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Altered default mode network activity in patient with anxiety disorders: An fMRI study
Abstract
Anxiety disorder, a common mental disorder in our clinical practice, is characterized by unprovoked anxiety. Medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC), which closely involved in emotional processing, are critical regions in the default mode network. We used functional magnetic resonance imaging (fMRI) to investigate whether default mode network activity is altered in patients with anxiety disorder. Ten anxiety patients and 10 healthy controls underwent fMRI while listening to emotionally neutral words alternating with rest (Experiment 1) and threat-related words alternating with emotionally neutral words (Experiment 2). In Experiment 1, regions of deactivation were observed in patients and controls. In Experiment 2, regions of deactivation were observed only in patients. The observed deactivation patterns in the two experiments, which included MPFC, PCC, and inferior parietal cortex, were similar and consistent with the default model network. Less deactivation in MPFC and greater deactivation in PCC were observed for patients group comparing to controls in Experiment 1. Our observations suggest that the default model network is altered in anxiety patients and dysfunction in MPFC and PCC may play an important role in anxiety psychopathology.
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“Researchers have found that RSFC is associated with a variety of individual differences, such as, personality [3], depression [47, 48], anxiety [50, 107], autism [18], dementia [6] and Alzheimer’s disease [93].”
From Predicting Brain Functional Connectivity Using Mobile Sensing (2020) · cites this paper as [107]
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Reply to More on Placebo Response
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Metadata
- Authors
- Zhao, X.-H., Wang, P.-J., Li, C.-B., Hu, Z.-H., Xi, Q., Wu, W.-Y., & Tang, X.-W.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Xi, Qian
- ORCID
- Xi, Qian
- Venue
- European Journal of Radiology
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 63
- Issue
- 3
- Pages
- 373-378
- ISSN
- 0720-048X (ISSN-L)
- OpenAlex
- W1991128616
- Cited by
- 222
- References
- 23
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 11 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 10 · 2015: 16 · 2014: 11 · 2013: 10 · 2012: 11
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Radiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- anxiety disorders, default mode network, medial prefrontal cortex, posterior cingulate cortex, neural deactivation, threat words, emotional words, inferior parietal cortex, emotional processing
- MeSH terms
- Adult, Anxiety Disorders, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Models, Neurological, Case-Control Studies
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