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Cognitive impairments four months after COVID-19 hospital discharge: pattern, severity and association with illness variables.
Open accessAbstract
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic has affected more than 100 million people and clinics are being established for diagnosing and treating lingering symptoms, so called long-COVID. A key concern are neurological and long-term cognitive complications. At the same time, the prevalence and nature of the cognitive sequalae of COVID-19 are unclear. The present study aimed to investigate the frequency, pattern and severity of cognitive impairments 3-4 months after COVID-19 hospital discharge, their relation to subjective cognitive complaints, quality of life and illness variables. We recruited patients at their follow-up visit at the respiratory outpatient clinic, Copenhagen University Hospital, Bispebjerg, approximately four months after hospitalisation with COVID-19. Patients underwent pulmonary, functional and cognitive assessments. Twenty-nine patients were included. The percentage of patients with clinically significant cognitive impairment ranged from 59% to 65% depending on the applied cut-off for clinical relevance of cognitive impairment, with verbal learning and executive functions being most affected. Objective cognitive impairment scaled with subjective cognitive complaints, lower work function and poorer quality of life. Cognitive impairments were associated with d-dimer levels during acute illness and residual pulmonary dysfunction. In conclusion, these findings provide new evidence for frequent cognitive sequelae of COVID-19 and indicate an association with the severity of the lung affection and potentially restricted cerebral oxygen delivery. Further, the associations with quality of life and functioning call for systematic cognitive screening of patients after recovery from severe COVID-19 illness and implementation of targeted treatments for patients with persistent cognitive impairments.
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RETRACTED: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study
Huang, C., Huang, L., Wang, Y., Li, X., Ren, L., Gu, X., Kang, L., Guo, L., Liu, M., Zhou, X., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32656-8 · Cited by 4,084
RetractedNeurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1127 · Cited by 7,166
Celli, B. R., MacNee, W., Agustí, A. G. N., Anzueto, A. R., Berg, B., Buist, A. S., Calverley, P. M., Chavannes, N. H., Dillard, T. A., Fahy, B. F., et al. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00014304 · Cited by 4,410
The Validity and Reproducibility of a Work Productivity and Activity Impairment Instrument
Reilly, M. C., Zbrozek, A. S., & Dukes, E. M. (1993) · PharmacoEconomics · doi:10.2165/00019053-199304050-00006 · Cited by 3,071
The Cognitive Failures Questionnaire (CFQ) and its correlates
Broadbent, D. E., Cooper, P. F., FitzGerald, P., & Parkes, K. R. (1982) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.1982.tb01421.x · Cited by 3,054
Neurologic features in severe SARS-CoV-2 infection
Helms, J., Kremer, S., Merdji, H., Clere-Jehl, R., Schenck, M., Kummerlen, C., Collange, O., Boulay, C., Fafi-Kremer, S., Ohana, M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2008597 · Cited by 2,674
Development and validation of a questionnaire to measure asthma control
Juniper, E. F., O′byrne, P. M., Guyatt, G. H., Ferrie, P. J., & King, D. R. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.14d29.x · Cited by 2,473
Li, Y., Bai, W., & Hashikawa, T. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25728 · Cited by 2,266
Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
Oxley, T. J., Mocco, J., Majidi, S., Kellner, C. P., Shoirah, H., Singh, I. P., Leacy, R. A. D., Shigematsu, T., Ladner, T. R., Yaeger, K., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2009787 · Cited by 2,114
Nervous system involvement after infection with COVID-19 and other coronaviruses
Wu, Y., Xu, X., Chen, Z., Duan, J., Hashimoto, K., Yang, L., Liu, C., & Yang, C. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.03.031 · Cited by 2,046
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“…et al., 2020; Havervall et al., 2021; Jacobson et al., 2021; Johnsen et al., 2021; Latronico et al., 2020; Logue et al., 2021; Menges et al., 2021; Miskowiak et al., 2021; Munblit et al., 2021; Orrù et al., 2021; Osmanov et al., 2021; Pereira et al., 2021; Qu et al., 2021; Rass et al., 2021;…”
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“Mean age Time since acute COVID19 Inclusion criteria Exclusion criteria Main findings Miskowiak et al., 2021 (Denmark) To investigate frequency, pattern and severity of cognitive impairments 3–4 months after COVID19 Cohort study SCIP-D; TMT; CFQ 29 17 (59”
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“TABLE 2 Study designs and quality scoring using Newcastle-Ottawa Scale for non-randomized studies in meta-analyses and classification according to AHRQ standards Study Design Bias Rating Newcastle Ottawa AHRQ Selection Comparability Outcome/exposure Amalakanti. et al. 2021 Case control ** * * Poor Manera et al. 2021 C…”
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Metadata
- Authors
- Miskowiak, K., Johnsen, S., Sattler, S., Nielsen, S., Kunalan, K., Rungby, J., Lapperre, T., & Porsberg, C.
- Affiliations
- Bispebjerg Hospital (DK)
- University of Copenhagen (DK)
- University of Antwerp (BE)
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 46
- Pages
- 39-48
- ISSN
- 0924-977X (ISSN-L)
- PMC
- PMC8006192
- OpenAlex
- W3148312871
- Cited by
- 365
- References
- 45
- Citations by year
- 2026: 12 · 2025: 45 · 2024: 60 · 2023: 97 · 2022: 115 · 2021: 36
- FWCI
- 36.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Neuropsychopharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- Funders
- Lundbeck Foundation
- Topics
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- COVID-19 pandemic, long COVID, cognitive impairment, hospital discharge, subjective cognitive complaints, quality of life, executive function, verbal learning, D-dimer, pulmonary dysfunction, cerebral oxygen delivery, cognitive screening
- MeSH terms
- COVID-19, Aged, Denmark, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Patient Discharge, Prospective Studies, Severity of Illness Index, Time Factors, Cognitive Dysfunction
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