works
Harshaw, C., Leffel, J. K., & Alberts, J. R. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.12.007 · Cited by 39 · see citing works
Brownlee, I. A. (2014) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2014.09.005 · Cited by 39 · see citing works
Intranasal Neuropeptide Administration To Target the Human Brain in Health and Disease
Spetter, M. S., & Hallschmid, M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00047 · Cited by 35 · see citing works
Oxytocin and Vasopressin Systems in Obesity and Metabolic Health: Mechanisms and Perspectives
Ding, C., & Magkos, F. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00355-z · Cited by 36 · see citing works
Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation
Chiurazzi, M., Maro, M. D., Cozzolino, M., & Colantuoni, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103450 · Cited by 34 · see citing works
Association between the Oxytocin Receptor Gene Polymorphism (rs53576) and Bulimia Nervosa
Kim, Y., Kim, J., Kim, C., Shin, J., & Treasure, J. L. (2015) · European Eating Disorders Review · doi:10.1002/erv.2354 · Cited by 33 · see citing works
Daubenbüchel, A. M. M., Özyurt, J., Boekhoff, S., Warmuth‐Metz, M., Eveslage, M., & Muller, H. L. (2019) · Pediatric Obesity · doi:10.1111/ijpo.12527 · Cited by 32 · see citing works
Oxytocin reduces food sharing in capuchin monkeys by modulating social distance
Brosnan, S. F., Talbot, C. F., Essler, J. L., Leverett, K., Flemming, T., Dougall, P., Heyler, C., & Zak, P. J. (2015) · Behaviour · doi:10.1163/1568539x-00003268 · Cited by 30 · see citing works
Oxytocin as an Anti-obesity Treatment
Niu, J., Tong, J., & Blevins, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.743546 · Cited by 30 · see citing works
Self-citationLiu, C. M., Hsu, T. M., Suarez, A. N., Subramanian, K. S., Fatemi, R. A., Cortella, A. M., Noble, E. E., Roitman, M. F., & Kanoski, S. E. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104855 · Cited by 28 · see citing works
Al-Rawashdeh, A., Kasabri, V. N., Bulatova, N., Akour, A. A., Zayed, A. A., Momani, M. S., Khawaja, N. M., Bustanji, H., & Hyassat, D. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.08.008 · Cited by 27 · see citing works
Oxytocin Ameliorates Impaired Behaviors of High Fat Diet-Induced Obese Mice
Hayashi, R., Kasahara, Y., Hidema, S., Fukumitsu, S., Nakagawa, K., & Nishimori, K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00379 · Cited by 28 · see citing works
Weingarten, M. F. J., Scholz, M. R., Wohland, T., Horn, K., Stümvoll, M., Kovacs, P. L., & Tönjes, A. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00643 · Cited by 28 · see citing works
Oxytocin and Prader-Willi Syndrome
Kabasakalian, A., Ferretti, C. J., & Hollander, E. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_28 · Cited by 26 · see citing works
The adaptation of maternal energy metabolism to lactation and its underlying mechanisms
Anhê, G. F., & Bordin, S. A. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111697 · Cited by 25 · see citing works
Revisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder
Dinsdale, N. L., & Crespi, B. J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.09.005 · Cited by 27 · see citing works
Hormonal factors in the control of the browning of white adipose tissue
Hu, J., & Christian, M. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0017 · Cited by 22 · see citing works
Neuroimaging and neuroendocrine insights into food cravings and appetite interventions in obesity
Huang, J., Wang, C., Zhang, H.-B., Zheng, H., Huang, T., & Di, J. (2023) · Psychoradiology · doi:10.1093/psyrad/kkad023 · Cited by 22 · see citing works
Skinner, J. A., Garg, M. L., Dayas, C. V., Fenton, S., & Burrows, T. L. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nux078 · Cited by 22 · see citing works
Skinner, J. A., Campbell, E. J., Dayas, C. V., Garg, M. L., & Burrows, T. L. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.09.002 · Cited by 21 · see citing works
The New Frontier in Oxytocin Physiology: The Oxytonic Contraction
Camerino, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145144 · Cited by 21 · see citing works
Labyb, M., Chrétien, C., Caillon, A., Rohner‐Jeanrenaud, F., & Altirriba, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010088 · Cited by 18 · see citing works
Erdenebayar, O., Kato, T., Kawakita, T., Kasai, K., Kadota, Y., Yoshida, K., Iwasa, T., & Irahara, M. (2020) · Endocrine Journal · doi:10.1507/endocrj.ej19-0586 · Cited by 16 · see citing works
Oxytocin as a potential pharmacological tool to combat obesity
Olszewski, P. K., Noble, E. E., Paiva, L., Ueta, Y., & Blevins, J. E. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13106 · Cited by 15 · see citing works
Self-citationTransgenerational effects of a hypercaloric diet
Joaquim, A. O., Coelho, C. D. P., Motta, P. D., Bondan, E. F., Teodorov, E., Martins, M. D. F. M., Kirsten, T. B., Casarin, R. C. V., Bonamin, L. V., & Bernardi, M. M. (2015) · Reproduction Fertility and Development · doi:10.1071/rd15165 · Cited by 15 · see citing works
Neural Regulation of Feeding Behavior
Hao, S., Yang, Y., Helmy, M., & Wang, H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-7086-5_3 · Cited by 15 · see citing works
Associations of oxytocin with metabolic parameters in obese women of childbearing age
Du, F.-M., Hong-Yu, K., Duan, B., Liu, D., & Yu, X. (2019) · Endokrynologia Polska · doi:10.5603/ep.a2019.0028 · Cited by 15 · see citing works
Asker, M., Krieger, J., Liles, A., Tinsley, I. C., Borner, T., Marić, I., Doebley, S. A., Furst, C. D., Börchers, S., Longo, F., et al. (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14937 · Cited by 14 · see citing works
Involvement of central nesfatin-1 neurons on oxytocin-induced feeding suppression in rats
Saito, R., Sonoda, S., Ueno, H., Motojima, Y., Yoshimura, M., Maruyama, T., Hashimoto, H., Tanaka, K., Yamamoto, Y., Kusuhara, K., et al. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.06.049 · Cited by 14 · see citing works
Thermoregulatory disorders in Huntington disease
Weydt, P., Dupuis, L., & Petersén, Å. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64074-1.00047-1 · Cited by 13 · see citing works
Liu, Y., Deng, Y.-C., Zhu, Z., Rao, B., Shang, H.-L., Wang, L., Li, T., Wang, Y., Wang, J., Zhang, Q., et al. (2025) · Theranostics · doi:10.7150/thno.109104 · Cited by 15 · see citing works
Hasselbalch, K. C., Lanng, K. R. B., Birkeland, M., & Sjögren, M. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05626-5 · Cited by 12 · see citing works
Fernandes-Breitenbach, F., Peres-Ueno, M. J., Santos, L. F. G., Brito, V. G. B., Castoldi, R. C., Louzada, M. J. Q., Chaves-Neto, A. H., Oliveira, S. H. P., & Dornelles, R. C. M. (2022) · Bone · doi:10.1016/j.bone.2022.116452 · Cited by 12 · see citing works
Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics
Spikol, E. D., Laverriere, C. E., Robnett, M., Carter, G., Wolfe, E. M., & Glasgow, E. F. (2016) · Diseases · doi:10.3390/diseases4010013 · Cited by 11 · see citing works
Beneficial Dog Bacteria Up-Regulate Oxytocin and Lower Risk of Obesity
Varian, B. J., Levkovich, T., Poutahidis, T., & Ibrahim, Y. M. (2017) · Journal of Probiotics & Health · doi:10.4172/2329-8901.1000149 · Cited by 11 · see citing works
Agabio, R., & Farci, A. M. G. (2016) · Clinical Pharmacology & Biopharmaceutics · doi:10.4172/2167-065x.1000155 · Cited by 10 · see citing works
Guo, L. Y., Sun, H., Zhao, Q., Xu, Z., Zhang, Z., Liu, D., Qadri, Q. R., Ma, P., Wang, Q., & Pan, Y. (2021) · Animal Genetics · doi:10.1111/age.13034 · Cited by 9 · see citing works
Age-related obesity is a heritage of the evolutionary past
Tereshina, E. V., & Ivanenko, S. I. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914070013 · Cited by 9 · see citing works
Roth, C. L., D'Ambrosio, G., & Elfers, C. (2016) · Journal of Systems and Integrative Neuroscience · doi:10.15761/jsin.1000114 · Cited by 9 · see citing works
Becetti, I., Singhal, V., Nimmala, S., Lee, H., Lawson, E. A., Bredella, M. A., & Misra, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210144 · Cited by 8 · see citing works
Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity
Alponti, R. F., Viana, L. G., Yamanouye, N., & Silveira, P. F. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0321 · Cited by 7 · see citing works
Novel adipocyte aminopeptidases are selectively upregulated by insulin in healthy and obese rats
Alponti, R. F., Alves, P. L., & Silveira, P. F. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0266 · Cited by 7 · see citing works
Klein, B., Tamir, H., Anwar, M., Ludwig, R. J., Kaidbey, J. H., Glickstein, S. B., & Welch, M. G. (2018) · Journal of Visualized Experiments · doi:10.3791/58341 · Cited by 7 · see citing works
Oxytocin, eating behavior, and metabolism in humans
Kerem, L., & Lawson, E. A. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00006-9 · Cited by 7 · see citing works
Current and Future Pharmacological Interventions for Acquired Hypothalamic Obesity
Roth, C. L., Doelman-Oldenburger, N. J., & van Santen, H. M. (2026) · Drugs · doi:10.1007/s40265-025-02280-z · Cited by 7 · see citing works
The Associations Between Endogenous Oxytocin Levels and Emotion Recognition in Bipolar Disorder
Taş, C., Brown, E. C., Onur, E., Aydemır, Ö., & Brüne, M. (2015) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.5455/bcp.20140514043545 · Cited by 6 · see citing works
Heseding, H. M., Jahn, K., Eberlein, C. K., Wieting, J., Maier, H. B., Proskynitopoulos, P. J., Glahn, A., Bleich, S., Frieling, H., & Deest, M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02014-9 · Cited by 5 · see citing works
Intranasal oxytocin reduces attentional bias to food stimuli
Burmester, V., Butler, G., & Terry, P. (2021) · Appetite · doi:10.1016/j.appet.2021.105684 · Cited by 4 · see citing works
Kenkel, W. M., Ahmed, S., Partie, M. E., & Rogers, K. (2024) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105499 · Cited by 4 · see citing works
Schneider, J. E., & Deviche, P. (2017) · Integrative and Comparative Biology · doi:10.1093/icb/icx113 · Cited by 4 · see citing works
Li, S., Kim, Y., Chen, J. D. Z., & Madhoun, M. F. (2021) · Obesity Surgery · doi:10.1007/s11695-020-05177-w · Cited by 4 · see citing works
Aulinas, A., Galbiati, F., Wronski, M., Carter, C. S., Nazarloo, S., Holman, K., Golden, E. R., Muhammed, M., Hadaway, N. A., Asanza, E., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf237 · Cited by 3 · see citing works
Leptin Interaction with Brain Orexigenic and Anorexigenic Pathways
Baskin, D. G. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_3 · Cited by 3 · see citing works
A pilot study of metabolic fitness effects of weight-supported walking in women with obesity
Godwin, E. M., Uglialoro, A. D., Ali, A., Yearwood, L., Banerji, M. A., & Kral, J. G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211529 · Cited by 2 · see citing works
Godwin, E. M., Uglialoro, A. D., Ali, A., Yearwood, L., Banerji, M. A., & Kral, J. G. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/202986 · Cited by 2 · see citing works
Decreased Oxytocin Mediates PVN–CA2 and PVN–PrL in Sleep Deprivation-Induced Social Memory Deficits
Liu, Y., Deng, Y., Gao, Y., Rao, B., Wang, Y., Zhang, Y., Yi, K., Cang, Y., Li, H., Bi, L., et al. (2025) · Research · doi:10.34133/research.1076 · Cited by 1 · see citing works
Hypothalamic Dysfunction (Hypothalamic Syndromes)
Gan, H., Cerbone, M., & Dattani, M. (2022) · doi:10.1093/med/9780198870197.003.0032 · Cited by 1 · see citing works
AL-Nouaaimi, M. M., Kasabri, V. N., Akour, A. A., Boulatova, N., Aref, A. M., Momani, M. S., Al-Selawi, R., & Bustanji, Y. K. (2016) · Jordan Journal of Pharmaceutical Sciences · Cited by 1 · see citing works
Central Oxytocin and Energy Balance: More Than Feelings
González‐García, I., Fernø, J., & López, M. (2017) · Endocrinology · doi:10.1210/en.2017-00557 · Cited by 1 · see citing works
Naserallah, R., Kasabri, V. N., Akour, A. A., Naffa, R. G., Bustanji, Y. K., & Khawaja, N. M. (2018) · Jordan Journal of Pharmaceutical Sciences · Cited by 1 · see citing works
Evaluation the levels of some hormones in women with polycystic ovary syndrome
Mohemeed, N. A. A., & Razzak, F. S. A. (2019) · Tikrit Journal of Pure Science · doi:10.25130/tjps.v24i5.412 · Cited by 1 · see citing works
Levels of leptin, irisin, oxytocin and insulin in obese and normal weight Iraqi young men
Hammoud, A. S., & Salman, M. I. (2023) · Biomedicine · doi:10.51248/.v43i4.3106 · Cited by 1 · see citing works
Liu, Y., Bondarenko, A., Zhang, H., Luan, P., Zhang, Q., Wang, B., Najam, S. S., Liang, X., Syed, A. A. S., Lin, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.02.601503 · Cited by 1 · see citing works
Ocitocina, um “medicamento” ainda em potencial terapêutico para distúrbios psiquiátricos
de Deus, D. M. V., & de Freitas, P. S. (2017) · REVISTA HUM@NAE
Oxytocin for treating Prader-Willi Syndrome
Nichols, P., Carter, B., Han, J. C., & Thaker, V. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013685
Maternal overweight and obesity : impact on obstetric outcomes in adolescents and oxytocin in labor
Isgren, A. R. (2021) · Linköping University medical dissertations · doi:10.3384/diss.diva-173147
Geary, N., & Asarian, L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.03942-8
- Authors
- Blevins, J. E., & Ho, J. M.
- Affiliations
- United States Department of Veterans Affairs (US)
- Corresponding author
- Blevins, James E.
- ORCID
- Blevins, James E.
- Venue
- Reviews in Endocrine and Metabolic Disorders
- Published
- 2013-09-25
- Volume
- 14
- Issue
- 4
- Pages
- 311-329
- ISSN
- 1389-9155 (ISSN-L)
- 1573-2606
- PMC
- PMC4213929
- OpenAlex
- W2068155003
- Cited by
- 108
- References
- 235
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 14 · 2016: 14 · 2015: 12 · 2014: 10
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Reviews in Endocrine and Metabolic Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX001213)
- Office of Research and Development
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK017047)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- oxytocin, body weight regulation, obesity, diet-induced obesity, leptin resistance, energy balance, dietary intake, dorsal vagal complex, hypothalamus, amygdala, Fos expression, oxytocin therapy
- MeSH terms
- Adult, Animals, Appetite Depressants, Appetite Regulation, Body Weight, Energy Metabolism, Humans, Oxytocin, Signal Transduction, Weight Loss
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review