The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Altered default mode network activity in patient with anxiety disorders: An fMRI study
Abstract
Anxiety disorder, a common mental disorder in our clinical practice, is characterized by unprovoked anxiety. Medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC), which closely involved in emotional processing, are critical regions in the default mode network. We used functional magnetic resonance imaging (fMRI) to investigate whether default mode network activity is altered in patients with anxiety disorder. Ten anxiety patients and 10 healthy controls underwent fMRI while listening to emotionally neutral words alternating with rest (Experiment 1) and threat-related words alternating with emotionally neutral words (Experiment 2). In Experiment 1, regions of deactivation were observed in patients and controls. In Experiment 2, regions of deactivation were observed only in patients. The observed deactivation patterns in the two experiments, which included MPFC, PCC, and inferior parietal cortex, were similar and consistent with the default model network. Less deactivation in MPFC and greater deactivation in PCC were observed for patients group comparing to controls in Experiment 1. Our observations suggest that the default model network is altered in anxiety patients and dysfunction in MPFC and PCC may play an important role in anxiety psychopathology.
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“Researchers have found that RSFC is associated with a variety of individual differences, such as, personality [3], depression [47, 48], anxiety [50, 107], autism [18], dementia [6] and Alzheimer’s disease [93].”
From Predicting Brain Functional Connectivity Using Mobile Sensing (2020) · cites this paper as [107]
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Cites
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358
Greicius, M. D., Srivastava, G., Reiss, A. L., & Menon, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308627101 · Cited by 3,684
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Common blood flow changes across visual tasks: II. Decreases in cerebral cortex
Shulman, G. L., Fiez, J. A., Corbetta, M., Buckner, R. L., Miezin, F. M., Raichle, M. E., & Petersen, S. E. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.5.648 · Cited by 1,890
A cognitive-motivational analysis of anxiety.
Mogg, K., & Bradley, B. P. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(98)00063-1 · Cited by 1,642
Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115
A Parametric Manipulation of Factors Affecting Task-induced Deactivation in Functional Neuroimaging
McKiernan, K. A., Kaufman, J. N., Kucera-Thompson, J., & Binder, J. R. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903321593117 · Cited by 1,080
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Research works printed but not linked: 1
- Zhao, 2006, Prefrontal and superior temporal lobe hyperactivity as a biological substrate of anxiety disorders, Chin Med J (in Chinese), 86, 955
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Items 201–222 of 222
Messina, I. (2013) · Padua@research (University of Padova)
van Tol, M. (2011)
Cochrane, M. (2018) · UVic’s Research and Learning Repository (University of Victoria)
Davis, K. E., Hirsch, E., Gee, D. G., Andover, M. S., & Roy, A. K. (2021) · Research Square · doi:10.21203/rs.3.rs-799470/v1
Associations Between Adolescent Cannabis Use Trajectories and Anxiety
Duperrouzel, J. C. (2019) · FIU - Digital Commons (Florida International University) · doi:10.25148/etd.fidc008985
Current Awareness in NMR in Biomedicine
(2008) · NMR in Biomedicine · doi:10.1002/nbm.1282
Why Sleep Is Altered Across a Wide Range of Neuropsychiatric Disorders (NPD)?
Das, S. K., & Krishnan, V. (2022) · Springer eBooks · doi:10.1007/978-981-16-0123-1_2
Mishra, P., & Kalagnanam, S. S. (2022) · Palgrave studies in workplace spirituality and fulfillment · doi:10.1007/978-3-030-90669-6_2
Motion networks predict head motion during rest- and task-fMRIPreprint
Tomasi, D. G., & Volkow, N. D. (2022) · Research Square · doi:10.21203/rs.3.rs-1918395/v1
Wurscher, K., & Schauer, A. E. (2017) · Journal of Emerging Investigators · doi:10.59720/16-093
Zhou, L., Liu, Q., Liu, S., Lü, X., Li, Q., He, Y., Ren, C., & Chen, G. (2023) · Research Square · doi:10.21203/rs.3.rs-3585473/v1
Jia, X., & Zhou, C. (2023) · Journal of Artificial Intelligence & Cloud Computing · doi:10.47363/jaicc/2023(2)124
Sheldrake, E., Nishat, E., Wheeler, A. L., Goldstein, B. I., Reed, N. P., & Scratch, S. E. (2024) · Brain Injury · doi:10.1080/02699052.2024.2416545
Pairwise Learning for Autism Spectrum Disorder Imbalanced Classification
Liu, S., Wu, Q., & Yang, X. (2024) · IEEE Eurasia Conference on Biomedical Engineering, Healthcare and Sustainability (ECBIOS) · doi:10.1109/ecbios61468.2024.10885487
Jung, E. Y., & Kim, M. J. (2025) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaf109
Qamar, P., Díaz, D. E., Benson, B. E., Pine, D. S., Kirk, P. A., & Michalska, K. J. (2026) · Scientific Reports · doi:10.1038/s41598-025-34410-8
Sleem, D., & Craig, M. (2026) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2026.108145
Kamel, N., Ha, L. C., Sanei, S., & Kim, T. T. T. (2026) · Research Square · doi:10.21203/rs.3.rs-8718846/v1
Tan, S. L., Pawlak, M., Bray, S., & Kopala‐Sibley, D. C. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.04.038
Džinalija, N., van den Heuvel, O. A., Simpson, H. B., Ivanov, I., Alonso, P., Bertolín, S., Bruin, W. B., Fortea, L., Fullana, M. A., Hagen, K., et al. (2026) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2026.113879
Zhou, L., Mao, Y., Liu, Q., Liu, S., Lu, X., Zheng, T., Ren, C., & Chen, G. (2026) · Brain Topography · doi:10.1007/s10548-026-01265-9
Metadata
- Authors
- Zhao, X.-H., Wang, P.-J., Li, C.-B., Hu, Z.-H., Xi, Q., Wu, W.-Y., & Tang, X.-W.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Xi, Qian
- ORCID
- Xi, Qian
- Venue
- European Journal of Radiology
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 63
- Issue
- 3
- Pages
- 373-378
- ISSN
- 0720-048X (ISSN-L)
- OpenAlex
- W1991128616
- Cited by
- 222
- References
- 23
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 11 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 10 · 2015: 16 · 2014: 11 · 2013: 10 · 2012: 11
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Radiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- anxiety disorders, default mode network, medial prefrontal cortex, posterior cingulate cortex, neural deactivation, threat words, emotional words, inferior parietal cortex, emotional processing
- MeSH terms
- Adult, Anxiety Disorders, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Models, Neurological, Case-Control Studies
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