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Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans

Open access
Swan, Shanna H.·2008·Environmental Research

Abstract

After briefly discussing human exposure to phthalates --diesters of 1,2-benzenedicarboxylic acid (phthalic acid) -- this article first presents recent findings from the Study for Future Families, a multi-center pregnancy study in which the human analogue of the phthalate syndrome was first identified. This is one of an increasing number of studies that have investigated human endpoints in relation to environmental exposure to these ubiquitous compounds. This literature, which includes a range of human health endpoints following prenatal, neonatal, childhood and adult exposures, is then summarized. At least one significant association has been reported for urinary metabolites of di-n-butyl phthalate (DBP), butylbenzyl phthalate (BzBP), diethyl phthlate (DEP) and di-isononyl phthalate (DINP) and for three of the urinary metabolites of di(2-ethylhexyl) phthalate (DEHP). Many of the findings reported in humans –most of which have been in males-- are consistent with the anti-androgenic action that has been demonstrated for several phthalates. Replication of the results described here and further mechanistic studies are needed to strengthen links between phthalates and adverse health outcomes.

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Metadata

Authors
Swan, S. H.
Venue
Environmental Research
Publisher
Elsevier BV
Published
2008-10
Volume
108
Issue
2
Pages
177-184
ISSN
0013-9351 (ISSN-L)
OpenAlex
W2117009957
Cited by
856
References
5
FWCI
22.02
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. https://app.cochat.ai/papers/10.1016/j.envres.2008.08.007
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Swan, S. H. (2008). Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environmental Research. https://doi.org/10.1016/j.envres.2008.08.007

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.