Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population
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Dioxin exposure has experimentally been associated with changes in DNA methylation, an epigenetic change that is associated with disease. The present study aims to investigate if serum levels of dioxin and other persistent environmental pollutants are related to global DNA methylation in a human sample. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (all aged 70), global DNA methylation was measured by the Luminometric Methylation Assay in 524 subjects. Twenty-three different POPs, including 16 PCBs, five pesticides, one dioxin (OCDD) and one brominated flame retardant (BDE47) were analysed by HRGC/HRMS. Ten single nucleotide polymorphisms (SNPs) in the Aryl hydrocarbon (Ah)-receptor were analysed by mini-sequencing. High levels of toxic equivalency (TEQ) for PCBs and dioxin were associated with DNA hypermethylation (p=0.030). This was mainly attributed to coplanar non-ortho PCBs. While no significant associations were found between DNA methylation and SNPs in the Ah-receptor, an interaction was found between the SNP rs2237297 and TEQ so that TEQ was associated with hypermethylation (p=0.009) only in subjects with one G-allele (n=103). Also high levels of the PCB126 congener, the OCDD, and the pesticide metabolite p,p'-DDE were related to DNA hypermethylation (p=0.01, 0.03 and 0.003, respectively). In conclusion, in a sample of elderly subjects, high TEQ including PCBs and the dioxin OCDD and high serum levels of PCB126, OCDD, and p,p'-DDE were related to global DNA hypermethylation in a cross-sectional analysis.
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DL and NDL PCBs have opposing actions on DNA methylation, with DL PCBs shifting the balance toward DNA hypermethylation and NDL PCBs favoring DNA hypomethylation.
“There is evidence to suggest that the DL and NDL PCBs have opposing actions on DNA methylation, with DL PCBs shifting the balance toward DNA hypermethylation, as was observed in the Sweden study [ 39 ], and NDL PCBs favoring DNA hypomethylation as observed in the Korean and Inuit studies [ 36 , 38 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [39]
In a separate study of 524 elderly men and women (70 years of age) living in Uppsala, Sweden, high levels of DL PCBs were associated with global DNA hypermethylation.
“Conversely, in a separate study of 524 elderly men and women (70 years of age) living in Uppsala, Sweden, high levels of DL PCBs were associated with global DNA hypermethylation [ 39 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [39]
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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984 · see citing works
Van den Berg, M., Birnbaum, L. S., Denison, M., De Vito, M., Farland, W., Feeley, M., Fiedler, H., Hakansson, H., Hanberg, A., Haws, L., et al. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl055 · Cited by 3,785 · see citing works
Toxic Equivalency Factors (TEFs) for PCBs, PCDDs, PCDFs for Humans and Wildlife
van den Berg, M., Birnbaum, L. S., Bosveld, A. T. C., Brunström, B., Cook, P. M., Feeley, M., Giesy, J. P., Hanberg, A., Hasegawa, R., Kennedy, S. W., et al. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106775 · Cited by 3,301 · see citing works
Role for DNA methylation in genomic imprinting
Li, E., Beard, C., & Jaenisch, R. (1993) · Nature · doi:10.1038/366362a0 · Cited by 2,070 · see citing works
Role for DNA methylation in genomic imprinting
Li, E., Beard, C., & Jaenisch, R. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90228-3 · Cited by 1,691 · see citing works
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
Yang, A. S. (2004) · Nucleic Acids Research · doi:10.1093/nar/gnh032 · Cited by 1,033 · see citing works
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
Bell, J. T., Pai, A. A., Pickrell, J. K., Gaffney, D. J., Pique-Regi, R., Degner, J. F., Gilad, Y., & Pritchard, J. K. (2011) · Genome Biology · doi:10.1186/gb-2011-12-1-r10 · Cited by 838 · see citing works
Richardson, B., Scheinbart, L., Strahler, J. R., Gross, L. A., Hanash, S., & Johnson, M. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780331109 · Cited by 565 · see citing works
Chouliaras, L., Mastroeni, D., Delvaux, E., Grover, A., Kenis, G., Hof, P. R., Steinbusch, H. W. M., Coleman, P. D., Rutten, B. P. F., & van den Hove, D. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.021 · Cited by 422 · see citing works
Lind, L., Fors, N., Hall, J., Marttala, K., & Stenborg, A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184769.22061.da · Cited by 364 · see citing works
Self-citationRusiecki, J. A., Baccarelli, A., Bollati, V., Tarantini, L., Moore, L. E., & Bonefeld-Jorgensen, E. C. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11338 · Cited by 352 · see citing works
The Belgian PCB/Dioxin Incident: Analysis of the Food Chain Contamination and Health Risk Evaluation
Bernard, A., Broeckaert, F., Poorter, G. D., Cock, A. D., Hermans, C. R. J. R., Saegerman, C., & Houins, G. (2002) · Environmental Research · doi:10.1006/enrs.2001.4274 · Cited by 248 · see citing works
Does SINE evolution preclude Alu function?
Schmid, C. W. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.20.4541 · Cited by 230 · see citing works
Kim, K.-Y., Kim, D.-S., Lee, S.-K., Lee, I.-K., Kang, J.-H., Chang, Y.-S., Jacobs, D. R., Steffes, M., & Lee, D.-H. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901131 · Cited by 216 · see citing works
Pesatori, A. C., Consonni, D., Rubagotti, M., Grillo, P., & Bertazzi, P. A. (2009) · Environmental Health · doi:10.1186/1476-069x-8-39 · Cited by 206 · see citing works
Ha, M.-H., Lee, D., & Jacobs, D. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10184 · Cited by 197 · see citing works
Ruike, Y., Imanaka, Y., Sato, F., Shimizu, K., & Tsujimoto, G. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-137 · Cited by 195 · see citing works
Association Between Type 2 Diabetes and Exposure to Persistent Organic Pollutants
Airaksinen, R., Rantakokko, P., Eriksson, J. G., Blomstedt, P., Kajantie, E., & Kiviranta, H. (2011) · Diabetes Care · doi:10.2337/dc10-2303 · Cited by 172 · see citing works
Fierens, S., Mairesse, H., Heilier, J.-F., de Burbure, C., Focant, J.-F. ̧., Eppe, G., Pauw, E. D., & Bernard, A. (2003) · Biomarkers · doi:10.1080/1354750032000158420 · Cited by 171 · see citing works
Using LUMA: a Luminometric-Based Assay for Global DNA-Methylation
Mohsen, K., Johansson, S., & Ekström, T. J. (2006) · Epigenetics · doi:10.4161/epi.1.1.2587 · Cited by 168 · see citing works
Rylander, L., Nilsson‐Ehle, P., & Hagmar, L. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2005.04.107 · Cited by 124 · see citing works
Background exposure to persistent organic pollutants predicts stroke in the elderly
Lee, D., Lind, P., Jacobs, D. R., Salihović, S., van Bavel, B., & Lind, L. (2012) · Environment International · doi:10.1016/j.envint.2012.06.009 · Cited by 78 · see citing works
Self-citationMurphy, T. M., Mullins, N., Ryan, M., Foster, T., Kelly, C., McClelland, R., O'Grady, J., Corcoran, E., Brady, J., Reilly, M., et al. (2013) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00865.x · Cited by 74 · see citing works
Salihović, S., Mattioli, L., Lindström, G., Lind, L., Lind, P., & van Bavel, B. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.11.006 · Cited by 69 · see citing works
Self-citationGlobal DNA Hypomethylation in Peripheral Blood Mononuclear Cells as a Biomarker of Cancer Risk
Friso, S., Udali, S., Guarini, P., Pellegrini, C., Pattini, P., Moruzzi, S., Girelli, D., Pizzolo, F., Martinelli, N., Corrocher, R., et al. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0859 · Cited by 67 · see citing works
Walters, R., Williamson, E., English, D. R., Young, J. P., Rosty, C., Clendenning, M., Walsh, M. D., Parry, S., Ahnen, D. J., Baron, J. A., et al. (2013) · Epigenetics · doi:10.4161/epi.25178 · Cited by 49 · see citing works
Yang, B., Sun, H., Lin, W. J., Hou, W., Li, H., Zhang, L., Li, F., Gu, Y., Song, Y., Li, Q., et al. (2011) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2011.05.009 · Cited by 43 · see citing works
Lind, Y. S., Lind, P., Salihović, S., van Bavel, B., & Lind, L. (2013) · Environmental Research · doi:10.1016/j.envres.2013.02.007 · Cited by 37 · see citing works
Self-citationBrunnberg, S., Andersson, P., Poellinger, L., & Hanberg, A. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.09.015 · Cited by 30 · see citing works
McClure, E. A., North, C. M., Kaminski, N. E., & Goodman, J. I. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfq396 · Cited by 25 · see citing works
Salzano, M., Marabotti, A., Milanesi, L., & Facchiano, A. M. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.039 · Cited by 19 · see citing works
Vlaykova, T. I., Mitkova, A. V., Stancheva, G. S., Kadiyska, T., Gulubova, M. V., Yovchev, Y., Cirovski, G., Chilingirov, P., Damyanov, D., Kremensky, I. M., et al. (2011) · PubMed · Cited by 17 · see citing works
Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk
Guarini, P., Udali, S., Pattini, P., Moruzzi, S., Girelli, D., Pizzolo, F., Martinelli, N., Olivieri, O., Choi, S., & Friso, S. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.248.1 · Cited by 5 · see citing works
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Environmental Influences on the Epigenome: Exposure- Associated DNA Methylation in Human Populations
Martin, E. M., & Fry, R. C. (2018) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040617-014629 · Cited by 640 · see citing works
Ruiz-Hernandez, A., Kuo, C.-C., Rentero-Garrido, P., Tang, W., Redón, J., Ordovás, J. M., Navas‐Acién, A., & Téllez-Plaza, M. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0055-7 · Cited by 208 · see citing works
Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism
Tran, N. Q. V., & Miyake, K. (2017) · International Journal of Genomics · doi:10.1155/2017/7526592 · Cited by 183 · see citing works
Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167 · see citing works
Association of Environmental Toxins With Amyotrophic Lateral Sclerosis
Su, F., Goutman, S. A., Chernyak, S. A., Mukherjee, B., Callaghan, B. C., Batterman, S., & Feldman, E. L. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.0594 · Cited by 162 · see citing works
Epigenetic impacts of endocrine disruptors in the brain
Walker, D. M., & Gore, A. C. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.09.002 · Cited by 94 · see citing works
Legoff, L., D’Cruz, S. C., Tevosian, S. G., Primig, M., & Smagulova, F. O. (2019) · Cells · doi:10.3390/cells8121559 · Cited by 91 · see citing works
Persistent Organic Pollutants as Risk Factors for Obesity and Diabetes
Yang, C., Kong, A. P. S., Cai, Z., & Chung, A. C. K. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0966-0 · Cited by 81 · see citing works
Angelopoulou, E., Paudel, Y. N., Papageorgiou, S. G., & Piperi, C. (2022) · Brain Sciences · doi:10.3390/brainsci12020175 · Cited by 73 · see citing works
Marques-Rocha, J. L., Milagro, F. I., Mansego, M. L., Mourão, D. M., Martínez, J. A., & Bressan, J. (2016) · Epigenetics · doi:10.1080/15592294.2015.1135286 · Cited by 72 · see citing works
Kim, S., Cho, Y. H., Lee, I., Kim, W., Won, S., Ku, J., Moon, H., Park, J., Kim, S., Choi, G., et al. (2018) · Environment International · doi:10.1016/j.envint.2018.06.039 · Cited by 64 · see citing works
Rusiecki, J. A., Freeman, L. E. B., Bonner, M. R., Alexander, M. S., Chen, L., Andreotti, G., Barry, K. H., Moore, L. E., Byun, H., Kamel, F., et al. (2016) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22067 · Cited by 63 · see citing works
Chatterjee, N., Yang, J., & Choi, J. (2016) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2016.01.006 · Cited by 61 · see citing works
Jiang, Y., Xia, W., Yang, J., Zhu, Y., Chang, H., Liu, J., Huo, W., Xu, B., Chen, X., Li, Y., et al. (2015) · Toxicology · doi:10.1016/j.tox.2015.01.001 · Cited by 60 · see citing works
PCB126 inhibits adipogenesis of human preadipocytes
Gadupudi, G. S., Gourronc, F. A., Ludewig, G., Robertson, L. W., & Klingelhutz, A. J. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.09.015 · Cited by 58 · see citing works
Epigenetic Effects of Polybrominated Diphenyl Ethers on Human Health
Poston, R. G., & Saha, R. N. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16152703 · Cited by 59 · see citing works
Epigenetic regulation of gene expression in response to environmental exposures: From bench to model
Li, D., Yang, Y. X., Li, Y., Zhu, X., & Li, Z. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145998 · Cited by 56 · see citing works
Epigenome-Wide DNA Methylation and Pesticide Use in the Agricultural Lung Health Study
Hoang, T. T., Qi, C., Paul, K. C., Lee, M. K., White, J. D., Richards, M., Auerbach, S. S., Long, S., Shrestha, S., Wang, T., et al. (2021) · Environmental Health Perspectives · doi:10.1289/ehp8928 · Cited by 55 · see citing works
Farag, A. A., Youssef, H. S., Sliem, R. E., Gazzar, W. B. E., Nabil, N., Mokhtar, M. M., Marei, Y. M., Ismail, N. S., Radwaan, S. E., Badr, A. M., et al. (2023) · Toxicology · doi:10.1016/j.tox.2023.153545 · Cited by 55 · see citing works
Itoh, H., Iwasaki, M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., Yoshida, T., Yokoyama, K., & Tsugane, S. (2014) · Science of The Total Environment · doi:10.1016/j.scitotenv.2014.05.035 · Cited by 53 · see citing works
Curtis, S. W., Cobb, D. O., Kilaru, V., Terrell, M. L., Kennedy, E. M., Marder, M. E., Barr, D. B., Marsit, C. J., Marcus, M., Conneely, K. N., et al. (2019) · Epigenetics · doi:10.1080/15592294.2019.1565590 · Cited by 50 · see citing works
Lipid metabolism is associated with developmental epigenetic programming
Marchlewicz, E. H., Dolinoy, D. C., Tang, L., Milewski, S., Jones, T. R., Goodrich, J. M., Soni, T., Domino, S. E., Song, P. X. ‐., Burant, C., et al. (2016) · Scientific Reports · doi:10.1038/srep34857 · Cited by 51 · see citing works
Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food
(CONTAM), E. P. O. C. I. T. F. C., Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Högstrand, C., Hoogenboom, L. A. P., Leblanc, J., et al. (2024) · EFSA Journal · doi:10.2903/j.efsa.2024.8497 · Cited by 49 · see citing works
Effects of atrazine and chlorpyrifos on DNA methylation in the brain and gonad of the common carp
Xing, H., Wang, C., Wu, H., Chen, D., Li, S., & Xu, S. (2014) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2014.11.002 · Cited by 48 · see citing works
Yi, Q., Wang, C., Wang, J., Zhang, X., Zhou, Z., Zhao, M., & Lu, C. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-02255-5 · Cited by 43 · see citing works
Transgenerational epigenetics and environmental justice
Rothstein, M. A., Harrell, H. L., & Marchant, G. E. (2017) · Current Zoology · doi:10.1093/eep/dvx011 · Cited by 42 · see citing works
Association between serum persistent organic pollutants and DNA methylation in Korean adults
Lee, M. H., Cho, E. R., Lim, J., & Jee, S. H. (2017) · Environmental Research · doi:10.1016/j.envres.2017.06.017 · Cited by 39 · see citing works
Dioxins as potential risk factors for autism spectrum disorder
Guo, Z., Xie, H. Q., Zhang, P., Luo, Y., Xu, T., Liu, Y., Fu, H., Xu, S. L., Valsami‐Jones, E., Boksa, P., et al. (2018) · Environment International · doi:10.1016/j.envint.2018.10.028 · Cited by 39 · see citing works
Barbosa, E., dos Santos, A. L. A., Peteffi, G. P., Schneider, A., Müller, D., Rovaris, D. L., Bau, C. H. D., Linden, R., Antunes, M. V., & Charão, M. F. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3674-7 · Cited by 39 · see citing works
Gene × environment interactions in autism spectrum disorders
Keil, K. P., & Lein, P. J. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2022.11.001 · Cited by 37 · see citing works
Goodman, S. J., Chappell, G. A., Guyton, K. Z., Pogribny, I. P., & Rusyn, I. (2021) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2021.108408 · Cited by 36 · see citing works
Georgiadis, P., Gavriil, M., Rantakokko, P., Ladoukakis, E., Botsivali, M., Kelly, R. S., Bergdahl, I. A., Kiviranta, H., Vermeulen, R. C. H., Spaeth, F., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.01.068 · Cited by 33 · see citing works
van den Dungen, M. W., Murk, A. J., Kampman, E., Steegenga, W. T., & Kok, D. E. G. (2017) · Current Zoology · doi:10.1093/eep/dvx001 · Cited by 31 · see citing works
Thorson, J. L. M., Beck, D., Maamar, M. B., Nilsson, E. E., & Skinner, M. K. (2020) · Environmental Health · doi:10.1186/s12940-020-00666-y · Cited by 31 · see citing works
Li, M., Wang, R., Su, C., Li, J., & Wu, Z. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19073862 · Cited by 30 · see citing works
Xu, P., Chen, Z., Wu, L., Chen, Y., Xu, D., Shen, H., Han, J., Wang, X., & Lou, X. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.06.425 · Cited by 29 · see citing works
Humphrey, K. M., Pandey, S., Martin, J., Hagoel, T. J., Grand’Maison, A., & Ohm, J. E. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.11.002 · Cited by 27 · see citing works
Aluru, N., Karchner, S. I., Krick, K. S., Zhu, W. Z., & Liu, J. (2018) · Current Zoology · doi:10.1093/eep/dvy005 · Cited by 26 · see citing works
Wu, H., Cohn, B. A., Cirillo, P. M., Santella, R. M., & Terry, M. B. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.02.010 · Cited by 24 · see citing works
Meltzer, G., Watkins, B.-X., Vieira, D. L., Zelikoff, J. T., & Boden-Albala, B. M. (2020) · Journal of Racial and Ethnic Health Disparities · doi:10.1007/s40615-020-00700-2 · Cited by 25 · see citing works
Wielsøe, M., Tarantini, L., Bollati, V., Long, M., & Bonefeld‐Jørgensen, E. C. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13424 · Cited by 24 · see citing works
Maître, L., Jedynak, P., Gallego-Paüls, M., Ciaran, L., Audouze, K., Casas, M., & Vrijheid, M. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115788 · Cited by 24 · see citing works
Mahire, S., Tiwana, A. S., Khan, A. M., Nalawade, P. M., Bandekar, G., Trehan, N., Mukkannawar, U., Kaur, S., Pandit, V. U., & Kamble, P. N. (2023) · Arabian Journal of Geosciences · doi:10.1007/s12517-023-11675-9 · Cited by 22 · see citing works
Alexander, M. S., Koutros, S., Bonner, M. R., Barry, K. H., Alavanja, M. C. R., Andreotti, G., Byun, H., Chen, L., Freeman, L. E. B., Hofmann, J. N., et al. (2017) · Current Zoology · doi:10.1093/eep/dvx005 · Cited by 22 · see citing works
Su, K., Li, M., Lee, N.-W., Ho, B., Cheng, C.-L., Chuang, Y.-C., Yu, S., & Guo, Y. L. (2019) · Environmental Research · doi:10.1016/j.envres.2019.01.001 · Cited by 22 · see citing works
Park, E. Y., Kim, J., Park, E., Oh, J., Kim, B., & Lim, M. K. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.129596 · Cited by 22 · see citing works
Histone acetylation is involved in TCDD-induced cleft palate formation in fetal mice
Yuan, X., Qiu, L., Pu, Y., Liu, C., Zhang, X., Wang, C., Pu, W., & Fu, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5348 · Cited by 22 · see citing works
Associations between persistent organic pollutants and type 1 diabetes in youth
Bresson, S. E., Isom, S. P., Jensen, E. T., Huber, S., Oulhote, Y., Rigdon, J., Lovato, J. F., Liese, A. D., Pihoker, C., Dabelea, D., et al. (2022) · Environment International · doi:10.1016/j.envint.2022.107175 · Cited by 21 · see citing works
New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins
Xie, H. Q., Xu, T., Chen, Y., Li, Y., Xia, Y., Xu, S. L., Wang, L., Tsim, K. W. K., & Zhao, B. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.06.030 · Cited by 21 · see citing works
Qu, X., Ming-Zhang, Yuanfang, Wang, H., & Zhang, Y. (2017) · Reproductive Sciences · doi:10.1177/1933719117711258 · Cited by 21 · see citing works
Curtis, S. W., Cobb, D. O., Kilaru, V., Terrell, M. L., Marder, M. E., Barr, D. B., Marsit, C. J., Marcus, M., Conneely, K. N., & Smith, A. K. (2020) · Epigenetics · doi:10.1080/15592294.2020.1795605 · Cited by 21 · see citing works
Curtis, S. W., Conneely, K. N., Marder, M. E., Terrell, M. L., Marcus, M., & Smith, A. K. (2018) · Epigenomics · doi:10.2217/epi-2017-0174 · Cited by 20 · see citing works
Traditional Chinese Medicine: A Class of Potentially Reliable Epigenetic Drugs
Zhu, D., Li, A., Lv, Y., & Fan, Q. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.907031 · Cited by 19 · see citing works
Rohr, P., Karen, S., Francisco, L. F. V., de Oliveira, M. A., Neto, M. F. D. S., & Silveira, H. C. S. (2024) · Current Zoology · doi:10.1093/eep/dvae005 · Cited by 19 · see citing works
DNA methylation modifications: mediation to stipulate pesticide toxicity
Mahna, D., Puri, S., & Sharma, S. (2020) · International Journal of Environmental Science and Technology · doi:10.1007/s13762-020-02807-9 · Cited by 19 · see citing works
Curtis, S. W., Cobb, D. O., Kilaru, V., Terrell, M. L., Marder, M. E., Barr, D. B., Marsit, C. J., Marcus, M., Conneely, K. N., & Smith, A. K. (2019) · Epigenetics · doi:10.1080/15592294.2019.1629232 · Cited by 17 · see citing works
Polychlorinated biphenyl exposure and DNA methylation in the Anniston Community Health Survey
Pittman, G. S., Wang, X., Campbell, M. R., Coulter, S. J., Olson, J. R., Pavúk, M., Birnbaum, L. S., & Bell, D. A. (2019) · Epigenetics · doi:10.1080/15592294.2019.1666654 · Cited by 16 · see citing works
Sabi, S. H., Khabour, O. F., Alzoubi, K. H., Cobb, C. O., & Eissenberg, T. (2020) · Inhalation Toxicology · doi:10.1080/08958378.2020.1754972 · Cited by 16 · see citing works
Itoh, H., Harada, K. H., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., Yokoyama, K., Zhu, J., Sassa, M. H., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159923 · Cited by 13 · see citing works
Negi, C. K., Bláhová, L., Phan, A., Bajard, L., & Bláha, L. (2024) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.4c00223 · Cited by 13 · see citing works
Rodent Models of Autism, Epigenetics, and the Inescapable Problem of Animal Constraint
Lahvis, G. P. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3777-6_9 · Cited by 12 · see citing works
Park, S. Y., Kim, K.-S., Lee, Y.-M., Kim, M.-J., Jacobs, D. R., Porta, M., Kim, D.-S., & Lee, D.-H. (2015) · Biomarkers · doi:10.3109/1354750x.2014.1002806 · Cited by 11 · see citing works
Cheng, F., Shen, R., Zheng, Z., Chen, Z. J., Huang, P.-J., Feng, Z., Li, X., Lin, N., Zheng, M., Liang, Y., et al. (2025) · Cell Discovery · doi:10.1038/s41421-025-00795-z · Cited by 11 · see citing works
Fogliano, C., Motta, C. M., Acloque, H., Avallone, B., & Carotenuto, R. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165300 · Cited by 11 · see citing works
Kuzmina, N. S., Luong, T. M., & Rubanovich, A. V. (2020) · Russian Journal of Genetics · doi:10.1134/s1022795420100063 · Cited by 10 · see citing works
Dioxin-like compound exposures and DNA methylation in the Anniston Community Health Survey Phase II
Pittman, G. S., Wang, X., Campbell, M. R., Coulter, S. J., Olson, J. R., Pavúk, M., Birnbaum, L. S., & Bell, D. A. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.140424 · Cited by 10 · see citing works
Pierozan, P., Höglund, A., Theodoropoulou, E., & Karlsson, O. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174864 · Cited by 9 · see citing works
Aluru, N., & Engelhardt, J. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac044 · Cited by 9 · see citing works
Perrot‐Applanat, M., Pimpie, C., Cano-Sancho, G., Antignac, J., & Pocard, M. D. (2021) · Cancers · doi:10.3390/cancers13194874 · Cited by 8 · see citing works
Chbihi, K., Menouni, A., Hardy, E. M., Creta, M., Grova, N., Nieuwenhuyse, A. V., Godderis, L., Jaâfari, S. E., & Duca, R. C. (2023) · Environment International · doi:10.1016/j.envint.2023.108409 · Cited by 8 · see citing works
Persistent organic pollutants and risk of cutaneous malignant melanoma among women
Darvishian, M., Bhatti, P., Gaudreau, É., Abanto, Z. U., Choi, C. Q., Gallagher, R. P., Spinelli, J. J., & Lee, T. K. (2021) · Cancer Reports · doi:10.1002/cnr2.1536 · Cited by 8 · see citing works
Thangavelu, S. K., Mohan, M., Ramachandran, I., & Arunakaran, J. (2021) · Andrologia · doi:10.1111/and.14160 · Cited by 7 · see citing works
Awaji, A. A., Alhamdi, H. W. S., Alshehri, K. M., Alfaifi, M. Y., Shati, A. A., Elbehairi, S. E. I., Radwan, N., Hafez, H. S., Elshaarawy, R. F. M., & Welson, M. (2024) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2024.112720 · Cited by 7 · see citing works
Global Analysis of DNA 5-Methylcytosine Using the Luminometric Methylation Assay, LUMA
Luttropp, K., Sjöholm, L. K., & Ekström, T. J. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2715-9_16 · Cited by 7 · see citing works
Self-citationEffects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis
Barouti, Z., Heidari‐Beni, M., Shabanian-Boroujeni, A., Mohammadzadeh, M., Pahlevani, V., Poursafa, P., Mohebpour, F., & Kelishadi, R. (2022) · Archives of Public Health · doi:10.1186/s13690-022-00907-1 · Cited by 7 · see citing works
Lee, J.-Y., Lee, K. M., Lee, D. H., & Kim, D. S. (2017) · Biomarkers · doi:10.1080/1354750x.2017.1417482 · Cited by 7 · see citing works
ALISTAR, C. F., Nica, I. C., Lazar, M. N., Vasile, G. G., Gheorghe, Ş., Croitoru, A.-M., Dolete, G., Mihăiescu, D. E., Ficai, A., Crăciun, N., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19127510 · Cited by 6 · see citing works
AHR in the skin: From the mediator of chloracne to a therapeutic panacea?
Merches, K., Haarmann‐Stemmann, T., Weighardt, H., Krutmann, J., & Esser, C. (2017) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.02.002 · Cited by 5 · see citing works
Desaulniers, D. M., Cummings‐Lorbetskie, C., Li, N., Xiao, G.-H., Marro, L., Khan, N., & Leingartner, K. (2016) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2016.1231644 · Cited by 4 · see citing works
Guo, M., Li, S., Cheng, Y., Xin, J., Zhou, J., Xu, S., Ben, S., Wang, M., Zhang, Z., & Gu, D. (2024) · Environment International · doi:10.1016/j.envint.2024.108924 · Cited by 3 · see citing works
Park, Y., Sung, N., Kim, E., Jeong, J., Sim, J., Park, M. J., Lydon, J. P., Guan, X., & Han, S. J. (2025) · Endocrinology · doi:10.1210/endocr/bqaf146 · Cited by 3 · see citing works
Miller, R. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803239-8.00007-7 · Cited by 3 · see citing works
Sareisian, L. (2014) · NORA - Norwegian Open Research Archives · Cited by 3 · see citing works
Tuminello, S., Durmuş, N., Snuderl, M., Chen, Y., Shao, Y., Reibman, J., Arslan, A. A., & Taioli, E. (2024) · Biomolecules · doi:10.3390/biom14101302 · Cited by 2 · see citing works
Li, N., Wang, J., Li, K., Yang, P., Wang, Y., Xu, C., He, N., Ji, K., Song, H., Zhang, M., et al. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-28591-w · Cited by 1 · see citing works
Guo, Y., You, Y., Guan, X., Yin, Y., Yin, Z., Zhong, G., Jia, C., Wen, Y., Li, W., Zhao, H., et al. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141727 · Cited by 1 · see citing works
Moore, L. E., Karami, S., & Rusiecki, J. A. (2015) · Molecular and integrative toxicology · doi:10.1007/978-1-4471-6678-8_11
Determinants of Cord Blood DNA Methylation Variability in a Mexican-American Birth Cohort
Yousefi, P. (2016) · eScholarship (California Digital Library)
DNA methylation in Daphnia Magna
Athanàsio, C. G. (2016)
Persistent organic pollutants : aberrant DNA methylation underlying potential health effects
van den Dungen, M. W. (2016) · doi:10.18174/378722
Influence of E-Waste Dismantling on DNA Damage and Methylation in People Living Near Recycling SitesPreprint
Li, N., Wang, J., Li, K., Yang, P., Sun, X., Wang, Y., Xu, C., He, N., Ji, K., Song, H., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4140044
Polychlorinated Biphenyl-126 Activates AXL/ERb/DNMT3A Axis to Drive Endometriosis ProgressionPreprint
Park, Y., Sung, N., Kim, E., Jeong, J., Sim, J., Park, M. J., Lydon, J. P., Guan, X., & Han, S. J. (2025) · Research Square · doi:10.21203/rs.3.rs-6631264/v1
Xu, Y., Gong, Y., Ding, C., Zhang, H., Hao, D., Zhao, X., Wang, J., 童天朗, & Li, X. (2025) · International Journal of Environmental Health Research · doi:10.1080/09603123.2025.2604163
Saifi, M. A., Javed, M., Jindal, G., & Raisuddin, S. (2026) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-026-00759-z
- Authors
- Lind, L., Penell, J., Luttropp, K., Nordfors, L., Syvänen, A.-C., Axelsson, T., Salihovic, S., van Bavel, B., Fall, T., Ingelsson, E., & Lind, P. M.
- Affiliations
- Uppsala University (SE)
- Karolinska Institutet (SE)
- Corresponding author
- Lind, P. Monica
- ORCID
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 59
- Pages
- 456-461
- ISSN
- 0160-4120 (ISSN-L)
- OpenAlex
- W2077502047
- Cited by
- 94
- References
- 33
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 7 · 2020: 8 · 2019: 9 · 2018: 7 · 2017: 10 · 2016: 15 · 2015: 5 · 2014: 4
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Environment International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- persistent organic pollutants, dioxins, polychlorinated biphenyls, PCB 126, p,p'-DDE, brominated flame retardants, pesticides, toxic equivalents, aryl hydrocarbon receptor, single nucleotide polymorphisms, epigenetics, older adults, PIVUS study
- MeSH terms
- Polychlorinated Dibenzodioxins, Aged, Cross-Sectional Studies, Dichlorodiphenyl Dichloroethylene, Dioxins, Environmental Pollutants, Female, Humans, Male, Pesticides, Polychlorinated Biphenyls, Prospective Studies, Receptors, Aryl Hydrocarbon, DNA Methylation, Halogenated Diphenyl Ethers
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