The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Cadmium and atherosclerosis: A review of toxicological mechanisms and a meta-analysis of epidemiologic studies
Open accessAbstract
Abstract Cadmium has been proposed to be the one of the factors of atherosclerosis development, although the existing data are still controversial. The primary objective of the present study is the review and the meta‐analysis of studies demonstrating the association between Cd exposure and atherosclerosis as well as review of the potential mechanisms of such association. We performed a systematic search in the PubMed‐Medline database using the MeSH terms cadmium, cardiovascular disease, atherosclerosis, coronary artery disease, myocardial infarction, stroke, mortality and humans up through December 20, 2017. Elevated urinary Cd levels were associated with increased mortality for cardiovascular disease (HR = 1.34, 95% CI: 1.07–1.67) as well as elevated blood Cd levels (HR = 1.78, 95% CI: 1.24–2.56). Analysis restricted to never smokers showed similar, though more imprecise, results. Consistently, we also observed an association between Cd exposure markers (blood and urine) and coronary heart disease, stroke, and peripheral artery disease. Moreover, Cd exposure was associated with atherogenic changes in lipid profile. High Cd exposure was associated with higher TC levels (OR = 1.48, 95% CI: 1.10–2.01), higher LDL‐C levels (OR = 1.31, 95% CI 0.99–1.73) and lower HDL‐C levels (OR = 1.96, 95% CI: 1.09–3.55). The mechanisms of atherogenic effect of cadmium may involve oxidative stress, inflammation, endothelial dysfunction, enhanced lipid synthesis, up‐regulation of adhesion molecules, prostanoid dysbalance, as well as altered glycosaminoglycan synthesis.
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Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
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“Recent studies have demonstrated that environmental pollution plays a significant role in CVD (Pope et al., 2004) and atherosclerosis in particular (Lawal, 2017).”
BackgroundFeigin, V. L., Norrving, B., & Mensah, G. A. (2017) · Circulation Research · doi:10.1161/circresaha.116.308413 · Cited by 2,184
Epidemiology of Peripheral Artery Disease
Criqui, M. H., & Aboyans, V. (2015) · Circulation Research · doi:10.1161/circresaha.116.303849 · Cited by 1,785 · cited 2×
“Of these, about 50% were attributed to coronary heart disease (CHD), followed closely by stroke (Feigin et al., 2017), while peripheral vascular disease (PVD) contributed only 1–2% (Criqui and Aboyans, 2015).”
BackgroundCadmium dietary exposure in the European population: Cadmium dietary exposure in Europe
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Lead, Cadmium, Smoking, and Increased Risk of Peripheral Arterial Disease
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Modulation of paraoxonase (PON1) activity
Costa, L. G., Vitalone, A., Cole, T. B., & Furlong, C. E. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.08.027 · Cited by 488
Cadmium exposure in the population: from health risks to strategies of prevention
Nawrot, T. S., Staessen, J. A., Roels, H. A., Munters, E., Cuypers, A., Richart, T., Ruttens, A., Smeets, K., Clijsters, H., & Vangronsveld, J. (2010) · BioMetals · doi:10.1007/s10534-010-9343-z · Cited by 430
Cited by
The effects of cadmium toxicity
Genchi, G., Sinicropi, M. S., Lauria, G., Carocci, A., & Catalano, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113782 · Cited by 2,722
Cadmium Toxicity and Health Effects—A Brief Summary
Charkiewicz, A. E., Omeljaniuk, W. J., Nowak, K., Garley, M., & Nikliński, J. (2023) · Molecules · doi:10.3390/molecules28186620 · Cited by 435
Endocrine-disrupting chemicals exposure: Cardiometabolic health risk in humans
Ma, C.-X., Ma, X.-N., Li, H.-L., Mauricio, D., & Fu, S.-B. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02938-8 · Cited by 19
Metadata
- Authors
- Tinkov, A. A., Filippini, T., Ajsuvakova, O. P., Skalnaya, M. G., Aaseth, J., Bjørklund, G., Gatiatulina, E. R., Popova, E. V., Nemereshina, O. N., Huang, P.-T., Vinceti, M., & Skalny, A. V.
- Venue
- Environmental Research
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 162
- Pages
- 240-260
- ISSN
- 0013-9351 (ISSN-L)
- OpenAlex
- W2793657836
- Cited by
- 264
- References
- 78
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Tinkov, A. A., Filippini, T., Ajsuvakova, O. P., Skalnaya, M. G., Aaseth, J., Bjørklund, G., Gatiatulina, E. R., Popova, E. V., Nemereshina, O. N., Huang, P.-T., Vinceti, M., & Skalny, A. V. (2018). Cadmium and atherosclerosis: A review of toxicological mechanisms and a meta-analysis of epidemiologic studies. Environmental Research. https://doi.org/10.1016/j.envres.2018.01.008
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