Perinatal Exposure to Bisphenol-A Impairs Spatial Memory through Upregulation of Neurexin1 and Neuroligin3 Expression in Male Mouse Brain
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Bisphenol-A (BPA), a well known endocrine disruptor, impairs learning and memory in rodents. However, the underlying molecular mechanism of BPA induced impairment in learning and memory is not well known. As synaptic plasticity is the cellular basis of memory, the present study investigated the effect of perinatal exposure to BPA on the expression of synaptic proteins neurexin1 (Nrxn1) and neuroligin3 (Nlgn3), dendritic spine density and spatial memory in postnatal male mice. The pregnant mice were orally administered BPA (50 µg/kgbw/d) from gestation day (GD) 7 to postnatal day (PND) 21 and sesame oil was used as a vehicle control. In Morris water maze (MWM) test, BPA extended the escape latency time to locate the hidden platform in 8 weeks male mice. RT-PCR and Immunoblotting results showed significant upregulation of Nrxn1 and Nlgn3 expression in both cerebral cortex and hippocampus of 3 and 8 weeks male mice. This was further substantiated by in-situ hybridization and immunofluorescence techniques. BPA also significantly increased the density of dendritic spines in both regions, as analyzed by rapid Golgi staining. Thus our data suggest that perinatal exposure to BPA impairs spatial memory through upregulation of expression of synaptic proteins Nrxn1 and Nlgn3 and increased dendritic spine density in cerebral cortex and hippocampus of postnatal male mice.
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Pre- and perinatal exposures to BPA at or below the TDI (≤50 μg/kg/day) have resulted in adverse effects on memory processes in rodents.
“In rodents, pre- and perinatal exposures to BPA at or below the TDI (tolerable daily intake; ⩽50 μg/kg/day) have resulted in adverse effects on memory processes [4–9].”
From The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation (2017) · cites this paper as [6]
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- Retracted
- Authors
- Kumar, D., & Thakur, M. K.
- Affiliations
- Banaras Hindu University (IN)
- Corresponding author
- Thakur, Mahendra Kumar
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-10-17
- Volume
- 9
- Issue
- 10
- Pages
- e110482
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4201550
- OpenAlex
- W1997235734
- Cited by
- 37
- References
- 71
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 9 · 2016: 4 · 2015: 5
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2019-07-18)
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Council of Scientific and Industrial Research, India
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- bisphenol A, perinatal exposure, endocrine disruptors, spatial memory, learning and memory impairment, synaptic proteins, dendritic spine density, hippocampus, cerebral cortex, synaptic plasticity, male mice
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Calcium-Binding Proteins, Cerebral Cortex, Female, Hippocampus, Male, Membrane Proteins, Nerve Tissue Proteins, Neuronal Plasticity, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Cell Adhesion Molecules, Neuronal, Gene Expression Regulation, Developmental, Maze Learning, Neural Cell Adhesion Molecules, Dendritic Spines, Mice, Spatial Memory
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