Global Burden of Stroke
Open accessAbstract
On the basis of the GBD (Global Burden of Disease) 2013 Study, this article provides an overview of the global, regional, and country-specific burden of stroke by sex and age groups, including trends in stroke burden from 1990 to 2013, and outlines recommended measures to reduce stroke burden. It shows that although stroke incidence, prevalence, mortality, and disability-adjusted life-years rates tend to decline from 1990 to 2013, the overall stroke burden in terms of absolute number of people affected by, or who remained disabled from, stroke has increased across the globe in both men and women of all ages. This provides a strong argument that "business as usual" for primary stroke prevention is not sufficiently effective. Although prevention of stroke is a complex medical and political issue, there is strong evidence that substantial prevention of stroke is feasible in practice. The need to scale-up the primary prevention actions is urgent.
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Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S. Y., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61728-0 · Cited by 14,070 · see citing works
Self-citationLim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805 · see citing works
Self-citationMurray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888 · see citing works
Self-citationRoth, G. A., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32203-7 · Cited by 8,600 · see citing works
Self-citationNaghavi, M., Abajobir, A. A., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abera, S. F., Aboyans, V., Adetokunboh, O., Afshin, A., Agrawal, A., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32152-9 · Cited by 4,821 · see citing works
Self-citationFeigin, V. L., Forouzanfar, M. H., Krishnamurthi, R., Mensah, G. A., Connor, M., Bennett, D. A., Moran, A. E., Sacco, R. L., Anderson, L., Truelsen, T., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61953-4 · Cited by 3,899 · see citing works
Self-citationO'Donnell, M. J., Xavier, D., Liu, L., Zhang, H., Chin, S. L., Rao-Melacini, P., Rangarajan, S., Islam, S., Pais, P., McQueen, M. J., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60834-3 · Cited by 3,448 · see citing works
Feigin, V. L., Lawes, C. M., Bennett, D. A., Barker-Collo, S. L., & Parag, V. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70025-0 · Cited by 2,855 · see citing works
Self-citationO'Donnell, M. J., Chin, S. L., Rangarajan, S., Xavier, D., Liu, L., Zhang, H., Rao-Melacini, P., Zhang, X., Pais, P., Agapay, S., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30506-2 · Cited by 2,296 · see citing works
Measuring the global burden of disease
Murray, C. J. L., & Lopez, A. D. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1201534 · Cited by 1,818 · see citing works
GBD 2010: design, definitions, and metrics
Murray, C. J., Ezzati, M., Flaxman, A. D., Lim, S., Lozano, R., Michaud, C., Naghavi, M., Salomon, J. A., Shibuya, K., Vos, T., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61899-6 · Cited by 1,103 · see citing works
Wang, H., Dwyer-Lindgren, L., Lofgren, K. T., Rajaratnam, J. K., Marcus, J. R., Levin-Rector, A., Levitz, C. E., Lopez, A. D., & Murray, C. J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61719-x · Cited by 810 · see citing works
Putaala, J., Yesilot, N., Waje-Andreassen, U., Pitkäniemi, J., Vassilopoulou, S., Nardi, K., Odier, C., Hofgart, G., Engelter, S., Burow, A., et al. (2012) · Stroke · doi:10.1161/strokeaha.112.662866 · Cited by 168 · see citing works
Medin, J., Nordlund, A., & Ekberg, K. (2004) · Stroke · doi:10.1161/01.str.0000125866.78674.96 · Cited by 135 · see citing works
Trends in Substance Abuse Preceding Stroke Among Young Adults: A Population-Based Study
de los Ríos, F., Kleindorfer, D. O., Khoury, J., Broderick, J. P., Moomaw, C. J., Adeoye, O., Flaherty, M. L., Khatri, P., Woo, D., Alwell, K., et al. (2012) · Stroke · doi:10.1161/strokeaha.112.667808 · Cited by 130 · see citing works
Remarkable Decline in Ischemic Stroke Mortality is Not Matched by Changes in Incidence
Vaartjes, I., O’Flaherty, M., Capewell, S., Kappelle, J., & Bots, M. (2013) · Stroke · doi:10.1161/strokeaha.112.677724 · Cited by 103 · see citing works
Feigin, V., & Vander Hoorn, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16436-2 · Cited by 94 · see citing works
Self-citationEthnic and Geographic Variation in Stroke Mortality Trends
Gillum, R. F., Kwagyan, J., & Obisesan, T. O. (2011) · Stroke · doi:10.1161/strokeaha.111.625343 · Cited by 61 · see citing works
Methodology of the Global and Regional Burden of Stroke Study
(2012) · Neuroepidemiology · doi:10.1159/000334744 · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Katan, M., & Luft, A. (2018) · Seminars in Neurology · doi:10.1055/s-0038-1649503 · Cited by 2,137 · see citing works
Global, regional, and country-specific lifetime risks of stroke, 1990 and 2016
Collaborators, T. G. 2. L. R. O. S. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1804492 · Cited by 1,503 · see citing works
Physical fitness training for stroke patients
Saunders, D. H., Sanderson, M., Hayes, S., Kilrane, M., Greig, C. A., Brazzelli, M., & Mead, G. E. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003316.pub6 · Cited by 759 · see citing works
Tian, Y., Liu, H., Zhao, Z., Xiang, X., Li, M., Juan, J., Song, J., Cao, Y., Wang, X., Chen, L., et al. (2018) · PLoS Medicine · doi:10.1371/journal.pmed.1002668 · Cited by 234 · see citing works
A hybrid machine learning approach to cerebral stroke prediction based on imbalanced medical dataset
Liu, T., Fan, W., & Wu, C. (2019) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2019.101723 · Cited by 220 · see citing works
Han, B., Zhou, S., Zhang, Y., Chen, S., Xi, W., Liu, C., Zhou, X., Yuan, M., Yu, X., Li, L., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adg1323 · Cited by 143 · see citing works
A Human-AI Collaborative Approach for Clinical Decision Making on Rehabilitation Assessment
Lee, M. H., Siewiorek, D. P., Smailagic, A., Bernardino, A., & Bermúdez i Badia, S. B. (2021) · Proceedings of the 2021 CHI Conference on Human Factors in Computing Systems · doi:10.1145/3411764.3445472 · Cited by 137 · see citing works
Wang, L., Song, Q., Wang, C., Wu, S., Deng, L., Li, Y., Zheng, L., & Liu, M. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.116445 · Cited by 125 · see citing works
Interventions for psychological health of stroke caregivers: a systematic review
Panzeri, A., Rossi Ferrario, S., & Vidotto, G. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02045 · Cited by 96 · see citing works
Wu, D., Zhang, G., Zhao, C., Yang, Y., Miao, Z., & Xu, X. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.04.004 · Cited by 83 · see citing works
Lee, M. H., & Chew, C. J. (2023) · Proceedings of the ACM on Human-Computer Interaction · doi:10.1145/3610218 · Cited by 78 · see citing works
Farhangi, M. A., Vajdi, M., & Asghari-Jafarabadi, M. (2020) · Nutrition Journal · doi:10.1186/s12937-020-00592-2 · Cited by 72 · see citing works
Lee, M. H., Siewiorek, D. P., Smailagic, A., Bernardino, A., & Bermúdez i Badia, S. (2020) · Proceedings of the ACM on Human-Computer Interaction · doi:10.1145/3415227 · Cited by 57 · see citing works
miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases
Xu, J., Zheng, Y., Wang, L., Liu, Y., Wang, X., Li, Y., & Chi, G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01091-6 · Cited by 55 · see citing works
Maskery, M. P., Holscher, C., Jones, S. P., Price, C. I., Strain, W. D., Watkins, C. L., Werring, D. J., & Emsley, H. C. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20952011 · Cited by 51 · see citing works
Mahmoud, S. S., Pallaud, R. F., Kumar, A., Faisal, S., Wang, Y., & Fang, Q. (2023) · Sensors · doi:10.3390/s23020857 · Cited by 25 · see citing works
Cerebrovascular disease after placental abruption: A population-based prospective cohort study
Ananth, C. V., Hansen, A. V., Elkind, M. S. V., Williams, M. A., Rich-Edwards, J. W., & Nybo Andersen, A.-M. (2019) · Neurology · doi:10.1212/wnl.0000000000008122 · Cited by 23 · see citing works
Park, S., Tang, A., Pollock, C., & Sakakibara, B. M. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-055527 · Cited by 12 · see citing works
Gladwyn-Khan, M., & Morris, R. (2023) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s135246582200042x · Cited by 13 · see citing works
- Authors
- Feigin, V. L., Norrving, B., & Mensah, G. A.
- Affiliations
- Lund University (SE)
- National Institutes of Health (US)
- Venue
- Circulation Research
- Published
- 2017-02-03
- Volume
- 120
- Issue
- 3
- Pages
- 439-448
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2488953036
- Cited by
- 2,184
- References
- 19
- Citations by year
- 2026: 150 · 2025: 225 · 2024: 238 · 2023: 218 · 2022: 286 · 2021: 325 · 2020: 320 · 2019: 253 · 2018: 125 · 2017: 26 · 2016: 7 · 2015: 7 · 2014: 1
- FWCI
- 154.55
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
- Keywords
- stroke, global burden of disease, disability-adjusted life years, stroke incidence, stroke prevalence, stroke mortality, sex differences, age groups, primary stroke prevention
- MeSH terms
- Humans, Risk Factors, Sex Characteristics, Global Health, Cost of Illness, Stroke
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