Perfluorooctanesulfonate (PFOS) conversion from N-ethyl-N-(2-hydroxyethyl)-perfluorooctanesulfonamide (EtFOSE) in male sprague dawley rats after inhalation exposure
Abstract
Ethyl-N-(2-hydroxyethyl)-perfluorooctanesulfonamide (EtFOSE) was one of the key building blocks for many of the perfluorooctanesulfonyl-based chemistry and laboratory studies have shown that EtFOSE can metabolically degrade to perfluorooctanesulfonate (PFOS). Non-occupational contribution sources to PFOS are thought to occur in general population via diets, drinking water, air and dust. For workers, however, the exposure route was mostly airborne and the exposure source was predominantly to precursor compounds such as EtFOSE. We undertook this study to investigate how much EtFOSE was converted to PFOS in the serum for male rats after 6h of exposure to EtFOSE vapor (whole body) at ambient temperature, which simulated a work place exposure scenario. There were no abnormal clinical observations and all rats gained weight during study. Interim tail-vein blood samples, collected up to 21 days after exposure, were analyzed for Et-FOSE and PFOS concentrations by LC-MS/MS. Upon inhalation exposure, the biotransformation of EtFOSE to PFOS in serum in the male rats was rapid and very little EtFOSE was detected in the serum within 24h after EtFOSE exposure. The highest conversion to PFOS in serum after exposure to EtFOSE vapor appeared to occur between Day 8-14 post exposure. Considering the potential surface and fur adsorption of test compound in the whole-body exposure system, our data would support that at least 10% of the inhaled EtFOSE was biotransformed to PFOS in the serum based…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In EtFOSE pathway 3, EtFOSE generates PFOS directly from desulfonamide in one step.
“(3) EtFOSE generates PFOS directly from desulfonamide in one step (Chang et al., 2017).”
From Biotransformation of perfluoroalkyl acid precursors from various environmental systems: advances and perspectives (2021) · cites this paper as Chang et al., 2017
Cites
Shoeib, M., Harner, T., Wilford, B. H., Jones, K. C., & Zhu, J. (2005) · Environmental Science & Technology · doi:10.1021/es048340y · Cited by 328 · see citing works
Martin, J. W., Muir, D. C. G., Moody, C. A., Ellis, D. A., Kwan, W. C., Solomon, K. R., & Mabury, S. A. (2002) · Analytical Chemistry · doi:10.1021/ac015630d · Cited by 299 · see citing works
Benskin, J. P., Ikonomou, M. G., Gobas, F. A. P. C., Begley, T. H., Woudneh, M. B., & Cosgrove, J. R. (2013) · Environmental Science & Technology · doi:10.1021/es304336r · Cited by 169 · see citing works
Perfluoroalkyl acids and their precursors in indoor air sampled in children's bedrooms
Winkens, K., Koponen, J., Schuster, J., Shoeib, M., Vestergren, R., Berger, U., Karvonen, A. M., Pekkanen, J., Kiviranta, H., & Cousins, I. T. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2016.12.010 · Cited by 113 · see citing works
Goosey, E., & Harrad, S. (2012) · Environment International · doi:10.1016/j.envint.2012.04.007 · Cited by 102 · see citing works
Penetration of Ammonium Perfluorooctanoate Through Rat and Human Skin In Vitro
Fasano, W. J., Kennedy, G. L., Szostek, B., Farrar, D. G., Ward, R. J., Haroun, L., & Hinderliter, P. M. (2005) · Drug and Chemical Toxicology · doi:10.1081/dct-39707 · Cited by 54 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zhang, W., Pang, S., Lin, Z., Mishra, S., Bhatt, P., & Chen, S. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2020.115908 · Cited by 280 · see citing works
- Authors
- Chang, S., Mader, B. T., Lindstrom, K. R., Lange, C. C., Hart, J. A., Kestner, T. A., Schulz, J. F., Ehresman, D. J., & Butenhoff, J. L.
- Affiliations
- 3M (United States) (US)
- Corresponding author
- Chang, Sue
- Venue
- Environmental Research
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 155
- Pages
- 307-313
- ISSN
- 0013-9351 (ISSN-L)
- OpenAlex
- W2592755324
- Cited by
- 9
- References
- 6
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2020: 1 · 2017: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- PFOS, biotransformation, inhalation exposure, internal dosimetry, occupational exposure, perfluorinated compounds, Sprague-Dawley rats
- MeSH terms
- Administration, Inhalation, Animals, Biotransformation, Fluorocarbons, Male, Sulfonamides, Rats, Sprague-Dawley, Alkanesulfonic Acids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
