Effects of statin therapy on abdominal aortic aneurysm growth: a meta-analysis and meta-regression of observational comparative studies
Open accessAbstract
Objective To determine whether statin therapy reduces the growth rate of small abdominal aortic aneurysms (AAAs).Design A meta-analysis and a meta-regression of comparative studies.Materials Eligible studies were randomized controlled trials or observational comparative studies of statin therapy versus placebo or no statin, enrolling individuals with small (<55 mm in diameter) AAAs and reporting AAA growth rate as an outcome.Methods Study-specific estimates (standardized mean differences [SMDs]) were combined in the fixed- and random-effects model.Results Seven adjusted and 4 unadjusted observational comparative studies enrolling 4647 patients with a small AAA were identified. Pooled analysis of all 11 studies suggested a significant reduction in AAA growth rate among patients assigned to statin therapy versus no statin (SMD, -0.420; 95% confidence interval [CI], -0.651 to -0.189). Combining the 7 high-quality studies providing adjusted data for growth rates generated an attenuated but still statistically significant result favoring statin therapy (SMD, -0.367; 95% CI, -0.566 to -0.168). The meta-regression coefficient for the baseline diameter was statistically significant (-0.096; 95% CI, -0.132 to -0.061).Conclusion Statin therapy is likely effective in prevention of the growth of small AAAs, and may be more beneficial as the baseline diameter increases.
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Based on a recent meta-analysis, statin therapy is likely effective in preventing growth of small abdominal aortic aneurysms less than 55 mm in diameter.
“Based on a recent meta-analysis, statin therapy is likely effective in the prevention of growth of small (<55 mm in diameter) abdominal aortic aneurysms.419”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [419]
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2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw272 · Cited by 3,162 · see citing works
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- Authors
- Takagi, H., Yamamoto, H., Iwata, K., Goto, S., & Umemoto, T.
- Affiliations
- Shizuoka Medical Center (JP)
- Corresponding author
- Takagi, H.
- Venue
- European Journal of Vascular and Endovascular Surgery
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 44
- Issue
- 3
- Pages
- 287-292
- ISSN
- 1078-5884 (ISSN-L)
- OpenAlex
- W2093977052
- Cited by
- 111
- References
- 34
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 11 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 13 · 2013: 9 · 2012: 3
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Journal of Vascular and Endovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic aneurysm repair treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Keywords
- statin therapy, abdominal aortic aneurysm, aneurysm growth rate, small aneurysms, aneurysm prevention, cholesterol-lowering drugs
- MeSH terms
- Humans, Prognosis, Time Factors, Aortic Aneurysm, Abdominal, Disease Progression, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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