The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
POxylation as an alternative stealth coating for biomedical applications
Open accessAbstract
Polyethylene glycol (PEG) polymers are currently used in a variety of medical formulations to reduce toxicity, minimize immune interactions and improve pharmacokinetics. Despite its widespread use however, the presence of anti-PEG antibodies indicates that this polymer has the potential to be immunogenic and antigenic. Here we present an alternative polymer, poly(2-oxazoline) (POx) for stealth applications, specifically shielding of a proteinaceous nanoparticle from recognition by the immune system. Tobacco mosaic virus (TMV) was used as our testbed due to its potential for use as a nanocarrier for drug delivery and molecular imaging applications.
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“This study, along with others, indicate that PMeOx may actually have superior anti-fouling properties to that of PEG [89].”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [89]
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Cites
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Engineering targeted viral vectors for gene therapy
Waehler, R., Russell, S. J., & Curiel, D. T. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2141 · Cited by 687
Perry, J. L., Reuter, K. G., Kai, M. P., Herlihy, K. P., Jones, S. W., Luft, J. C., Napier, M. A., Bear, J. E., & DeSimone, J. M. (2012) · Nano Letters · doi:10.1021/nl302638g · Cited by 622
Garay, R. P., El-Gewely, R., Armstrong, J. K., Garratty, G., & Richette, P. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.720969 · Cited by 587
In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer
Lizotte, P. H., Wen, A. M., Sheen, M. R., Fields, J., Rojanasopondist, P., Steinmetz, N. F., & Fiering, S. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.292 · Cited by 487
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Poly (2-oxazoline) s as polymer therapeutics
Luxenhofer, R., Han, Y., Schulz, A., Tong, J., He, Z., Kabanov, A. V., & Jordan, R. (2012) · Macromolecular Rapid Communications · doi:10.1002/marc.201200354 · Cited by 470
Self-citationPolyoxazoline: Chemistry, Properties, and Applications in Drug Delivery
Viegas, T. X., Bentley, M. D., Harris, J. M., Fang, Z., Yoon, K., Dizman, B., Weimer, R., Mero, A., Pasut, G., & Veronese, F. M. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200049d · Cited by 432
Viral Vectors for Gene Therapy: Translational and Clinical Outlook
Kotterman, M. A., Chalberg, T. W., & Schaffer, D. V. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-104938 · Cited by 424
Characterization of Nanoparticles for Therapeutics
Hall, J. B., Dobrovolskaia, M. A., Patri, A. K., & McNeil, S. E. (2007) · Nanomedicine · doi:10.2217/17435889.2.6.789 · Cited by 413
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- Hall, 2014, Nanomedicine, 1
- Woller, 2014, Front. Oncol., 1
- Bruckman, 2013, vol. 1108, 173
Cited by
Sorted by citations
Hwang, D., Ramsey, J. D., & Kabanov, A. V. (2020) · Advanced drug delivery reviews · doi:10.1016/j.addr.2020.09.009 · Cited by 699
“This study, alongwith others, indicate that PMeOx may actually have superior anti-fouling properties to that of PEG [89].”
ResultStealth Coating of Nanoparticles in Drug-Delivery Systems
Fam, S. Y., Chee, C. F., Yong, C. Y., Ho, K. L., Mariatulqabtiah, A. R., & Tan, W. S. (2020) · Nanomaterials · doi:10.3390/nano10040787 · Cited by 430
Poly(2-oxazoline)s based biomaterials: a comprehensive and critical update
Lorson, T., Lübtow, M. M., Wegener, E., Haider, M. S., Borova, S., Nahm, D., Jordan, R., Sokolski-Papkov, M., Kabanov, A. V., & Luxenhofer, R. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.022 · Cited by 391
Self-citationCell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy
Dash, P., Piras, A. M., & Dash, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.012 · Cited by 267
The in vivo fate of polymeric micelles
Cai, Y., Qi, J., Lu, Y., He, H., & Wu, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114463 · Cited by 154
Metadata
- Authors
- Bludau, H., Czapar, A. E., Pitek, A. S., Shukla, S., Jordan, R., & Steinmetz, N. F.
- Affiliations
- Technische Universität Dresden (DE)
- Case Western Reserve University (US)
- Case Comprehensive Cancer Center (US)
- Corresponding author
- Jordan, Rainer
- Steinmetz, Nicole F.
- Venue
- European Polymer Journal
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 88
- Pages
- 679-688
- ISSN
- 0014-3057 (ISSN-L)
- PMC
- PMC5510027
- OpenAlex
- W2547204128
- Cited by
- 112
- References
- 47
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 8 · 2023: 15 · 2022: 13 · 2021: 7 · 2020: 16 · 2019: 14 · 2018: 10 · 2017: 6
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Polymer Journal (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R03 EB020602, T32 GM007250, TL1 TR000441)
- Case Western Reserve University
- Deutscher Akademischer Austauschdienst France
- National Science Foundation (CHE 1306447)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- poly(2-oxazoline), stealth coatings, anti-PEG antibodies, tobacco mosaic virus, drug delivery nanocarriers, molecular imaging
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