Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats
Abstract
The effects of oxytocin (OT) on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in female rats. Gastrointestinal motility was assessed in rats 15 min after intragastric instillation of a test meal containing charcoal and Na(2)(51)CrO(4). Gastric emptying was determined by measuring the amount of radiolabeled chromium contained in the small intestine as a percentage of the initial amount received. Gastrointestinal transit was evaluated by calculating the geometric center of distribution of the radiolabeled marker. Blood samples were collected for CCK radioimmunoassay. After administration of OT (0.2-0.8 mg/kg), gastric emptying and gastrointestinal transit were inhibited, whereas the plasma concentration of CCK was increased in a dose-dependent manner. Atosiban, an oxytocin receptor antagonist, effectively attenuated the OT- induced inhibition of gastric emptying and gastrointestinal transit. However, administration of atosiban alone had no effect on gastric emptying and gastrointestinal transit. The selective CCK(1) receptor antagonists, devazepide and lorglumide, effectively attenuated the OT-induced inhibition of gastric emptying and gastrointestinal transit. L-365, 260, a selective CCK(2) receptor antagonist, did not alter the OT-induced inhibition of gastric emptying and gastrointestinal transit. These results suggest that OT inhibits gastric emptying and gastrointestinal transit in female rats via a mechanism involving CCK stimulation and CCK(1) receptor activation.
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Studies in rats demonstrate that intraperitoneal oxytocin increases levels of the peripheral satiety hormone CCK and inhibits gastric emptying; these effects are blocked by administration of a CCK-1 receptor antagonist.
“Studies in rats demonstrate that intraperitoneal oxytocin increases levels of the peripheral satiety hormone CCK and inhibits gastric emptying; these effects are blocked by administration of a CCK-1 receptor antagonist(29, 30).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [29]
Oxytocin may reduce food intake by inhibiting gastric emptying.
“Oxytocin may also reduce food intake by inhibiting gastric emptying.”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [29]
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Oxytocin reduces caloric intake in men
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- Authors
- Wu, C.-L., Hung, C.-R., Chang, F.-Y., Francis Pau, K.-Y., & Wang, P. S.
- Affiliations
- National Yang Ming University (TW)
- National Cheng Kung University (TW)
- Taipei Veterans General Hospital (TW)
- Corresponding author
- Wang, Paulus S.
- Venue
- Naunyn-Schmiedeberg s Archives of Pharmacology
- Published
- 2003-04
- Volume
- 367
- Issue
- 4
- Pages
- 406-413
- ISSN
- 0028-1298 (ISSN-L)
- OpenAlex
- W2084628367
- Cited by
- 51
- References
- 57
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Naunyn-Schmiedeberg s Archives of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- oxytocin, gastric emptying, gastrointestinal transit, cholecystokinin, CCK-A receptor, CCK2 receptor, atosiban, devazepide, lorglumide, L-365,260, oxytocin receptor antagonist, female rats, gastrointestinal motility
- MeSH terms
- Animals, Benzodiazepinones, Cholecystokinin, Dose-Response Relationship, Drug, Female, Gastric Emptying, Gastrointestinal Agents, Gastrointestinal Transit, Hormone Antagonists, Oxytocin, Phenylurea Compounds, Proglumide, Receptors, Cholecystokinin, Vasotocin, Rats, Sprague-Dawley, Devazepide, Rats
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