Perinatal Exposure to Low-Dose Bisphenol A Impairs Spatial Learning and Memory in Male Rats
Open accessAbstract
Bisphenol A (BPA) is an estrogenic endocrine disruptor used for producing polycarbonate plastics and epoxy resins. This study investigated the effects of perinatal BPA exposure on learning and memory, general activity, and emotionality in male Sprague Dawley rats using a battery of behavioral tests, including an appetite-motivated maze test (MAZE test) used to assess spatial learning and memory. Mother rats were orally administered BPA (50 or 500 μg∙kg(-1)/day) or vehicle (1 ml∙kg(-1)/day) from gestational day 10 to postnatal day 14. In the MAZE test, compared to the offspring of vehicle-treated rat mothers, male offspring of mothers exposed to 50 μg∙kg(-1)/day of BPA, but not those of mothers exposed to 500 μg∙kg(-1)/day of BPA, needed significantly more time to reach the reward. Although male offspring of mothers exposed to 50 μg∙kg(-1)/day of BPA showed an increase in a behavioral measure of wariness after repeated testing in the open-field test, no significant effects were observed in locomotor activities. No significant differences were observed in any other behavioral test including the elevated plus-maze test. The present study suggests that perinatal exposure to low-dose BPA specifically and non-monotonically impairs spatial learning and memory in male offspring rats.
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Cites
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209 · see citing works
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Walf, A. A., & Frye, C. A. (2007) · Nature Protocols · doi:10.1038/nprot.2007.44 · Cited by 3,035 · see citing works
Hall, C. S. (1934) · Journal of comparative psychology · doi:10.1037/h0071444 · Cited by 1,365 · see citing works
Welshons, W. V., Nagel, S. C., & Saal, F. S. V. (2006) · Endocrinology · doi:10.1210/en.2005-1159 · Cited by 968 · see citing works
Saal, F. S. V., Cooke, P. S., Buchanan, D. L., Palanza, P., Thayer, K. A., Nagel, S. C., Parmigiani, S., & Welshons, W. V. (1998) · Toxicology and Industrial Health · doi:10.1177/074823379801400115 · Cited by 757 · see citing works
Saal, F. S. V., Timms, B. G., Montano, M. M., Palanza, P., Thayer, K. A., Nagel, S. C., Dhar, M. D., Ganjam, V. K., Parmigiani, S., & Welshons, W. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2056 · Cited by 701 · see citing works
Morris, R., Schenk, F., Tweedie, F., & Jarrard, L. E. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00014.x · Cited by 661 · see citing works
Hikida, T., Kimura, K., Wada, N., Funabiki, K., & Nakanishi, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.011 · Cited by 592 · see citing works
Akingbemi, B. T., Sottas, C. M., Koulova, A., Klinefelter, G. R., & Hardy, M. P. (2003) · Endocrinology · doi:10.1210/en.2003-1174 · Cited by 516 · see citing works
Prenatal Bisphenol A Exposure Induces Preneoplastic Lesions in the Mammary Gland in Wistar Rats
Durando, M., Kass, L., Piva, J., Sonnenschein, C., Soto, A. M., Luque, E. H., & Muñoz‐de‐Toro, M. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9282 · Cited by 323 · see citing works
Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats
Kubo, K., Arai, O., Omura, M., Watanabe, R., Ogata, R., & Aou, S. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(02)00251-1 · Cited by 311 · see citing works
Conolly, R. B., & Lutz, W. K. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfh007 · Cited by 266 · see citing works
Martino‐Andrade, A. J., Grande, S. W., Talsness, C. E., Grote, K., & Chahoud, I. (2006) · Toxicology · doi:10.1016/j.tox.2006.07.022 · Cited by 216 · see citing works
Xu, X.-H., Zhang, J., Wang, Y.-M., Ye, Y.-P., & Luo, Q.-Q. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.02.012 · Cited by 211 · see citing works
Cabaton, N. J., Wadia, P. R., Rubin, B. S., Zalko, D., Schaeberle, C. M., Askenase, M. H., Gadbois, J. L., Tharp, A. P., Whitt, G. S., Sonnenschein, C., et al. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1002559 · Cited by 211 · see citing works
Adewale, H. B., Jefferson, W. N., Newbold, R. R., & Patisaul, H. B. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.078261 · Cited by 198 · see citing works
Poimenova, A., Markaki, E., Rahiotis, C., & Kitraki, E. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.051 · Cited by 174 · see citing works
Fujimoto, T., Kubo, K., & Aou, S. (2005) · Brain Research · doi:10.1016/j.brainres.2005.11.028 · Cited by 157 · see citing works
Kwon, S. (2000) · Toxicological Sciences · doi:10.1093/toxsci/55.2.399 · Cited by 133 · see citing works
Normal Reproductive Organ Development in Wistar Rats Exposed to Bisphenol A in the Drinking Water
Cagen, S. Z., Waechter, J. M., Dimond, S. S., Breslin, W. J., Butala, J. H., Jekat, F. W., Joiner, R. L., Shiotsuka, R. N., Veenstra, G. E., & Harris, L. R. (1999) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.1999.1340 · Cited by 125 · see citing works
Reproductive function in rats exposed neonatally to bisphenol A and estradiol benzoate
Nagao, T., Saito, Y., Usumi, K., Kuwagata, M., & Imai, K. (1999) · Reproductive Toxicology · doi:10.1016/s0890-6238(99)00017-9 · Cited by 122 · see citing works
Ogiue-Ikeda, M., Tanabe, N., Mukai, H., Hojo, Y., Murakami, G., Tsurugizawa, T., Takata, N., Kimoto, T., & Kawato, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.010 · Cited by 119 · see citing works
Developmental Neurotoxicity Study of Dietary Bisphenol A in Sprague-Dawley Rats
Stump, D. G., Beck, M. J., Radovsky, A., Garman, R. H., Freshwater, L. L., Sheets, L. P., Marty, M. S., Waechter, J. M., Dimond, S. S., Miller, J. P. V., et al. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq025 · Cited by 117 · see citing works
Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague–Dawley rats
Doerge, D. R., Twaddle, N. C., Vanlandingham, M. M., Brown, R. P., & Fisher, J. W. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.07.009 · Cited by 113 · see citing works
Vandenberg, L. N., Wadia, P. R., Schaeberle, C. M., Rubin, B. S., Sonnenschein, C., & Soto, A. M. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.06.028 · Cited by 102 · see citing works
Zhou, R., Bai, Y., Yang, R., Zhu, Y., Chi, X., Li, L., Chen, L., Sokabe, M., & Chen, L. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.031 · Cited by 92 · see citing works
Xu, X., Dong, T., Hong, X., Chen, L., & Xie, L. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.027 · Cited by 88 · see citing works
Gonçalves, C. R., Cunha, R. W., Barros, D. M., & Martínez, P. E. (2010) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2010.06.003 · Cited by 80 · see citing works
Endocrine disruptors as a threat to neurological function
Weiss, B. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.03.014 · Cited by 73 · see citing works
Jones, B. A., & Watson, N. V. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.011 · Cited by 72 · see citing works
Lactational transfer of bisphenol A in Sprague–Dawley rats
Doerge, D. R., Vanlandingham, M. M., Twaddle, N. C., & Delclos, K. B. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.09.022 · Cited by 71 · see citing works
Xu, X., Xie, L., Hong, X., Ruan, Q., Lü, H., Zhang, Q., Zhang, G., & Liu, X. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2012.12.065 · Cited by 68 · see citing works
Komatsu, T., Chiba, T., Yamaza, H., Yamashita, K., Shimada, A., Hoshiyama, Y., Henmi, T., Ohtani, H., Higami, Y., de Cabo, R., et al. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.01.008 · Cited by 61 · see citing works
Self-citationPassage of Bisphenol A into the Fetus of the Pregnant Rat
Miyakoda, H., Tabata, M., Onodera, S., & Tkeda, K. (1999) · Eisei kagaku · doi:10.1248/jhs.45.318 · Cited by 61 · see citing works
Kunz, N., Camm, E. J., Somm, E., Lodygensky, G. A., Darbre, S., Aubert, M. L., Hüppi, P. S., Sizonenko, S. V., & Rolf Gruetter, A. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.09.009 · Cited by 59 · see citing works
Matsuda, S., Matsuzawa, D., Ishii, D., Tomizawa, H., Sajiki, J., & Shimizu, E. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.03.016 · Cited by 47 · see citing works
Ros‐Simó, C., Moscoso‐Castro, M., Ruiz‐Medina, J., Ros, J., & Valverde, O. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12247 · Cited by 35 · see citing works
Flagged first, then by citations
Research works printed but not linked: 7
- Xu X, Tian D, Hong X, Chen L, Xie L. Sexspecific influence of exposure to bisphenolA between adolescence and young adulthood on mouse behaviors. Neuropharmacology. 2011;61: 565-573.
- Xu XH, Zhang J, Wang YM, Ye YP, Luo QQ. Perinatal exposure to bisphenolA impairs learningmemory by concomitant downregulation of Nmethyldaspartate receptors of hippo campus in male offspring mice. Horm Behav. 2010;58:326-333.
- Zhou R, Bai Y, Yang R, Zhu Y, Chi X, Li L, et al. Abnormal synaptic plasticity in basolateral amygdala may account for hyperactivity and attentiondeficit in male rat exposed perinatally to lowdose bisphenolA. Neuropharmacology. 2011;60:789-798.
- Doerge DR, Vanlandingham M, Twaddle NC, Delclos KB. Lactational transfer of bisphenol A in SpragueDawley rats. Toxicol Lett. 2010;199:372-376.
- Conolly RB, Lutz WK. Nonmonotonic doseresponse relation ships: mechanistic basis, kinetic modeling, and implications for risk assessment. Toxicol Sci. 2004;77:151-157.
- Adewale HB, Jefferson WN, Newbold RR, Patisaul HB. Neonatal bisphenolA exposure alters rat reproductive develop ment and ovarian morphology without impairing activation of gonadotropinreleasing hormone neurons. Biol Reprod. 2009;81: 690-699.
- Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR, Lee DH, et al. Hormones and endocrinedisrupting chemicals: lowdose effects and nonmonotonic dose responses. Endocr Rev. 2012;33:378-455.
Cited by
Sorted by citations
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407 · see citing works
Neuro-toxic and Reproductive Effects of BPA
Santoro, A., Chianese, R., Troisi, J., Richards, S. M., Nori, S. L., Fasano, S., Guida, M., Plunk, E. C., Viggiano, A., Pierantoni, R., et al. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190726112101 · Cited by 281 · see citing works
Xie, X., Ma, X., Guo, L., Fan, Y., Zeng, G., Zhang, M., & Li, J. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.09.080 · Cited by 280 · see citing works
Street, M. E., Angelini, S., Bernasconi, S., Burgio, E., Cassio, A., Catellani, C., Cirillo, F., Deodati, A., Fabbrizi, E., Fanos, V., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061647 · Cited by 261 · see citing works
Bisphenol A: Human exposure and neurobehavior
Mustieles, V., Pérez‐Lobato, R., Olea, N., & Fernández, M. F. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.06.002 · Cited by 203 · see citing works
Thyroid-disrupting chemicals and brain development: an update
Mughal, B. B., Fini, J., & DEMENEIX, B. A. (2018) · Endocrine Connections · doi:10.1530/ec-18-0029 · Cited by 170 · see citing works
Lifestyle, Pregnancy and Epigenetic Effects
Barua, S., & Junaid, M. A. (2015) · Epigenomics · doi:10.2217/epi.14.71 · Cited by 129 · see citing works
Mallozzi, M., Bordi, G., Garò, C., & Caserta, D. (2016) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21137 · Cited by 125 · see citing works
Low‐dose effect of developmental bisphenol A exposure on sperm count and behaviour in rats
Hass, U., Christiansen, S., Boberg, J., Rasmussen, M., Mandrup, K. R., & Axelstad, M. (2016) · Andrology · doi:10.1111/andr.12176 · Cited by 112 · see citing works
Expanding the test set: Chemicals with potential to disrupt mammalian brain development
Mundy, W. R., Padilla, S., Breier, J. M., Crofton, K. M., Gilbert, M. E., Herr, D. W., Jensen, K. F., Radio, N. M., Raffaele, K. C., Schumacher, K., et al. (2015) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2015.10.001 · Cited by 98 · see citing works
Perinatal exposure to endocrine disruptors: sex, timing and behavioral endpoints
Palanza, P., Nagel, S. C., Parmigiani, S., & Saal, F. S. V. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.11.017 · Cited by 96 · see citing works
Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms
Hu, F., Li, T., Gong, H., Chen, Z., Jin, Y., Xu, G., & Wang, M. (2017) · Advanced Science · doi:10.1002/advs.201600493 · Cited by 87 · see citing works
Johnson, S. A., Javurek, A. B., Painter, M. S., Ellersieck, M. R., Welsh, T. H., Camacho, L., Lewis, S. M., Vanlandingham, M. M., Ferguson, S. A., & Rosenfeld, C. S. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.09.005 · Cited by 88 · see citing works
Prenatal phenolic compounds exposure and neurobehavioral development at 2 and 7years of age
Lin, C., Chien, C.-J., Tsai, M., Hsieh, C., Hsieh, W., & Chen, P. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.06.160 · Cited by 66 · see citing works
Exposure to endocrine disrupting chemicals and neurodevelopmental alterations
Pinson, A., Bourguignon, J. P., & Parent, A. (2016) · Andrology · doi:10.1111/andr.12211 · Cited by 62 · see citing works
Suresh, S., Ankul Singh, S., & Vellapandian, C. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104939 · Cited by 61 · see citing works
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies
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Palanza, P., Paterlini, S., Brambilla, M., Ramundo, G., Caviola, G., Gioiosa, L., Parmigiani, S., Saal, F. S. V., & Ponzi, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.015 · Cited by 59 · see citing works
Wu, D., Wu, F., Lin, R., Meng, Y., Wei, W., Sun, Q., & Jia, L. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.04.023 · Cited by 56 · see citing works
Mhaouty‐Kodja, S., Belzunces, L., Lavier, M.-C. C., Schroeder, H., Chevrier, C., & Pasquier, E. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.03.017 · Cited by 47 · see citing works
The effect of the aquatic contaminants bisphenol-A and PCB-95 on the zebrafish lateral line
Hayashi, L., Sheth, M., Young, A. P., Kruger, M., Wayman, G. A., & Coffin, A. B. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.12.010 · Cited by 45 · see citing works
Prenatal Bisphenol A exposure and early childhood neurodevelopment in Shandong, China
Pan, R., Wang, C., Shi, R., Zhang, Y., Wang, Y., Cai, C., Ding, G., Yuan, T., Tian, Y., & Gao, Y. (2019) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2019.03.002 · Cited by 44 · see citing works
Jiang, W., Cao, L., Wang, F., Ge, H., Wu, P.-C., Li, X.-W., & Chen, G.-H. (2016) · AGE · doi:10.1007/s11357-016-9947-5 · Cited by 38 · see citing works
Sex-specific Effects of Endocrine-disrupting Chemicals on Brain Monoamines and Cognitive Behavior
Hilz, E. N., & Gore, A. C. (2022) · Endocrinology · doi:10.1210/endocr/bqac128 · Cited by 38 · see citing works
Bisphenol A and cognitive function in school-age boys: Is BPA predominantly related to behavior?
Rodríguez‐Carrillo, A., Mustieles, V., Pérez‐Lobato, R., Molina-Molina, J.-M., Reina-Pérez, I., Vela-Soria, F., Rubio, S., Olea, N., & Fernández, M. F. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.06.006 · Cited by 35 · see citing works
Kohara, Y., Kuwahara, R., Kawaguchi, S., Jojima, T., & Yamashita, K. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.006 · Cited by 35 · see citing works
Self-citationReview of the Effects of Perinatal Exposure to Endocrine-Disrupting Chemicals in Animals and Humans
Nelson, W., Wang, Y., Sakwari, G. H., & Ding, Y. (2019) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/398_2019_30 · Cited by 32 · see citing works
Wu, D., Liu, H., Liu, Y., Wei, W., Sun, Q., Wen, D., & Jia, L. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112307 · Cited by 32 · see citing works
Peluso, M. E. M., Munnia, A., & Ceppi, M. (2014) · Toxicology · doi:10.1016/j.tox.2014.09.008 · Cited by 31 · see citing works
Helli, B., Navabi, S. P., Hosseini, S. A., Sabahi, A., Khorsandi, L., Amirrajab, N., Mahdavinia, M., Rahmani, S., & Dehghani, M. A. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04048-0 · Cited by 26 · see citing works
Wu, X., Li, S., Zhang, M., Bai, S., Ni, Y., Xu, Q., Fan, Y., Lu, C., Xu, Z., Ji, C., et al. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.137935 · Cited by 25 · see citing works
Endocrine-disrupting chemicals and behaviour: A high risk to take?
Bakoyiannis, I., Kitraki, E., & Stamatakis, A. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101517 · Cited by 23 · see citing works
Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats
Kawaguchi, S., Kuwahara, R., Kohara, Y., Uchida, Y., Oku, Y., & Yamashita, K. (2014) · The Journal of Toxicological Sciences · doi:10.2131/jts.40.43 · Cited by 21 · see citing works
Self-citationKohara, Y., Kawaguchi, S., Kuwahara, R., Uchida, Y., Oku, Y., & Yamashita, K. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.12.005 · Cited by 20 · see citing works
Self-citationDias, G. R. M., Giusti, F. C. V., de Novais, C. O., de Oliveira, M. A. L., Paiva, A. G., Kalil-Cutti, B., Mahoney, M. M., & Graceli, J. B. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1571689 · Cited by 14 · see citing works
Komada, M., Nagao, T., & Kagawa, N. (2020) · The Journal of Toxicological Sciences · doi:10.2131/jts.45.639 · Cited by 14 · see citing works
Liu, Z.-H., Yang, Y., Ge, M.-M., Xu, L., Tang, Y., Hu, F., Xu, Y., & Wang, H.-L. (2015) · Toxicology Research · doi:10.1039/c4tx00093e · Cited by 14 · see citing works
Lupu, D.-I., Cediel-Ulloa, A., & Rüegg, J. (2023) · Neuroendocrinology · doi:10.1159/000531669 · Cited by 13 · see citing works
Bisphenol A Does Not Affect Memory Performance in Adult Male Rats
Kuwahara, R., Kawaguchi, S., Kohara, Y., Jojima, T., & Yamashita, K. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-0017-6 · Cited by 13 · see citing works
Self-citationRytel, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102962 · Cited by 12 · see citing works
Endocrine Disrupting Chemicals and Behavior
Arambula, S. E., & Patisaul, H. B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65191-7 · Cited by 12 · see citing works
Nowicki, B. A., Hamada, M. A., Robinson, G. Y., & Jones, D. C. (2016) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2016.1204577 · Cited by 10 · see citing works
Fallahnezhad, S., Ghorbani-Taherdehi, F., Sahebkar, A., Nadim, A., Kafashzadeh, M., Kafashzadeh, M., & Valokola, M. G. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01257-9 · Cited by 8 · see citing works
Wang, C., Shu, Y., Xu, L., Liu, Q., Zhang, B., & Zhang, H. (2021) · Toxicology and Industrial Health · doi:10.1177/0748233720984624 · Cited by 8 · see citing works
AI/ML-based computational models for toxicity prediction
Barua, S., Balaji, B., & Balaji, S. (2026) · Environmental Science and Pollution Research · doi:10.1007/s11356-025-37354-8 · Cited by 8 · see citing works
Hu, F., Zhang, L., Li, T., Wang, H., Liang, W., & Zhou, Y. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.035 · Cited by 6 · see citing works
Prenatal low-dose bisphenol A enhances behavioral responses induced by a predator odor
Fujimoto, T., Kubo, K., Nishikawa, Y., & Aou, S. (2015) · The Journal of Toxicological Sciences · doi:10.2131/jts.40.569 · Cited by 5 · see citing works
Frankfurt, M., Luine, V. N., & Bowman, R. E. (2020) · Vitamins and hormones · doi:10.1016/bs.vh.2020.04.004 · Cited by 3 · see citing works
Zhang, W., Zhang, L., Liang, W., Wang, H., & Hu, F. (2023) · Toxicology · doi:10.1016/j.tox.2023.153718 · Cited by 2 · see citing works
Set shifting ability of rats perinatally exposed to bisphenol A and a high fat diet
Cuenod, B. A. (2016) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Dillard, J., Carter, A. W., Ower, G., Paitz, R. T., & Bowden, R. M. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112614
- Authors
- Kuwahara, R., Kawaguchi, S., Kohara, Y., Cui, H., & Yamashita, K.
- Affiliations
- Nagasaki University (JP)
- ORCID
- Yamashita, Kimihiro
- Venue
- Journal of Pharmacological Sciences
- Publisher
- Japanese Pharmacological Society
- Published
- 2013
- Volume
- 123
- Issue
- 2
- Pages
- 132-139
- ISSN
- 1347-8613 (ISSN-L)
- 1347-8648
- OpenAlex
- W2090939668
- Cited by
- 52
- References
- 37
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 1
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Nagasaki University's Academic Output SITE (Nagasaki University) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (22510069)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- bisphenol A, perinatal exposure, endocrine disruptors, spatial learning and memory, male offspring, locomotor activity, non-monotonic dose-response, developmental neurotoxicity
- MeSH terms
- Bisphenol A Compounds, Animals, Behavior, Animal, Benzhydryl Compounds, Dose-Response Relationship, Drug, Emotions, Female, Male, Maternal-Fetal Exchange, Memory, Memory Disorders, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Sprague-Dawley, Maze Learning, Maternal Exposure, Rats, Endocrine Disruptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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