Cited by 66Suicide and Self-Harm StudiesNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

Plasma serotonin levels and suicidal behavior in adolescents

Tyano, Samuel, Zalsman, Gil, Ofek, Hadas, Blum, Ilanan, Apter, Alan, Wolovik, Luisa, Sher, Leo, Sommerfeld, Eliane +2 more·2006·European Neuropsychopharmacology

Abstract

To evaluate the relationship between plasma serotonin (p5-HT) levels and psychometric measures in suicidal adolescents vs. controls, 211 adolescents from three sites in Israel were divided into four groups: suicidal psychiatric inpatients (n=35); non-suicidal psychiatric inpatients (n=30); adolescents referred to the emergency room (ER) due to a suicide attempt (n=51); and a community-based control group from 4 high schools in the same catchment areas (n=95). All were interviewed and assessed for violence, aggression, depression, impulsivity, anger, anxiety, and p5-HT. p5-HT levels were significantly lower in the control group compared to all other groups. A significant negative correlation was found between p5-HT level and suicidal behavior severity among the suicidal inpatients. p5-HT did not discriminate between the psychiatric diagnostic categories and was significantly lower in ER violent compared to non-violent subjects. Gender, depression, and anger were associated with suicidal behavior in all four groups. Beck Depression Inventory (BDI) scores together with p5-HT levels discriminated between healthy controls and other groups. p5-HT level in combination with some of the psychometric scales may serve as a safe and inexpensive peripheral marker of psychopathology, and may help to differentiate between sub-populations of suicidal adolescents. The biological mechanism behind the serotonin dysregulation in suicidal adolescents requires further investigation.

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Crossref · 10.1016/j.euroneuro.2005.05.005

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Authors
Tyano, S., Zalsman, G., Ofek, H., Blum, I., Apter, A., Wolovik, L., Sher, L., Sommerfeld, E., Harell, D., & Weizman, A.
Affiliations
  • Tel Aviv University (IL)
  • Geha Mental Health Center (IL)
  • Columbia University (US)
Corresponding author
Zalsman, Gil
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2006-01
Volume
16
Issue
1
Pages
49-57
ISSN
0924-977X (ISSN-L)
OpenAlex
W1999380874
Cited by
66
References
48
Citations by year
2026: 1 · 2025: 3 · 2023: 6 · 2022: 10 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 5
FWCI
4.65
Type
journal article
Language
en
Open access
closed
Locations
  • European Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
plasma serotonin, suicidal behavior, adolescents, suicide attempts, depression, anger, impulsivity, aggression, serotonin dysregulation, peripheral biomarkers, psychopathology, suicide risk assessment
MeSH terms
Adolescent, Adolescent Behavior, Aggression, Mental Disorders, Child, Chromatography, High Pressure Liquid, Depressive Disorder, Electrochemistry, Female, Humans, Male, Personality Inventory, Psychiatric Status Rating Scales, Psychometrics, Serotonin, Sex Factors, Suicide, Attempted

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