Plasma serotonin levels and suicidal behavior in adolescents
Abstract
To evaluate the relationship between plasma serotonin (p5-HT) levels and psychometric measures in suicidal adolescents vs. controls, 211 adolescents from three sites in Israel were divided into four groups: suicidal psychiatric inpatients (n=35); non-suicidal psychiatric inpatients (n=30); adolescents referred to the emergency room (ER) due to a suicide attempt (n=51); and a community-based control group from 4 high schools in the same catchment areas (n=95). All were interviewed and assessed for violence, aggression, depression, impulsivity, anger, anxiety, and p5-HT. p5-HT levels were significantly lower in the control group compared to all other groups. A significant negative correlation was found between p5-HT level and suicidal behavior severity among the suicidal inpatients. p5-HT did not discriminate between the psychiatric diagnostic categories and was significantly lower in ER violent compared to non-violent subjects. Gender, depression, and anger were associated with suicidal behavior in all four groups. Beck Depression Inventory (BDI) scores together with p5-HT levels discriminated between healthy controls and other groups. p5-HT level in combination with some of the psychometric scales may serve as a safe and inexpensive peripheral marker of psychopathology, and may help to differentiate between sub-populations of suicidal adolescents. The biological mechanism behind the serotonin dysregulation in suicidal adolescents requires further investigation.
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In adolescents, peripheral markers of serotonin function appear altered.
“In adolescents, peripheral markers of serotonin function also appear altered.”
From Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review (2026) · cites this paper as [26]
Lower plasma and whole-blood serotonin levels, reduced platelet aggregation responses, and diminished tryptophan concentrations have been observed in suicidal youth.
“Lower plasma and whole-blood serotonin levels, reduced platelet aggregation responses, and diminished tryptophan concentrations have all been observed in suicidal youth (26, 27).”
From Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review (2026) · cites this paper as [26]
Cites
Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation
Beck, A. T., Steer, R. A., & Carbin, M. G. (1988) · Clinical Psychology Review · doi:10.1016/0272-7358(88)90050-5 · Cited by 11,696 · see citing works
Suicide as an outcome for mental disorders: A meta-analysis
Harris, E. C., & Barraclough, B. (1997) · British Journal of Psychiatry · doi:10.1192/bjp.170.3.205 · Cited by 2,589 · see citing works
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260 · cited 3× · see citing works
“This finding is also known from studies in both adults (Apter et al., 1990, 1993a,b; Mann, 2003) and adolescents (Apter et al.”
Aggression in humans correlates with cerebrospinal fluid amine metabolites
Brown, G. L., Goodwin, F. K., Ballenger, J. C., Goyer, P. F., & Major, L. F. (1979) · Psychiatry Research · doi:10.1016/0165-1781(79)90053-2 · Cited by 1,133 · see citing works
Brent, D. A. (1995) · Suicide and Life-Threatening Behavior · doi:10.1111/j.1943-278x.1995.tb00490.x · Cited by 437 · see citing works
The Multidimensional Anger Inventory.
Siegel, J. M. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.1.191 · Cited by 397 · see citing works
The measurement of suicidality, aggressivity and impulsivity
Plutchik, R., & van Praag, H. (1989) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(89)90107-3 · Cited by 342 · see citing works
Suicide attempts in children and adolescents
Garfinkel, B. D., Froese, A., & Hood, J. E. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.10.1257 · Cited by 326 · see citing works
Major depression and the risk of attempted suicide
Malone, K. M., Haas, G. L., Sweeney, J. A., & Mann, J. J. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00015-f · Cited by 302 · see citing works
Mann, J. J. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820060022003 · Cited by 281 · see citing works
Higher Expression of Serotonin 5-HT2A Receptors in the Postmortem Brains of Teenage Suicide Victims
Pandey, G. N., Dwivedi, Y., Rizavi, H. S., Ren, X., Pandey, S. C., Pesold, C., Roberts, R. C., Conley, R. R., & Tamminga, C. A. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.3.419 · Cited by 281 · see citing works
Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients
John Mann, J., & Malone, K. M. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00217-x · Cited by 278 · see citing works
Anxiety, impulsivity and depressed mood in relation to suicidal and violent behavior
Apter, A., Plutchik, R., & van Praag, H. M. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03321.x · Cited by 267 · see citing works
Self-citationvan Praag, H. M. (1987) · Journal of Affective Disorders · doi:10.1016/0165-0327(87)90067-x · Cited by 264 · see citing works
Pfeffer, C. R. (1986) · Medical Entomology and Zoology · Cited by 229 · see citing works
Apter, A. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820140064007 · Cited by 227 · see citing works
Self-citationApter, A., van Praag, H. M., Plutchik, R., Sevy, S. M., Korn, M. L., & Brown, S. (1990) · Psychiatry Research · doi:10.1016/0165-1781(90)90086-k · Cited by 223 · see citing works
Self-citationApter, A., Gothelf, D., Orbach, I., Weizman, R., RATZONI, G., Har‐Even, D., & Tyano, S. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199507000-00015 · Cited by 203 · see citing works
Self-citationPersonality Disorder, Tendency to Impulsive Violence, and Suicidal Behavior in Adolescents
Brent, D. A., JOHNSON, B., BARTLE, S., Bridge, J. A., RATHER, C., Matta, J., Connolly, J. F., & Constantine, D. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199301000-00010 · Cited by 197 · see citing works
The epidemiology of teen suicide: an examination of risk factors.
Shaffer, D. (1988) · PubMed · Cited by 186 · see citing works
Platelet serotonin-2A receptors: a potential biological marker for suicidal behavior
Pandey, G. N., Pandey, S. C., Dwivedi, Y., Sharma, R. P., Janicak, P. G., & Davis, J. M. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.6.850 · Cited by 176 · see citing works
Prolactin Response to Fenfluramine and Suicide Attempt Lethality in Major Depression
Malone, K. M., Corbitt, E. M., Li, S., & Mann, J. J. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.168.3.324 · Cited by 157 · see citing works
Suicidal Behaviors in Young Adolescents
Garrison, C. Z., Jackson, K. L., Addy, C. L., McKeown, R. E., & Waller, J. L. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115809 · Cited by 149 · see citing works
Mann, J. J., McBride, P., Anderson, G. M., & Mieczkowski, T. A. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90106-a · Cited by 140 · see citing works
Psychobiology of suicidal behavior.
Mann, J. J., & Stanley, M. (1986) · PubMed · Cited by 136 · see citing works
Psychometric properties of the K-SADS-PL in an Israeli adolescent clinical population.
Shanee, N., Apter, A., & Weizman, A. (1997) · PubMed · Cited by 120 · see citing works
Self-citationClinical practice. Adolescent depression.
Brent, D., & Birmaher, B. (2002) · New England Journal of Medicine · doi:10.1056/nejmcp012249 · Cited by 114 · see citing works
Correlates of risk of suicide in violent and nonviolent psychiatric patients
Apter, A., Kotler, M., Sevy, S. M., Plutchik, R., Brown, S. L., Foster, H. G., Hillbrand, M., Korn, M. L., & van Praag, H. M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.7.883 · Cited by 112 · see citing works
Self-citationSerotonin and its place in the pathogenesis of depression.
Coppen, A. J., & Doogan, D. P. (1988) · PubMed · Cited by 102 · see citing works
Serotonin and Suicidal Behaviora
Mann, J. J., Arango, V., & Underwood, M. D. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16903.x · Cited by 91 · see citing works
Psychometric Properties of the K-SADS-P in an Israeli Adolescent Inpatient Population
Apter, A. S., Orvaschel, H., LASEG, M., MOSES, T., & Tyano, S. (1989) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198901000-00011 · Cited by 91 · see citing works
Self-citationvan Praag, H. M. (1996) · Psychiatry Research · doi:10.1016/s0165-1781(96)02923-x · Cited by 87 · see citing works
Zalsman, G., Frisch, A., Bromberg, M., Gelernter, J. E., Michaelovsky, E., Campino, A., Erlich, Z., Tyano, S., Apter, A. S., & Weizman, A. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1261 · Cited by 87 · see citing works
Self-citationBiological suicide research: Outcome and limitations
van Praag, H. M. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90314-8 · Cited by 87 · see citing works
Sarrias, M. J., Cabré, P., Martı́nez, E., & Artigas, F. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02319.x · Cited by 81 · see citing works
State and Trait Anxiety in Adolescent Suicide Attempters
Ohring, R., Apter, A., Ratzoni, G., Weizman, R., Tyano, S., & Plutchik, R. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199602000-00007 · Cited by 72 · see citing works
Self-citationOn the Accurate Determination of Serotonin in Human Plasma
Beck, O., Wallén, N. H., Bröijersén, A., Larsson, P. T., & Hjemdahl, P. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2243 · Cited by 66 · see citing works
Zalsman, G., Frisch, A., King, R. A., Pauls, D. L., Grice, D. E., Gelernter, J. E., Alsobrook, J. P., Michaelovsky, E., Apter, A., Tyano, S., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1406 · Cited by 52 · see citing works
Self-citationSerotonergic Function and Suicidal Behavior in Personality Disordersa
Träskman‐Bendz, L., Åsberg, M., & Schalling, D. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb27896.x · Cited by 48 · see citing works
Altered protein kinase a in brain of learned helpless rats: effects of acute and repeated stress
Dwivedi, Y., Mondal, A. C., Shukla, P. K., Rizavi, H. S., & Lyons, J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.018 · Cited by 45 · see citing works
Generalizable Treatment Strategies for Suicidal Behavior
Blumenthal, S. J., & Kupfer, D. J. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb27911.x · Cited by 42 · see citing works
Sher, L., Oquendo, M. A., Li, S., Ellis, S. P., Brodsky, B. S., Malone, K. M., Cooper, T. B., & Mann, J. J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00040-9 · Cited by 39 · see citing works
Self-citationZalsman, G., Anderson, G. M., Peskin, M., Frisch, A., KING, R. A., Vekslerchik, M., Sommerfeld, E., Michaelovsky, E., Sher, L., Weizman, A., et al. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-004-0244-6 · Cited by 28 · see citing works
Self-citationOfek, H., Weizman, T., & Apter, A. S. (1998) · PubMed · Cited by 24 · see citing works
Self-citationAffective and Psychotic Psychopathology in Hospitalized Adolescents
Apter, A. S., Bleich, A., & Tyano, S. (1988) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198801000-00018 · Cited by 23 · see citing works
Self-citation
Flagged first, then by citations
2 of the 48 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Annual Research Review: Suicide among youth – epidemiology, (potential) etiology, and treatment
Cha, C. B., Franz, P. J., M. Guzmán, E., Glenn, C. R., Kleiman, E. M., & Nock, M. K. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12831 · Cited by 602 · see citing works
The neuropsychiatry of impulsivity
Chamberlain, S. R., & Sahakian, B. J. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3280ba4989 · Cited by 419 · see citing works
Biological basis of suicide and suicidal behavior
Pandey, G. N. (2013) · Bipolar Disorders · doi:10.1111/bdi.12089 · Cited by 226 · see citing works
Is impulsivity a link between childhood abuse and suicide?
Braquehais, M. D., Oquendo, M. A., Baca‐García, E., & Sher, L. (2009) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2009.05.003 · Cited by 200 · see citing works
Self-citationWasserman, D., Carli, V., Iosue, M., Javed, A., & Herrman, H. (2021) · Asia-Pacific Psychiatry · doi:10.1111/appy.12452 · Cited by 168 · see citing works
Brand, T., & Anderson, G. M. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.163824 · Cited by 119 · see citing works
Sarter, M., Bruno, J. P., & Parikh, V. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301285 · Cited by 100 · see citing works
Keyvani, F., Zheng, H., Kaysir, M. R., Mantaila, D. F., Nejad, P. G., Rahman, F. A., Quadrilatero, J., Ban, D., & Poudineh, M. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202301624 · Cited by 79 · see citing works
Neuropharmacological modulation of cognition
Chamberlain, S. R., Müller, U., Robbins, T. W., & Sahakian, B. J. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000247613.28859.77 · Cited by 79 · see citing works
Zalsman, G., Patya, M., Frisch, A., Ofek, H., Schapir, L., Blum, I., Harell, D., Apter, A. S., Weizman, A., & Tyano, S. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.518628 · Cited by 74 · see citing works
Self-citationBlanaru, M., Bloch, B., Vadas, L., Arnon, Z., Ziv, N., Kremer, I., & Haimov, I. (2012) · Mental Illness · doi:10.4081/mi.2012.e13 · Cited by 71 · see citing works
Lithium and suicide prevention in bipolar disorder
Benard, V., Vaïva, G., Masson, M., & Geoffroy, P. A. (2016) · L Encéphale · doi:10.1016/j.encep.2016.02.006 · Cited by 59 · see citing works
Blood Levels of Serotonin Are Differentially Affected by Romantic Love in Men and Women
Langeslag, S. J. E., van der Veen, F. M., & Fekkes, D. (2012) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000071 · Cited by 53 · see citing works
Deliberate self-harm in adolescents
Portzky, G., & van Heeringen, K. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3281c49ff1 · Cited by 53 · see citing works
Neurobiology of Depression in Children and Adolescents
Zalsman, G., Oquendo, M. A., Greenhill, L., Goldberg, P. H., Kamali, M., Martin, A., & Mann, J. J. (2006) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2006.05.010 · Cited by 53 · see citing works
Self-citationFanelli, G., & Serretti, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.007 · Cited by 52 · see citing works
Yuan, X., Ouaskioud, O., Yin, X., Li, C., Ma, P., Yang, Y., Yang, P., Xie, L., & Ren, L. M. (2023) · Micromachines · doi:10.3390/mi14071452 · Cited by 51 · see citing works
Relationship between whole blood serotonin and repetitive behaviors in autism
Kolevzon, A., Newcorn, J. H., Kryzak, L., Chaplin, W., Watner, D., Hollander, E., Smith, C. J., Cook, E. H., & Silverman, J. M. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.02.008 · Cited by 50 · see citing works
Iorfino, F., Hickie, I. B., Lee, R. S. C., Lagopoulos, J., & Hermens, D. F. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0852-3 · Cited by 44 · see citing works
Hu, S., Li, X., & Yang, L. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1234409 · Cited by 39 · see citing works
Factores asociados con la conducta suicida en adolescentes
Vargas-Murga, H., & Saavedra, J. E. (2013) · Revista de Neuro-Psiquiatría · doi:10.20453/rnp.v75i1.1539 · Cited by 38 · see citing works
Sinha, S. N., Kumpati, R. K., Ramavath, P. N., Sangaraju, R., Gouda, B., & Chougule, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-21054-1 · Cited by 28 · see citing works
Moroianu, L.-A., Curis, C., Ardeleanu, V., Stoian, A. P., Vasilica, C., Barbu, R. E., & Moroianu, M. (2022) · Medicina · doi:10.3390/medicina58050652 · Cited by 27 · see citing works
Interaction of Child and Family Psychopathology Leading to Suicidal Behavior
Zalsman, G., Levy, T., & Shoval, G. (2008) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2008.01.009 · Cited by 26 · see citing works
Self-citation- Genetics of Suicidal Behavior in Children and Adolescents
Dwivedi, Y. (2012) · CRC Press eBooks · doi:10.1201/b12215-20 · Cited by 21 · see citing works
Li, C., Cai, Q., Su, Z., Chen, Z., Cao, J., & Xu, F. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1149511 · Cited by 20 · see citing works
Kim, J., Kang, H., Kim, J.-W., Choi, W., Lee, J., Kim, S., Shin, I., Kim, M., Chun, B. J., & Stewart, R. J. (2022) · Psychological Medicine · doi:10.1017/s0033291722001180 · Cited by 18 · see citing works
Keyvani, F., Zheng, H., Kaysir, M. R., Mantaila, D. F., Nejad, P. G., Rahman, F. A., Quadrilatero, J., Ban, D., & Poudineh, M. (2023) · Angewandte Chemie · doi:10.1002/ange.202301624 · Cited by 18 · see citing works
Preventing suicide in adolescents with alcohol use disorders
Makhija, N. J., & Sher, L. (2007) · International Journal of Adolescent Medicine and Health · doi:10.1515/ijamh.2007.19.1.53 · Cited by 18 · see citing works
Self-citationCosta, J. E., Gomes, C. C., Cota, L. O. M., Pataro, A. L., Silva, J. F. C., Gomez, R. S., & Costa, F. O. (2008) · Journal of Oral Science · doi:10.2334/josnusd.50.193 · Cited by 18 · see citing works
Plasma serotonin levels in young violent offenders: Aggressive responding and personality correlates
Zhou, J., Wang, X., Li, L., Cao, X., Xu, L., & Sun, Y. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.05.021 · Cited by 18 · see citing works
Concept of Suicide: Neurophysiological/Genetic Theories and Possible Oxytocin Relevance
Pădurariu, M., Prepelita, R., Ciobica, A. S., Dobrin, R., Timofte, D. V., Ștefănescu, C., & Chiriță, R. (2016) · Neurophysiology · doi:10.1007/s11062-016-9603-9 · Cited by 17 · see citing works
Depressed suicidal adolescent males have an altered cortisol response to a pharmacological challenge
Ghaziuddin, N., King, C. A., Welch, K., & Ghaziuddin, M. (2013) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2013.10.005 · Cited by 16 · see citing works
Stress and Vulnerability: A Developing Model for Suicidal Risk
López‐Castromán, J., Olié, É., & Courtet, P. (2014) · Springer eBooks · doi:10.1007/978-3-319-09964-4_5 · Cited by 16 · see citing works
- Peripheral Biomarkers for Suicide
Dwivedi, Y. (2012) · CRC Press eBooks · doi:10.1201/b12215-26 · Cited by 11 · see citing works
Increased Plasma Serotonin in Complex Regional Pain Syndrome Type 1
Wesseldijk, F., Fekkes, D., Huygen, F. J. P. M., Bogaerts-Taal, E., & Zijlstra, F. J. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318172c2f4 · Cited by 11 · see citing works
Las Ideas Equivocadas sobre la Depresión Infantil y Adolescente y su Tratamiento
Sanz, J., & García‐Vera, M. P. (2020) · Clínica y Salud · doi:10.5093/clysa2020a4 · Cited by 9 · see citing works
Peripheral and neural correlates of self-harm in children and adolescents: a scoping review
Sparrow-Downes, V. M., Trincao-Batra, S., Cloutier, P., Helleman, A., Salamatmanesh, M., Gardner, W., Baksh, A., Kapur, R., Sheridan, N., Suntharalingam, S., et al. (2021) · BMC Psychiatry · doi:10.1186/s12888-022-03724-6 · Cited by 9 · see citing works
İntihar Davranışının Nörobiyolojisi
Aydın, M., Hacımusalar, Y., & Hocaoğlu, Ç. (2018) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.382119 · Cited by 7 · see citing works
Suicidal Ideation, Suicide Attempts and Completed Suicide in Adolescents: Neurobiological Aspects
Sarchiapone, M., D’Aulerio, M., & Iosue, M. (2015) · Advances in biological psychiatry · doi:10.1159/000435767 · Cited by 7 · see citing works
Research on potential biomarker correlates for suicidal behavior: A review
Kim, S., & Lee, K.-U. (2017) · Asia-Pacific Psychiatry · doi:10.1111/appy.12291 · Cited by 8 · see citing works
Zalsman, G., Rehavi, M., Roz, N., Laor, N., Weizman, A., & Toren, P. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0643-4 · Cited by 6 · see citing works
Self-citationEarly Childhood Adversity, Stress, and Developmental Pathways of Suicide Risk
Ortin‐Peralta, A., Myruski, S., Rosario‐Williams, B., & Xu, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-82465-5_3 · Cited by 5 · see citing works
Pak, T. K., Ayvaci, E. R., Carmody, T. J., Jamma, L., Feng, Z., Nekovei, A., Emslie, G. J., & Trivedi, M. H. (2025) · iScience · doi:10.1016/j.isci.2025.112290 · Cited by 4 · see citing works
Stress-Related Blood Biomarkers
Szczepek, A. J., & Mazurek, B. (2017) · Springer eBooks · doi:10.1007/978-3-319-58397-6_6 · Cited by 4 · see citing works
Andover, M. S., Wren, A., Schatten, H. T., Morris, B. W., Shashoua, M. Y., & Holman, C. S. (2014) · Springer eBooks · doi:10.1007/978-1-4899-7497-6_33 · Cited by 3 · see citing works
Neuro-modulatory targets of aggression, depression and suicidal behaviour
Borkar, D. S., Pande, D., & Yadav, R. S. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.06.054 · Cited by 2 · see citing works
Kim, J., Kang, H., Kim, J., Choi, W., Kim, S., Kim, J. M., Chun, B. J., Ahn, Y., & Jeong, M. H. (2023) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2023.21.2.386 · Cited by 2 · see citing works
Kim, J., Kim, J., Kang, H., Choi, W., Ryu, S., Lee, J., Kim, S., Kim, J.-C., Chun, B. J., Shin, I., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1046715 · Cited by 2 · see citing works
Falcone, T., Staniskyte, M., Forcén, F., & Vengoechea, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-74391-2_1 · Cited by 1 · see citing works
Altun, İ. K., Kılıç, N., Yıldızoğlu, E., & Atagün, M. İ. (2019) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.384067 · Cited by 1 · see citing works
Suicide et environnement social
(2013) · Dunod eBooks · doi:10.3917/dunod.court.2013.01.0157 · Cited by 1 · see citing works
Neurobiology of Depression in Childhood and Adolescence
Bark, C., & Resch, F. (2008) · KARGER eBooks · doi:10.1159/000118516 · Cited by 1 · see citing works
Tentativas de suicidio atendidas no Hospital de Clinicas da Unicamp
Stefanello, S. (2007) · doi:10.47749/t/unicamp.2007.402030 · Cited by 1 · see citing works
Salehi, M., Saeidi, M., Amanat, M., Barias, T., Anyeji, U., Alzein, O., & Gunturu, S. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1738009
Depression in Infants, Children and Adolescents
Tyano, S. (2009) · Wiley eBooks · doi:10.1002/9780470745892.ch4e
Self-citationChung, E. (2009) · CRC Press eBooks · doi:10.1201/b13320-9
Current awareness in human psychopharmacology
(2006) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.733
Chung, E. (2009) · CRC Press eBooks · doi:10.1201/b13320-5
Psikiyatrik Boyutlarıyla Dürtüsellik
Yeşiloğlu, C., Sun, T., Demirkol, M. E., & Tamam, L. (2025) · Arşiv Kaynak Tarama Dergisi · doi:10.17827/aktd.1698682
Sparrow-Downes, V. M., Trincao-Batra, S., Cloutier, P., Helleman, A., Salamatmanesh, M., Gardner, W. P., Baksh, A., Kapur, R., Sheridan, N., Suntharalingam, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19710994
Sparrow-Downes, V. M., Trincao-Batra, S., Cloutier, P., Helleman, A., Salamatmanesh, M., Gardner, W. P., Baksh, A., Kapur, R., Sheridan, N., Suntharalingam, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19710991
Sparrow-Downes, V. M., Trincao-Batra, S., Cloutier, P., Helleman, A., Salamatmanesh, M., Gardner, W. P., Baksh, A., Kapur, R., Sheridan, N., Suntharalingam, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19711000
Sparrow-Downes, V. M., Trincao-Batra, S., Cloutier, P., Helleman, A., Salamatmanesh, M., Gardner, W. P., Baksh, A., Kapur, R., Sheridan, N., Suntharalingam, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19710997
Mental health and wellbeing of children
(2026) · Frontiers research topics · doi:10.3389/978-2-8325-8953-3
- Authors
- Tyano, S., Zalsman, G., Ofek, H., Blum, I., Apter, A., Wolovik, L., Sher, L., Sommerfeld, E., Harell, D., & Weizman, A.
- Affiliations
- Tel Aviv University (IL)
- Geha Mental Health Center (IL)
- Columbia University (US)
- Corresponding author
- Zalsman, Gil
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 16
- Issue
- 1
- Pages
- 49-57
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W1999380874
- Cited by
- 66
- References
- 48
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 6 · 2022: 10 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- plasma serotonin, suicidal behavior, adolescents, suicide attempts, depression, anger, impulsivity, aggression, serotonin dysregulation, peripheral biomarkers, psychopathology, suicide risk assessment
- MeSH terms
- Adolescent, Adolescent Behavior, Aggression, Mental Disorders, Child, Chromatography, High Pressure Liquid, Depressive Disorder, Electrochemistry, Female, Humans, Male, Personality Inventory, Psychiatric Status Rating Scales, Psychometrics, Serotonin, Sex Factors, Suicide, Attempted
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