Retrospective Analysis of the Global Antibiotic Residues That Exceed the Predicted No Effect Concentration for Antimicrobial Resistance in Various Environmental Matrices
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BACKGROUND: Antimicrobial resistance (AMR) is a growing public health concern. Recent research has suggested that interactions between pathogens and antibiotic residues in various environmental matrices promote the development and spread of AMR in the environment. The levels of antibiotic residues in the aquatic environment have been analysed globally. Recently, Predicted No Effect Environmental Concentration (PNEC) values for many antibiotics have been suggested, based on their estimated minimal selective concentrations for selected bacterial species. The PNEC values can serve as a guide on the maximum levels of antibiotic residues in an environmental matrix, below which resistance is unlikely to develop. AIM: We aimed to determine which of the antibiotics, considered as "priority antibiotics" by the World Health Organisation (WHO), most frequently exceeded their PNEC values in the global aquatic environment. METHODS: We obtained data from the German Environment Agency pharmaceutical database on means, medians or single values of 12 antibiotic types in five different environmental matrices [municipal wastewater treatment plant effluent, industrial wastewater effluent, hospital wastewater effluent, surface water, and drinking water] across 47 countries. We compared the mean levels of the 12 antibiotics in each environmental matrix to their suggested PNEC values to determine which antibiotic types exceeded PNEC and were most likely to select for resistance. We also determined which environmental matrices and countries had the highest burden of antibiotic residues. RESULTS: Our study revealed that 7.9% of all analyses of antibiotic residues performed in the environmental matrices globally exceeded PNEC. Ciprofloxacin and clarithromycin had the greatest proportion (>30%) of residues exceeding PNEC. Hospital wastewater and industrial wastewater had the highest burden of antibiotic residues exceeding PNEC. No antibiotics exceeded PNEC in drinking water. CONCLUSION: While most environmental monitoring studies have focused on municipal wastewater treatment plants, the limited number of studies on hospital wastewater and industrial wastewater revealed that a large number of antibiotic residues coming from these sources exceeded their PNEC values. Our study highlights the importance of implementing on-site treatment systems that aim to destroy antibiotics prior to discharging wastewater to surface waters. Attention needs to be focused on the role that environmental matrices, particularly our wastewater sites, play in promoting antibiotic resistance. Novel treatment technologies need to be developed and implemented to increase the removal efficiencies of treatment plants and from antibiotic manufacturing, and decrease the discharge of antibiotic residues into aquatic environments.
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Sulfamethoxazole levels detected in environmental samples occasionally exceed the predicted no-effect concentration threshold in the low microgram per Liter range, indicating a risk to aquatic ecosystems.
“its levels detected in environmental samples occasionally exceed the so-called predicted no-effect concentration (PNEC) threshold value, which resides in the low microgram per Liter range, indicating a risk to aquatic ecosystems [11,12].”
From Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion (2025) · cites this paper as [11]
Cites
(2016) · Cited by 2,888 · see citing works
Environmental factors influencing the development and spread of antibiotic resistance
Bengtsson-Palme, J., Kristiansson, E., & Larsson, D. G. J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux053 · Cited by 1,167 · see citing works
Joss, A., Żabczyński, S., Göbel, A., Hoffmann, B., Löffler, D., McArdell, C. S., Ternes, T. A., Thomsen, A., & Siegrist, H. (2006) · Water Research · doi:10.1016/j.watres.2006.02.014 · Cited by 1,162 · see citing works
Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success
Redgrave, L. S., Sutton, S. B., Webber, M. A., & Piddock, L. J. V. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.04.007 · Cited by 1,016 · see citing works
Bengtsson‐Palme, J., & Larsson, D. G. J. (2015) · Environment International · doi:10.1016/j.envint.2015.10.015 · Cited by 996 · see citing works
What is a resistance gene? Ranking risk in resistomes
Martínez, J., Coque, T., & Baquero, F. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3399 · Cited by 938 · see citing works
Woerther, P., Burdet, C., Chachaty, É., & Andremont, A. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00023-13 · Cited by 698 · see citing works
The Scourge of Antibiotic Resistance: The Important Role of the Environment
Finley, R. L., Collignon, P., Larsson, D. G. J., McEwen, S. A., Li, X.-Z., Gaze, W. H., Reid-Smith, R., Timinouni, M., Graham, D. W., & Topp, E. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit355 · Cited by 636 · see citing works
Karanika, S., Karantanos, T., Arvanitis, M., Grigoras, C. A., & Mylonakis, E. E. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw283 · Cited by 455 · see citing works
Guo, X., Li, J., Yang, F., Yang, J., & Yin, D. (2014) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2014.06.035 · Cited by 175 · see citing works
Detection of Antibiotics in Drinking Water Treatment Plants in Baghdad City, Iraq
Mahmood, A. R., Al-Haideri, H. H., & Hassan, F. M. (2019) · Advances in Public Health · doi:10.1155/2019/7851354 · Cited by 166 · see citing works
Hu, Y., Jiang, L., Zhang, T., Jin, L., Han, Q., Zhang, D., Lin, K., & Cui, C. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2018.08.012 · Cited by 160 · see citing works
Angeles, L. F., Mullen, R. A., Huang, I. J., Wilson, C., Khunjar, W., Sirotkin, H. I., McElroy, A. E., & Aga, D. S. (2019) · Environmental Science Water Research & Technology · doi:10.1039/c9ew00559e · Cited by 152 · see citing works
Self-citationHirte, K., Seiwert, B., Schüürmann, G., & Reemtsma, T. (2015) · Water Research · doi:10.1016/j.watres.2015.11.028 · Cited by 140 · see citing works
Prevalence of antibiotic resistance genes among human gut-derived bifidobacteria
Duranti, S., Lugli, G. A., Mancabelli, L., Turroni, F., Milani, C., Mangifesta, M., Ferrario, C., Anzalone, R., Viappiani, A., van Sinderen, D., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.02894-16 · Cited by 103 · see citing works
Removal efficiency of commonly prescribed antibiotics via tertiary wastewater treatment
Burch, K. D., Han, B., Pichtel, J., & Zubkov, T. S. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-04170-w · Cited by 100 · see citing works
Antibiotic resistance and the environment—there and back again
Berkner, S., Konradi, S., & Schönfeld, J. (2014) · EMBO Reports · doi:10.15252/embr.201438978 · Cited by 90 · see citing works
Treatment of Antibiotics in Wastewater Using Advanced Oxidation Processes (AOPs)
Ayşe, K. U. R. T., Mert, B. K., Özengi̇n, N., Sivrioğlu, Ö., & Yonar, T. (2017) · InTech eBooks · doi:10.5772/67538 · Cited by 83 · see citing works
Angeles, L. F., Islam, S., Aldstadt, J., Saqeeb, K. N., Alam, M., Khan, M. A., Johura, F., Ahmed, S. I., & Aga, D. S. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.136285 · Cited by 80 · see citing works
Self-citationArsand, J. B., Hoff, R. B., Jank, L., Meirelles, L. N., Díaz‐Cruz, M. S., Pizzolato, T. M., & Barceló, . (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.06.122 · Cited by 65 · see citing works
INCREASING CIPROFLOXACIN RESISTANCE AMONG PREVALENT URINARY TRACT BACTERIAL ISOLATES IN BANGLADESH
IQBAL, J., Rahman, M., Kabir, M., & Rahman, M. (1997) · Japanese Journal of Medical Science and Biology · doi:10.7883/yoken1952.50.241 · Cited by 45 · see citing works
Ljungquist, O., Schönbeck, M., Riesbeck, K., & Tham, J. (2019) · Infection and Drug Resistance · doi:10.2147/idr.s205163 · Cited by 6 · see citing works
Flagged first, then by citations
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Löffler, P., Escher, B. I., Baduel, C., Virta, M., & Lai, F. Y. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c09854 · Cited by 225 · see citing works
Li, S., Zhu, Y. B., Zhong, G., Huang, Y., & Jones, K. C. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c00993 · Cited by 184 · see citing works
Jiang, W. H., Li, Z., Liu, C., Wang, D., Yan, G., Liu, B., & Che, G. (2020) · Journal of Alloys and Compounds · doi:10.1016/j.jallcom.2020.157166 · Cited by 178 · see citing works
Cai, Y., Sun, T., Li, G., & An, T. (2021) · ACS ES&T Engineering · doi:10.1021/acsestengg.1c00110 · Cited by 167 · see citing works
McCorquodale‐Bauer, K., Grosshans, R., Zvomuya, F., & Cicek, N. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161876 · Cited by 141 · see citing works
Zhou, W., Shi, W. M., Du, X., Han, Y., Tang, Y., Ri, S., Ju, K., Kim, T., Huang, L., Zhang, W., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11600 · Cited by 132 · see citing works
Orimolade, B. O., Oladipo, A. O., Idris, A. O., Feleni, U., Azizi, S., Mâaza, M., Lebelo, S. L., & Mamba, B. B. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163522 · Cited by 113 · see citing works
Nugraha, M. W., Kim, S., Roddick, F., Xie, Z., & Fan, L. (2025) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2025.106960 · Cited by 86 · see citing works
Murgolo, S., Ceglie, C. D., Iaconi, C. D., & Mascolo, G. (2021) · Current Opinion in Green and Sustainable Chemistry · doi:10.1016/j.cogsc.2021.100473 · Cited by 82 · see citing works
Perry, M. R., Lepper, H. C., McNally, L., Wee, B. A., Munk, P., Warr, A., Moore, B., Kalima, P., Philip, C., Husman, A. M. D. R., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.703560 · Cited by 75 · see citing works
Buelow, E., Ploy, M.-C., & Dagot, C. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.10.005 · Cited by 75 · see citing works
Amobonye, A., Aruwa, C. E., Aransiola, S. A., Omame, J., Alabi, T. D., & Lalung, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1207792 · Cited by 71 · see citing works
Distribution, transfer, ecological and human health risks of antibiotics in bay ecosystems
Liu, D., Xu, Y., Junaid, M., Zhu, Y., & Wang, J. (2021) · Environment International · doi:10.1016/j.envint.2021.106949 · Cited by 68 · see citing works
Chen, Q., Liu, C., Liu, R., Hou, Y., Bi, J., Yu, J. C., & Wu, L. (2024) · Separation and Purification Technology · doi:10.1016/j.seppur.2024.129768 · Cited by 62 · see citing works
Manaia, C. M., Aga, D. S., Cytryn, E. J., Gaze, W. H., Graham, D. W., Guo, J., Leonard, A. F. C., Li, L., Murray, A. K., Nunes, O. C., et al. (2022) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5555 · Cited by 61 · see citing works
Self-citationNguyen, T.-D., Itayama, T., Ramaraj, R., Iwami, N., Shimizu, K., Dao, T., Pham, L. T., & Maseda, H. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118095 · Cited by 54 · see citing works
Huang, Y., Zhu, K., Hu, Z., Chen, Y., Li, X., Jiang, Z., Sillanpää, M. E. T., Zhao, J. H., Qiu, R., & Yan, K. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133611 · Cited by 50 · see citing works
Li, Y., Taggart, M. A., McKenzie, C., Zhang, Z., Lü, Y., Pap, S., & Gibb, S. W. (2020) · Journal of Environmental Sciences · doi:10.1016/j.jes.2020.07.013 · Cited by 49 · see citing works
Sun, W., & Zheng, Z. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135100 · Cited by 48 · see citing works
Shuai, X., Zhou, Z., Zhu, L., Achi, C., Lin, Z., Liu, Z., Yu, X., Zhou, J., Lin, Y., & Chen, H. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133790 · Cited by 47 · see citing works
Li, J., O'Brien, J. W., Tscharke, B. J., Verhagen, R., He, C., Shimko, K. M., Shao, X., Zhai, N., Hulleman, T., Mueller, J. F., et al. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c00425 · Cited by 47 · see citing works
Sims, N. F., Kannan, A. M., Holton, E., Jagadeesan, K. K., Mageiros, L., Standerwick, R., Craft, T. M., Barden, R., Feil, E. J., & Kasprzyk‐Hordern, B. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122020 · Cited by 46 · see citing works
Imran, M., Abdullah, A. Z., Khan, M. E., & Mohammad, A. (2024) · Journal of Environmental Management · doi:10.1016/j.jenvman.2024.123759 · Cited by 45 · see citing works
Global perspectives on residual antibiotics: environmental challenges and trends
Thakur, R., Singh, A., Dhanwar, R. S., Kadam, S., Waghmare, U., Lodha, T. D., Lopes, B. S., & Prakash, O. (2025) · Discover Sustainability · doi:10.1007/s43621-025-01048-5 · Cited by 45 · see citing works
Durcik, M., Grobin, A., Roškar, R., Trontelj, J., & Mašič, L. P. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138712 · Cited by 42 · see citing works
Lv, H., Yu, W., Li, Y., Sun, X., Hou, X., Bian, Z., Wang, H., & Wei, Y. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.159656 · Cited by 41 · see citing works
Hu, J., Lyu, Y., Liu, Y., You, X., Helbling, D. E., & Sun, W. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.4c12926 · Cited by 41 · see citing works
Yang, Y., Ji, Y., Gao, Y., Lin, Z. L., Lin, Y. C., Lu, Y., & Zhang, L. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114135 · Cited by 38 · see citing works
Lopez-Herguedas, N., Irazola, M., Alvarez-Mora, I., Orive, G., Lertxundi, U., Olivares, M., Zuloaga, O., & Prieto, A. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.162281 · Cited by 38 · see citing works
Wu, X., Xiong, J., Fei, C.-J., Dai, T., Zhu, T.-F., Zhao, Z., Pan, J., Nie, L., Chen, J., 宁波大学海洋学院生物化学与分子生物学实验室, 浙. 宁. 3., et al. (2022) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.159 · Cited by 35 · see citing works
Antonelli, R. Q., Malpass, G. R. P., & Teixeira, A. C. S. C. (2023) · Separation and Purification Technology · doi:10.1016/j.seppur.2023.125290 · Cited by 34 · see citing works
Ndlovu, T., Kgosietsile, L., Motshwarakgole, P., & Ndlovu, S. I. (2023) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed8080381 · Cited by 32 · see citing works
de Heredia, I. B., González-Gaya, B., Zuloaga, O., Garrido, I., Acosta, T., Etxebarría, N., & Ruíz-Romera, E. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174062 · Cited by 32 · see citing works
Baba, H., Nishiyama, M., Watanabe, T., & Kanamori, H. (2022) · Antibiotics · doi:10.3390/antibiotics11070849 · Cited by 32 · see citing works
Recent advances in electrochemical sensing and remediation technologies for ciprofloxacin
Kini, V., S, S. C., Mondal, D., Nethaji, S., Nag, P., & Sadani, K. (2025) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-35852-9 · Cited by 30 · see citing works
Antibiotics in wastewater treatment plants and receiving waterbodies: Occurrence, Removal and Risks
Bekele, R. S., Heiderscheidt, E., Rossi, P. M., Moges, M. E., & Janka, E. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.127702 · Cited by 29 · see citing works
A sulfamethoxazole molecularly imprinted two-dimensional photonic crystal hydrogel sensor
Cao, Y., Liu, G., Zheng, B., Wang, X., Li, H., Wang, G., Zhao, L., & Wang, Y. (2021) · Soft Matter · doi:10.1039/d1sm00176k · Cited by 27 · see citing works
Wang, Y., Ma, B., Liu, M., Chen, E., Xu, Y. X., & Zhang, M. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.793355 · Cited by 27 · see citing works
Zhang, Y., Tang, W., Wang, Y., Nian, M., Jiang, F., Zhang, J., & Chen, Q. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153859 · Cited by 27 · see citing works
Mortimer, M., Winchell, A., & Holden, P. A. (2020) · Environment International · doi:10.1016/j.envint.2020.106053 · Cited by 27 · see citing works
Savin, M., Sib, E., Heinemann, C., Eichel, V. M., Nurjadi, D., Klose, M., Hammerl, J. A., Binsker, U., & Mutters, N. T. (2024) · Environment International · doi:10.1016/j.envint.2024.108603 · Cited by 26 · see citing works
Antimicrobial peptides in livestock: a review with a one health approach
Robles, O., Osuna, G., Plisson, F., & Barrientos‐Salcedo, C. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1339285 · Cited by 26 · see citing works
Reymann, T., Kerner, M., & Kümmerer, K. (2020) · Bioresource Technology Reports · doi:10.1016/j.biteb.2020.100512 · Cited by 26 · see citing works
Potential environmental toxicity of sewage effluent with pharmaceuticals
Bisognin, R. P., Wolff, D. B., Carissimi, É., Prestes, O. D., Zanella, R., Storck, T. R., & Clasen, B. E. (2020) · Ecotoxicology · doi:10.1007/s10646-020-02264-7 · Cited by 26 · see citing works
Gupta, B., Saidulu, D., Srivastava, A., Rawat, A., Singh, A., Bhatnagar, A., & Gupta, A. K. (2023) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2023.110128 · Cited by 25 · see citing works
Duong, L. T. K., Nguyen, T. T. T., Nguyen, L. M., Hien, H. T., Nguyen, L. M., & Tran, T. V. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119144 · Cited by 25 · see citing works
Bezerra, C. A. G., Santos, J. P. T. D. S., Bessegato, G. G., Zanta, C. L. D. P. E. S., Colle, V. D., & Tremiliosi‐Filho, G. (2021) · Electrochimica Acta · doi:10.1016/j.electacta.2021.139712 · Cited by 25 · see citing works
Bu, J., Wan, Q., Deng, Z., Liu, H., Li, T., Zhou, C., & Zhong, S. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134880 · Cited by 25 · see citing works
Chen, P., Jiang, J., Zhang, S., Wang, X., Guo, X., & Li, F. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138410 · Cited by 25 · see citing works
Baoum, A. A., & Amin, M. S. (2022) · Optical Materials · doi:10.1016/j.optmat.2021.111956 · Cited by 24 · see citing works
Maszczyk, P., Kiersztyn, B., Gozzo, S., Kowalczyk, G., Lamana, J. J., Szpunar, J., Pijanowska, J., Jines-Muñoz, C., Zebrowski, M. Ł., & Babkiewicz, E. (2022) · Water · doi:10.3390/w14213403 · Cited by 24 · see citing works
Pu, Y., Pan, J., Yao, Y., Ngan, W. Y., Yang, Y., Li, M., & Habimana, O. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116737 · Cited by 24 · see citing works
Yan, B., Huang, X., Chen, K., Liu, H., Wei, S., Wu, Y., & Wang, L. (2021) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2021.05.041 · Cited by 22 · see citing works
Wang, W., Lu, T., Chen, C., & Liao, C. (2024) · Water Research · doi:10.1016/j.watres.2024.121721 · Cited by 22 · see citing works
Wang, K., Yuan, Z., Zhang, S., Reguyal, F., Shi, B., Zhang, Y., Wang, H., & Liu, R. (2025) · ACS ES&T Water · doi:10.1021/acsestwater.4c01226 · Cited by 21 · see citing works
‘Primary’ antibiotics in wastewater treatment plants
Adhikari, S., Lee, H. H., & Kim, D. (2024) · iScience · doi:10.1016/j.isci.2024.110789 · Cited by 21 · see citing works
Revitt, D. M., Lundy, L., & Fatta‐Kassinos, D. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124286 · Cited by 21 · see citing works
Antibiotic Residues in UK Foods: Exploring the Exposure Pathways and Associated Health Risks
Seo, J., Kloprogge, F., Smith, A. M., Karu, K., & Ciric, L. (2024) · Toxics · doi:10.3390/toxics12030174 · Cited by 20 · see citing works
Ji, J., Li, H., & Liu, S. (2025) · Applied Sciences · doi:10.3390/app15095182 · Cited by 19 · see citing works
Moura, L. D. L., & Picão, R. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85160-2.00023-8 · Cited by 19 · see citing works
Grobin, A., Roškar, R., & Trontelj, J. (2023) · Analytical Methods · doi:10.1039/d3ay00602f · Cited by 17 · see citing works
Han, Y., Hu, L., Chen, C.-E., Liu, S., Gao, F.-Z., Zhao, J., Liu, Y., Zhao, J., & Ying, G. (2025) · ACS ES&T Water · doi:10.1021/acsestwater.4c00977 · Cited by 16 · see citing works
Fang, Z., Zhao, X., Zhang, Z., Wu, J., Cheng, J., Lei, D., Li, N., Ge, R., He, Q., & Sun, X. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133453 · Cited by 15 · see citing works
Zhang, Y., Cui, Z., Yuan, R., Chen, H., & Zhou, B. (2025) · Process Safety and Environmental Protection · doi:10.1016/j.psep.2024.12.125 · Cited by 15 · see citing works
A smart meat packaging to show ciprofloxacin residues based on immunochromatography
Tafti, M. H. B., Eshaghi, M. R., & Rajaei, P. (2021) · Meat Science · doi:10.1016/j.meatsci.2021.108605 · Cited by 15 · see citing works
Yang, W., Dong, H., Tian, Y., Tong, Y., Lu, J., Liao, L., & Niu, J. (2024) · Separation and Purification Technology · doi:10.1016/j.seppur.2024.130044 · Cited by 14 · see citing works
Insights into antibiotic resistance promoted by quinolone exposure
Bush, N. G., Díez-Santos, I., Krishna, P. S., Clavijo, B., & Maxwell, A. (2024) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00997-24 · Cited by 14 · see citing works
Zhu, B., Jiang, G., Kong, C., Sun, J., Liu, F., Wang, Y., Zhao, C., & Liu, C. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-19852-1 · Cited by 14 · see citing works
Balarabe, B. Y. (2023) · Hybrid Advances · doi:10.1016/j.hybadv.2023.100107 · Cited by 14 · see citing works
Molecular mechanisms of antibiotic inhibition on microbial dissimilatory iron reduction
Ouyang, B., Lv, Z., Gan, C., Yang, C., Tong, L., & Shi, J. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138348 · Cited by 13 · see citing works
Guo, Z., Boeing, W. J., Xu, Y., Borgomeo, E., Liu, D., & Zhu, Y. (2022) · Exposure and Health · doi:10.1007/s12403-022-00529-6 · Cited by 13 · see citing works
Tabrizi, A. M. A., Kakhki, S., Kakhki, S., Foroughi, M., & Azqhandi, M. H. A. (2022) · Process Safety and Environmental Protection · doi:10.1016/j.psep.2022.09.067 · Cited by 13 · see citing works
Circular Health: exploiting the SDG roadmap to fight AMR
Mantegazza, L., Pascali, A. M. D., Munoz, O. S., Manes, C., Scagliarini, A., & Capua, I. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1185673 · Cited by 13 · see citing works
Yusuf, I., Muhammad, Z., Amin, B. M., Shuaibu, M. D., Hamza, N., Isah, H. D., Abdullahi, N. B., Ene, P. J., Shuaibu, S. S., Doguwa, N., et al. (2023) · Access Microbiology · doi:10.1099/acmi.0.000641.v4 · Cited by 12 · see citing works
Kaw, H. Y., Yu, J., Ma, X., Yang, Q., Zhu, L., & Wang, W. (2024) · Environment International · doi:10.1016/j.envint.2024.108830 · Cited by 12 · see citing works
Masiyambiri, V., Balarabe, B. Y., Adjama, I., Moussa, H., Oumarou, M. N. I., & Sodo, A. M. I. (2023) · American Journal of Life Science and Innovation · doi:10.54536/ajlsi.v1i3.1092 · Cited by 12 · see citing works
Wu, D., Xia, M., Yan, A., Jiang, H., Fan, J., Zhou, S., Wei, X., Liu, S., & Chen, B. (2023) · Scientific Reports · doi:10.1038/s41598-023-38577-w · Cited by 12 · see citing works
Ersan, G., Gaber, M. S., Perreault, F., & Garcia‐Segura, S. (2024) · Water Research · doi:10.1016/j.watres.2024.121528 · Cited by 11 · see citing works
Lu, L., Wang, L., Pang, K., Ma, S., Liu, Y., Zhao, J., Liu, R., & Xia, X. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126363 · Cited by 10 · see citing works
Sá, H., Silva, B., Tavares, T., & Michelin, M. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.167154 · Cited by 10 · see citing works
Tucker, K., Stone, W., Botes, M., Feil, E. J., & Wolfaardt, G. M. (2022) · Frontiers in Water · doi:10.3389/frwa.2022.883282 · Cited by 10 · see citing works
Lorenz, S., Suaifan, G. A. R. Y., & Kümmerer, K. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.136724 · Cited by 10 · see citing works
Baoum, A. A., & Amin, M. S. (2021) · Applied Nanoscience · doi:10.1007/s13204-021-01792-w · Cited by 10 · see citing works
Antibiotic resistance in wastewater, does the context matter? Poland and Portugal as a case study
Vaz‐Moreira, I., Harnisz, M., Abreu-Silva, J., Rolbiecki, D., Korzeniewska, E., Łuczkiewicz, A., Manaia, C. M., & Płaza, G. A. (2021) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2021.2000828 · Cited by 10 · see citing works
Human health risk assessment associated with the reuse of treated wastewater in arid areas
Shomar, B., & Rovira, J. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123478 · Cited by 9 · see citing works
Tantavanich, S., Damdib, S., Chimupala, Y., Jaideekard, M., Tonanon, N., & Siyasukh, A. (2025) · Chemical Engineering Science · doi:10.1016/j.ces.2025.121647 · Cited by 9 · see citing works
Zhou, Q., Guo, F., Bian, C., Liu, X., Xiao, X., Hu, R., Lin, J., Wang, W., Lei, H., & Dong, X. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.138529 · Cited by 9 · see citing works
Strokal, M., Kumar, R., Bak, M. P., Jones, E. R., Beusen, A. H. W., Flörke, M., Grizzetti, B., Nkwasa, A., Schweden, K., Ural-Janssen, A., et al. (2025) · Environmental Research Water · doi:10.1088/3033-4942/adf571 · Cited by 9 · see citing works
Valizadeh, M., Rehman, F. U., Hassanzadeh, M. A., Beigomi, M., & Fazeli‐Nasab, B. (2021) · International Journal of Infection · doi:10.5812/iji.114563 · Cited by 9 · see citing works
Wang, S., Jia, R., Xu, Z., Su, Y. K., Yue, Y.-Q., Zhang, X., & Dong, Z.-X. (2026) · Journal of Membrane Science · doi:10.1016/j.memsci.2026.125311 · Cited by 8 · see citing works
Jebara, A., Hassen, W., Ousleti, A., Mabrouk, L., Jaziri, A., Bella, G. D., & Mansour, H. B. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-02842-9 · Cited by 8 · see citing works
Wang, S., Kebede, S., Abate, E., Amir, A., Calderon, E., Hoet, A. E., Ikram, A., LeJeune, J. T., Mekuria, Z. H., Suzuki, S., et al. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90945-7.00021-x · Cited by 8 · see citing works
Xu, J., Zhou, T., Bi, Y., Guo, H., Su, Y., Wang, L., Shao, M., Wang, Y., & Guo, X. (2023) · Inorganic Chemistry Frontiers · doi:10.1039/d3qi02081a · Cited by 8 · see citing works
Ekhosuehi, A., Ikhimiukor, O. O., Essandoh, H. M. K., Asiedu, N. Y., Aighewi, I. T., Sunmonu, G. T., Odih, E. E., Oaikhena, A. O., Cyril‐Okoh, D., Yeboah, C., et al. (2024) · Environmental Microbiology Reports · doi:10.1111/1758-2229.70018 · Cited by 7 · see citing works
Zhang, L., Li, H., Liu, D., Wang, L., Dong, D., & Guo, Z. (2024) · Water Air & Soil Pollution · doi:10.1007/s11270-024-07406-9 · Cited by 7 · see citing works
Yaqoub, A. R., Jamil, L. A., & Moinfar, S. (2023) · New Journal of Chemistry · doi:10.1039/d2nj05461b · Cited by 7 · see citing works
Yang, Z., Yin, Q., Wu, Z., Han, Y., Zhang, Y., He, K., & Lü, H. (2025) · New Contaminants · doi:10.48130/newcontam-0025-0009 · Cited by 6 · see citing works
Lin, H., Du, C., Xu, N., Wang, Y., & Sun, C. (2026) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2026.139539 · Cited by 6 · see citing works
Cameron, A., Connolly, J., Esiovwa, R., Henriquez, F. L., Hursthouse, A. S., Mukherji, S., & Mukherji, S. (2025) · Global Health Action · doi:10.1080/16549716.2025.2491200 · Cited by 6 · see citing works
Nguyen, T.-D., Itayama, T., Iwami, N., Shimizu, K., Dao, T., Pham, L. T., & Maseda, H. (2023) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/10807039.2023.2225625 · Cited by 6 · see citing works
- Authors
- Booth, A., Aga, D. S., & Wester, A. L.
- Affiliations
- University of Cape Town (ZA)
- New York University (US)
- Norwegian Institute of Public Health (NO)
- Corresponding author
- Booth, Amy
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 141
- Pages
- 105796
- ISSN
- 0160-4120 (ISSN-L)
- OpenAlex
- W3025485957
- Cited by
- 154
- References
- 22
- Citations by year
- 2026: 13 · 2025: 37 · 2024: 28 · 2023: 32 · 2022: 22 · 2021: 16 · 2020: 6
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Update notices
- erratum (2020-10-01)
- Open access
- gold
- doi.org
- Licence
- Locations
- Environment International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Topics
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- antibiotic residues, antimicrobial resistance, predicted no-effect concentration, wastewater treatment plant effluent, hospital wastewater, industrial wastewater, surface water, drinking water, ciprofloxacin, clarithromycin, antibiotic removal, environmental monitoring
- MeSH terms
- Anti-Bacterial Agents, Environmental Monitoring, Retrospective Studies, Water Pollutants, Chemical, Drug Resistance, Bacterial, Wastewater
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