Cited by 111Aortic aneurysm repair treatmentsAortic Disease and Treatment ApproachesAbdominal vascular conditions and treatments

Effects of statin therapy on abdominal aortic aneurysm growth: a meta-analysis and meta-regression of observational comparative studies

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Takagi, H., Yamamoto, H., Iwata, K., Goto, S., Umemoto, T.·2012·European Journal of Vascular and Endovascular Surgery

Abstract

Objective To determine whether statin therapy reduces the growth rate of small abdominal aortic aneurysms (AAAs).Design A meta-analysis and a meta-regression of comparative studies.Materials Eligible studies were randomized controlled trials or observational comparative studies of statin therapy versus placebo or no statin, enrolling individuals with small (<55 mm in diameter) AAAs and reporting AAA growth rate as an outcome.Methods Study-specific estimates (standardized mean differences [SMDs]) were combined in the fixed- and random-effects model.Results Seven adjusted and 4 unadjusted observational comparative studies enrolling 4647 patients with a small AAA were identified. Pooled analysis of all 11 studies suggested a significant reduction in AAA growth rate among patients assigned to statin therapy versus no statin (SMD, -0.420; 95% confidence interval [CI], -0.651 to -0.189). Combining the 7 high-quality studies providing adjusted data for growth rates generated an attenuated but still statistically significant result favoring statin therapy (SMD, -0.367; 95% CI, -0.566 to -0.168). The meta-regression coefficient for the baseline diameter was statistically significant (-0.096; 95% CI, -0.132 to -0.061).Conclusion Statin therapy is likely effective in prevention of the growth of small AAAs, and may be more beneficial as the baseline diameter increases.

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Crossref · 10.1016/j.ejvs.2012.06.021

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  • Based on a recent meta-analysis, statin therapy is likely effective in preventing growth of small abdominal aortic aneurysms less than 55 mm in diameter.

    “Based on a recent meta-analysis, statin therapy is likely effective in the prevention of growth of small (<55 mm in diameter) abdominal aortic aneurysms.419”

    From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [419]

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Authors
Takagi, H., Yamamoto, H., Iwata, K., Goto, S., & Umemoto, T.
Affiliations
Shizuoka Medical Center (JP)
Corresponding author
Takagi, H.
Venue
European Journal of Vascular and Endovascular Surgery
Publisher
Elsevier BV
Published
2012-09
Volume
44
Issue
3
Pages
287-292
ISSN
1078-5884 (ISSN-L)
OpenAlex
W2093977052
Cited by
111
References
34
Citations by year
2026: 4 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 11 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 13 · 2013: 9 · 2012: 3
FWCI
1.53
Type
journal article
Language
en
Open access
Locations
  • European Journal of Vascular and Endovascular Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic aneurysm repair treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
Keywords
statin therapy, abdominal aortic aneurysm, aneurysm growth rate, small aneurysms, aneurysm prevention, cholesterol-lowering drugs
MeSH terms
Humans, Prognosis, Time Factors, Aortic Aneurysm, Abdominal, Disease Progression, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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