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Cited by 422Pharmaceutical and Antibiotic Environmental ImpactsAntibiotic Resistance in BacteriaAntibiotic Use and Resistance

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Distribution of antibiotic resistance genes in the environment

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Zhuang, Mei, Achmon, Yigal, Cao, Yuping, Liang, Xiaomin, Chen, Liang, Wang, Hui, Siame, Bupe A., Leung, Ka Yin·2021·Environmental Pollution
DOI 10.1016/j.envpol.2021.117402
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Abstract

The prevalence of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in the microbiome is a major public health concern globally. Many habitats in the environment are under threat due to excessive use of antibiotics and evolutionary changes occurring in the resistome. ARB and ARGs from farms, cities and hospitals, wastewater treatment plants (WWTPs) or as water runoffs, may accumulate in water, soil, and air. We present a global picture of the resistome by examining ARG-related papers retrieved from PubMed and published in the last 30 years (1990-2020). Natural Language Processing (NLP) was used to retrieve 496,640 papers, out of which 9374 passed the filtering test and were further analyzed to determine the distribution and diversity of ARG subtypes. The papers revealed seven major antibiotic families together with their respective ARG subtypes in different habitats on six continents. Asia, especially China, had the highest number of ARGs related papers compared to other countries/regions/continents. ARGs belonging to multidrug, glycopeptide, and β-lactam families were the most common in reports from hospitals and sulfonamide and tetracycline families were common in reports from farms, WWTPs, water and soil. We also highlight the 'omics' tools used in resistome research, describe some factors that shape the development of resistome, and suggest future work needed to better understand the resistome. The goal was to show the global nature of ARB and ARG…

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Cited by

Sorted by citations

Metadata

Authors
Zhuang, M., Achmon, Y., Cao, Y., Liang, X., Chen, L., Wang, H., Siame, B. A., & Leung, K. Y.
Affiliations
  • Technion – Israel Institute of Technology (IL)
  • Shantou University (CN)
  • Trinity Western University (CA)
Corresponding author
Leung, Ka Yin
ORCID
Venue
Environmental Pollution
Publisher
Elsevier BV
Published
2021-09
Volume
285
Pages
117402
ISSN
0269-7491 (ISSN-L)
DOI
10.1016/j.envpol.2021.117402
OpenAlex
W3160863557
Cited by
422
References
4
Citations by year
2026: 82 · 2025: 123 · 2024: 89 · 2023: 61 · 2022: 53 · 2021: 14
FWCI
2.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Environmental Pollution (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
  • Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Keywords
antibiotic resistance genes, antibiotic-resistant bacteria, resistome, multidrug resistance, glycopeptide resistance, beta-lactam resistance, sulfonamide resistance, tetracycline resistance, wastewater treatment plants, agricultural environment, hospital environment, soil and water contamination, One Health
MeSH terms
Angiotensin-Converting Enzyme Inhibitors, Anti-Bacterial Agents, Drug Resistance, Microbial, Genes, Bacterial, Humans, Tetracycline, Angiotensin Receptor Antagonists

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