Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized mice.
Abstract
Cannabinoids are psychoactive compounds with many pharmacological properties such as analgesia, sedation and catalepsy most of which are mediated by cannabinoid CB1 receptors. In the present study, we evaluated whether the ovarian sex hormones are involved in the cannabinoid-induced catalepsy and analgesia in ovariectomized female mice. Female NMRI mice (weighing 25-30 g) were divided into 3 main groups: unoperated, sham-operated and ovariectomized. Both the catalepsy and analgesia induced by different doses of the synthetic cannabinoid WIN 55,212-2 (2 and 4 mg/kg, i.p.) were examined in the groups in the presence or absence of the cannabinoid CB1 antagonist AM251 (0.5 mg/kg). We also evaluated effects of estradiol valerate (10 mg/kg) and progesterone (25 mg/kg) on catalepsy and analgesia induced by WIN 55,212-2 in ovariectomized mice. The antinociceptive effect of WIN 55,212-2 was significantly (P<0.01) enhanced in ovariectomized mice, which was prevented by pretreatment with estradiol but not by progesterone. There was no significant difference in the cannabinoid-induced catalepsy between control and ovariectomized mice. However, pretreatment with progesterone but not estradiol potentiated the cataleptic effect of low dose of WIN 55,212-2 (2 mg/kg) in ovariectomized mice (P<0.01). The present data demonstrated for the first time that ovarian sex steroids could modulate both cannabinoid-induced catalepsy and analgesia in female ovariectomized mice.
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WIN2's efficacy on the thermal tail flick test in mice is reduced by estradiol.
“Kalbasi and colleagues [25] found that WIN2’s efficacy on the thermal tail flick test in mice is reduced by estradiol”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [25]
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Estrogenic regulation of limbic cannabinoid receptor binding
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“Kalbasi and colleagues [25] found that WIN2’s efficacy on the thermal tail flick test in mice is reduced by estradiol, whereas Craft and Leitl [13] found that D(9)-tetrahydrocannabinol’s efficacy on tail withdrawal and paw pressure tests in rats is enhanced by estradiol.”
Background
- Authors
- Kalbasi Anaraki, D., Sianati, S., Sadeghi, M., Ghasemi, M., Javadi, P., Ejtemaei Mehr, S., & Dehpour, A. R.
- Affiliations
- University of Tehran (IR)
- Corresponding author
- Dehpour, Ahmad Reza
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 586
- Issue
- 1-3
- Pages
- 189-196
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1975095319
- Cited by
- 22
- References
- 70
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 3 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cannabinoids, WIN 55,212-2, catalepsy, analgesia, CB1 receptor, ovariectomy, estradiol valerate, progesterone, AM251, female mice, sex differences
- MeSH terms
- Analgesics, Animals, Behavior, Animal, Cannabinoids, Catalepsy, Dose-Response Relationship, Drug, Estradiol, Estrogens, Female, Hot Temperature, Morpholines, Naphthalenes, Ovariectomy, Pain Measurement, Piperidines, Progesterone, Pyrazoles, Benzoxazines, Mice
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