Effects of prenatal and postnatal exposure to a low dose of bisphenol A on behavior and memory in rats
Abstract
Endocrine disruptors (EDs) are increasingly common chemicals in the environment. Bisphenol A (BPA), used to manufacture polycarbonate plastics, is an ED recognized for its estrogenic, anti-estrogenic, and anti-androgenic effects. Behavior is considered a vital characteristic for an animal's life cycle. This study evaluated the effect of exposure to low doses of BPA during pregnancy and/or lactation on several aspects of rat behavior, including memory, locomotion, and the exploratory instinct. Pups at 16 weeks of age (females and males) were divided into groups according to the mother's exposure to BPA (40μg/kg/day): CON (vehicle only); PRE (during pregnancy); LAC (during lactation); PRE-LAC (during both pregnancy and lactation). In the PRE-LAC group, exposure to BPA impaired both short-term (STM) and long-term memory (LTM) in inhibitory avoidance and the object recognition task, and also affected locomotor activity and spatial memory. Some sex-specific behavioral characteristics disappeared in the LAC group. Sex-specific memory and behavior impairment were caused by BPA exposure during brain organogenesis and differentiation.
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Perinatal BPA exposure results in less glutamate release from presynaptic neurons.
“perinatal BPA exposure results in less glutamate release from presynaptic neurons.32”
From Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms (2017) · cites this paper as [32]
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Low-dose effects of bisphenol A on early sexual development in male and female rats
Christiansen, S., Axelstad, M., Boberg, J., Vinggaard, A. M., Pedersen, G. A., & Hass, U. (2014) · Reproduction · doi:10.1530/rep-13-0377 · Cited by 108 · see citing works
Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms
Hu, F., Li, T., Gong, H., Chen, Z., Jin, Y., Xu, G., & Wang, M. (2017) · Advanced Science · doi:10.1002/advs.201600493 · Cited by 87 · see citing works
Berk, M., Williams, L. J., Andreazza, A. C., Pasco, J. A., Dodd, S., Jacka, F. N., Moylan, S., Reiner, E. J., & Magalhaes, P. V. S. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005142 · Cited by 77 · see citing works
Perinatal Exposure to Low-Dose Bisphenol A Impairs Spatial Learning and Memory in Male Rats
Kuwahara, R., Kawaguchi, S., Kohara, Y., Cui, H., & Yamashita, K. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13093fp · Cited by 52 · see citing works
Kumar, D., & Thakur, M. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110482 · Cited by 37 · see citing works
RetractedChen, X., Wang, Y., Xu, F., Wei, X., Zhang, J., Wang, C., Wei, H., Xu, S., Yan, P., Zhou, W., et al. (2017) · Neural Plasticity · doi:10.1155/2017/5196958 · Cited by 24 · see citing works
“…Laboratory of Ecology, Zhejiang Normal University, Jinhua 321004, China Correspondence should be addressed to Xiaohong Xu; xuxh63@zjnu.cn and Qinwen Wang; wangqinwen@nbu.edu.cn Received 12 September 2016; Revised 11 December 2016; Accepted 25 December 2016; Published 31 January 2017 Academic…”
Background
- Authors
- Gonçalves, C. R., Cunha, R. W., Barros, D. M., & Martínez, P. E.
- Affiliations
- Universidade Federal do Rio Grande (BR)
- Corresponding author
- Martínez, Pablo Elías
- Venue
- Environmental Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 30
- Issue
- 2
- Pages
- 195-201
- ISSN
- 1382-6689 (ISSN-L)
- OpenAlex
- W2098064603
- Cited by
- 80
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 4 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 11 · 2013: 16 · 2012: 4
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Environmental Toxicology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- bisphenol A, endocrine disruptors, prenatal exposure, postnatal exposure, lactation, memory impairment, short-term memory, long-term memory, passive avoidance, object recognition, locomotor activity, exploratory behavior, sex differences, brain differentiation, developmental neurotoxicity
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